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DeNardo SJ, O'Grady LF, Richman CM, Goldstein DS, O'Donnell RT, DeNardo DA, Kroger LA, Lamborn KR, Hellstrom KE, Hellstrom I, DeNardo GL Radioimmunotherapy for advanced breast cancer using I-131-ChL6 antibody. Anticancer Res. 17:1997;1745-1752.
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5
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0030816178
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Radioimmunotherapy for breast cancer using indium-111/yttrium-90 BrE-3: Results of a phase I clinical trial
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DeNardo SJ, Kramer EL, O'Donnell RT, Richman CM, Salako QA, Shen S, Noz M, Glenn SD, Ceriani RL, DeNardo GL Radioimmunotherapy for breast cancer using indium-111/yttrium-90 BrE-3: results of a phase I clinical trial. J Nucl Med. 38:1997;1180-1185.
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Ceriani, R.L.9
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0000735189
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Phase I study of high-dose radioimmunotherapy with 90-Y-hu-BrE-3 followed by autologous stem cell support (ASCS) in patients with metastatic breast cancer [abstract]
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•] describe current effective studies of RIT in breast cancer, with PBSC support.
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•] describe current effective studies of RIT in breast cancer, with PBSC support.
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Griffith, I.J.10
Denardo, G.L.11
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9
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0032322612
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Intraperitoneal radioimmunotherapy for refractory epithelial ovarian cancer with 177Lu-CC49
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This paper describes the first RIT/Taxol combination in patients with ovarian cancer.
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Meredith RF, Alvarez R, Khazaeli MB, LoBuglio A Intraperitoneal radioimmunotherapy for refractory epithelial ovarian cancer with 177Lu-CC49. Minerva Biotechnologica. 10:1998;100-107. This paper describes the first RIT/Taxol combination in patients with ovarian cancer.
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Meredith, R.F.1
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Lobuglio, A.4
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0031985010
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Radioimmunotherapy after chemotherapy compared to chemotherapy alone in the treatment of advanced ovarian cancer: A matched analysis
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This article demonstrates statistically significant, enhanced survival that is associated with the use of RIT as an adjuvant in ovarian cancer therapy.
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Nicholson S, Gooden CSR, Hird V, Maraveyas A, Mason P, Lambert HE, Meares CF, Epenetos AA Radioimmunotherapy after chemotherapy compared to chemotherapy alone in the treatment of advanced ovarian cancer: a matched analysis. Oncology Rep. 5:1998;223-226. This article demonstrates statistically significant, enhanced survival that is associated with the use of RIT as an adjuvant in ovarian cancer therapy.
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Nicholson, S.1
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Epenetos, A.A.8
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11
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0023071843
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Treatment of a patient with B cell lymphoma by I-131 Lym-1 monoclonal antibodies
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DeNardo SJ, DeNardo GL, O'Grady LF, Macey DJ, Mills SL, Epstein AL, Peng J-S, McGahan JP Treatment of a patient with B cell lymphoma by I-131 Lym-1 monoclonal antibodies. Int J Biol Markers. 2:1987;49-53.
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Epstein, A.L.6
Peng, J.-S.7
McGahan, J.P.8
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12
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84987480164
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Treatment of B cell malignancies with I-131 Lym-1 monoclonal antibodies
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DeNardo SJ, DeNardo GL, O'Grady LF, Hu E, Sytsma VM, Mills SL, Levy NB, Macey DJ, Miller CH, Epstein AL Treatment of B cell malignancies with I-131 Lym-1 monoclonal antibodies. Int J Cancer. 3(suppl 3):1988;96-101.
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Fisher, S.10
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14
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9044254117
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Yttrium-90-labeled anti-CD20 monoclonal antibody therapy of recurrent B-cell lymphoma
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Knox SJ, Goris ML, Trisler K, Negrin R, Davis T, Liles T-M Grillo-Lopez, AJ Chinn, P Varns, C Ning S-Cet al. Yttrium-90-labeled anti-CD20 monoclonal antibody therapy of recurrent B-cell lymphoma. Clin Cancer Res. 2:1996;457-470.
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Aj, C.7
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White CA, Halpern SE, Parker BA, Miller RA, Hupf HB, Shawler DL, Collins HA, Royston I Radioimmunotherapy of relapsed B-cell lymphoma with yttrium 90 anti-idiotype monoclonal antibodies. Blood. 87:1996;3640-3649.
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Collins, H.A.7
Royston, I.8
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16
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0029163551
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131I-B1 (anti-CD20) antibody therapy with autologous stem cell transplantation for relapsed B cell lymphomas. Lancet. 346:1995;336-340.
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17
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0027484445
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Vose J, Saleh M, Lister A, Rohatiner A, Knox S, Radford J, Zelenetz AD, Stagg R, Tidmarsh G, Wahl R, Kaminiski MS Iodine-131 Anti-B1 antibody for non-Hodgkin's lymphoma (NHL): overall clinical trial experience [abstract]. Proc Am Soc Clin Oncol. 17:1998;10.
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19
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0003101584
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I-131 anti-B1 antibody for previously untreated follicular lymphoma (FL): Clinical and molecular remissions [abstract]
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The authors report the first use of RIT for previously untreated lymphoma and demonstrate uniquely high response rates.
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Kaminski MS, Gribbin T, Estes J, Ross CW, Regan D, Zasadny K, Tamminen J, Kison P, Tuck M, Fisher Set al. I-131 anti-B1 antibody for previously untreated follicular lymphoma (FL): clinical and molecular remissions [abstract]. Proc Am Soc Clin Oncol. 17:1998;2. The authors report the first use of RIT for previously untreated lymphoma and demonstrate uniquely high response rates.
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Proc Am Soc Clin Oncol
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Kaminski, M.S.1
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131I-Lym-1 antibody. Cancer Biother Radiopharm. 13:1998;239-254.
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Raventos, A.8
Kroger, L.A.9
Macey, D.J.10
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22
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0031759837
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131I-Lym-1 antibody for fractionated radioimmunotherapy of non-Hodgkin's lymphoma
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The authors demonstrate that >50% of heavily pretreated lymphoma patients showed at least a PR after the first of several RIT doses; all three patients given the MTD had CRs with non-myeloablative doses.
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131I-Lym-1 antibody for fractionated radioimmunotherapy of non-Hodgkin's lymphoma. J Clin Oncol. 16:1998;3246-3256. The authors demonstrate that >50% of heavily pretreated lymphoma patients showed at least a PR after the first of several RIT doses; all three patients given the MTD had CRs with non-myeloablative doses.
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J Clin Oncol
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Denardo, G.L.1
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Levy, N.B.6
McGahan, J.P.7
Salako, Q.A.8
Shen, S.9
Lewis, J.P.10
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23
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0031471674
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Increased survival associated with radiolabeled Lym-1 therapy for non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukemia (CLL)
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DeNardo GL, Lamborn KR, Goldstein DS, Kroger LA, DeNardo SJ Increased survival associated with radiolabeled Lym-1 therapy for non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukemia (CLL). Cancer. 80(suppl 12):1997;2706-2711.
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Denardo, S.J.5
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24
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Feldman E, Kalaycio M, Schulman P, Frankel S, Weiner G, Schwatzberg L, Velez-Garcia E, Jurcic J, Scheinberg D, Wedel N Humanized monoclonal anti-CD33 antibody HuM195 in the treatment of relapsed/refractory acute myelogenous leukemia (AML): preliminary report of a phase II study [abstract]. Proc Am Soc Clin Oncol. 18:1999;4.
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Radiolabeled anti-CD33 monoclonal antibody M195 for myeloid leukemias
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90Y-HuM195 will be useful as part of a pretransplant regimen for the ablation of leukemia.
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90Y-HuM195 will be useful as part of a pretransplant regimen for the ablation of leukemia.
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27
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Phase I trial of targeted alpha-particle therapy for myeloid leukemias with bismuth-213-HuM195 (anti-CD33) [abstract]
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••] report the first studies to show that targeted α-particle therapy is feasible in humans and provide targeting ratios (comparing tumors with whole-body doses) that are 1000-10,000-times those calculated for β-emitting nuclides in leukemia patients.
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••] report the first studies to show that targeted α-particle therapy is feasible in humans and provide targeting ratios (comparing tumors with whole-body doses) that are 1000-10,000-times those calculated for β-emitting nuclides in leukemia patients.
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DeNardo SJ, Richman CM, Goldstein DS, Shen S, Salako QA, Kukis DL, Meares CF, Yuan A, Welborn JL, DeNardo GL Yttrium-90/indium-111-DOTA-peptide-chimeric L6: pharmacokinetics, dosimetry and initial results in patients with incurable breast cancer. Anticancer Res. 17:1997;1735-1744.
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Synergistic therapy of breast cancer with Y-90-chimeric L6 and paclitaxel in the xenografted mouse model: Development of a clinical protocol
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The authors describe the synergistic effect of Taxol and RIT in preclinical studies and the approach that applies the time/dose information to clinical protocol development.
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