Use of a primate model system to identify Chlamydia trachomatis protein antigens recognized uniquely in the context of infection

Microbiology

Volumn 145, Issue 8, 1999, Pages 2077-2085

  Bannantine, John P ^a,b   Rockey, Daniel D ^a,b  

^a OREGON STATE UNIVERSITY   (United States)

^b NATIONAL ANIMAL DISEASE CENTER   (United States)

Author keywords

Bacterial pathogenesis; Chlamydia; Primate; STDs

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL DNA; BACTERIUM ANTIBODY; HYBRID PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY BLOOD LEVEL; ARTICLE; CHLAMYDIA TRACHOMATIS; CHLAMYDIASIS; CONTROLLED STUDY; DNA LIBRARY; DNA SEQUENCE; ESCHERICHIA COLI; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; MALE; MOLECULAR CLONING; MONKEY; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; TREPONEMA PALLIDUM;

CHLAMYDIA TRACHOMATIS; TREPONEMA PALLIDUM;

EID: 0032822659     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/13500872-145-8-2077     Document Type: Article

References (30)

1. Akins, D. R., Robinson, E., Shevchenko, D., Elkins, C., Cox, D. L. & Radolf, J. D. (1997). Tromp1, a putative rare outer membrane protein, is anchored by an uncleaved signal sequence to the Treponema pallidum cytoplasmic membrane. J Bacteriol 179, 5076-5086.
2. Bachmaier, K., Neu, N., de la Maza, L. M., Pal, S., Hessel, A. & Penninger, J. M. (1999). Chlamydia infections and heart disease linked through antigenic mimicry. Science 283, 1335-1339.
3. Bannantine, J. P., Rockey, D. D. & Hackstadt, T. (1998a). Tandem genes of Chlamydia psittaci that encode proteins localized to the inclusion membrane. Mol Microbiol 28, 1017-1026.
4. Bannantine, J. P., Stamm, W. E., Suchland, R. J. & Rockey, D. D. (1998b). Chlamydia trachomatis IncA is localized to the inclusion membrane and is recognized by antisera from infected humans and primates. Infect Immun 66, 6017-6021.
5. Blanco, D. R., Walker, E. M., Haake, D. A., Champion, C. I., Miller, J. N. & Lovett, M. A. (1990). Complement activation limits the rate of in vitro treponemicidal activity and correlates with antibody-mediated aggregation of Treponema pallidum rare outer membrane protein. J Immunol 144, 1914-1921.
6. Blanco, D. R., Champion, C. I., Exner, M. M., Erdjument-Bromage, H., Hancock, R. E., Tempst, P., Miller, J. N. & Lovett, M. A. (1995). Porin activity and sequence analysis of a 31-kilodalton Treponema pallidum subsp. pallidum rare outer membrane protein (Tromp1). J Bacteriol 177, 3556-3562.
7. Blanco, D. R., Champion, C. I., Exner, M. M., Shang, E. S., Skare, J. T., Hancock, R. E., Miller, J. N. & Lovett, M. A. (1996). Recombinant Treponema pallidum rare outer membrane protein 1 (Tromp1) expressed in Escherichia coli has porin activity and surface antigenic exposure. J Bacteriol 178, 6685-6692.
8. Caldwell, H. D., Kromhout, J. & Schachter, J. (1981). Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatis. Infect Immun 31, 1161-1176.
9. Cole, S. T., Brosch, R., Parkhill, J. & 39 other authors (1998). Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393, 537-544.
10. Danesh, J., Collins, R. & Petro, R. (1997). Chronic infections and coronary heart disease : is there a link? Lancet 350, 430-436.
11. Fleischmann, R. D., Adams, M. D., White, O. & 37 other authors (1995). Whole-genome random sequencing and assembly of Haetnophilus influenzae Rd. Science 269, 496-512.
12. Hackstadt, T., Messer, R., Cieplak, W. & Peacock, M. G. (1992). Evidence for the proteolytic cleavage of the 120-kilodalton outer membrane protein of rickettsiae: identification of an avirulent mutant deficient in processing. Infect Immun 60, 159-165.
13. Hahn, D. L., Dodge, R. W. & Golubjatnikov, R. (1991). Association of Chlamydia pneumoniae (strain TWAR) infection with wheezing, asthmatic bronchitis, and adult-onset asthma. JAMA (J Am Med Assoc) 266, 225-230.
14. Hardham, J. M., Stamm, L. V., Porcella, S. F. & 7 other authors (1997). Identification and transcriptional analysis of a Treponema pallidum operon encoding a putative ABC transport system, an iron-activated represser protein homolog, and a glycolytic pathway enzyme homolog. Gene 197, 47-64.
15. Hillis, S. D., Owens, L. M., Marchbanks, P. A., Amsterdam, L. F. & MacKenzie, W. R. (1997). Recurrent chlamydial infections increase the risks of hospitalization for ectopic pregnancy and pelvic inflammatory disease. Am J Obstet Gynecol 176, 103-107.
16. Lewinski, M. A., Miller, J. N., Champion, C. I., Walker, E. M., Borenstein, L. A., Gayek, R. J., Lovett, M. A. & Blanco, D. R. (1995). Treponemicidal antibody measured by the "washed-killing" assay correlates with immunity in experimental rabbit syphilis. Sex Transm Dis 22, 31-38.
17. Morrison, R. P., Manning, D. S. & Caldwell, H. D. (1992). Immunology of Chlamydia trachomatis infections - immunoprotective and immunopathogenetic responses. In Sexually Transmitted Diseases, pp. 57-84. Edited by T. C. Quinn. New York: Raven Press.
18. Perine, P. L. & Stamm, W. E. (1999). Lymphogranuloma venereum. In Sexually Transmitted Diseases, pp. 423-433. Edited by K. K. Holmes, P. F. Sparling & P. A. Mardh. New York: McGraw-Hill.
19. Rockey, D. D. & Rosquist, J. L. (1994). Protein antigens of Chlamydia psittaci present in infected cells but not detected in the infectious elementary body. Infect Immun 62, 106-112.
20. Rockey, D. D., Heinzen, R. A. & Hackstadt, T. (1995). Cloning and characterization of a Chlamydia psittaci gene coding for a protein localized in the inclusion membrane of infected cells. Mol Microbiol 15, 617-626.
21. Rockey, D. D., Chesebro, B. B., Heinzen, R. A. & Hackstadt, T. (1996). A 28 kDa major immunogen of Chlamydia psittaci shares identity with Mip proteins of Legionella spp. and Chlamydia trachomatis - cloning and characterization of the C. psittaci miplike gene. Microbiology 142, 945-953.
22. Stephens, R. S., Kalman, S., Lammel, C. & 9 other authors (1998). Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis. Science 282, 754-759.
23. Su, H., Morrison, R. P., Watkins, N. G. & Caldwell, H. D. (1990). Identification and characterization of T helper cell epitopes of the major outer membrane protein of Chlamydia trachomatis. J Exp Med 172, 203-212.
24. Su, H., Messer, R., Whitmire, W., Fischer, E., Portis, J. C. & Caldwell, H. D. (1998). Vaccination against chlamydial genital tract infection after immunization with dendritic cells pulsed ex vivo with nonviable Chlamydiae. J Exp Med 188, 809-818.
25. Thomas, W. R., Callow, M. G., Dilworth, R. J. & Audesho, A. A. (1990). Expression in Escherichia coli of a high-molecular-weight protective surface antigen found in nontypeable and type b Haemophilus influenzae. Infect Immun 58, 1909-1913.
26. Thylefors, B., Negral, A. D., Pararajasegaram, R. & Dadzie, K. Y. (1995). Global data on blindness. Bull WHO 73, 115-121.
27. Tomb, J.-F., White, O., Kerlavage, A. R. & 39 other authors (1997). The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 388, 539-547.
28. Wasserheit, J. N. (1994). Effect of changes in human ecology and behavior on patterns of sexually transmitted diseases, including human immunodeficiency virus infection. Proc Natl Acad Sci USA 91, 2430-2435.
29. Yuan, Y., Lyng, K., Zhang, Y. X., Rockey, D. D. & Morrison, R. P. (1992). Monoclonal antibodies define genus-specific, species-specific, and cross-reactive epitopes of the chlamydial 60 kilodalton heat shock protein (hsp60): specific immunodetection and purification of chlamydial hsp60. Infect Immun 60, 2288-2296.
30. Zhang, D., Yang, X., Berry, J., Shen, C., McClarty, G. & Brunham, R. C. (1997). DNA vaccination with the major outer-membrane protein gene induces acquired immunity to Chlamydia trachomatis (mouse pneumonitis) infection. J Infect Dis 176, 1035-1040.