YM337, a platelet glycoprotein IIb/IIIa antagonist, lessens photochemically-induced ischemic brain damage in monkeys

Drug Development Research

Volumn 47, Issue 4, 1999, Pages 162-169

  Kaku, Seiji ^a,b   Umemura, Kazuo ^a   Yano, Shinya ^a   Suzuki, Ken Ichi ^b   Kawasaki, Tomihisa ^b   Nakashima, Mitsuyoshi ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

Animal models; Cerebral ischemia; Humanized antibody; Middle cerebral artery

Indexed keywords

FIBRINOGEN RECEPTOR ANTAGONIST; OZAGREL; UNCLASSIFIED DRUG; YM 337;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING TIME; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG RECEPTOR BINDING; HISTOPATHOLOGY; INTRAVENOUS DRUG ADMINISTRATION; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; SQUIRREL MONKEY; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION INHIBITION;

EID: 0032855706     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2299(199908)47:4<162::AID-DDR2>3.0.CO;2-9     Document Type: Article

References (29)

1. Andersen LA, Gormsen J. 1977. Platelet aggregation and fibrinolytic activity in transient cerebral ischemia. Acta Neurol Scand 55:76-82.
2. Born GVR. 1990. Aspirin and platelets in relation to cerebrovascular disease. Stroke 21(12 suppl):IV29-IV31.
3. Chen ST, Hsu CY, Hogan EL, Maricq H, Balentine JD. 1986. A model of focal ischemic stroke in the rat: reproducible extensive cortical infarction. Stroke 17:738-743.
4. Co MS, Yano S, Hsu RK, Landolfi NF, Vasquez M, Cole M, Tso JT, Bringman T, Laird W, Hudson D, Kawamura K, Suzuki K, Furuichi K, Queen C, Masuho Y. 1994. A humanized antibody specific for platelet integrin gpIIb/IIIa. J Immunol 152:2968-2976.
5. Coller BS. 1992. Inhibitors of the platelet glycoprotein IIb/IIIa receptor as conjunctive therapy for coronary artery thrombolysis. Coron Artery Dis 3:1016-1029.
6. Coller BS, Scudder LE, Beer J, Gold HK, Foils JD, Cavagnaro J, Jordan R, Wagner C, Iuliucci J, Knight D, Ghrayeb J, Smith C, Weisman HF, Berger H. 1991. Monoclonal antibodies to platelet glycoprotein Ilb/IIIa as antithrombotic agents, Ann NY Acad Sci 614:193-213.
7. Couch JR, Hassanein RS. 1976. Platelet aggregation, stroke, and transient ischemic attack in middle-aged and elderly patients. Neurology 26:885-895.
8. Crowell RM, Olsson Y, Klatzo I, Ommaya A. 1970. Temporary occlusion of the middle cerebral artery in the monkey: clinical and pathological observations. Stroke 1:439-448.
9. Diener HC, Cunha L, Forbes C, Sivenius J, Smets P, Lowenthal A. 1996. European stroke prevention study. 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci 143:1-13.
10. Dougherty JH, Levy DE, Weksler BB. 1977. Platelet activation in acute cerebral ischemia: serial measurements of platelet function in cerebrovascular disease. Lancet 1:821-824.
11. Heye N, Cervos-Navarro J. 1996. Microthromboemboli in acute infarcts: analysis of 40 autopsy cases. Stroke 27:431-434.
12. Heye N, Campos A, Kannuki S, Cervos-Navarro J. 1991a. Effects of triflusal and acetylsalitilic acid on microthrombi formation in experimental brain ischaemia. Exp Pathol 41:31-36.
13. Heye N, Paetzold C, Cervos-Navarro Jl. 1991b. The role of microthrombi and microcirculatory factors in localization and evolution of focal cerebral ischemia. Neurosurg Rev 14:7-16.
14. Hudgins WR, Garcia JH. 1970. Transorbital approach to the middle cerebral artery of the squirrel monkey: a technique for experimental cerebral infarction applicable to ultrastructural studies. Stroke 1:107-111.
15. Kaku S, Kawasaki T, Hisamichi N, Sakai Y, Taniuchi Y, Inagaki O, Yano S, Suzuki K, Terazaki C, Masuho Y, Satoh N, Takenaka T, Yanagi K, Ohshima N. 1996. Antiplatelet and antithrombotic effects of YM337, the Fab fragment of a humanized anti-GPIIb/ IIIa monoclonal antibody in monkeys. Thromb Haemost 75: 679-684.
16. Kaku S, Umemura K, Mizuno A, Kawasaki T, Nakashima M. 1997. Evaluation of the disintegrin, triflavin, in a rat middle cerebral artery thrombosis model. Eur J Pharmacol 321:301-305.
17. Kaku S, Umemura K, Mizuno A, Yano S, Suzuki K, Kawasaki T, Nakashima M. 1998. Evaluation of a GPIIb/IIIa antagonist YM337 in a primate model of middle cerebral artery thrombosis. Eur J Pharmacol 345:185-192.
18. Kawai H, Nakai H, Suga M, Yuki S, Watanabe T, Saito K. 1997. Effects of a novel free radical scavenger, MCI-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model. J Pharmacol Exp Ther 281:921-927.
19. Korves M, Cervos-Navarro J. 1993. Microthrombi formation focal brain ischemia using Fischer 344 rats: influence of triflusal. Methods Find Exp Clin Pharmacol 15:721-727.
20. Matsuno H, Uematsu T, Umemura K, Takiguchi Y, Asai Y, Muranaka Y, Nakashima M. 1993. A simple and reproducible cerebral thrombosis model in rats induced by a photochemical reaction and the effect of a plasminogen-plasminogen activator chimera in this model. J Pharmacol Toxicol Methods 29:165-173.
21. Naito J, Komatsu H, Ujiie A, Hamano S, Kubota T, Tsuboshima M. 1983. Effects of thromboxane synthetase inhibitors on aggregation of rabbit platelet. Eur J Pharmacol 91:41-48.
22. Phillips DR, Charo IF, Parise LV, Fitzgerald LA. 1988. The platelet membrane glycoprotein IIb-IIIa complex. Blood 71:831-843.
23. Plow EF, Ginsberg MH. 1988. Cellular adhesion: GPIIb/IIIa as a prototypic adhesion receptor. Prog Hemost Thromb 9:117-56.
24. Rothrock JF, Hart RG. 1991. Antithrombotic therapy in cerebrovascular disease. Ann Intern Med 115:885-895.
25. Uchiyama S, Yamazaki M, Maruyama S, Handa M, Ikeda Y, Fukuyama M, Itagaki I. 1994. Shear-induced platelet aggregation in cerebral ischemia. Stroke 25:1547-1551.
26. 2 receptor antagonist, vapiprost, in a rat middle cerebral artery thrombosis model. Stroke 24:1077-1082.
27. Vicari AM, Giusti MC, Luoni R, Macagni A, Medaglini S, Seveso MP, Franceschi M. 1987. Platelet function and thrombin activity in patients with recent cerebral transient ischemic attacks. Stroke 18:892-895.
28. Wallace RC, Furlan AJ, Moliterno DJ, Stevens GH, Masary TJ, Perl J II. 1997. Basilar artery rethrombosis: succesful treatment with platelet glyeoprotein IIb/IIIa receptor inhibitor. Am J Neuroradiol 18:1257-1260.
29. 3. J Biochem 116:778-786.