Demonstration of urokinase expression in cancer cells of colon adenocarcinomas by immunohistochemistry and in situ hybridization

American Journal of Pathology

Volumn 155, Issue 4, 1999, Pages 1115-1120

  Harvey, Shashikumar R ^a   Sait, Sheila N J ^a   Xu, Yan ^a   Bailey, Joyce L ^a   Penetrante, Remedios M ^a   Markus, Gabor ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA; MONOCLONAL ANTIBODY; UROKINASE; UROKINASE RECEPTOR;

APICAL MEMBRANE; ARTICLE; BASEMENT MEMBRANE; CANCER CELL; COLON ADENOCARCINOMA; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROMA;

EID: 0032833646     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65214-5     Document Type: Article

References (32)

1. Danø K, Andreasen PA, Grøndahl-Hansen J, Kristensen P, Nielsen LS, Skriver L: Plasminogen activators, tissue degradation and cancer. Adv Cancer Res 1985, 44:139-266
2. Goldfarb RH, Liotta LA: Proteolytic enzymes in cancer invasion and metastasis. Semin Thromb Hemost 1986, 12:294-307
3. Markus G: Plasminogen activators in malignant growth. Progress in Fibrinolysis, vol. 6. Edited by JF Davidson, F Bachmann, CA Bouvier, EKO Kruithof. Edinburgh, Churchill Livingstone, 1983, pp 587-604
4. Andreasen PA, Kjoller L, Christensen L, Duffy MJ: The urokinase-type plasminogen activator system in cancer metastasis: a review. Int J Cancer 1997, 72:1-22
5. Mignatti P, Rifkin DB: Biology and biochemistry of proteinases in tumor invasion. Physiol Rev 1993, 73:161-195
6. Chapman H: Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration. Curr Opin Cell Biol 1997, 9:714-724
7. Markus G: The relevance of plasminogen activators in neoplastic growth: a review of recent literature. Enzyme 1988, 40:158-172
8. Markus G, Camiolo SM, Kohga S, Madeja JM, Mittelman A: Plasminogen activator secretion of human tumors in short-term organ culture, including a comparison of primary and metastatic colon tumors. Cancer Res 1983, 43:5517-5525
9. Harvey SR, Lawrence DD, Madeja JM, Abbey SJ, Markus G: Secretion of plasminogen activators by human colorectal and gastric explants. Clin Exp Metastasis 1988, 6:431-450
10. Kohga S, Harvey SR, Weaver RM, Markus G: Localization of plasminogen activators in human colon cancer by immunoperoxidase staining. Cancer Res 1985, 45:1787-1796
11. Kohga S, Harvey SR, Suzumiya J, Sumiyoshi A, Markus G: Comparison of the immunohistochemical localization of urokinase in normal and cancerous human colon tissue. Fibrinolysis 1989, 3:17-22
12. Grendahl-Hansen J, Ralfkiaer E, Kirkeby LT, Kristensen P, Lund LR, Dano K: Localization of urokinase-type plasminogen activator in stromal cells in adenocarcinomas of the colon in humans. Am J Pathol 1991, 138:111-117
13. Pyke C, Kristensen P, Ralfkiaer E, Grøndahl-Hansen J, Eriksen J, Blasi F, Danø K: Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells at invasive foci in human colorectal adenocarcinomas. Am J Pathol 1991, 138:1059-1067
14. Sier CFM, Fellbaum C, Verspaget HW, Schmitt M, Griffioen G, Graeff H, Hofler H, Lamers CBHW: Immunolocalization of urokinase-type plasminogen activator in adenomas and carcinomas of the colorectum. Histopathology 1991, 19:231-237
15. Costantini V, Sidoni A, Deveglia R, Cazzato OA, Bellezza G, Ferri I, Bucciarelli E, Nenci GG: Combined overexpression of urokinase, urokinase receptor, and plasminogen activator inhibitor-1 is associated with breast cancer progression. Cancer 1996, 77:1079-1088
16. Schmitt M, Chucholowski N, Busch E, Hellmann D, Wagner B, Goretzki L, Janicke F, Gunzler WA, Graeff H: Fluorescent probes as tools to assess the receptor for the urokinase-type plasminogen activator on tumor cells. Semin Thromb Hemost 1991, 17:291-302
17. Yamamoto M, Sawaya R, Mohanam S, Binday AK, Bruner JM, Oka K, Rao VH, Tomonaga M, Nicolson GL, Rao JS: Expression and localization of urokinase-type plasminogen activator in human astrocytomas in vivo. Cancer Res 1994, 54:3656-3661
18. Luther T, Magdolen V, Albrecht S, Kasper M, Riemer C, Kessler H, Graeff H, Muller M, Schmitt M: Epitope-mapped monoclonal antibodies as tools for functional and morphological analyses of the human urokinase receptor in tumor tissue. Am J Pathol 1997, 150:1231-1244
19. Feinberg AP, Vogelstein B: A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 1983, 132:6-13
20. Trask BJ, Massa H, Kenwrick S, Gitschier J: Mapping of human chromosome Xq28 by two-color fluorescence in situ hybridization of DNA sequences to interphase cell nuclei. Am J Hum Genet 1991, 48:1-15
21. Pyke C, Ralfkiaer E, Ronne E, Hoyer-Hansen G, Kirkeby L, Danø K: Immunohistochemical detection of the receptor for urokinase plasminogen activator in human colon cancer. Histopathology 1994, 24: 131-138
22. Ellis V, Behrendt N, Danø K: Plasminogen activation by receptor-bound urokinase. J Biol Chem 1991, 266:12752-12758
23. Hewitt R, Danø K: Stromal cell expression of components of matrix-degrading protease systems in human cancer. Enzyme Protein 1996, 49:163-173
24. Buo L, Lyberg T, Jorgensen L, Johansen HT, Aasen AO: Location of plasminogen activator (PA) and PA inhibitor in human colorectal adenocarcinomas. APMIS 1993, 101:325-241
25. Buo L, Meling GI, Karlsrud TS, Johansen HT, Aasen AO: Antigen levels of urokinase plasminogen activator and its receptor at the tumor-host interface of colorectal adenocarcinomas are related to tumor aggressiveness. Hum Pathol 1995, 26:1133-1138
26. Tan K, Powe DG, Gray T, Turner DR, Hewitt RE: Regional variations of urokinase-type plasminogen activator In human colorectal cancer: a quantitative study by image analysis. Int J Cancer 1995, 60:308-314
27. Boyd D, Florent G, Kim P, Brattain M: Determination of the levels of urokinase and its receptor in human colon carcinoma cell lines. Cancer Res 1988, 48:3112-3116
28. Boyd D, Ziober B, Chakrabarty S, Brattain M: Examination of urokinase protein/transcript levels and their relationship with laminin degradation in cultured colon carcinoma. Cancer Res 1989, 49:816-820
29. Hollas W, Blasi F, Boyd D: Role of urokinase receptor in facilitating extracellular matrix invasion by cultured colon cancer. Cancer Res 1991, 51:3690-3695
30. Quax PHA, Pedersen N, Masucci MT, Weenig-Verhoeff EJ, Danø K, Verheijen JH, Blasi F: Complementation between urokinase-produclng and receptor-producing cells in extracellular matrix degradation. Cell Regul 1991, 2:793-803
31. Grøndahl-Hansen J, Ralfkiaer E, Nielsen LS, Kristensen P, Frentz G, Danø K: Immunohistochemical localization of urokinase-and tissue-plasminogen activators in psoriatic skin. J Invest Dermatol 1987, 88:28-32
32. Kristensen P, Larsson L-I, Nielsen LS, Grøndahl-Hansen J, Andreasen PA, Danø K: Human endothelial cells contain one type of plasminogen activator. FEBS Lett 1984, 168:33-37