Monocytoid B cells are distinct from splenic marginal zone cells and commonly derive from unmutated naive B cells and less frequently from postgerminal center B cells by polyclonal transformation

Blood

Volumn 94, Issue 8, 1999, Pages 2800-2808

  Stein, Karoline ^a   Hummel, Michael ^a   Korbjuhn, Petra ^a   Foss, Hans Dieter ^a   Anagnostopoulos, Ioannis ^a   Marafioti, Theresa ^a   Stein, Harald ^a,b  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN D; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN M; RNA;

ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; GENE REARRANGEMENT; GERMINAL CENTER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOPHENOTYPING; LYMPHADENOPATHY; LYMPHOCYTE SUBPOPULATION; LYMPHOCYTE TRANSFORMATION; MONOCYTE; POLYCLONAL ACTIVATION; PRIORITY JOURNAL; SOMATIC MUTATION; SPLEEN CELL; TOXOPLASMA GONDII;

EID: 0032832827     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v94.8.2800.420a01_2800_2808     Document Type: Article

References (51)

1. Lennert K: Die Frühveränderungen der Lymphogranulomatose. Frankf Zeitschr Pathol 69:103, 1958
2. Miettinen M, Franssila K: Malignant lymphoma simulating lymph node toxoplasmosis. Histopathology 6:129, 1982
3. Mohrmann RL, Nathwani BN, Brynes BK, Sheibani K: Hodgkin's disease occurring in monocytoid B-cell clusters. Am J Clin Pathol 95:802, 1991
4. Menke D, Banks P: Neoplastic monocytoid B cells in malignant lymphomas of diverse histologic type. Lab Invest 56:50A, 1987
5. Nathwani BN: Diagnostic significance of morphologic patterns in lymph node proliferation, in Knowles DM (ed): Diagnostic Hematopathology. Baltimore, MD, Williams & Wilkins, 1992, p 407
6. Nathwani BN, Mohrmann RL, Brynes RK, Taylor CR, Hansmann ML, Sheibani K: Monocytoid B-cell lymphomas: An assessment of diagnostic criteria and a perspective on histogenesis. Hum Pathol 23:1061, 1992
7. Ngan BY, Warnke RA, Wilson M, Takagi K, Clearly ML, Dorfman RF: Monocytoid B-cell lymphoma: A study of 36 cases. Hum Pathol 22:409, 1991
8. Hernandez AM, Nathwani BN, Nguyen D, Shibata D, Chuan W, Nichols P, Taylor CR: Nodal benign and malignant monocytoid B cells with and without follicular lymphomas: A comparative study of follicular colonization, light chain restriction, bcl-2, and t(14;18) in 39 cases. Hum Pathol 26:625, 1995
9. Plank L, Hansmann ML, Fischer R: Monocytoid B-cell reaction associated with peripheral T-cell lymphomas. Pathol Res Pract 191: 1152, 1995
10. Schmid U, Cogliatti SB, Diss TC, Isaacson PG: Monocytoid/ marginal zone B-cell differentiation in follicle centre cell lymphoma. Histopathology 29:201, 1996
11. Plank L, Hansmann ML, Fischer R: Monocytoid B-cells occurring in Hodgkin's disease. Virch Arch 424:321, 1994
12. Ohsawa M, Kanno H, Naka N, Aozasa K: Occurrence of monocytoid B-lymphocytes in Hodgkin's disease. Mod Pathol 7:540, 1994
13. Lennert K: Diagnose und Ätiologie der Piringerschen Lymphadenitis. Verh Dtsch Ges Pathol 42:203, 1959
14. Lennert K: Lymphknoten: Diagnostik in Schnitt und Ausstrich: Cytologie und Lymphadenitis. Handbuch der Speziellen Pathologischen Anatomie und Histologie. Berlin, Germany, Springer-Verlag, 1961
15. Stansfeld AG: The histological diagnosis of toxoplasmic lymphadenitis. J Clin Pathol 14:565, 1961
16. Dorfman RF, Remington JS: Value of lymph-node biopsy in the diagnosis of acute acquired toxoplasmosis. N Engl J Med 289:878, 1973
17. Miettinen M: Histological differential diagnosis between lymph node toxoplasmosis and other benign lymph node hyperplasias. Histopathology 5:205, 1981
18. Cardoso DA, Harris NL, Bhan AK: Characterization of immature sinus histiocytes (monocytoid cells) in reactive lymph nodes by use of monoclonal antibodies. Hum Pathol 15:330, 1984
19. Stein H, Lennert K, Mason DY, Liangru S, Ziegler A: Immature sinus histiocytes. Their identification as a novel B-cell population. Am J Pathol 117:44, 1984
20. Sheibani K, Fritz RM, Winberg CD, Burke JS, Rappaport H: "Monocytoid" cells in reactive follicular hyperplasia with and without multifocal histiocytic reactions: An immunohistochemical study of 21 cases including suspected cases of toxoplasmic lymphadenitis. Am J Clin Pathol 81:453, 1984
21. Piris MA, Rivas C, Morente M, Oliva H, Rubio C: Immature sinus histiocytosis a monocytoid B-lymphoid reaction. J Pathol 148: 159, 1986
22. Burke JS, Sheibani K: Hairy cells and monocytoid B lymphocytes: Are they related? Leukemia 1:298, 1987
23. Van den Oord JJ, De Wolf-Peeters C, de Vos R, Desmet VJ: Immature sinus histiocytosis. Light- and electron-microscopic features, immunologic phenotype, and relationship with marginal zone lymphocytes. Am J Pathol 118:266, 1985
24. Piris MA, Rivas C, Morente M, Cruz MA, Rubio C, Oliva H: Monocytoid B-cell lymphoma, a tumour related to the marginal zone. Histopathology 12:383, 1988
25. Nizze H, Cogliatti SB, von Schilling C, Feller AC, Lennert K: Monocytoid B-cell lymphoma: Morphological variants and relationship to low-grade B-cell lymphoma of the mucosa-associated lymphoid tissue. Histopathology 18:403, 1991
26. Fend F, Kraus-Huonder B, Müller-Hermelink HK, Feller AC: Monocytoid B-cell lymphoma: Its relationship to and possible cellular origin from marginal zone cells. Hum Pathol 24:336, 1993
27. De Wolf-Peeters C, Pittaluga S, Dierlamm J, Wlodarska I, Van Den Berghe H: Marginal zone B-cell lymphomas including mucosa-associated lymphoid tissue type lymphoma (MALT), monocytoid B-cell lymphoma and splenic marginal zone cell lymphoma and their relation to the reactive marginal zone. Leuk Lymphoma 26:467, 1997
28. Küppers R, Hajadi M, Plank L, Rajewsky K, Hansmann ML: Molecular Ig gene analysis reveals that monocytoid B cell lymphoma is a malignancy of mature B cells carrying somatically mutated V region genes and suggests that rearrangement of the kappa-deleting element (resulting in deletion of the Ig kappa enhancers) abolishes somatic hypermutation in the human. Eur J Immunol 26:1794, 1996
29. Tierens A, Delabie J, Michiels L, Vandenberghe P, De Woolf-Peeters C: Marginal-zone B cells in the human lymph node and spleen show somatic hypermutations and display clonal expansion. Blood 93:226, 1999
30. Poppema S, Gilchrist M: Monocytoid B cells are bcl-2 negative in contrast to marginal zone cells and monocytoid B cell-lymphoma. Int J Surg Pathol 2:277, 1995
31. Kojima M, Nakamura S, Itoh H, Yoshida K, Shimizu K, Motoori T, Yamane N, Joshita T, Suchi T: Occurrence of monocytoid B cells in reactive lymph node lesions. Pathol Res Pract 194:559, 1998
32. Feller AC, Wacker HH, Moldenhauer G, Radzun HJ, Parwaresch MR: Monoclonal antibody Ki-B3 detects a formalin resistant antigen on normal and neoplastic B cells. Blood 70:629, 1987
33. Stein H, Gatter K, Asbahr H, Mason DY: Use of freeze-dried paraffin-embedded sections for immunohistologic staining with monoclonal antibodies. Lab Invest 52:676, 1985
34. Hsu SM, Raine L, Fanger H: The use of antiavidin antibody and avidin-biotin-peroxidase complex in immunoperoxidase technics. Am J Clin Pathol 75:816, 1981
35. Foss HD, Herbst H, Oelmann E, Samol J, Grebe M, Blankenstein T, Matthes J, Qin ZH, Falini B, Pileri S: Lymphotoxin, tumour necrosis factor and interleukin-6 gene transcripts are present in Hodgkin and Reed-Sternberg cells of most Hodgkin's disease cases. Br J Haematol 84:627, 1993
36. Milani S, Herbst H, Schuppan D, Hahn E, Stein H: In situ hybridisation for procollagen types I, III and IV mRNA in normal and fibrotic rat liver. Evidence for predominant expression in non-parenchymal liver cells. Hepatology 10:84, 1989
37. Marafioti T, Hummel M, Anagnostopoulos I, Foss HD, Falini B, Delsol G, Isaacson PG, Pileri S, Stein H: Origin of nodular lymphocyte-predominant Hodgkin's disease from a clonal expansion of highly mutated germinal-center B cells. N Engl J Med 337:453, 1997
38. Marks JD, Tristem M, Karpas A, Winter G: Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family-specific oligonucleotide probes. Eur J Immunol 21:985, 1991
39. Ramasamy I, Brisco M, Morley A: Improved PCR method for detecting monoclonal immunoglobulin heavy chain rearrangement in B cell neoplasms. J Clin Pathol 45:770, 1992
40. Hummel M, Tamaru J, Kalvelage B, Stein H: Mantle cell (previously centrocytic) lymphomas express VH genes with no or very little somatic mutations like the physiologic cells of the follicle mantle. Blood 84:403, 1994
41. Cook GP, Tomlinson IM: The human immunoglobulin VH repertoire. Immunol Today 16:237, 1995
42. Tamaru J, Hummel M, Marafioti T, Kalvelage B, Stein H: Burkitt's lymphomas express VH-genes with a moderate number of antigen-selected somatic mutations. Am J Pathol 147:1398, 1995
43. Klein U, Goossens T, Fischer M, Kanzler H, Braeuninger A, Rajewsky K, Küppers R: Somatic hypermutation in normal and transformed human B cells. Immunol Rev 162:261, 1998
44. Mason DY, Stein H, Naiem M, Abdulaziz Z: Immunohistological analysis of human lymphoid tissue by double immunoenzymatic labelling. J Cancer Res Clin Oncol 101:13, 1981
45. Klein U, Küppers R, Rajewsky K: Variable-region gene analysis of B-cell subsets derived from a 4-year old child. Somatically mutated memory B cells accumulated in the peripheral blood already at young age. J Exp Med 180:1383, 1994
46. Küppers R, Zhao M, Hansmann ML, Rajewsky K: Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. EMBO J 12:4955, 1993
47. Pascual V, Liu YJ, Magalski A, de Bouteiller O, Banchereau J, Capra JD: Analysis of somatic mutation in five B cell subsets of human tonsil. J Exp Med 180:329, 1994
48. Dunn-Walters DK, Isaacson PG, Spencer J: Analysis of mutations in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that MGZ of human spleen is a reservoir of memory B cells. J Exp Med 182:559, 1995
49. Denkers EY, Caspar P, Sher A: Toxoplasma gondii possesses a superantigen activity that selectively expands murine T cell receptor V beta 5-bearing CD8+ lymphocytes. J Exp Med 180:985, 1994
50. Purner MB, Berens RL, Tomavo S, Lecordier L, Cesbron-Delauw MF, Kotzin BL, Curiel TJ: Stimulation of human T lymphocytes obtained from Toxoplasma gondii-seronegative persons by proteins derived from T. gondii. J Infect Dis 177:746, 1998
51. Dunn-Walters DK, Isaacson PG, Spencer J: Sequence analysis of rearranged IgVH genes from microdissected human Peyer's patch marginal zone B cells. Immunology 88:618, 1996