Thermodynamic and circular dichroism studies differentiate inhibitor interactions with the stromelysin S1-S3 and S'1-S'3 subsites

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

Volumn 1434, Issue 2, 1999, Pages 304-316

  Sarver, Ronald W ^a   Yuan, Peng ^a   Marshall, Vincent P ^a   Petzold, Gary L ^a   Poorman, Roger A ^a   Dezwaan, Jack ^a   Stockman, Brian J ^a  

^a PFIZER INC   (United States)

Author keywords

Calorimetry; Circular dichroism; Inhibitor; Stromelysin

Indexed keywords

BENZENE DERIVATIVE; HYDROXAMIC ACID; STROMELYSIN; THIADIAZOLE DERIVATIVE; TYROSINE;

ARTICLE; BINDING SITE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENTHALPY; ENTROPY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN INTERACTION; THERMODYNAMICS; ULTRAVIOLET SPECTROSCOPY;

BINDING SITES; CALORIMETRY, DIFFERENTIAL SCANNING; CIRCULAR DICHROISM; DRUG DESIGN; ENZYME INHIBITORS; MATRIX METALLOPROTEINASE 3; MOLECULAR STRUCTURE; REGRESSION ANALYSIS; THERMODYNAMICS; THIADIAZOLES; UREA;

EID: 0032824421     PISSN: 01674838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4838(99)00172-7     Document Type: Article

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