VEGF levels in asthmatic airways do not correlate with plasma extravasation

Clinical and Experimental Allergy

Volumn 29, Issue 10, 1999, Pages 1390-1394

  Demoly, P ^a   Maly, F E ^b   Mautino, G ^a   Grad, S ^b   Gougat, C ^a   Sahla, H ^a   Godard, P ^a   Bousquet, J ^a  

^a HÔPITAL ARNAUD DE VILLENEUVE   (France)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Asthma; BAL fluid; Chronic bronchitis; Vascular endothelial growth factor; Vascular inflammation; VEGF

Indexed keywords

ALBUMIN; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; IMMUNOGLOBULIN A; SALBUTAMOL; VASCULOTROPIN;

ADULT; AIRWAY; ARTICLE; ASTHMA; BLOOD VESSEL PERMEABILITY; CHRONIC BRONCHITIS; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; INFLAMMATION; INHALATIONAL DRUG ADMINISTRATION; LUNG LAVAGE; PRIORITY JOURNAL;

ADULT; AGED; ASTHMA; BRONCHITIS; BRONCHOALVEOLAR LAVAGE FLUID; CAPILLARY PERMEABILITY; CHRONIC DISEASE; ENDOTHELIAL GROWTH FACTORS; HUMANS; IMMUNOGLOBULIN A; LYMPHOKINES; MIDDLE AGED; SERUM ALBUMIN; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0032866552     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.1999.00544.x     Document Type: Article

References (23)

1. 1 Cotran R, Kumar V, Robin S. Inflammation and repair In: Cotran R, Kumar V, Robin S, eds. Robbins Pathologic Basis of Disease. Philadephia: W.B. Saunders, 1989:39-87.
2. 2 Kuwano K, Bosken CH, Pare PD, Bai TR, Wiggs BR, Hogg JC. Small airways dimensions in asthma and in chronic obstructive pulmonary disease. Am Rev Respir Dis 1993; 148:1220-5.
3. 3 Saetta M Di-Stefano A, Rosina C, Thiene G, Fabbri LM. Quantitative structural analysis of peripheral airways and arteries in sudden fatal asthma. Am Rev Respir Dis 1991; 143:138-43.
4. 4 Beck L Jr, D'Amore PA. Vascular development: cellular and molecular regulation. FASEB J 1997; 11:365-73.
5. 5 Keyt BA, Berleau LT, Nguyen HV et al. The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency. J Biol Chem 1996; 271:7788-95.
6. 6 Ito A, Hirota S, Mizuno H et al. Expression of vascular permeability factor (VPF/VEGF) messenger RNA by plasma cells: possible involvement in the development of edema in chronic inflammation. Pathol Int 1995; 45:715-20.
7. 7 Dvorak HF, Brown LF, Detmar M, Dvorak AM. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 1995; 146:1029-39.
8. 8 Maniscalco WM, Watkins RH, D'Angio CT, Ryan RM. Hyperoxic injury decreases alveolar epithelial cell expression of vascular endothelial growth factor (VEGF) in neonatal rabbit lung. Am J Respir Cell Mol Biol 1997; 16:557-67.
9. 9 Brown LF, Yeo K-T, Berse B et al. Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J Exp Med 1992; 176:1375-9.
10. 10 Brown LF, Olbricht SM, Berswe B et al. Overexpression of vascular permeability factor (VPF/VEGF) and its endothelial cell receptors in delayed hypersensitivity skin reactions. J Immunol 1995; 154:2801-7.
11. 11 Detmar M, Brown L, Claffey K et al. Overexpression of vascular permeability factor and its receptors in psoriasis. J Exp Med 1994; 180:1141-6.
12. 12 Fava R, Olsen N, Spencer-Green G et al. Vascular permeability factor/endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue. J Exp Med 1994; 180:341-6.
13. 13 Demoly P, Simony-Lafontaine J, Chanez P et al. Cell proliferation in the bronchial mucosa of asthmatics and chronic bronchities. Am J Respir Crit Care Med 1994; 150:214-7.
14. 14 Global strategy for asthma management and prevention. WHO/ NHLBI workshop report. In: National Institutes of Health, National Heart, Lung and Blood Institute, Publication Number 95-3659, 1995.
15. 15 Greiff L, Erjefalt I, Svensson C et al. Plasma exudation and solute absorption across the airway mucosa. Clin Physiol 1993; 13:219-33.
16. 16 Van-Vyve T, Chanez P, Bernard A et al. Protein content in bronchoalveolar lavage fluid of patients with asthma and control subjects. J Allergy Clin Immunol 1995; 95:60-8.
17. 17 Persson CG, Epithelial cells: barrier functions and shedding-restitution mechanisms. Am J Respir Crit Care Med 1996; 153:S9-10.
18. 18 Foster WM, Langenback EG, Bergofsky EH. Lung mucociliary function in man: interdependence of bronchial and tracheal mucus transport velocities with lung clearance in bronchial asthma and healthy subjects. Ann Occup Hyg 1982; 26:227-44.
19. 19 Horiuchi T, Weller PF. Expression of vascular endothelial growth factor by human eosinophils: Upregulation by Granulocyte Macrophage Colony-stimulating Factor and interleukin-5. Am J Respir Cell Mol Biol 1997; 17:70-7.
20. 20 Nauck M, Roth M, Tamm M et al. Induction of vascular endothelial growth factor by platelet-activating factor and platelet-derived growth factor is downregulated by corticosteroids. Am J Respir Cell Mol Biol 1997; 16:398-406.
21. 21 Boschetto P, Rogers DP, Fabbri LM, Barnes PJ. Corticosteroid inhibition of airways microvascular leakage. Am Rev Respir Dis 1991; 143:605-9.
22. 22 Li X, Wilson JW. Increased vascularity of the bronchial mucosa in mild asthma. Am J Respir Crit Care Med 1997; 156:229-33.
23. 23 Van de Graaf EA, Out TA, Roos CM, Jansen HM. Respiratory membrane permeability and bronchial hyperreactivity in patients with stable asthma. Effects of therapy with inhaled steroids. Am Rev Respir Dis 1991; 143:362-8.