Selective binding of thyrotropin receptor autoantibodies to recombinant extracellular domain of thyrotropin/lutropin-chorionic gonadotropin receptor chimeric proteins

Thyroid

Volumn 9, Issue 9, 1999, Pages 879-886

  Seetharamaiah, Gattadahalli S ^a   Zhuang, Jun ^a   Huang, Juan ^a   Patibandla, Sai A ^a   Kaithamana, Shashi ^a   Tahara, Kazuo ^b   Kohn, Leonard D ^b   Prabhakar, Bellur S ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CHORIONIC GONADOTROPIN RECEPTOR; GROWTH HORMONE RECEPTOR; THYROTROPIN RECEPTOR; THYROTROPIN RECEPTOR ANTIBODY;

AMINO ACID SEQUENCE; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; CHIMERA; CONFORMATIONAL TRANSITION; GRAVES DISEASE; HUMAN; IMMUNOASSAY; PRIORITY JOURNAL; PROTEIN CONFORMATION; RECEPTOR AFFINITY; SEQUENCE HOMOLOGY;

EID: 0032835690     PISSN: 10507256     EISSN: None     Source Type: Journal    
DOI: 10.1089/thy.1999.9.879     Document Type: Article

References (35)

1. Smith BR, McLachlan SM, Furmaniak J 1988 Autoantibodies to the thyrotropin receptor. Endocr Rev 9:106-121.
2. Nagayama Y, Rapoport B 1992 The thyrotropin receptor 25 years after its discovery: new insight after its molecular cloning. Mol Endocrinol 6:145-156.
3. Vassart G, Dumont JE 1992 The thyrotropin receptor and the regulation of the thyrocyte function and growth. Endocr Rev 13:61-76.
4. Mori T, Akamizu T, Kosugi S, Sugawa H, Inoue D, Okuda J, Ueda Y 1994 Recent progress in TSH receptor studies with a new concept of "autoimmune thyrotropin receptor disease." Endocr J 41:1-11.
5. Kohn LD, Shimura H, Shimura Y, Hidaka A, Giuliani C, Napolitano G, Ohmori M, Laglia G, Saji M 1995 The thyrotropin receptor. Vit Horm 50:287-385.
6. Prabhakar BS, Fan JL, Seetharamaiah GS 1997 Thyrotropin-receptor-mediated diseases: a paradigm for receptor autoimmunity. Immunol Today 18:437-442.
7. Kohn LD, Hoffman WH, Tombaccini D, Marcocci C, Shimojo N, Watanabe Y, Amino N, Kohno Y, Hirai A, Tahara K 1997 Characterization of monoclonal thyroid stimulating and thyrotropin binding inhibiting autoantibodies from a Hashimoto's patient whose children had intrauterine and neonatal thyroid disease. J Clin Endocrinol Metab 82: 3998-4009.
8. Shimojo N, Kohno Y, Yamaguchi KI, Kikuoka SI, Hoshioka A, Niimi H, Hirai A, Tamura Y, Saito Y, Kohn LD, Tahara K 1996 Induction of Graves-like disease in mice by immunization with fibroblasts transfected with the thyrotropin receptor and a class II molecule. Proc Natl Acad Sci USA 93:11074-11079.
9. Yamaguchi KI, Shimojo N, Kikuoka S, Hoshioka A, Hirai A, Tahara K, Kohn LD, Kohno Y, Niimi H 1997 genetic control of anti-thyrotropin receptor antibody generation in H-2K mice immunized with thyrotropin receptor-transfected fibroblasts. J Clin Endocrinol Metab 82:4266-4269.
10. Kikuoka S, Shimojo N, Yamaguchi KI, Watanabe Y, Hoshioka A, Hirai A, Saito Y, Tahara K, Kohn LD, Maruyama N, Kohno Y, Niimi H 1998 The formation of thytropin receptor (TSHR) antibodies in a Graves' animal model requires the N-terminal segment of the TSHR extracellular domain. Endocrinology 139:1891-1898.
11. Tahara K, Ban T, Minegishi T, Kohn LD 1991 Immunoglobulins from Graves' disease patients interact with different sites on TSH receptor/LH-CG receptor chimeras than either TSH or immunoglobulins from idiopathic myxedema patients. Biochem Biophys Res Commun 179: 70-77.
12. Watanabe Y, Tahara K, Hirai A, Tada H, Kohn LD, Amino N 1997 Subtypes of anti-TSH receptor antibodies classified by various assays using CHO cells expressing wild-type or chimeric human TSH receptor. Thyroid 7:13-19.
13. Tahara K, Ishikawa N, Yamamoto K, Hirai A, Ito K, Tamura Y, Yoshida S, Saito Y, Kohn LD 1997 Epitopes for thyroid stimulating and blocking autoantibodies on the extracellular domain of the human thyrotropin receptor. Thyroid 7:867-877.
14. Nagayama Y, Kaufman KD, Seto P, Rapoport B 1989 Molecular cloning, sequence and functional expression of human thytropin receptor. Biochem Biophys Res Commun 165: 1184-1190.
15. Libert F, Lefort A, Gerard C, Permentier M, Perret J, Ludgate M, Dumont JE, Vassart G 1989 Cloning, sequencing and expression of human thytropin (TSH) receptor: Evidence of binding of autoantibodies. Biochem Biophys Res Commun 165:1250-1254.
16. Frazier AL, Robbins LS, Stork PJ, Sprengel R, Segaloff DL, Cone RD 1990 Isolation of TSH and LH/CG receptor cDNAs from human thyroid: Regulation by tissue specific splicing. Mol Endocrinol 90:1264-1276.
17. McFarland KC, Sprengel R, Philips HS, Kohler M, Rosemblit N, Nikolics K, Segaloff DL, Seeburg PH 1989 Lutropinchoriogonadotropin receptor: An unusual member of the G-protein coupled receptor family. Science 245:494-499.
18. Loosfelt H, Misrahi M, Atger M, Salesse R, Vu Hai-luu Thi MT, Jolivet A, Guiochon-Mantel A, Sar S, Jallal B, Gamier J, Milgrom E. 1989 Cloning and sequencing of porcine LH-hCG receptor: An unusual member of G-protein coupled receptor. Science 245:525-528.
19. Nagayama Y, Wadsworth HL, Russo D, Chazenbalk G, Rapoport B 1991 Binding domains of stimulatory and inhibitory thyrotropin (TSH) receptor autoantibodies determined with chimeric TSH-lutropin/chorionic gonadotropin receptors. J Clin Invest 88:336-340.
20. Nagayama Y, Rapoport B 1992 Role of the carboxyl-terminal half of the extracellular domain of the human thytropin receptor in signal transduction. Endocrinology 131:548-552.
21. Nagayama Y, Rapoport B. 1992 Thyroid stimulatory autoantibodies in different patients with autoimmune thyroid disease do not all recognize the same components of the human thyrotropin receptor: Selective role of receptor amino acids Ser25-Glu 30. J Clin Endocrinol Metab 75:1425-1430.
22. Jaume JC, Prummel MF, Wiersinga WM, McLachlan SM, Rapoport B 1993 Thyrotropin receptor autoantibodies recognizing two different epitopes of the TSH receptor: Lack of relationship to patient age, sex and ophthalmopathy. Thyroid 3:291-295.
23. Chazenbalk GD, Rapoport B 1995 Expression of the extracellular domain of the thyrotropin receptor in the baculovirus system using a promoter active earlier than the polyhedrin promoter. J Biol Chem 270:1543-1549.
24. Rapoport B, McLachlan SM, Kakinuma A, Chazenbalk GD 1996 Critical relationship between autoantibody recognition and thyrotropin receptor maturation as reflected in the acquisition of complex carbohydrate. J Clin Endocrinol Metab 81:2525-2533.
25. Seetharamaiah GS, Dallas JS, Patibandla SA, Thotakura NR, Prabhakar BS 1997 Requirement of glycosylation of the human thyrotropinreceptor ectodomain for its reactivity with autoantibodies in patients' sera. J Immunol 158:2798-2804.
26. Hidaka A, Ban T, Panesar NS, Minegishi T, Kohn LD, Tahara K 1994 Thyrotropin stimulation of the lutropin/choriogonadotropin receptor: Different sites mediate agonist activity and high affinity binding. Thyroid 4:447-457.
27. Kirn WB, Cho BY, Park HY, Lee HK, Kohn LD, Tahara K, Koh CS 1996 Epitopes for thyroid stimulating antibodies in Graves' sera: A possible link of heterogeneity to differences in response to antithyroid drug treatment. J Clin Endocrinol Metab 81:1758-1767.
28. Whitford M, Stewart S, Kuzio J, Faulkner P 1989 Identification and sequence analysis of a gene encoding gp67, an abundant envelope glycoprotein of the baculovirus Autographa. J Virol 63:1393-1399.
29. Frankel A, Roberts H, Afrin L, Vesely J, Willingham M 1994 Expression of ricin B chain in Spodoptera frugiperda. Biochem J 303:787-794.
30. Patibandla SA, Seetharamaiah GS, Dallas JS, Thotakura NR, Peake RL, Prabhakar BS 1997 Differential reactivities of recombinant glycosylated ectodomains of mouse and human thyrotropin receptors with patient autoantibodies. Endocrinology 138:1559-1566.
31. Tkacz JS, Lampen JO 1975 Tunicamycin inhibition of polyisoprenyl N-actylglucosaminyl pyrophosphate formation in calf-liver microsomes. Biochem Biophys Res Commun 65: 248-257.
32. Torres GE, Egan TM, Voigt MM 1998 N-linked glycosylation is essential for the functional expression of the recombinant P2X2 receptor. Biochemistry 37:14845-14851.
33. Seetharamaiah GS, Dallas JS, Prabhakar BS 1999 Glycosylated ectodomain of the human thyrotropin receptor induces antibodies capable of reacting with multiple blocking antibody epitopes. Autoimmunity 29:21-31.
34. Seetharamaiah GS, Wagle NM, Morris JC, Prabhakar BS 1995 Generation and characterization of monoclonal antibodies to the human thyrotropin (TSH) receptor: Antibodies can bind to discrete conformational or linear epitopes and block TSH binding. Endocrinology 136:2817-2824.
35. Kim WB, Chung HK, Lee HK, Kohn LD, Tahara K, Cho BY 1997 Changes in epitopes for thyroid stimulating antibodies in Graves' disease sera during treatment of hyperthyroidism: Therapeutic implications. J Clin Endocrinol Metab 82: 1953-1988.