Effect of phenylacetic acid feeding on the process of cellular autolysis in submerged batch cultures of Penicillium chrysogenum

Journal of Biotechnology

Volumn 75, Issue 2-3, 1999, Pages 173-185

  White, Stewart ^a   Berry, David R ^b   McNeil, Brian ^b  

^a Davidson Bldg Inst Biomed L   (United Kingdom)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Autolysis; Image analysis; Morphology; Phenylacetic acid

Indexed keywords

ACETIC ACID; ANTIBIOTICS; BIOMASS; BIOSYNTHESIS; COMPUTER AIDED ANALYSIS; GROWTH KINETICS; IMAGE ANALYSIS; MORPHOLOGY; TOXICITY;

CELLULAR AUTOLYSIS; PENICILLIUM CHRYSOGENUM; PHENYLACETIC ACID FEEDING;

BATCH CELL CULTURE;

PENICILLIN DERIVATIVE; PHENYLACETIC ACID;

ARTICLE; AUTOLYSIS; BIOREACTOR; DRUG SYNTHESIS; FUNGUS CULTURE; NONHUMAN; PENICILLIUM CHRYSOGENUM; PRIORITY JOURNAL;

BACTERIOLYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; FERMENTATION; PENICILLIUM CHRYSOGENUM; PHENYLACETATES;

EID: 0032852025     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1656(99)00158-3     Document Type: Article

References (49)

1. Alfonso C., Cribiero L., Reyes F. Penicillin amidohydrolases in fungal autolysis. Microbiol. Immunol. 33:1989;69-74.
2. Brakhage A.A. Molecular regulation of β-lactam biosynthesis in filamentous fungi. Microbiol. Mol. Biol. Rev. 62:1998;547-585.
3. Bundgaard H., Ilver K. A new spectrophometric method for the determination of penicillins. J. Pharm. Pharmac. 24:1972;790-794.
4. Burton, S.A.Q., Watson-Craik, I.A. Nitrogen balances in landfills. Department of the environment contractor report. Report No. CWM A1256/97. Waste Management Information Bureau. Abingdon, Oxfordshire, UK 1997.
5. Christensen L.H., Mandrup G., Nielsen J., Villadsen J. A robust liquid chromatographic method for measurement of medium components during penicillin fermentations. Anal. Chem. Acta. 296:1994;51-62.
6. Christensen L.H., Neilsen J., Villadsen J. Degradation of penicillin V in fermentation media. Biotech. Bioeng. 44:1994;165-169.
7. Cronenberg C.C.H., Ottengraf S.P.P., Vand Den Heunz J.C., Pottel F., Sziele D., Schügerl K., Bellgardt K.H. Influence of age and structure of Penicillium chrysogenum pellets on the internal concentration profiles. Bioproc. Eng. 10:1994;209-216.
8. Cui Y.Q., Ouwehand J.N.W., van der Lans R.G.J.M., Giuseppin M.L.F., Luyben K.C.A.M. Aspects of the use of complex media for submerged fermentation of Aspergillus awamori. Enzyme Microb. Technol. 23:1998;168-177.
9. Cui Y.Q., van der Lans R.G.J.M., Giuseppin M.L.F., Luyben K.C.A.M. Influence of fermentation conditions and scale on the submerged fermentation of Aspergillus awamori. Enzyme Microb. Technol. 23:1998;157-167.
10. Cui Y.Q., Okkerse W.J., van der Lans R.G.J.M., Luyben K.C.A.M. Modeling and measurements of fungal growth and morphology in submerged fermentations. Biotech. Bioeng. 60:1998;216-229.
11. Dubios M., Gilles K.A., Hamilton J.K., Rebers P.A., Smith F. Colorimetric method for determination of sugars and related substances. Anal. Chem. 28:1956;350-356.
12. Eriksen S.H., Soderblom T.B., Jensen B., Olsen J. Uptake of phenylacetic acid by two strains of Penicillium chrysogenum. Biotech. Bioeng. 60:1998;310-316.
13. Fencl Z. Cell ageing and autolysis. Smith J.E., Berry D.R. The Filamentous Fungi III. 1974;389-405 Edward Arnold, New York.
14. Fernandez-Canon J.M., Reglero A., Martinez-Blanco H., Luengo J.M. I. Uptake of phenylacetic acid by Penicillium chrysogenum WIS 54-1255: a critical regulatory point in benzylpenicillin biosynthesis. J. Antibiot. 43:1989;1398-1409.
15. Harvey L.M., McNeil B., Berry D.R., White S. Autolysis in batch cultures of Penicillium chrysogenum at varying agitation rates. Enzyme Microb. Technol. 22:1998;448-458.
16. Henriksen C.M., Nielsen J., Villadsen J. High exogenous concentrations of phenoxyacetic acid are crucial for a high penicillin V productivity in Penicillium chrysogenum. Microbiology. 144:1998;2001-2006.
17. Hernawan T., Fleet G. Chemical and cytological changes during the autolysis of yeasts. J. Ind. Microbiol. 14:1995;440-450.
18. Hersbach G.J.M., Van Der Beek C.P., Van Dijck P.W.M. The penicillins: properties, biosynthesis and fermentation. Vandamme E.J. Drugs and the Pharmaceutical Sciences (22), Biotechnology of Industrial Antibiotics. 1984;45-140 Marcel Dekker, New York.
19. Justen P., Paul G.C., Nienow A.W., Thomas C.R. A mathematical model for agitation-induced fragmentation of Penicillium chrysogenum. Bioproc. Eng. 18:1998;7-16.
20. Konig B., Seewald C., Schugerl K. Process engineering investigations of penicillin production. Eur. J. Appl. Microbiol. Biotechnol. 12:1981;205-211.
21. Krabben P., Nielsen J. Modelling the mycelium morphology of Penicillium species in submerged cultures. Adv. Biochem. Eng. Biotech. 60:1998;125-152.
22. Lahoz R., Reyes F., Perez-Leblic M.I. Lytic enzymes in the autolysis of filamentous fungi. Mycopathologia. 60:1976;45-49.
23. Luengo J.M. Enzymatic synthesis of hydrophobic penicillins. J. Antibiot. 48:1995;1195-1212.
24. Makagiansar H.Y., Shamlou A.P., Thomas C.R., Lilly M.D. The influence of mechanical forces on the morphology and penicillin production of Penicillium chrysogenum. Bioproc. Eng. 9:1993;83-90.
25. McNeil B., Berry D.R., Harvey L.M., Grant A., White S. Measurement of autolysis in submerged batch cultures of Penicillium chrysogenum. Biotech. Bioeng. 57:1998;297-305.
26. Moyer, Coghill The effect of phenylacetic acid on penicillin production. J. Bacteriol. 53:1947;329-341.
27. Nielsen J. Physiological engineering aspects of Penicillium chrysogenum. DSc. Technical University of Denmark, Lyngby, Denmark 1994.
28. Nielsen J., Krabben P. Hyphal growth and fragmentation of Penicillium chrysogenum in submerged cultures. Biotech. Bioeng. 46:1995;588-598.
29. Paul G.C., Thomas C.R. A structured model for hyphal differentiation and penicillin production using Penicillium chrysogenum. Biotech. Bioeng. 51:1996;558-572.
30. Paul G.C., Thomas C.R. Characterisation of mycelial morphology using image analysis. Adv. Biochem. Eng. Biotechnol. 60:1998;1-59.
31. Paul G.C., Kent C.A., Thomas C.R. Hyphal vacuolation and fragmentation in Penicillium chrysogenum. Biotech. Bioeng. 44:1994;655-660.
32. Pusztahelyi T., Pócsi I., Kozma J., Szentirmai A. Ageing of Penicillium chrysogenum cultures under carbon starvation: I morphological changes and secondary metabolite production. Biotechnol. Appl. Biochem. 25:1997;81-86.
33. Pusztahelyi T., Pócsi I., Szentirmai A. Ageing of Penicillium chrysogenum cultures under carbon starvation: II protease and N-acetyl-β-D-hexosaminidase production. Biotechnol. Appl. Biochem. 25:1997;87-93.
34. Reyes F., Lahoz R., Moreno A.V. Synthesis of 1,3-β-glucanase and β-N-acetylglucosaminidase during autolysis of Neurospora crassa. J. Gen. Microbiol. 126:1981;347-353.
35. Reyes F., Martinez J., Alfonso C., Copa-Patiño J.L., Soliveri J. Cephalosporin C acylase in the autolysis of filamentous fungi. J. Pharm. Pharmacol. 42:1990;128-131.
36. Reyes F., Calatayud J., Vazquez C., Martinez M.J. N-acetylglucosaminidase from Aspergillus nidulans which degrades chitin oligomers during autolysis. FEMS Microbiol. Lett. 65:1989;83-88.
37. Riemay K.H., Troger R. Autolysis in fungi. I Autolysis in coprinus and fungal cultures. Z. Allg. Mikrob. 18:1978;523-540.
38. Riemay K.H., Troger R. Autolysis in fungi. II Autolytic degradation of carbohydrates, proteins and nucleic acids. Z. Allg. Mikrob. 18:1978;617-625.
39. Righelato R.C., Trinci A.P.J., Pirt S.J. The influence of maintenance energy and growth rate on the metabolic activity, morphology and conidation of Penicillium chrysogenum. J. Gen. Microbiol. 50:1968;399-412.
40. 14C-L-aspartic acid. J. Basic Microbiol. 26:1986;475-482.
41. Santamaria F., Reyes F. Proteases produced during autolysis of filamentous fungi. Trans. Br. Mycol. Soc. 91:1988;217-220.
42. Schugerl K., Gerlach S.R., Siedenberg D. Influence of the process parameters on the morphology and enzyme production of Aspergilli. Adv. Biochem. Eng. Biotech. 60:1998;195-270.
43. Shamlou P.A., Makagriansar H.Y., Ison A.P., Lilly M.D., Thomas C.R. Turbulent breakage of filamentous microorganisms in submerged culture in mechanically stirred bioreactors. Chem. Eng. Sci. 49:1994;2621-2631.
44. Slaughter C., Nomura T. Activity of the vacuolar proteases of yeast and the significance of the cytosolic protease inhibitors during the post-fermentation decline phase. J. Inst. Brew. 98:1992;335-338.
45. Sylvester J.C., Coghill R.D. The penicillin fermentation. Underkofler L.A., Hickey R.J. Industrial Fermentations, (II). 1954;219-263 Chemical Publishing Co. Inc, New York.
46. Trinci A.P.J., Righelato R.C. Changes in constituents and ultrastructure of hyphal compartments during autolysis of glucose starved Penicillium chrysogenum. J. Gen. Microbiol. 60:1970;239-249.
47. Trinci A.P.J. Regulation of hyphal branching and hyphal orientation. Jennings D.H., Rayner A.D.M. The Ecology and Physiology of the Fungal Mycelium. 1984;23-52 Cambridge University Press, London.
48. Vanhoutte B., Pons M.N., Thomas C.R., Louvel L., Vivier H. Characterisation of Penicillium chrysogenum physiology in submerged cultures by colour and monochrome image analysis. Biotech. Bioeng. 48:1995;1-11.
49. Zabrinskie D.W., Arminger W.B., Phillips D.H., Albano P.A. Trader's Guide to Fermentation Media Formulation. 1980;Trader's Protein, Memphis, TN, 38108, USA.