Differential sensitivity of double minute chromosomes to hydroxyurea treatment in cultured methotrexate-resistant mouse cells

Mutation Research - Mutation Research Genomics

Volumn 406, Issue 2-4, 1999, Pages 55-62

  Nevaldine, Barbara H ^a   Rizwana, Rabia ^a   Hahn, Peter J ^a  

^a SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

Author keywords

Dihydrofolate reductase gene; Double minute chromosome; Hydroxyurea resistance; Pulsed field gel electrophoresis

Indexed keywords

DIHYDROFOLATE REDUCTASE; EPIDERMAL GROWTH FACTOR RECEPTOR; HYDROXYUREA; METHOTREXATE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CHROMOSOME LOSS; DOUBLE MINUTE CHROMOSOME; DRUG SENSITIVITY; GENE AMPLIFICATION; GENETIC MODEL; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; RECEPTOR GENE;

ANIMALS; CELL SURVIVAL; CHROMOSOMES; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; ELECTROPHORESIS, GEL, PULSED-FIELD; GENE DOSAGE; HYDROXYUREA; METHOTREXATE; MICE; MUTATION; NUCLEIC ACID SYNTHESIS INHIBITORS; TETRAHYDROFOLATE DEHYDROGENASE; TUMOR CELLS, CULTURED;

ANIMALIA; MAMMALIA;

EID: 0032846520     PISSN: 13835726     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5726(98)00010-7     Document Type: Article

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