NMDA antagonists and tolerance to drugs affecting the central nervous system

CNS Drug Reviews

Volumn 5, Issue 2, 1999, Pages 165-176

  Khanna, J M ^a   Morato, G S ^b   Ferreira, Vania M M ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

Barbiturates; Benzodiazepines; CNS; Ethanol; Learning; NMDA; Opioids; Tolerance

Indexed keywords

4 (3 PHOSPHONOPROPYL) 2 PIPERAZINECARBOXYLIC ACID; ALCOHOL; AMPHETAMINE DERIVATIVE; BARBITAL; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE DERIVATIVE; CHLORDIAZEPOXIDE; COCAINE; DECAHYDRO 6 PHOSPHONOMETHYL 3 ISOQUINOLINECARBOXYLIC ACID; DIAZEPAM; DIZOCILPINE; GLUTAMIC ACID; KETAMINE; LORAZEPAM; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; OPIATE; OPIATE AGONIST; PENTOBARBITAL; PHENOBARBITAL;

ALCOHOL TOLERANCE; DRUG CROSS TOLERANCE; DRUG MECHANISM; DRUG SENSITIZATION; DRUG TOLERANCE; HUMAN; LEARNING; LONG TERM POTENTIATION; MEMORY; NERVE CELL EXCITABILITY; NERVE CELL PLASTICITY; NONHUMAN; REVIEW; SECOND MESSENGER;

EID: 0032825326     PISSN: 1080563X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1527-3458.1999.tb00096.x     Document Type: Review

References (116)

1. Anis NA, Berry NR, Lodge D. The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurons by N-methyl-D-aspartate. Br J Pharmacol 1983;79:565-575.
2. Ascher P, Nowak L. Electrophysiological studies of NMDA receptors. Trends Neurosci 1987;10:284-289.
3. Atweh SF, Kuhar MJ. Distribution and physiological significance of opioid receptors in the brain. Br Med Bull 1983;39:47-52.
4. Baker TB, Tiffany ST. Morphine tolerance as habituation. Psychol Rev 1985;92:78-108.
5. Barreto PS, Lemos T, Morato GS. NMDA-receptor antagonists block the development of rapid tolerance to ethanol in mice. Addict Biol 1998;3:55-64.
6. Ben-Eliyahu S, Marek P, Vaccarino AL, Mogil JS, Sternberg WF, Liebeskind JC. The NMDA receptor antagonist MK-801 prevents long-lasting non-associative morphine tolerance in the rat. Brain Res 1992;575:304-308.
7. Bhargava HN. Diversity of agents that modify opioid tolerance, physical dependence, abstinence syndrome and self-administrative behavior. Pharmacol Rev 1994;46:293-324.
8. Bhargava HN. Non-competitive antagonism of N-methyl-D-aspartate receptor inhibits tolerance to the analgesic action of U-50,488H, a K-opiate receptor agonist in the rat. Gen Pharmacol 1995;26:1055-1060.
9. 2-opioid receptor agonist in mice. Brain Res 1996;719:56-61.
10. Bilsky EJ, Inturrisi CE, Sadée W, Hruby VJ, Porreca F. Competitive and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective μ-or δ-opioid agonists in mice. Pain 1996;68:229-237.
11. Bitrán M, Kalant H. Learning factor in rapid tolerance to ethanol-induced motor impairment. Pharmacol Biochem Behav 1991;39:917-922.
12. BlissTVP, Collingridge GL. A synaptic model of memory: Long-term potentiation in the hippocampus. Nature 1993;361:31-39.
13. Bozarth MA, Wise RA. Anatomically distinct opiate receptor fields mediate reward and physical dependence. Science 1984;224:515-517.
14. Chapman PF, Atkins CM, Allen MT, Haley JE, Steinmetz JE. Inhibition of nitric oxide synthesis impairs two different forms of learning. Neuroreport 1992;3:567-570.
15. Collingridge GL, Bliss, TVP. NMDA receptors - their role in long-term potentiation. Trends Neurosci 1987;10:288-293.
16. Crews FT, Steck JC, Chandler LJ, Yu CJ, Day, A. Ethanol, stroke, brain damage, and excitotoxicity. Pharmacol Biochem Behav 1998;59:981-991.
17. 1-dopamine receptor sensitization in neonatal 6-OHDA-lesioned rats is blocked by an NMDA antagonist. Brain Res 1990:512:284-290.
18. De Mentis MG, Devoto P, Meloni D, Gambarana C, Giorgi G, Tangliamonte A. NMDA receptor inhibition prevents tolerance to cocaine. Pharmacol Biochem Behav 1992;42:179-182.
19. Diamond I, Gordon AS. Cellular and molecular neuroscience of alcoholism. Physiol Rev 1997;77:1-20.
20. Ferreira VMM, Morato GS. Influence of age and of pre-treatment with D-cycloserine on the behavior of ethanol-treated rats tested in the elevated plus-maze apparatus. Addict Biol 1996;1:395-404.
21. Ferreira VMM, Morato GS. D-cycloserine blocks the effects of ethanol and HA-966 in rats tested in the elevated plus-maze. Alcohol Clin Exp Res 1997;21(9):1638-1642.
22. File SE, Fernandes C. Dizocilpine prevents the development of tolerance to the sedative effects of diazepam in rats. Pharmacol Biochem Behav 1994;47:823-826.
23. Freund, Anderson KJ. Glutamate receptors in the cingulate cortex, hippocampus, and cerebellar vermis of alcoholics. Alcohol Clin Exp Res 1999;23:1-6.
24. Gianoulakis C, De Waele J-P. Genetics of alcoholism: Role of the endogenous opioid system. Metab Brain Disord 1994;9:105-131.
25. Gillan MG, Kosterlitz HW. Spectrum of the mu-, delta-and kappa-binding sites in homogenates of rat brain. Br J Pharmacol 1982;77:461-469.
26. Goldstein DB. The effects of drugs on membrane fluidity. Annu Rev Pharmacol Toxicol 1984;24:43-64.
27. González P, Cabello P, Germany A, Norris B, Contreras E. Decrease of tolerance to, and physical dependence on morphine, by glutamate receptor antagonists. Eur J Pharmacol 1997;332:257-262.
28. Grant KA, Hoffman PL, Tabakoff B. Neurobiological and behavioral approaches to tolerance and dependence. In: Edwards G, Lader M, eds. The Nature of Dependence. Oxford: Oxford University Press, 1990;135-169.
29. Grisel JE, Watkins LR, Maier SF. Associative and non-associative mechanisms of morphine analgesic tolerance are neurochemically distinct in the rat spinal cord. Psychopharmacology 1996;128:248-255.
30. 3H]MK-801 to brain regions and spinal cord of the rat. Brain Res 1994;639:269-274.
31. Gulya K, Grant KA, Valverius P, Hoffman PL, Tabakoff B. Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal. Brain Res 1991;547:129-134.
32. Gutstein HB, Trujillo KA. MK-801 inhibits the development of morphine tolerance at spinal sites. Brain Res 1993;626:332-334.
33. Hoffman PL, Tabakoff B. Alcohol dependence: A commentary on mechanisms. Alcohol 1996;31:333-340.
34. Hollmann M, Heinemann S. Cloned glutamate receptors. Ann Rev Neurosci 1994;17:31-108.
35. James IF, Goldstein A. Site-directed alkylation of multiple opioid receptors. I. Binding selectivity. Mol Pharmacol 1984;25:337-342.
36. Johnson JW, Ascher P. Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 1987;325:529-531.
37. Kaczmarek L, Kossut M, Skangiel-Kramska J. Glutamate receptors in cortical plasticity: Molecular and cellular biology. Physiol Rev 1997;77:217-255..
38. Kalant H. Current state of knowledge about the mechanisms of alcohol tolerance. Addict Biol 1996;1:133-141.
39. Kalant H, Khanna JM. Methods for the study of tolerance. In: Adler MW, Cowan A, eds, Testing & Evaluation of Drugs of Abuse. Wiley-Liss Inc., 1990;43-66.
40. Kalant H, LeBlanc AE, Gibbins RJ. Tolerance to, and dependence on, some non-opiate psychotropic drugs. Pharmacol Rev 1971;23:135-191
41. Kant GJ, Wright WL, Robinson T III, D'Angelo P. Effects of MK-801 on learning and memory as assessed using a novel water maze. Pharmacol Biochem Behav 1991;39:479-485.
42. Karcz-Kubicha M, Liljequist S. Effects of post-ethanol administration of NMDA and non-NMDA receptor antagonists on the development of ethanol tolerance in C57BI mice. Psychopharmacology 1995;120:49-56.
43. Karler R, Calder LD, Chandry IA, Turkanis SA. Blockade of "reverse tolerance" to cocaine and amphetamine by MK-801. Life Sci 1989;45:599-606.
44. Khanna JM, Chau A, Shah G. Characterization of the phenomenon of rapid tolerance to ethanol. Alcohol 1996;13:621-628.
45. Khanna JM, Chau A, Shah G. Effect of NMDA antagonists on rapid tolerance to benzodiazepines. Brain Res Bull 1997;42:99-103.
46. Khanna JM, Kalant H, Chau A, Shah G. Effect of NMDA antagonists on development of rapid tolerance to various barbiturates. Alcohol 1998;15:9-18.
47. Khanna JM, Kalant H, Chau A, Shah G, Morato GS. Interaction between N-methyl-D-aspartate (NMDA) and serotonin (5-HT) on ethanol tolerance. Brain Res Bull 1994;35:31-35.
48. Khanna JM, Kalant H, Lê AD, LeBlanc AE. Role of serotonergic and adrenergic systems in alcohol tolerance. Prog Neuro-Psychopharmacol 1981;5:459-465.
49. Khanna JM, Kalant H, Shah G, Chau A. Effect of D-cycloserine on rapid tolerance to ethanol. Pharmacol Biochem Behav 1993;45:983-986.
50. Khanna JM, Kalant H, Shah G, Chau A. Effect of (+)MK-801 and ketamine on rapid tolerance to ethanol. Brain Res Bull 1992;28:311-314.
51. Khanna JM, Kalant H, Shah G, Weiner J. Rapid tolerance as an index of chronic tolerance. Pharmacol Biochem Behav 1991;38:427-432.
52. Khanna JM, Lê AD, Kalant H, Chau A, Shah G. Effect of lipid solubility on the development of chronic cross-tolerance between ethanol and different alcohols and barbiturates. Pharmacol Biochem Behav 1997;57:101-110.
53. Khanna JM, Mihic SJ, Weiner J, Shah G, Wu PH, Kalant H. Differential inhibition by NMDA antagonists of rapid tolerance to, and cross-tolerance between, ethanol and chlordiazepoxide. Brain Res 1992;574:251-256.
54. Khanna JM, Morato GS, Chau A, Shah G. D-cycloserine enhances rapid tolerance to ethanol motor incoordination. Pharmacol Biochem Behav 1995;52:609-614.
55. Khanna JM, Morato GS, Chau A. Shah G. Influence of nitric oxide synthase inhibition on the development of rapid tolerance to ethanol. Brain Res Bull 1995;37:599-604.
56. Khanna JM, Morato GS, Chau A, Shah G, Kalant H. Effect of NMDA antagonists on rapid and chronic tolerance to ethanol: Importance of intoxicated practice. Pharmacol Biochem Behav 1994;48:755-763.
57. Khanna JM, Morato GS, Chau A, Shah G, Kalant H. Inhibition of nitric oxide synthesis impairs rapid tolerance to ethanol. Brain Res Bull 1993;32:43-47.
58. Khanna JM, Shah G, Chau A. Effect of NMDA antagonists on rapid tolerance to ethanol under two different testing paradigms. Pharmacol Biochem Behav 1997;57:693-697.
59. Khanna JM, Shah JM, Weiner G, Wu P, Kalant H. Effect of NMDA antagonists on rapid tolerance to ethanol. Eur J Pharmacol 1993;230:23-31.
60. Khanna JM, Wu PH, Weiner J, Kalant H. NMDA antagonist inhibits rapid tolerance to ethanol. Brain Res Bull 1991;26:643-645.
61. Koff JM, Pritchard GA, Greenblatt DJ, Miller LG. The NMDA receptor competitive antagonist CPP modulates benzodiazepine tolerance and discontinuation. Pharmacology 1997;55:217-227.
62. Lê AD, Khanna JM, Kalant H, LeBlanc AE. Effect of L-tryptophan on the acquisition of tolerance to ethanol-induced motor impairment and hypothermia. Psychopharmacology (Berl.) 1979;61:125-129.
63. Lê AD, Khanna JM, Kalant H, LeBlanc AE. Effect of modification of brain serotonin (5-HT), norepinephrine (NE) and dopamine (DA) on ethanol tolerance. Psychopharmacology 1981;75:231-235.
64. Lê AD, Kalant H. Learning as a factor in ethanol tolerance. In: Erinoff L, ed. Neurobiology of Drug Abuse: Learning and Memory, NIDA Research Monograph Series No. 97. Washington, DC, DHHS, 1990;193-207.
65. Leadem CA, Yagenova SV. Effects of specific activation of mu-, delta-, and kappa-opioid receptors on the secretion of luteinizing hormone and prolactin in the ovariectomized rat. Neuroendocrinology 1987;45:109-117.
66. LeBlanc AE, Kalant H, Gibbins R. Acute tolerance to ethanol in the rat. Psychopharmacologia 1975;41:43-46.
67. Lovinger DM, White G, Weight FF. Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 1989;243:1721-1724.
68. Lutfy K, Hurlbut DE, Weber E. Blockade of morphine-induced analgesia and tolerance in mice by MK-801. Brain Res 1993;616:83-88.
69. Lutfy K, Shen K-Z, Kwon I-S, Cai SX, Woodward RM, Keana JFW, Weber E. Blockade of morphine tolerance by ACEA-1328, a novel NMDA receptor/glycine site antagonist. Eur J Pharmacol 1995;273:187-189.
70. Mansour A, Fox CA, Akil H, Watson SJ. Opioid-receptor mRNA expression in the rat CNS: Anatomical and functional implications. Trends Neurosci 1995;18:22-29.
71. Mao J, Price DD, Mayer DJ. Mechanisms of hyperalgesia and morphine tolerance: A current view of their possible interactions. Pain 1995;62:259-274.
72. Marek P, Ben-Eliyahu S, Gold M, Liebeskind JC. Excitatory amino acid antagonists (kynurenic acid and MK-801) attenuate the development of morphine tolerance in the rat. Brain Res 1991;547:77-81.
73. Marek P, Ben-Eliyahu S, Vaccarino AL, Liebeskind JC. Delayed application of MK-801 attenuates development of morphine tolerance in rats. Brain Res 1991;558:163-165.
74. Marin RH, Salvatierra NA, Ramirez OA. Rapid tolerance to benzodiazepine modifies rat hippocampal synaptic plasticity. Neurosci Lett 1996;215:149-152.
75. Martin G, Przewlocki R, Siggins GR. Chronic morphine treatment selectively augments metabotropic glutamate receptor-induced inhibition of N-methyl-D-aspartate receptor-mediated neurotransmission in nucleus accumbens. J Pharmacol Exp Ther 1999;288:30-35.
76. Mayer ML, Vyklicky Jr L, Semagor E. A physiologist's view of the N-methyl-D-aspartate receptor: An allosteric ion channel with multiple regulatory sites. Drug Dev Res 1989;17:263-280.
77. Meldrum B, Garthwaite J. Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol Sci 1990;11:379-387.
78. Monahan JB, Handelmann GE, Hood WF, Cordi AA. D-cycloserine, a positive modulator of the N-methyl-D-aspartate receptor, enhances performance of learning tasks in rats. Pharmacol Biochem Behav 1989;34:649-653.
79. Morato GS, Khanna JM. N-methyl-D-aspartate receptors, nitric oxide, and ethanol tolerance. Braz J Med Biol Res 1996;29:1415-1426.
80. Morris RG, Anderson E, Lynch GS, Baudry M. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature 1986;319:774-776.
81. Nankai M, Klarica M, Fage D, Carter C. The pharmacology of native N-methyl-D-aspartate receptor subtypes: Different receptors control the release of different striatal and spinal transmitters. Prog Neuropsychopharmacol Biol Psychiatr 1998;22:35-64.
82. Nevo I, Hamon M. Neurotransmitter and neuromodulatory mechanisms involved in alcohol abuse and alcoholism. Neurochem Int 1995;26:305-336.
83. Oh S, Hoshi K, Ho IK. Role of NMDA receptors in pentobarbital tolerance/dependence. Neurochem Res 1997;22:767-774.
84. Olson GA, Olson RD, Kastin AB. Endogenous Opiates: 1989 Review. Peptides 1990;11:1277-1304.
85. Peoples RW, Weight FF. Cutoff in potency implicates alcohol inhibition of N-methyl-D-aspartate receptors in alcohol inhibition. Proc Nail Acad Sci USA 1995;92:2825-2829.
86. Pert CB, Snyder SH. Opiate receptor: demonstration in nervous tissue. Science 1973;179:1011-1014.
87. Rafi-Tari S, Kalant H, Liu J-F, Silver I, Wu PH. Dizocilpine prevents the development of tolerance to ethanol-induced error on a circular maze test. Psychoparmacology 1996;125:23-32.
88. Recasens M. Putative molecular mechanisms underlying long term potentiation (LTP): The key role of excitatory amino acid receptors. Thérapie 1995;50:19-34.
89. Robinson TE, Becker JB. Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis. Brain Res Rev 1986;11:157-198.
90. Seeman P. The membrane actions of anesthetics and tranquilizers. Pharmacol Rev 1972;24:583-654.
91. 3H]etorphine to rat-brain homogenate. Proc Natl Acad Sci USA 1973;70:1947-1949.
92. Simonds, W. F. The molecular basis of opioid receptor function. Endocr Rev 1988;9:200-212.
93. Snyder SH, Bredt DS. Nitric oxide as a neuronal messenger. Trends Pharmacol Sci 1991;12:125-127.
94. Speisky MB, Kalant H. Site of interaction of serotonin and desglycinamide-arginine-vasopressin in maintenance of ethanol tolerance. Brain Res 1985;326:281-290.
95. Staubli U, Rogers G, Lynch G. Facilitation of glutamate receptors enhances memory. Proc Natl Acad Sci USA 1994;91:777-781.
96. Stefano GB, Scharrer B, Bilfinger TV, Salzet M, Fricchione GL. A novel view of opiate tolerance. Adv Neuroimmunol 1996;6:265-277.
97. Steppuhn KG, Turski L. Diazepam dependence prevented by glutamate antagonists. Proc Natl Acad Sci USA 1993;90:6889-6893.
98. Su M-T, Lin W-B, Lue, W-M, Cheng C-Y, Tao P-L. Blockade of the development of morphine tolerance by U-50,488, an AVP antagonist or MK-801 in the rat hippocampal slice. Br J Pharmacol 1998;123:625-630.
99. Szabó G, Tabakoff B, Hoffman PL. The NMDA receptor antagonist, dizocilpine, differentially affects environment-dependent and environment-independent ethanol tolerance. Psychopharmacology (Berl.) 1994;113:511-517.
100. Tabakoff B, Hellevuo K, Hoffman PL. Alcohol. In: Schuster CR, Gust SW, Kuhar MJ, eds. Handbook of Experimental Pharmacology. Pharmacological Aspects of Drug Dependence. Vol. 118 Berlin: Springer-Verlag, 1996;373-458.
101. Tabakoff B, Hoffman PL. Alcohol Addiction: An enigma among us. Neuron 1996;16:909-912.
102. Terenius L. Characteristics of the "receptor" for narcotic analgesics in synaptic plasma membrane fraction from rat brain. Acta Pharmacol Toxicol 1973;33:377-384.
103. Thiels E, Weisz DJ, Berger TW. In vivo modulation of N-methyl-D-aspartate receptor-dependent long-term potentiation by the glycine modulatory site. Neuroscience 1992;46:501-509.
104. Tiseo PJ, Inturrisi CE. Attenuation and reversal of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist, LY274614. J Pharmacol Exp Ther 1993;264:1090-1096.
105. Trujillo KA, Akil H. Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801. Science 1991;251:85-87.
106. Trujillo KA, Akil H. Excitatory amino acids and drugs of abuse: A role for N-methyl-D-aspartate receptors in drug tolerance, sensitization and physical dependence. Drug Alcohol Depend 1995;38:139-154.
107. Tsai G, Coyle JT. The role of glutamatergic neurotransmission in the pathophysiology of alcoholism. Annu Rev Med 1998;49:173-184.
108. Tsai G, Gastfriend DR, Coyle JT. The glutamatergic basis of human alcoholism. Am J Psychiatry 1995;152:332-340.
109. Uchihashi Y, Kuribara H, Isa Y, Morita T, Sato T. The disruptive effects of ketamine on passive avoidance learning in mice: Involvement of dopaminergic mechanism. Psychopharmacology 1994;116:40-44.
110. Unterwald EM, Zukin RS. The endogenous opioidergic system. In: Reid LD, ed., Opioids, Bulimia, and Alcohol Abuse. Ann Arbor, MI: Springer-Verlag 1990;49-72.
111. Vaccarino AL, Clavier MC. Blockade of tolerance to stress-induced analgesia by MK-801 in mice. Pharmacol Biochem Behav 1997:56:435-439.
112. Williams K, Dawson VL, Romano C, Dichter MA, Molinoff PB. Characterization of polyamines having agonist, antagonist, and inverse agonist effects at the polyamine recognition site of the NMDA receptor. Neuron 1990;5:99-208.
113. Wong EHF, Kemp JA, Priestley T, Knight AR, Woodruff GN, Iverson LL. The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc Natl Acad Sci USA 1986;83:7104-7108.
114. Wong C-S, Cheung C-H, Luk H-N, Ho S-T, Tung C-S. Effects of NMDA receptor antagonists on inhibition of morphine tolerance in rats: Binding at μ-opioid receptors. Eur J Pharmacol 1996;297:27-33.
115. Wu PH, Mihic SJ, Liu J-F, Lê AD, Kalant H. Blockade of chronic tolerance to ethanol by the NMDA antagonist (+)-MK-801. Eur J Pharmacol 1993;231:157-164.
116. 1-opioid receptor agonist. Peptides 1996;17:233-236.