Ramiprilat prevents the development of acute coronary endothelial dysfunction in the dog

Basic Research in Cardiology

Volumn 94, Issue 4, 1999, Pages 238-245

  Martorana, P A ^a   Ruetten, H ^a   Goebel, B ^a   Koehl, D ^a   Roegner, B ^a   Schoelkens, B A ^a   Keil, M ^a  

^a SANOFI   (France)

Author keywords

Angiotensin converting enzyme inhibition; Dog; Endothelial dysfunction; Ischemia and reperfusion

Indexed keywords

ACETYLCHOLINE; GLYCERYL TRINITRATE; RAMIPRILAT; SEROTONIN; SODIUM CHLORIDE; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOLE; ARTICLE; BIOPSY; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY DISEASE; DOG; FEMALE; HEART MUSCLE ISCHEMIA; INTRACORONARY INFUSION; LEUKOCYTE ADHERENCE; MALE; NONHUMAN; PREVENTIVE MEDICINE; REPERFUSION; SCANNING ELECTRON MICROSCOPY; VASCULAR ENDOTHELIUM;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; CORONARY CIRCULATION; CORONARY VESSELS; DOGS; ENDOTHELIUM, VASCULAR; FEMALE; MALE; MICROSCOPY, ELECTRON, SCANNING; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; RAMIPRIL;

EID: 0032825861     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003950050148     Document Type: Article

References (40)

1. Antony I, Lerebours G, Nitenberg A (1960) Angiotensin-converting enzyme inhibition restores flow-dependent forearm blood flow and cold pressor test-induced dilations in coronary arteries of hypertensive patients. Circulation 94: 3115-3122
2. Becker RH, Wiemer G, Linz W (1991) Preservation of endothelial function by ramipril in rabbits on a long-term atherogenic diet. J Cardiovasc Pharmacol 18: S110-S115
3. Bossaller C, Auch-Schwelk W, Weber T, Gotze S, Grafe M, Graf K, Fleck E (1994) Endothelium-dependent relaxation are augmented in rats chronically treated with the angiotensin converting enzyme inhibitor enalapril. J Cardiovasc Pharmacol 24: 372-379
4. Clozel M, Kuhn H, Hefti F, Baumgarten HR (1991) Endothelial dysfunction and subendothelial monocyte macrophages in hypertension: effect of angiotensin converting enzyme inhibition. Hypertension 18: 132-141
5. Dauber IM, VanBenthuysen KM, McMurtry IF, Wheeler GS, Lesnefsky EJ, Horwitz LD, Weil JV (1990) Functional coronary microvascular injury evident as increased permeability due to brief ischemia and reperfusion. Circ Res 66: 986-998
6. de Cavanag EMV, Inserra F, Ferder L, Romano L, Ercole L, Fraga CG (1995) Superoxide dismutase and glutathion peroxidase are increased by enalapril and captopril in mouse liver. FEBS Lett 361: 22-24
7. Drexler H, Zeiher AM, Meizer K, Just H (1991) Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolemic patients by L-arginine. Lancet 338: 1546-1550
8. Egashira K, Inou T, Hirooka Y, Kai H, Sugimachi M, Suzuki S, Kuga T, Urabe Y, Takeshita A (1993) Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans. Circulation 88: 77-81
9. Ehring T, Krajkar M, Baumgart D, Kompa S, Hümmelgen M, Heusch G (1995) Cholinergic and α-adrenergic coronary constriction with increasing ischemia-reperfusion injury. Am J Physiol 268 (Heart Circ Physiol 37): H886-H894
10. Entman ML, Smith CW (1994) Postreperfusion inflammation: a model for reaction to injury in cardiovascular disease. Cardiovasc Res 28: 1301-1311
11. Förstermann U, Mügge A, Alheid U, Haverich A, Frölich J (1988) Selective attenuation of endothelium-mediated vasodilation in atherosclerotic human coronary arteries. Circ Res 62: 185-190
12. Hawkins HK, Entman ML, Zhu JY, Youker KA, Berens K, Dore M, Smith CW (1996) Acute inflammatory reaction after myocardial ischemic injury and reperfusion. Development and use of a neutrophil-specific antibody. Am J Pathol 148: 1957-1969
13. Horwitz LD, Kaufman D, Keller MW, Kong Y (1994) Time course of coronary endothelial healing after injury due to ischemia and reperfusion. Circulation 90: 2439-2447
14. Kloner RA, Giacomelli F, Alker KJ, Hale SL, Matthews R, Bellows S (1991) Influx of neutrophils into the walls of large coronary arteries in response to ischemia/reperfusion. Circulation 84: 1758-1772
15. Kloner RA, Rude RE, Carlson N, Naroko PR, DeBoer LWV, Braunwald E (1980) Ultrastructural evidence of microvascular damage and myocardial cell injury after coronary artery occlusion: which comes first? Circulation 62: 945-952
16. Kupatt C, Habazettl H, Zahler S, Weber C, Becker BF, Messmer K, Gerlach E (1997) ACE-inhibition prevents postischemic coronary leukocyte adhesion and leukocyte-dependent reperfusion injury. Cardiovasc Res 36: 386-395
17. Linz W, Martorana PA, Wiemer G, Wirth K, Schölkens BA (1996) Role of kinins in myocardial ischemia. In: Karmazyn M (ed) Myocardial Ischemia: Mechanisms, Reperfusion, Protection, Basel: Birkhäuser Verlag, pp 231-241
18. Mancini GBJ, Henry GC, Macaya C, O'Neill BJ, Pucillo AL, Carere RG, Wargovich TJ, Mudra H, Lüscher TF, Kubaner MI, Haber HE, Uprichard ACG, Pepine CJ, Pitt B (1996) Angiotensin-converting enzyme inhibition with quinapril improves endothelial vasomotor dysfunction in patients with coronary artery disease: the TREND study (Trial on Reversing Endothelial Dysfunction). Circulation 94: 258-265
19. Martorana PA, Goebel B, Ruetten H, Koehl D, Keil M (1998) Coronary endothelial dysfunction after ischemia and reperfusion in the dog: a functional and morphological investigation. Bas Res Cardiol 93: 257-263
20. Martorana PA, Kettenbach B, Breipohl G, Linz W, Schölkens BA (1990) Reduction of infarct size by local angiotensin-converting enzyme inhibition is abolished by a bradykinin antagonist. Eur J Pharmacol 182: 395-396
21. Metha JL, Nichols WW, Donnelly WH, Lawson DL, Saldeen TGP (1989) Impaired canine coronary vasodilator response to acetylcholine and bradykinin after occlusion-reperfusion. Circ Res 64: 43-54
22. Mullane KM, Smith CW (1990) The role of leukocytes in ischemic damage, reperfusion injury and repair of the myocardium. In: Piper HM (ed) Pathophysiology of Severe Ischemic Myocardial Injury. Dordrecht: Kluwer Academic Publishers, pp 239-267
23. Nakamura M, Funakoshi T, Arakawa N, Yoshida H, Makita S, Hiramori K (1994) Effect of angiotensin-converting enzyme inhibitors on endothelium-dependent peripheral vasodilation in patients with chronic heart failure. J Am Coll Cardiol 24: 1321-1327
24. O'Driscoli G, Green D, Rankin J, Stanton K, Taylor R (1997) Improvement in endothelial function by angiotensin converting enzyme inhibition in insulin-dependent diabetes mellitus. J Clin Invest 100: 678-684
25. Piana RN, Wang SY, Friedman M, Sellke FW (1996) Angiotensin-converting enzyme inhibition preserves endothelium-dependent coronary microvascular responses during short-term ischemia-reperfusion. Circulation 93: 544-551
26. Rajagopalan S, Kurz S, Münzel T, Tarpey M, Freeman B, Griendling K, Harrison D (1996) Angiotensin II mediated hypertension in the rat incresases vascular superoxide production via membrane NADH/ NADPH oxidase activation: contribution to alterations of vasomotor tone. J Clin Invest 97: 1916-1923
27. Ribeiro Jorge PA, Osaki MR, de Almeida E, Dalva M, Neto LC (1997) Endothelium-dependent coronary flow in ischemia reperfusion. Exp Tox Pathol 49: 147-151
28. Sala A, Aliev GM, Rossoni G, Berti F, Bucellati C, Burmstock G, Folco G, Maclouf J (1996) Morphological and functional changes of coronary vasculature caused by transcellular biosynthesis of sulfidopeptide leukotriene in isolated heart of rabbit. Blood 87: 1824-1832
29. Sheridan FM, Cole P, Ramage D (1996) Leukocyte adhesion to the coronary microvasculature during ischemia and reperfusion in an in vivo canine model. Circulation 93: 1784-1787
30. Sobey CG, Dusting GJ, Grossman HJ, Woodman OL (1990) Impaired vasodilatation of epicardial coronary arteries and resistance vessels following myocardial ischemia and reperfusion in anesthetized dogs. Cor Art Dis 1: 363-374
31. VanBenthuysen KM, McMurtry IF, Horwitz LD (1987) Reperfusion after acute coronary occlusion in dogs impairs endothelium-dependent relaxation to acetylcholine and augments contractile reactivity in vitro. J Clin Invest 79: 265-274
32. Vanhoutte PM, Perrault LP, Vilaine JP (1997) Endothelial dysfunction and vascular disease. In: Rubanyi GM, Dzau VJ (eds) The Endothelium in Clinical Practice. New York, Basel, Hong Kong: Marcel Dekker Inc., pp 265-289
33. Werns SW, Walton JA, Hsia HH, Nabel EG, Sanz ML, Pitt B (1989) Evidence of endothelial dysfunction in angiographically normal coronary arteries of patients with coronary artery disease. Circulation 79: 287-291
34. Werrmann JG, Cohen SM (1994) Comparison of effects of angiotensin-converting enzyme inhibition with those of angiotensin II receptor antagonism on functional and metabolic recovery in postischemic working rat heart as studied by (31P) nuclear magnetic resonance. J Cardiovasc Pharmacol 24: 573-586
35. 2-Bildung in Endothelzellen ist Bradykininvermittelt. Kardiol 80 (Suppl 3): 120
36. Yang BC, Phillips MI, Ambuehl PEJ, Shen LP, Mehta P, Mehta JL (1997) Increase in angiotensin II type 1 receptor expression immediately after ischema-reperfusion in isolated rat hearts. Circulation 96: 922-926
37. Zahler S, Kupatt C, Mobert J, Becker BF, Gerlach E (1997) Effect of ACE-inhibition on redox status and expression of P-selectin of endothelial cells subjected to oxidative stress. J Mol Cell Cardiol 29: 2953-2960
38. Zeiher AM, Drexler H, Saurbier B, Just H (1993) Endothelium-mediated coronary blood flow modulation in humans: effects of age, atherosclerosis, hypercholesterolemia, and hypertension. J Clin Invest 92: 652-662
39. Zeiher AM, Drexler H, Wollschläger H, Just H (1991) Modulation of coronary vasomotor tone. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation 83: 391-401
40. Zeiher AM, Schächinger V (1994) Coronary endothelial vasodilator dysfunction: clinical relevance and therapeutic implications. Zeitschr Kardiol 83 (Suppl 3): 7-14