High exogenous concentrations of phenoxyacetic acid are crucial for a high penicillin V productivity in Penicillium chrysogenum

Microbiology

Volumn 144, Issue 7, 1998, Pages 2001-2006

  Henriksen, Claus M ^a,b   Nielsen, Jens ^a   Villadsen, John ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b CHR HANSEN A S   (Denmark)

Author keywords

By products; Penicillin V; Penicillium chrysogenum; Phenoxyacetic acid; Steady state continuous cultivation

Indexed keywords

6 AMINOPENICILLANIC ACID; GLUCOSE; PENICILLIN V; PHENOXYACETIC ACID;

ARTICLE; MICHAELIS MENTEN KINETICS; NONHUMAN; PENICILLIUM CHRYSOGENUM; PRIORITY JOURNAL;

PENICILLIUM; PENICILLIUM CHRYSOGENUM;

EID: 0031825078     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/00221287-144-7-2001     Document Type: Article

References (9)

1. Alvarez, E., Meesschaert, B., Montenegro, E., Gutiérrez, S., Díez, B., Barredo, J. L. & Martín, J. F. (1993). The isopenicillin-N acyltransferase of Penicillium chrysogenum has isopenicillin-N amidohydrolase, 6-aminopenicillanic acid acyltransferase and penicillin amidase activities, all of which are encoded by the single penDE gene. Eur J Biochem 215, 323-332.
2. Christensen, L. H., Nielsen, J. & Villadsen, J. (1991). Delay and dispersion in an in-situ membrane probe for bioreactors. Chem Eng Sci 46, 3304-3307.
3. Christensen, L H., Mandrup, G., Nielsen, J. & Villadsen, J. (1994). A rubost LC method for measurement of medium components during penicillin fermentations. Anal Chim Acta 296, 51-62.
4. Christensen, L. H., Henriksen, C. M., Nielsen, J., Villadsen, J. & Egel-Mitani, M. (1995). Continuous cultivation of Penicillium chrysogenum. Growth on glucose and penicillin production. J Biotechnol 42, 95-107.
5. Henriksen, C. M., Holm, S. S., Schipper, D., Joørgensen, H. S., Nielsen, J. & Villadsen, J. (1997). Kinetic studies on the carboxylation of 6-amino-penicillanic acid to 8-hydroxy-penillic acid. Proc Biochem 32, 85-91.
6. Henriksen, C. M., Nielsen, J. & Villadsen, J. (1998). Modelling of the protonophoric uncoupling by phenoxyacetic acid of the plasma membrane potential of Penicillium chrysogenum. Biotechnol Bioeng (in press).
7. Joørgensen, H. S., Nielsen, J., Villadsen, J. & Moøllgaard, H. (1995). Analysis of the penicillin V biosynthesis during fed-batch cultivations with a high yielding strain of Penicillium chrysogenum. Appl Microbiol Biotechnol 43, 123-130.
8. Lein, J. (1986). The Panlabs penicillin strain improvement program. In Overproduction of Microbial Metabolites, pp. 105-139. Edited by Z. Va-nek & Z. Hostalek. Boston, MA: Butterworths.
9. Nielsen, J. & Villadsen, J. (1993). Bioreactors: description and modelling. In Biotechnology, 2nd edn, vol. 3, pp. 77-104. Edited by G. Stephanopoulos. Weinheim: VCH.