Analysis of antibody responses against coxsackie virus B4 protein 2C and the diabetes autoantigen GAD65

Journal of Medical Virology

Volumn 59, Issue 2, 1999, Pages 256-261

  Vreugdenhil, Gienke R ^a,c   Batstra, Manou R ^b   Aanstoot, Henk Jan ^b   Melchers, Willem J G ^a   Galama, Jochem M D ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Autoantibody; Entero virus; Molecular mimicry; Nonstructural proteins; Type I diabetes mellitus

Indexed keywords

AUTOANTIGEN;

ANTIBODY RESPONSE; ARTICLE; AUTOIMMUNITY; CLINICAL ARTICLE; COXSACKIE VIRUS B4; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PATHOGENESIS;

ANTIBODIES, VIRAL; ANTIBODY SPECIFICITY; AUTOANTIBODIES; AUTOIMMUNE DISEASES; CHILD; DIABETES MELLITUS; ENTEROVIRUS B, HUMAN; GLUTAMATE DECARBOXYLASE; HUMANS; MOLECULAR MIMICRY; VIRAL PROTEINS;

COXSACKIEVIRUS; ENTERO VIRUS; ENTEROVIRUS; HUMAN ENTEROVIRUS B; RNA VIRUSES;

EID: 0032840183     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9071(199910)59:2<256::AID-JMV21>3.0.CO;2-H     Document Type: Article

References (38)

1. Atkinson MA, Bowman MA, Campbell L, Darrow BL, Kaufman DL, Maclaren NK. 1994. Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. J Clin Invest 94:2125-2129.
2. Baekkeskov S, Aanstoot HJ, Christgau S, Reetz A, Solimena M, Cascalho M, Folli F, Richter H, Olesen, DeCamilli P. 1990. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 347:151-156.
3. Banatvala JE, Bryant J, Schernthaner G, Borkenstein M, Schober E, Brown D, De-Silva LM, Menser MA, Silink M. 1985. Coxsackie B, mumps, rubella, and cytomegalovirus specific IgM responses in patients with juvenile-onset insulin-dependent diabetes mellitus in Britain, Austria, and Australia. Lancet 336:1409-1412.
4. Champsaur HF, Bottazzo GF, Bertrams J, Assan R, Bach C. 1982. Virologic, immunologic, and genetic factors in insulin-dependent diabetes mellitus. J Pediatr 100:15-20.
5. Dahlquist G, Frisk G, Ivarsson SA, Svanberg L, Forsgren M, Diderholm H. 1995. Indications that maternal coxsackie B virus infection during pregnancy is a risk factor for childhood-onset IDDM. Diabetologia 38:1371-1373.
6. Ehrenfeld E, Brown D, Jia XY, Summers DF. 1995. Antibodies against viral nonstructural proteins in response to infection with poliovirus. J Infect Dis 171:845-850.
7. Ellis TM, Atkinson MA. 1996. The clinical significance of an autoimmune response against glutamic acid decarboxylase. Nat Med 2: 148-153.
8. Frisk G, Friman G, Tuvemo T, Fohlman J, Diderholm H. 1992. Coxsackie B virus IgM in children at onset of type 1 (insulin-dependent) diabetes mellitus: evidence for Ig induction by a recent or current infection. Diabetologia 35:249-253.
9. Gamble DR, Kinsley ML, FitzGerald MG, Bolton R, and Taylor KW. 1969. Viral antibodies in diabetes mellitus. Br Med J 3:627-630.
10. Graham S, Wang EC, Jenkins O, Borysiewicz LK. 1993. Analysis of human T-cell response to picornaviruses: identification of T-cell epitopes close to B-cell epitopes in poliovirus. J Virol 67:1627-1637.
11. Hiltunen M, Hyoty H, Knip M, Ilonen J, Reijonen H, Vahasalo P, Roivainen M, Lonnrot M, Leinikki P, Hovi T, Akerblom HK. 1997. Islet cell antibody seroconversion in children is temporally associated with enterovirus infections. J Infect Dis 175:554-560.
12. Holland J, Spindler K, Horodyski F, Grabau E, Nichol S, VandePol S. 1982. Rapid evolution of RNA genomes. Science 215:1577-1585.
13. Hou J, Said C, Franchi D, Dockstader P, Chatterjee NK. 1994. Antibodies to glutamic acid decarboxylase and p2-C peptides in sera from coxsackie virus B4-infected mice and IDDM patients. Diabetes 43:1260-1266.
14. Hyöty H, Hiltunen M, Knip M, Laakkonen M, Vahasalo P, Karjalainen J, Koskela P, Roivainen M, Leinikki P, Hovi T, Childhood Diabetes in Finland (DiMe) Study Group. 1995. A prospective study of the role of coxsackie B and other enterovirus infections in the pathogenesis of type 1 diabetes. Diabetes 44:652-657.
15. Katz JD, Benoist C, Mathis D. 1995. T helper cell subsets in insulin dependent diabetes. Science 268:1185-1188.
16. Kaufman DL, Clare Salzer M, Tian J, Forsthuber T, Ting GS, Robinson P, Atkinson MA, Sercarz EE, Tobin AJ, Lehmann PV. 1993. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in marine insulin-dependent diabetes. Nature 366:69-72.
17. Kuno S, Itagaki, A, Yamazaki I, Katsumoto T, Kurimura T. 1984.Pathogenecity of newly isolated coxsackievirus B4 for mouse pancreas. Acta Virol 28:433-436.
18. Lönnrot M, Hyöty H, Knip M, Roivainen M, Kulmala P, Leinikki P, Akerblom HK. 1996. Antibody cross reactivity induced by the homologous regions in glutamic acid decarboxylase (GAD(65)) and 2C protein of coxsackievirus B4. Clin Exp Immunol 104:398-405.
19. Lönnrot M, Knip M, Roivainen M, Koskela P, Akerblom HK, Hyoty H. 1998. Onset of type 1 diabetes mellitus in infancy after enterovirus infections. Diabetes Med 15:431-434.
20. Melnick JL. 1996. Enteroviruses: polioviruses, coxsackie viruses, echoviruses and newer enteroviruses. In: Fields BN, Knipe DM, Howley PM, editors. Virology. Philadelphia: Lippincott-Raven. p 655-712.
21. Ohashi PS, Oehen S, Aichele P, Pircher H, Odermatt B, Herrera P, Higuchi Y, Buerki K, Hengartner H, Zinkernagel RM. 1993. Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-alpha. J Immunol 150:5185-5194.
22. Petersen JS, Marshall MO, Baekkeskov S, Hejnaes KR, Hoier Madsen M, Dyrberg T. 1993. Transfer of type 1 (insulin-dependent) diabetes mellitus associated autoimmunity to mice with severe combined immunodeficiency (SCID). Diabetologia 36:510-515.
23. 65 antibodies in diabetes and other autoimmune diseases using a simple radioligand assay. Diabetes 43:459-467.
24. Ramsingh AI, Chapman N, Tracy S. 1997. Coxsackieviruses and diabetes. Bioessays 19:793-800.
25. Richter W, Mertens T, Schoel B, Muir P, Ritzkowsky A, Scherbaum WA, Boehm BO. 1994. Sequence homology of the diabetes-associated autoantigen glutamate decarboxylase with coxsackie B4-2C protein and heat shock protein 60 mediates no molecular mimicry of autoantibodies. J Exp Med 180:721-726.
26. Rossini AA, Greiner DL, Friedman HP. 1993. Immunopathogenesis of diabetes mellitus. Diabetes Rev 1:43.
27. Schloot NC, Roep BO, Wegmann DR, Yu L, Wang TB, Eisenbarth GS. 1997. T-cell reactivity to GAD65 peptide sequences shared with coxsackie virus protein in recent-onset IDDM, post-onset IDDM patients and control subjects. Diabetologia 40:332-338.
28. See DM, Tilles JG. 1995. Pathogenesis of virus-induced diabetes in mice. J Infect Dis 171:1131-1138.
29. Szopa TM, Ward T, Dronfield DM, Portwood ND, Taylor KW. 1990. Coxsackie B4 viruses with the potential to damage beta cells of the islets are present in clinical isolates. Diabetologia 33:325-328.
30. Szopa TM, Titchener PA, Portwood ND, Taylor KW. 1993. Diabetes mellitus due to viruses-some recent developments. Diabetologia 36:687-695.
31. Tian J, Lehmann PV, Kaufman DL. 1994. T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele. J Exp Med 180:1979-1984.
32. Tian J, Atkinson MA, Clare Salzer M, Herschenfeld A, Forsthuber T, Lehmann PV, Kaufman DL. 1996. Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J Exp Med 183: 1561-1567.
33. Tisch R, Yang XD, Singer SM, Liblau RS, Fugger L, McDevitt HO. 1993. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366:72-75.
34. van Kuppeveld FJ, Galama JM, Zoll J, van den Hurk PJ, and Melchers WJG. 1996. Coxsackie B3 virus protein 2B contains cationic amphipathic helix that is required for viral RNA replication. J Virol 70:3876-3886.
35. van Kuppeveld FJ, Hoenderop JGJ, Smeets RLL, Willems PHGM, Dijkman HBPM, Galama JMD, Melchers WJG. 1997. Coxsackievirus protein 2B modifies endoplasmic reticulum membrane and plasma membrane permeability and facilitates virus release. EMBO J 16:3519-3532.
36. 65 is highly conserved in the coxsackie B-like enteroviruses and binds to the diabetes associated HLA-DR3 molecule. Diabetologia 41:40-46.
37. Yoon JW, Austin M, Onodera T, Notkins AL. 1979. Isolation of a virus from the pancreas of a child with diabetic ketoacidosis. N Engl J Med 300:1173-1179.
38. Zoll J, Galama J, Melchers W. 1994. Intratypic genome variability of the coxsackievirus B1 2A protease region. J Gen Virol 75:687-692.