Improved process for production of recombinant yeast-derived monomeric human G-CSF

Applied Microbiology and Biotechnology

Volumn 52, Issue 3, 1999, Pages 338-344

  Bae, C S ^b   Yang, D S ^b   Lee, J ^a   Park, Y H ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Hanhyo Institute of Technology   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ARTICLE; BIOTECHNOLOGY; CULTURE MEDIUM; DRUG DETERMINATION; DRUG PURIFICATION; DRUG SYNTHESIS; FREEZE DRYING; NONHUMAN; POLYMERIZATION; SACCHAROMYCES CEREVISIAE;

BIOPOLYMERS; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, GEL; CULTURE MEDIA; DRUG STABILITY; FERMENTATION; FREEZE DRYING; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; HYDROGEN-ION CONCENTRATION; INDUSTRIAL MICROBIOLOGY; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCES CEREVISIAE;

EID: 0032832909     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002530051529     Document Type: Article

References (16)

1. Arakawa T, Prestrelski SJ, Narhi LO, Boone TC, Kenney WC (1993) Cysteine 17 of recombinant human granulocyte colony-stimulating factor is partially solvent-exposed. J Protein Chem 12: 525-531
2. Bae CS, Yang DS, Jang KR, Seong BL, Lee J (1998) Enhanced secretion of human granulocyte colony-stimulating factor directed by a novel hybrid fusion peptide from recombinant Saccharomyces cerevisiae at high cell concentration. Biotechnol Bioeng 57: 600-609
3. Chung BH, Park KS (1998) Simple approach to reducing proteolysis during secretory production of human parathyroid hormone in Saccharomyces cerevisiae. Biotechnol Bioeng 57: 245-249
4. Chung BH, Seo DJ, Nam SW, Na JG, Chang YK (1997) Optimization of feeding strategy for overproduction of human lipocortin-I in Saccharomyces cerevisiae controlled by the GAL10 promoter. J Ferm Bioeng 84: 466-470
5. Costantino HR, Langer R, Klibanov AM (1995) Aggregation of a lyophilized pharmaceutical protein, recombinant human albumin: effect of moisture and stabilization by excipients. Bio/Technology 13: 493-496
6. Gill RT, Cha HJ, Jain A, Rao G, Bentley WE (1998) Generating controlled reducing environments in aerobic recombinant Escherichia coli fermentations: effects on cell growth, oxygen uptake, heat shock protein expression, and in vivo CAT activity. Biotechnol Bioeng 59: 248-259
7. Gillis S, Urdal DL, Clevenger W, Klinke R, Sassenfeld H, Price V, Cosman D (1988) Production of recombinant human colony stimulating factors in yeast. Behring Inst Mitt 83: 1-7
8. Kerwin BA, Heller MC, Levin SH, Randolph TW (1998) Effects of Tween 80 and sucrose on acute short-term stability and long-term storage at -20 degrees C of a recombinant hemoglobin. J Pharm Sci 87: 1062-1068
9. Kubota N, Orita T, Hattori K, Oheda M, Ochi N, Yamazaki T (1990) Structural characterization of natural and recombinant human granulocyte colony-stimulating factors. J Biochem 107: 486-492
10. Layton JE, Morstyn G, Fabri LJ, Reid GE, Burgess AW, Simpson RJ, Nice EC (1991) Identification of a functional domain of human granulocyte colony-stimulating factor using neutralizing monoclonal antibodies. J Biol Chem 266: 23815-23823
11. Mire-Sluis AR, Das RG, Thorpe R (1995) The international standard for granulocyte colony stimulating factor (G-CSF): evaluation in an international collaborative study. J Immunol Methods 179: 117-126
12. Oheda M, Hasegawa M, Hattori K, Kuboniwa H, Kojima T, Orita T, Tomonou K, Yamazaki T, Ochi N (1990) O-linked sugar chain of human granulocyte colony-stimulating factor protects it against polymerization and denaturation allowing it to retain its biological activity. J Biol Chem 265: 11432-11435
13. Robinson AS, Wittrup KD (1995) Constitutive overexpression of secreted heterologous proteins decreases extractable BiP and protein disulfide isomerase levels in Saccharomyces cerevisiae. Biotechnol Prog 11: 171-177
14. Romanos MA, Score CA, Clare JJ (1992) Foreign gene expression in yeast: a review. Yeast 8: 423-488
15. Souza LM, Boone TC, Gabrilove J, Lai PH, Zsebo KM, Murdock DC, Chazin VR, Bruszewski J, Lu H, Chen KK, Barendt J, Platzer E, Moore MAS, Mertelsmann R, Weite K (1986) Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells. Science 232: 61-65
16. Tsuchiya M, Nomura H, Asano S, Kaziro Y, Nagata S (1987) Characterization of recombinant human granulocyte-colony-stimulating factor produced in mouse cells. EMBO J 6: 611-616