Urinary metabolites of a novel quinoxaline non-nucleoside reverse transcriptase inhibitor in dog, cynomolgus monkey and mini-pig

Xenobiotica

Volumn 29, Issue 9, 1999, Pages 957-967

  Ismail, I M ^a   Dear, G J ^a   Mutch, P J ^a   Davies, L H ^a   Plumb, R S ^a   Sweatman, B C ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 ETHYL 6 FLUORO 4 ISOPROPOXYCARBONYL 3,4 DIHYDRO QUINOXALIN 2(1H) ONE; GLUCURONIC ACID; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; DOG; DRUG CONJUGATION; DRUG GLUCURONIDATION; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG TRANSFORMATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MONKEY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORAL DRUG ADMINISTRATION; PROTON NUCLEAR MAGNETIC RESONANCE; SWINE; URINARY EXCRETION;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; MACACA FASCICULARIS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MOLECULAR STRUCTURE; QUINOXALINES; REVERSE TRANSCRIPTASE INHIBITORS; SPECIES SPECIFICITY; SWINE;

EID: 0032854392     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/004982599238191     Document Type: Article

References (12)

1. BURTON, K. I., EVERETT, J. R., NEWMAN, M. J., PULLEN, F. S., RICHARDS, D. S. and SWANSON, A. G., 1997, On-line liquid chromatography coupled with high field NMR and mass spectrometry (LC-NMR-MS): a new technique for drug metabolite structure elucidation. Journal of Pharmaceutical and Biomedical Analysis, 15, 1903-1912.
2. DEAR, G. J., AYRTON, J., PLUMH, R., SWEATMAN, B. C., ISMAIL, I. M., ERASER, I. J. and MUTCH, P. J., 1998b, A rapid and efficient approach to metabolite identification using nuclear magnetic resonance spectroscopy, liquid chromatography/mass spectrometry and liquid chromatography/nuclear magnetic resonance spectroscopy/sequential mass spectrometry. Rapid Communications in Mass Spectrometry, 12, 2023-2030.
3. DEAR, G. J., FRASER, I. J., PATEL, D. K., LONG, J. and PLEASANCE, S., 1998a, Use of liquid chromatography-tandem mass spectrometry for the quantitative and qualitative analysis of an antipsychotic agent and its metabolites in human plasma and urine. Journal of Chromatography A, 794, 27-36.
4. DEAR, G. J., HARRELSON, J. C., JONES, A. E., JOHNSON, T. E. and PLEASANCE, S., 1995, Identification of urinary and biliary conjugated metabolites of the neuromuscular blocker 51W89 by liquid chromatography/mass spectrometry. Rapid Communications in Mass Spectometry, 9, 1457-1464.
5. 19F NMR spectroscopy study of the metabolism of flucloxacillin in rat urine. Journal of Pharmacy and Pharmacology, 37, 869-873.
6. HOLT, R. M., NEWMAN, M. J., PULLEN, F. S., RICHARDS, D. S. and SWANSON, A. G., 1997, High-performance liquid chromatography/NMR spectrometry/mass spectrometry: further advances in hyphenated technology. Journal of Mass Spectrometry, 32, 64-70.
7. LINDON, J. C., NICHOLSON, J. K., SIDELMANN, U. G. and WILSON, I. D., 1997, Directly coupled HPLC-NMR and its application to drug metabolism. Drug Metabolism Reviews, 29, 705-746.
8. NICHOLSON, J. K. and WILSON, I. D., 1989, High resolution proton magnetic resonance spectroscopy of biological fluids. Progress in NMR Spectroscopy, 21, 449-501.
9. PULLEN, F. S., SWANSON, A. G., NEWMAN, M. J. and RICHARDS, D.S., 1995, 'On-line' liquid chromatography/nuclear magnetic resonance mass spectrometry a powerful spectroscopic tool for the analysis of mixtures of pharmaceutical interest. Rapid Communications in Mass Spectrometry, 9, 1003-1006.
10. 1H NMR spectroscopy for drug metabolite detection and characterization: the identification of paracetamol metabolites in urine and bile. NMR in Biomedicine, 7, 295-303.
11. 19F nuclear magnetic resonance. Drug Metabolism and Disposition, 15, 718-724.
12. 19F studies of the metabolism of trifluoro methylaniline. In E. Reid, J. D. Robinson and I. D. Wilson (eds), Bioanalysis of Drug Metabolites (London: Plenum).