Decreased peripheral blood T cell cytokine gene expression rheumatoid arthritis

Scandinavian Journal of Rheumatology

Volumn 28, Issue 4, 1999, Pages 244-251

  Loubet Lescoulie P ^a   Constantin, A ^a,b   Mazieres B ^b   Tkaczuk, J ^b   De Preval C ^a   Cantagrel, Alain ^a,b  

^a CHU PURPAN   (France)

^b CHU RANGUEIL   (France)

Author keywords

Cytokines; Rheumatoid arthritis; Th1; Th2

Indexed keywords

COMPLEMENTARY DNA; CORTICOSTEROID; CYTOKINE; GAMMA INTERFERON; GOLD SALT; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; MESSENGER RNA; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; PREDNISONE; SALAZOSULFAPYRIDINE;

ADULT; AGED; ARTHRITIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; T LYMPHOCYTE;

ADULT; AGED; ARTHRITIS, RHEUMATOID; CELLS, CULTURED; CYTOKINES; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-2; INTERLEUKIN-4; MIDDLE AGED; REFERENCE VALUES; REGRESSION ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC;

EID: 0032830770     PISSN: 03009742     EISSN: None     Source Type: Journal    
DOI: 10.1080/03009749950155625     Document Type: Article

References (44)

1. Mosmann TR, Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 1996;17:138-46.
2. Romagnani S. Induction of Th1 and Th2 responses: A key role for the 'natural' immune response? Immunol Today 1992;13:379-81.
3. Maggi E, Parronchi P, Manetti R, Simonelli C, Piccini MP, Rugiu FS, et al. Reciprocal regulatory effects of IFNγ and IL4 on the in vitro development of human Th1 and Th2 clones. J Immunol 1992;148:2142-7.
4. Firestein GS, Xu WD, Townsend K, Broide D, Alvaro-Gracia J, Glasebrook A, et al. Cytokines in chronic inflammation arthritis. I. Failure to detect T cell lymphokines (interleukin 2 and interleukin 3) and presence of macrophage colony-stimulating factor (CSF-1) and a novel mast cell growth factor in rheumatoid synovitis. J Exp Med 1988;168:1573-86.
5. Miossec P, Briolay J, Dechanet J, Wijdenes J, Martinez-Valdez H, Banchereau J. Inhibition of the production of proinflammatory cytokines and immunoglobulins by interleukin-4 in an ex vivo model of rheumatoid synovitis. Arthritis Rheum 1992;35:874-83.
6. Chen E, Keystone EC, Fish EN. Restricted cytokine expression in rheumatoid arthritis. Arthritis Rheum 1993;36:901-10.
7. Chomarat P, Banchereau J, Miossec P. Differential effects of interleukins 10 and 4 on the production of interleukin-6 by blood and synovium monocytes in rheumatoid arthritis. Arthritis Rheum 1995;38:1046-54.
8. Miltenburg AMM, van Laar JM, de Kuiper R, Daha MR, Breedveld FC. T cells cloned from human rheumatoid synovial membrane functionally represent the Th1 subset. Scand J Immunol 1992;35:603-10.
9. Quayle AJ, Chomarat P, Miossec P, Kjeldsen-Kragh J, Førre Ø, Natvig JB. Rheumatoid inflammatory T-cell clones express mostly Th1 but also Th2 and mixed (Th0 like) cytokine patterns. Scand J Immunol 1993;38:75-82.
10. Simon AK, Seipelt E, Sieper J. Divergent T-cell cytokine patterns in inflammatory arthritis. Proc Natl Acad Sci USA 1994;91:8562-6.
11. Smeets TJM, Dolhain RJEM, Breedveld FC, Tak PP. Analysis of the cellular infiltrates and expression of cytokines in synovial tissue from patients with rheumatoid arthritis and from patients with reactive arthritis. J Pathol (in press).
12. Hertzog PJ, Emery P, Cheetham BF, Mackay IR, Linnane AW. Interferons in rheumatoid arthritis: Alterations in production and response related to disease activity. Clin Immunol Immunopathol 1988;48:192-201.
13. Kitas GD, Salmon M, Farr M, Gaston JSH, Bacon PA. Deficient interleukin 2 production in rheumatoid arthritis: Association with active disease and systemic complication. Clin Exp Immunol 1988;73:242-9.
14. Franchimont P, Reuter A, Vrindts-Gevaert Y, Bastings M, Malaise M, Sondag C, et al. Production of tumor necrosis α, interferon-γ and interleukin-2 by peripheral blood mononuclear cells of subjects suffering from rheumatoid arthritis. Scand J Rheumatol 1988;17:203-12.
15. Ruschen S, Stellberg W, Warnatz H. Kinetics of cytokine secretion by mononuclear cells of the blood from rheumatoid arthritis patients are different from those of healthy controls. Clin Exp Immunol 1992;89:32-7.
16. Schulze-Koops H, Lipsky PE, Kavanaugh AF, Davis LS. Elevated Th1- or Th0-like cytokine mRNA in peripheral circulation of patients with rheumatoid arthritis. Modulation by treatment with anti-ICAM-1 correlates with clinical benefit. J Immunol 1995;155:5029-37.
17. van Roon JAG, Verhoef CM, van Roy JLAM, Gmelig-Meyling FHJ, Huber-Bruning O, Lafeber FPJG, et al. Decrease in peripheral type 1 over type 2 T cell cytokine production in patients with rheumatoid arthritis correlates with an increase in severity of disease. Ann Rheum Dis 1997;56:656-60.
18. Rivas D, Mozo L, Zamorano J, Gayo A, Torre-Alonso JC, Rodriguez A, et al. Upregulated expression of IL-4 receptors and increased levels of IL-4 in rheumatoid arthritis patients. J Autoimmun 1995;8:587-600.
19. Al-Janadi M, Al-Balla S, Al-Dalaan A, Raziuddin S. Cytokine production by helper T cell populations from the synovial fluid and peripheral blood in patients with rheumatoid arthritis. J Rheumatol 1993;20:1647-53.
20. Dolhain RJEM, van der Heiden A, ter Haar N, Breedveld FC, Miltenburg AMM. Shift toward T lymphocytes with T helper 1 cytokine-secretion profile in the joints of patients with rheumatoid arthritis. Arthritis Rheum 1996;39:1961-9.
21. Swaag AJG, van den Brink HG, Aarden LA. Cytokine production in whole blood of patients with rheumatoid arthritis. Ann Rheum Dis 1997;56:693-5.
22. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
23. Wang AM, Doyle MV, Mark DF. Quantification of mRNA by the polymerase chain reaction: Proc Natl Acad Sci U S A 1989;86:9717-21.
24. Gilliland G, Perrin S, Blanchard K, Bunn F. Analysis of cytokine mRNA and DNA: Detection and quantitication by competitive polymerase chain reaction. Proc Natl Acad Sci U S A 1990;87:2725-9.
25. Pannetier C, Cochet M, Darche S, Kourilsky P. Une méthode de dosage quantitatif d'acides nucléiques par amplification enzymatique (méthode PCR) à saturation. C R Acad Sci Paris 1992;315:271-7.
26. Constantin A, Loubet-Lescoulié P, Lambert N, Yassine-Diab B, Abbal M, Mazières B, et al. Antiinflammatory and immunoregulatory action of methotrexate in the treatment of rheumatoid arthritis: Evidence for increased interleukin-4 and interleukin-10 gene expression demonstrated in vitro by competitive reverse transcriptase-polymerase chain reaction. Arthritis Rheum 1998;41:48-57.
27. Klinman DM, Nutman TB. Elispot assay to detect cytokine secreting murine and human cells. In: Coligen JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W, eds. Current Protocols in Immunology, 7th Ed. Brooklyn, NY: Greene Publishing Associates, 1994.
28. Soutar RL, Dillon J, Ralston SH. Control genes for reverse-transcription-polymerase chain reaction: A comparison of beta actin and glyceraldehyde phosphate dehydrogenase. Br J Haematol 1997;97:247-8.
29. Aono H, Hasunuma T, Fujisawa K, Nakajima T, Yamamoto K, Mita S, et al. Direct suppression of human synovial cell proliferation in vitro by salazosulfapyridine and bucillamine. J Rheumatol 1996;23:65-70.
30. Barrera P, Haagsma CJ, Boerbooms AM, Van Riel PL, Borm GF, Van de Putte LB, et al. Effect of methotrexate alone or in combination with sulphasalazine on the production and circulating concentrations of cytokines and their antagonists. Longitidinal evaluation in patients with rheumatoid arthritis. Br J Rheumatol 1995;34:745-55.
31. Yanni G, Nabil M, Farahat MR, Poston RN, Panayi GS. Intramuscular gold decreases cytokine expression and macrophage numbers in the rheumatoid synovial membrane. Ann Rheum Dis 1994;53:315-22.
32. Kanik KS, Hagiwara E, Yarboro CH, Schumacher HR, Wilder RL, Klinman DM. Distinct patterns of cytokine secretion characterize new onset synovitis versus chronic rheumatoid arthritis. J Rheumatol 1998;25:16-22.
33. Combe B, Pope RM, Fischbach M, Darnell B, Baron S, Talal N. Interleukin-2 in rheumatoid arthritis: Production of and response to interleukin-2 in rheumatoid synovial fluid, synovial tissue and peripheral blood. Clin Exp Immunol 1985;59:520-8.
34. Miyasaka N, Nakamura T, Russel IJ, Talal N. Interleukin 2 deficiences in rheumatoid arthritis and systemic lupus erythematosus. Clin Immunol Immunopathol 1984;31:109-17.
35. Al-Janadi M, Al-Balla S, Al-Dalaan A, Raziuddin S. Cytokine profile in systemic lupus erythematosus, rheumatoid arthritis, and other rheumatic diseases. J Clin Immunol 1993;13:58-67.
36. Bucht A, Larsson P, Weisbrot L, Thorne C, Pisa P, Smedegard G, et al. Expression of interferon-gamma (IFN-γ), IL-10, IL-12 and transforming growth factor-beta (TGF-β) mRNA in synovial fluid cells from patients in the early and late phases of rheumatoid arthritis (RA). Clin Exp Immunol 1996;103:357-67.
37. Al-Janadi M, Al-Dalaan A, Al-Balla S, Raziuddin S. CD4+ T cell inducible immunoregulatory cytokine response in rheumatoid arthritis. J Rheumatol 1996;23:809-14.
38. Llorente L, Richaud-Patin Y, Fior R, Alcocer-Varela J, Wijdenes J, Morel Fourrier B, et al. In vivo production of interleukin-10 by non-T cells in rheumatoid arthritis, Sjögren's syndrome and systemic lupus erythematosus. Arthritis Rheum 1994;37:1647-55.
39. Cush JJ, Splawski JB, Thomas R, McFarlin JE, Schulze-Koops H, Davis LS, et al. Elevated interleukin-10 levels in patients with rheumatoid arthritis. Arhtritis Rheum 1995;38:96-104.
40. Cohen SBA, Katsikis PD, Chu CQ, Thomssen H, Webb LMC, Maini RN, et al. High level of interleukin-10 production by the activated T cell polulation within the rheumatoid synovial membrane. Arthritis Rheum 1995;38:946-52.
41. Hagiwara E, Abbasi F, Mor G, Ishigatsubo Y, Klinman D. Phenotype and frequency of cells secreting IL-2, IL-4, IL-6, IL-10, IFN and TNF-α in human peripheral blood. Cytokine 1995;7:815-22.
42. Rulifson IC, Sperling AI, Fields PE, Fitch FW, Bluestone JA. CD28 costimulation promotes the production of Th2 cytokines. J Immunol 1997;158:658-65.
43. Maurice MM, Lankester AC, Bezemer AC, Geertsma MF, Tak PP, Breedveld FC, et al. Defective TCR-mediated signaling in synovial T cells in rheumatoid arthritis. J Immunol 1997;159:2973-8.
44. Cope AP, Londei M, Chu NR, Cohen SBA, Elliott MJ, Brennan FM, et al. Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex: Reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis. J Clin Invest 1994;94:749-60.