Dendritic cells play a crucial role in innate immunity to simple chemicals

Journal of Investigative Dermatology Symposium Proceedings

Volumn 4, Issue 2, 1999, Pages 158-163

  Aiba, Setsuya ^a   Tagami, Hachiro ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Contact hypersensitivity; Costimulatory molecules; Hapten; Innate immunity

Indexed keywords

CHEMICAL AGENT; HAPTEN;

APOPTOSIS; CELL FUNCTION; CONFERENCE PAPER; CONTACT ALLERGY; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNE SYSTEM; IMMUNITY; PATHOGENESIS;

EID: 0032851194     PISSN: 10870024     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jidsp.5640201     Document Type: Conference Paper

References (28)

1. Aiba S: Maturation of dendritic cells induced by cytokines and haptens. Tahoku J Exp Med 184:159-172, 1998
2. Aiba S, Katz SI: Phenotypic and functional characteristics of in vivo-activated Langerhans cells. J Immunol 145:2791-2796, 1990
3. Aiba S, Terunuma A, Manome H, Tagami H: Dendritic cells differently respond to haptens and irritants by their production of cytokines and expression of co-stimulatory molecules. Eur J Immunol 27:3031-3038, 1997
4. Erik AH, Katz SI: Early molecular events in the induction phase of contact sensitivity. Proc Natl Acad Sci USA 89:1398-1402, 1992a
5. Enk AH, Katz SI: Identification and induction of keratinocyte-derived IL-10. J Immunol 149:92-95, 1992b
6. Enk AH, Angeloni VL, Udey MC, Katz SI: An essential role for Langerhans cell-derived IL-1b in the initiation of primary immune responses in skin. J Immunol 150:3698-3704, 1993
7. Fearon DT, Locksley RM: The instructive role of innate immunity in the acquired immune response. Science 272:50-53, 1996
8. Girolomoni G, Zambruno G, Manfredini R, Zacchi V, Ferrari S, Cossarizza A, Giannetti A: Expression of B7 costimulatory molecule in cultured human epidermal Langerhans cells is regulated at the mRNA level. J Invest Dermatol 103:54-59, 1994
9. Henderson RA, Watkins SC, Flynn JL: Activation of human dendritic cells following infection with Mycobacterium tuberculosis. J Immunol 159:635-643, 1997
10. Heufler C, Koch F, Stanzl U, et al: Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-g production by T helper 1 cells. Eur J Immunol 26:659-668, 1996
11. Janeway CA Jr: Presidential address to the American Association of Immunologists. The road less traveled by: the role of innate immunity in the adaptive immune response. J Immunol 161:539-544, 1998
12. Kampgen E, Koch N, Koch F, Stoger P, Heufler C, Schuler C, Romani N: Class II major histocompatibility complex molecules of murine dendritic cells: synthesis, siatylation of invariant chain, and antigen processing capacity are down-regulated upon culture. Pro Natl Acad Sci USA 88:3014-3018, 1991
13. Kaye PM: Costimulation and the regulation of antimicrobial immunity. Immunol Today 16:423-427, 1995
14. Kripke ML, Munn CG, Jeevan A, Tang JM, Bucana C: Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization, J Immunol 145:2833-2838, 1990
15. Macatonia SE, Knight SC, Edwards AJ, Griffiths S, Fryer P: Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies. J Exp Med 166:1654-1667, 1987
16. Medzhitov R, Janeway CA Jr: Innate immunity: the virtues of a nonclonal system of recognition. Cell 91:295-298, 1997
17. Ozawa H, Nakagawa S, Tagami H, Aiba S: Interleukin-1b and granulocyte-macrophage colony-stimulating factor mediate Langerhans cell maturation differently. J Invest Dermatol 106:441-445, 1996
18. Romani N, Bruner S, Brang D, et al: Proliferating dendritic cell progenitors in human blood. J Exp Med 180:83-93, 1994
19. Romani N, Koide S, Crowley M, et al: Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells. J Exp Med 169:1169-1178, 1989a
20. Romani N, Lenz A, Glassel H, et al: Cultured human Langerhans cells resemble lymphoid dendritic cells in phenotype and function. J Invest Dermatol 93:600-609, 1989b
21. Rabartelli A, Poggi A, Zocchi MR: The selective engulfment of apoptotic bodies by dendritic cells is mediated by the alpha (v) b3 integrin and requires intracellular and extracellular calcium. Eur J Immunol 27:1893-1900, 1997
22. Sallusto T, Lanzavecchia A: Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 179:1109-1118, 1994
23. Scheicher C, Mehlig M, Dienes HP, Reske K: Uptake of microparticle-adsorbed protein antigen by bone marrow-derived dendritic cells results in up-regulation of interleukin-1 alpha and interleukin-12 p40/p35 and triggers prolonged, efficient antigen presentation. Eur J Immunol 25:1566-1572, 1995
24. Schuler G, Steinman RM: Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J Exp Med 161:526-546, 1985
25. Steinman RM: The dendritic cell system and its role in immunogenicity. Ann Rev Immunol 9:271-296, 1991
26. Stossel H, Koch F, Kampgen E, et al: Disappearance of certain acidic organelles (endosomes and Langerhans cell granules) accompanies loss of antigen processing capacity upon culture of epidermal Langerhans cells. J Exp Med 172:1471-1482, 1990
27. Symington FW, Brady W, Linsley PS: Expression and function of B7 on human epidermal Langerhans cells. J Immunol 150:1286-1295, 1993
28. Verhasselt V, Buelens C, Willems F, De Groote D, Haeffner-Cavaillon N, Goldman M: Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells: evidence for a soluble CD14-dependent pathway. J Immunol 158:2919-2925, 1997