Chemopreventive efficacy of low dose of pravastatin, an HMG-CoA reductase inhibitor, on 1, 2-dimethylhydrazine-induced colon carcinogenesis in ICR mice

Tohoku Journal of Experimental Medicine

Volumn 180, Issue 2, 1996, Pages 131-138

  Narisawa, Tomio ^a   Fukaura, Yoko ^a   Tanida, Noritoshi ^b   Hasebe, Makiko ^a   Ito, Michiko ^a   Aizawa, Rika ^a  

^a AKITA UNIVERSITY   (Japan)

^b HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Cancer prevention; Colon cancer; HMG CoA reductase; Pravastatin

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PRAVASTATIN;

ADENOCARCINOMA; ANIMAL EXPERIMENT; ARTICLE; CARCINOGENESIS; CHOLESTEROL BLOOD LEVEL; COLON CANCER; COLON MUCOSA; FEMALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; SQUAMOUS CELL CARCINOMA;

1,2-DIMETHYLHYDRAZINE; ADMINISTRATION, ORAL; ANIMALS; ANTICARCINOGENIC AGENTS; CARCINOGENS; COLONIC NEOPLASMS; DIMETHYLHYDRAZINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MICE; MICE, INBRED ICR; PRAVASTATIN; WATER SUPPLY;

EID: 0030498274     PISSN: 00408727     EISSN: None     Source Type: Journal    
DOI: 10.1620/tjem.180.131     Document Type: Article

References (24)

1. Casey, P.J., Solski, P.A., Der, C.J. & Buss, T.E. (1989) p 21 ras is modified by a farnesyl isoprenoid. Proc. Natl. Acad. Sci. USA, 86, 8323-8327.
2. Endo, A., Tsujita, Y., Kuroda, M. & Tanzawa, K. (1979) Effects of ML-236B on cholesterol metabolism in mice and rats: Lack of hypocholesterolemic activity in normal animals. Biochem. Biophys. Acta, 575, 266-276.
3. Fearon, E.R, & Vogelstein, B. (1990) A genetic model for colorectal tumorigenesis. Cell, 61, 759-767.
4. Goldstein, J.L. & Brown, M.S. (1990) Regulation of the mevalonate pathway. Nature, 343, 425-430.
5. Goldstein, J.L., Helgesen, J.A. & Brown, M.S. (1979) Inhibition of cholesterol synthesis with compactin renders growth of cultured cells dependent on the low density lipoprotein receptor. J. Biol. Chem., 254, 5403-5409.
6. Habenicht, A.J.R., Glomset, A.J. & Russell, R. (1980) Relation of cholesterol and mevalonic acid to the cell cycle in smooth muscle and Swiss 3T3 cells stimulated to divide by platelet-derived growth factor. J. Biol. Chem., 255, 5134-5140.
7. Jacoby, R.F., Llor, X., Teng, B.B., Davidson, N.O. & Brasitus, T.A. (1991) Mutations in the k-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa. J. Clin. Invest., 87, 624-630.
8. Kaneko, I., Hazama-Shimada, Y. & Endo, A. (1978) Inhibitory effects of lipid metabolism in cultured cells of ML-236B, a potent inhibitor of 3-hydroxy-3-methylgutaryl-coenzyme-A reductase. Eur. J. Biochem., 87, 313-321.
9. Kawata, S., Kakimoto, H., Ishiguro, H., Yamasaki, E., Inui, Y. &, Matsuzawa, Y. (1992) Effect of pravastatin, a potent 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitor, on survival of AH130 hepatoma-bearing rats. Jpn. J. Cancer Res., 83, 1120-1123.
10. Maltese, W.A., Defedini, R., Green, R.A., Sheridan, K.M. & Donley, D.K. (1985) Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J. Clin. Invest., 76, 1748-1754.
11. Narisawa, T., Fukaura, Y., Terada, K., Umezawa, A., Tanida, N., Yazawa, K. & Ishikawa, C. (1994) Prevention of 1,2-dimethylhydrazine-induced colon tumorigenesis by HMG-CoA reductase inhibitors, pravastatin and simvastatin, in ICR mice. Carcinogenesis, 15, 2045-2048.
12. Newman, A., Clutterbuck, R.D., Powles, R.L. & Millar, J.L. (1994) Selective inhibition of primary acute myeloid leukemia cell growth by lovastatin. Leukemia, 8, 274-280.
13. Pretlow, T.P., Brasitus, T.A., Fulton, N.C., Cheyer, C. & Kaplan, E.L. (1993) K-ras mutation in putative preneoplastic lesions in human colon. J. Natl. Cancer Inst., 85, 2004-2007.
14. Rudney, H. & Sexton, R.C. (1986) Regulation of cholesterol biosynthesis. Ann. Rev. Nutr., 6, 240-272.
15. Rush, R.J., Madhukar, B.V., Trosko, J.E. & Klaunig, L.E. (1993) Reversal of ras-induced inhibition of gap-junctinal intercellular communication, transformation, and tumorigenesis by lovastatin. Molec. Carcinogenesis, 7, 50-59.
16. Schafer, W.R., Kim, R., Sterne, R., Thorner, J., Kim, S.-H. & Rine, J. (1989) Genetic and pharmacological suppression of oncogenic mutations in ras genes of yeast and humans. Science, 245, 379-385.
17. Sebti, S.M., Thalcevic, G.T. & Jani, J.P. (1991) Lovastatin, a cholesterol biosynthesis inhibitor, inhibits the growth of human h-ras oneogene transformed cells in nude mice. Cancer Commun., 3, 141-147.
18. Soma, M.R., Baetta, R., Renzis, R., Mazzini, G., Davegna, C., Magrassi, L., Gutti, G., Pezzotta, S., Paoletti, R. & Fumagalli, R. (1995) In vivo enhanced antitumor activity of carmustin [N, N′-bis(2-chloroethyl)-N-nitrosourea] by simvastatin. Cancer, 55, 597-602.
19. Sumi, S., Beauchamp, R.D., Townsend, C.M., Jr., Uchida, T., Murakami, M., Rajaraman, S., Ishizuka, T. & Thompson, J.C. (1992) Inhibition of pancreatic adenocarcinoma cell growth of lovastatin. Gastroenterology, 103, 982-989.
20. Sumi, S., Beauchamp, R.D., Townsend, C.M., Jr., Pour, P.M., Ishizuka, J. & Thompson, J.C. (1994) Lovastatin inhibits pancreatic cancer growth regardless of ras mutation. Pancreas, 9, 657-661.
21. Tsujita, Y., Kuroda, M., Shimada, Y., Tanzawa, K., Arai, M., Kaneko, I., Tanaka, M., Masuda, H., Tarumi, C., Watanabe, Y. & Fujii, S. (1986) CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: Tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species. Biochem. Biophys. Acta, 877, 50-60.
22. Ura, H., Obara, T., Nishino, N., Tanno, S., Okumura, K. & Namiki, M. (1994) Cytotoxicity of simvastatin to pancreatic adenocarcinoma cells containing mutant ras gene. Jpn. J. Cancer Res., 85, 633-638.
23. Yamauchi, S., Linscheer, W. G. & Beach, D.H. (1991) Increase in serum and bile cholesterol and HMG-CoA reductase by lovastatin in rats. Am. J. Physiol., 260(G23), G625-630.
24. Zurkowski, P.A. (1964) A rapid method for cholesterol determination with a single agent. Clin. Chem., 10, 451-453.