The mechanics of exaggerated airway narrowing in asthma: The role of smooth muscle

Respiration Physiology

Volumn 118, Issue 1, 1999, Pages 1-13

  King, Gregory G ^a   Paré, Peter D ^a   Seow, Chun Y ^b  

^a The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Airways, narrowing, asthma; Disease, asthma; Mammals, humans; Smooth muscle, airways, airway narrowing

Indexed keywords

ACTIN MYOSIN INTERACTION; ASTHMA; BRONCHUS MUSCLE; FUNCTIONAL RESIDUAL CAPACITY; HUMAN; LUNG FLOW VOLUME CURVE; LUNG MECHANICS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SMOOTH MUSCLE CONTRACTILITY;

EID: 0032853363     PISSN: 00345687     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0034-5687(99)00076-6     Document Type: Article

References (87)

1. Antonissen L.A., Mitchell R.W., Kroeger E.A., Kepron W., Tse K.S., Stephens N.L. Mechanical alterations of airway smooth muscle in a canine asthmatic model. J. Appl. Physiol. 46:1979;681-687.
2. Bai T.R. Abnormalities in airway smooth muscle in fatal asthma: a comparison between trachea and bronchus. Am. Rev. Respir. Dis. 143:1991;441-443.
3. Berry R.B., Fairshter R.D. Partial and maximal expiratory flow-volume curves in normal and asthmatic subjects before and after inhalation of metaproterenol. Chest. 88:1985;697-702.
4. Brusasco V., Pellegrino R., Violante B., Crimi E. Relationship between quasi-static pulmonary hysteresis and maximal airway narrowing in humans. . J. Appl. Physiol. 72:1992;2075-2080.
5. Burns C.B., Taylor W.R., Ingram Jr R.H. Effects of deep inhalation in asthma: relative airway and parenchymal hysteresis. J. Appl. Physiol. 59:1985;1590-1596.
6. Carroll N., Elliot J., Morton A., James A. The structure of large and small airways in nonfatal and fatal asthma. Am. Rev. Respir. Dis. 147:1993;405-410.
7. Chan-Yeung M., Vedal S., Kus J., MacLean L., Enarson D., Tse K.S. Symptoms, pulmonary function, and bronchial hyperreactivity in western red cedar workers compared with those in office workers. Am. Rev. Respir. Dis. 130:1984;1038-1041.
8. Chan-Yeung M., MacLean L., Paggiaro P.L. Follow-up study of 232 patients with occupational asthma caused by western red cedar(Thuja plicata). J. Allergy Clin. Immunol. 79:1987;792-796.
9. Cockcroft D.W. Acquired persistent increase in nonspecific bronchial, reactivity associated with isocyanate exposure. Ann. Allergy. 48:1982;93-95.
10. Cockcroft D.W. The bronchial late response in the pathogenesis of asthma and its modulation by therapy. Ann. Allergy. 55:1985;857-862.
11. Colebatch H.J., Finucane K.E., Smith M.M. Pulmonary conductance and elastic recoil relationships in asthma and emphysema. J. Appl. Physiol. 34:1973;143-153.
12. de Jongste J.C., Mons H., Bonta I.L., Kerrebijn K.F. In vitro responses of airways from an asthmatic patient. Europ. J. Resp. Dis. 71:1987;23-29.
13. Dillon P.F., Aksoy M.O., Driska S.P., Murphy R.A. Myosin phosphorylation and the cross-bridge cycle in arterial smooth muscle. Science. 211:1981;495-497.
14. Ebina M., Yaegashi H., Chiba R., Takahashi T., Motomiya M., Tanemura M. Hyperreactive site in the airway tree of asthmatic patients revealed by thickening of bronchial muscles. Am. Rev. Respir. Dis. 141:1990;1327-1332.
15. Ebina M, Takahashi T, Chiba T Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma. A 3-D morphometric study. Am. Rev. Respir. Dis. 48:1993;720-726.
16. Fairshter R.D., Carilli A., Soriano A., Lin J., Pai U. The MVV/FEV1 ratio in normal and asthmatic subjects. Chest. 95:1989;76-81.
17. Fan T., Yang M., Halayko A., Mohapatra S.S., Stephens N.L. Airway responsiveness in two inbred strains of mouse disparate in IgE and IL-4 production. Am. J. Respir. Cell Mol. Biol. 17:1997;156-163.
18. Fay F.S., Hoffman R., Leclair S., Merriam P. Preparation of individual smooth muscle cells from the stomach of Bufo Marinus. Methods Enzymol. 85:1982;284-292.
19. Fish J., Peterman V., Cugell D. Effect of deep inspiration on airway conductance in subjects with allergic rhinitis and allergic asthma. J. Allergy Clin. Immunol. 60:1977;41-46.
20. Fish J., Kehoe T., Cugell D. Effect of deep inspiration on maximum expiratory flow rates in asthmatic subjects. Respiration. 36:1978;57-63.
21. Fish J.E., Ankin M.G., Kelly J.F., Peterman V.I. Regulation of bronchomotor tone by lung inflation in asthmatic and nonasthmatic subjects. J. Appl. Physiol. Respirat. Environ. Exercise Physiol. 50:1981;1079-1086.
22. Ford L.E., Seow C.Y., Pratusevich V.R. Plasticity in smooth muscle, a hypothesis. Can. J. Physiol. Pharmacol. 72:1994;1320-1324.
23. Fredberg J., Jones K., Nathan M., Raboudi S., Prakash Y., Shore S., Butler J., Butler S.G. Friction in airway smooth muscle: mechanism, latch and implications in asthma. J. Appl. Physiol. 81:1996;2704-2712.
24. Fredberg J.J., Inouye D., Miller B., Nathan M., Jafari S., Raboudi S.H., Butler J.P., Shore S.A. Airway smooth muscle, tidal stretches, and dynamically determined contractile states. Am. J. Respir. Crit. Care Med. 156:1997;1752-1759.
25. Fredberg J.J., Inouye D.S., Mijailovich M., Butler J.P. Perturbed equilbrium of myosin binding in airway smooth muscle and its implications in bronchspasm. Am. J. Respir. Crit. Care Med. 159:1999;959-967.
26. Gordon A.M., Huxley A.F., Julian F.J. The variation of isometric tension with sarcomere length in vertebrate muslce fibers. J. Physiol. Lond. 184:1966;170-192.
27. Gunst S.J., Mitzner W. Mechanical properties of contracted canine bronchial segments in vitro. J. Appl. Physiol. 50:1981;1236-1247.
28. Gunst S.J. Contractile force of canine airway smooth muscle during cyclical length changes. J. Appl. Physiol.: Respiratory: Environ. Exercise Physiol. 55:1983;759-769.
29. Gunst S.J., Warner D.O., Wilson T.A., Hyatt R.E. Parenchymal interdependence and airway response to methacholine in excised dog lobes. J. Appl. Physiol. 65:1988;2490-2497.
30. Gunst S.J., Stropp J.Q., Service J. Mechanical modulation of pressure-volume characteristics of contracted canine airways in vitro. J. Appl. Physiol. 68:1990;2223-2229.
31. Gunst S.J., Meiss R.A., Wu M.F., Rowe M. Mechanisms for the mechanical plasticity of tracheal smooth muscle. Am. J. Physiol. 268:1995;C1267-1276.
32. Hai C.M., Murphy R.A. Cross-bridge phosphorylation and regulation of latch state in smooth muscle. Am. J. Physiol. 254:1988;C99-106.
33. Hai C.M., Murphy R.A. Regulation of shortening velocity by cross-bridge phosphorylation in smooth muscle. Am. J. Physiol. 255:1988;C86-94.
34. Halayko A.J., Rector E., Stephens N.L. Airway smooth muscle cell proliferation: characterization of subpopulations by sensitivity to heparin inhibition. Am. J. Physiol. 274:1998;L17-25.
35. Halayko A.J., Stephens N.L. Potential role for phenotypic modulation of bronchial smooth muscle cells in chronic asthma. Can. J. Physiol. Pharmacol. 72:1994;1448-1457.
36. Harris D.E., Warshaw D.M. Length vs. active force relationship in single isolated smooth muscle cells. Am. J. Physiol. 260:1991;C1104-1112.
37. Huxley A. Muscle structure and theories of contraction. Progress Biophys. Biophys. Chem. 7:1957;255-318.
38. James A.L., Paré P.D., Hogg J.C. The mechanics of airway narrowing in asthma. Am. Rev. Respir. Dis. 139:1989;242-246.
39. Jiang H., Rao K., Liu X., Halayko A.J., Liu G. Early changes in airway smooth muscle hyperresponsiveness. Can. J. Physiol. Pharmacol. 72:1997;1440-1447.
40. King, G., Moore, B., Seow, S. and Paré, P., 1999. Time course of increased airway narrowing caused by inhibition of deep inspiration during methacholine challenge. Am. J. Respir. Crit. Care Med. (in press).
41. Kuwano K., Bosken C.H., Paré P.D., Bai T.R., Wiggs B.R., Hogg J.C. Small airways dimensions in asthma and in chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 148:1993;1220-1225.
42. Lambert R.K., Wiggs B.R., Kuwano K., Hogg J.C., Paré P.D. Functional significance of increased airway smooth muscle in asthma and COPD. J. Appl. Physiol. 74:1993;2771-2781.
43. Lambert R.K., Paré P.D. Lung parenchymal shear modulus, airway wall remodeling, and bronchial hyperresponsiveness. J. Appl. Physiol. 83:1997;140-147.
44. Li W., Stephens N.L. Auxotonic loading and airway smooth muscle shortening. Can. J. Physiol. Pharmacol. 72:1994;1458-1463.
45. Lim T.K., Pride N.B., Ingram Jr J.R. Effects of volume history during spontaneous and acutely induced air-flow obstruction in asthma. Am. Rev. Respir. Dis. 135:1987;591-596.
46. Lim T.K., Pride N.B., Ingram J.R.J. Effects of volume history during spontaneous and acutely induced air-flow obstruction in asthma. Am. Rev. Respir. Dis. 135:1987;591-596.
47. Macklem P.T. Mechanical factors determining maximum bronchoconstriction. Europ. Respir. J. Suppl. 6:1989;516s-519.
48. Macklem P.T. A theoretical analysis of the effect of airway smooth muscle load on airway narrowing. Am. J. Respir. Crit. Care Med. 153:1996;83-89.
49. Marthan R., Woolcock A.J. Is a myogenic response involved in deep inspiration-induced bronchoconstriction in asthmatics? Am. Rev. Respir. Dis. 140:1989;1354-1358.
50. McCully K.K., Faulkner J.A. Length-tension relationship of mammalian diaphragm muscles. J. Appl. Physiol. 54:1983;1681-1686.
51. Meiss R.A. Influence of intercellular tissue connections on airway muscle mechanics. J. Appl. Physiol. 86:1999;5-15.
52. Moore B.J., Verburgt L.M., King G.G., Paré P.D. The effect of deep inspiration on methacholine dose-response curves in normal subjects. Am. J. Respir. Crit. Care Med. 156:1997;1278-1281.
53. Moreno R.H., Hogg J.C., Paré P.D. Mechanics of airway narrowing. Am. Rev. Respir. Dis. 133:1986;1171-1180.
54. Mulvany M.J., Warshaw D.M. The active tension-length curve of vascular smooth muscle related to its cellular components. J. Gen. Physiol. 74:1979;85-104.
55. Nadel J.A., Tierney D.F. Effect of a previous deep inspiration on airway resistance in man. J. Appl. Physiol. 16:1966;717-719.
56. O'Byrne P.M. Allergen-induced airway hyperresponsiveness. J. Allergy Clin. Immunol. 81:1988;119-127.
57. Okazawa M., Ishida K., Road J., Schellenberg R.R., Paré P.D. In vivo and in vitro correlation of trachealis muscle contraction in dogs. J. Appl. Physiol. 73:1992;1486-1493.
58. Okazawa M., Bai T.R., Wiggs B.R., Paré P.D. Airway smooth muscle shortening in excised canine lung lobes. J. Appl. Physiol. 74:1993;1613-1621.
59. Okazawa M., Vedal S., Verburgt L., Lambert R.K., Paré P.D. Determinants of airway smooth muscle shortening in excised canine lobes. J. Appl. Physiol. 78:1995;608-614.
60. Orehek J., Charpin D., Velardocchio J.M., Grimaud C. Bronchomotor effect of bronchoconstriction-induced deep inspirations in asthmatics. Am. Rev. Respir. Dis. 121:1980;297-305.
61. Paré P.D., Bai T.R., Roberts C.R. The structural and functional consequences of chronic allergic inflammation of the airways. Ciba Foundation Symposium, 206. 71-86; Discussion. 86-89:1997;106-110.
62. Paré P.D., Roberts C.R., Bai T.R., Wiggs B.J. The functional consequences of airway remodeling in asthma. Monaldi Archiv. Chest Dis. 52:1997;589-596.
63. Parham W.M., Shepard R.H., Norman P.S., Fish J.E. Analysis of time course and magnitude of lung inflation effects on airway tone: relation to airway reactivity. Am. Rev. Respir. Dis. 128:1983;240-245.
64. Pavalko F., Adam L., Wu M., Walker T., Gunst S. Phosphorylation of dense-plaque proteins talin and paxillin during tracheal smooth muscle contraction. Am. J. Physiol. 268:1995;C563-571.
65. Pellegrino R., Violante B., Brusasco V. Maximal bronchoconstriction in humans. Relationship to deep inhalation and airway sensitivity. Am. J. Respir. Crit. Care Med. 153:1996;115-121.
66. Pliss L., Ingenito E., Ingram R.J. Responsiveness, inflammation, and effects of deep breaths on obstruction in mild asthma. J. Appl. Physiol. 66:1989;2298-2304.
67. Pratusevich V.R., Seow C.Y., Ford L.E. Plasticity in canine airway smooth muscle. J. Gen. Physiol. 105:1995a;73-94.
68. Pratusevich V.R., Seow C.Y., Ford L.E. A series-to-parallel transition during the rise of activation of smooth muscle. Biophys. J. 68:1995b;A16.
69. Rack P.M.H., Westbury D.R. The effect of length and stimulus rate on tension in the isometric cat soleus muscle. J. Physiol. (London). 204:1969;443.
70. Schellenberg R.R., Foster A. In vitro responses of human asthmatic airway and pulmonary vascular smooth muscle. Int. Archs. Allergy Appl. Immun. 75:1984;237-241.
71. Seow C.Y., Stephens N.L. Changes of tracheal smooth muscle stiffness during an isotonic contraction. Am. J. Physiol. 256:1989;C341-C350.
72. Shen X., Gunst S.J., Tepper R.S. Effect of tidal volume and frequency on airway responsiveness in mechanically ventilated rabbits. J. Appl. Physiol. 83:1997a;1202-1208.
73. Shen X., Wu M.F., Tepper R.S., Gunst S.J. Mechanisms for the mechanical response of airway smooth muscle to length oscillation. J. Appl. Physiol. 83:1997b;731-738.
74. Skloot G., Permutt S., Togias A. Airway hyperresponsiveness in asthma: a problem of limited smooth muscle relaxation. J. Clin. Invest. 96:1995;2393-2403.
75. Stephens N.L., Van Niekerk W. Isometric and isotonic contractions in airway smooth muscle. Can. J. Physiol. Pharmacol. 55:1977;833-838.
76. Stephens N.L., Kagan M.L., Packer C.S. Time dependence of shortening velocity in tracheal smooth muscle. Am. J. Physiol. 251:1986;C435-442.
77. Stephens N.L., Kong S.K., Seow C.Y. Mechanisms of increased shortening of sensitized airway smooth muscle. Prog. Clin. Biol. Res. 263:1988;231-254.
78. Sterk P.J., Bel E.H. Bronchial hyperresponsiveness: The need for a distinction between hypersensivity and excessive airway narrowing. Eur Respir J. 2:1989;267-274.
79. Sterk P.J., Daniel E.E., Zamel N., Hargreave F.E. Limited bronchoconstriction to methacholine using partial flow-volume curves in nonasthmatic subjects. Am. Rev. Respir. Dis. 132:1985;272-277.
80. Uvelius B. Isometric and isotonic length-tension relations and variations in cell length in longitudinal smooth muscle from rabbit urinary bladder. Acta Physiol. Scand. 97:1976;1-12.
81. Wang Y., Thompson L., Ingenito E., Ingram R.J. Effects of increasing doses of beta-agonists on airway and parenchymal hysteresis. J. Appl. Physiol. 68:1990;363-368.
82. Wheatley J.R., Paré P.D., Engel L.A. Reversibility of induced bronchoconstriction by deep inspiration in asthmatic and normal subjects. Eur. Respir. J. 2:1989;331-339.
83. Wiggs B.R., Bosken C., Paré P.D., James A., Hogg J.C. A model of airway narrowing in asthma and in chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 145:1992;1251-1258.
84. Wiggs B., Hrousis C., Drazen J., Kamm R. On the mechanism of mucosal folding in normal and asthmatic airways. J. Appl. Physiol. 83:1997;1814-1821.
85. Wilson J.W., Li X., Pain M. The lack of distensibility of asthmatic airways. Am. Rev. Respir. Dis. 148:1993;806-809.
86. Woolcock A.J., Salome C.M., Yan K. The shape of the dose-response curve to histamine in asthmatic and normal subjects. Am. Rev. Respir. Dis. 130:1984;71-75.
87. Xu J.Q., Gillis J.M., Craig R. Polymerization of myosin on activation of rat anococcygeus smooth muscle. J. Muscle Res. Cell Motil. 18:1997;381-393.