Anti-ulcer activity of SKP-450, a novel potassium channel activator, in rats

Pharmacological Research

Volumn 40, Issue 3, 1999, Pages 243-248

  Cheon, Hyae Gyeong ^a   Kim, Hyun Jung ^a   Mo, Hye Kyoung ^a   Yoo, Sung Eun ^a   Lee, Byung Ho ^a  

^a Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

Anti ulcer; Potassium channel activator; SKP 450

Indexed keywords

2 (1,3 DIOXOLAN 2 YL) 2 METHYL 6 NITRO 4 (2 OXO 1 PYRROLIDINYL) 2H 1 BENZOPYRAN; ADENOSINE TRIPHOSPHATE; ALCOHOL; ANTIULCER AGENT; GLIBENCLAMIDE; HISTAMINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; SODIUM HYDROXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; INTRADUODENAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; PYLORUS; RAT; STOMACH ACID SECRETION; STOMACH JUICE; STOMACH ULCER;

EID: 0032834141     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1999.0512     Document Type: Article

References (21)

1. Lee BH, Yoo SE, Shin HS. Hemodynamic profile of SKP-450, a new potassium-channel activator. J Cardiovasc Pharmacol 1998; 31: 85-94.
2. Shin HS, Seo HW, Yoo SE, Lee BH. Cardiovascular pharmacology of SKP-450, a new potassium channel activator, and its major metabolites SKP-818 and SKP-310. Pharmacology 1998a; 56: 111-24.
3. Shin HS, Seo HW, Oh JH, Lee BH. Antihypertensive effects of the novel potassium channel activator SKP-450 and its major metabolites in rats. Arzneim-Forsch /Drug Res 1998b; 48(II): 969-78.
4. + channel. J Pharmacol Exp Ther 1995; 275: 807-12.
5. + channel. A comparison with pinacidil and lemakalim. Circ Res 1991; 69: 1152-8.
6. Cook NS. The pharmacology of potassium channels and their therapeutic potential. Trends Pharmacol Sci 1988; 9: 21-8.
7. Hamilton TC, Weston AH. Cromakalim, nicorandil and pinacidil: novel drugs which open potassium channels in smooth muscle. Gen Pharmacol 1989; 20: 1-9.
8. 2+ concentration and mechanical activity induced by noradrenaline in the rabbit mesenteric artery. Br J Pharmacol 1991; 104: 227-33.
9. 2+ sensitivity of arterial smooth muscle. Arch Int Pharmacodyn 1993; 326: 33-51.
10. Doi K, Nagao T, Kawakubo K, Ibayashi S, Aoyagi K, Yano Y, Yamamoto C, Kanamoto K, Iida M, Sadoshima S, Fujishima M. Calcitonin gene-related peptide affords gastric mucosal protection by activating potassium channel in Wistar rat. Gastroenterolology 1998; 114: 71-6.
11. Li MKK, Tsui CP, Sung JJY, Scremin OU, Leung FW. Potassium channels participate in gastric mucosal protection in rats with partial portal vein ligation. Hepatology 1998; 27: 1530-5.
12. Iwata F, Koo A, Itoh M, Lam K, Leung JWC, Leung FW. Functional evidence linking potassium channels and afferent nerve-mediated mucosal protection in rat stomach. Life Sci 1997; 61: 1713-20.
13. Kortezova N, Bayguinov O, Papasova M. Effect of cromakalim on the smooth muscle of the cat gastric antrum. J Pharm Pharmacol 1992; 44: 875-8.
14. Shay H, Komabov SA, Fels SS, Meranze D, Grunstein M, Siplet H. A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology 1945; 4: 43-61.
15. Ghosh MW, Schild MO. Continuous recording of gastric secretin in the rat. Br J Pharmacol Chemother 1958; 13: 54-61.
16. Tamargo J, Delpon PE, Garcia-Rafanell J, Gomez L, Cavalcanti F. Cardiovascular effects of the novel potassium channel opener UR-8225. J Cardiovasc Pharmacol 1995; 26: 295-305.
17. Robert A, Nezamis JE, Lancaster C, Hanchar AJ. Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology 1979; 77: 433-43.
18. + currents in rabbit arterial smooth muscle via protein kinase A. J Physiol Lond 1994; 475: 9-13.
19. Larsson H, Carlsson E, Mattsson H, Lundell L, Sundler F, Sundell G, Wallmark B, Watanabe T, Hakanson R. Plasma gastrin and gastric enterochromaffin cell activation and proliferation. Studies with omeprozole and ranitidine in intact and antrectomized rat. Gastroenterolology 1986; 90: 391-9.
20. Guth PH. Pathogenesis of gastric mucosal injury. Annu Rev Med 1982; 33: 183-96.
21. Buchheit KH, Bertholet A. Inhibition of small intestine motility by cromakalim (BRL-34915). Eur J Pharmacol 1988; 154: 335-7.