In vivo upregulation of the blood-brain barrier GLUT1 glucose transporter by brain-derived peptides

Neuroscience Research

Volumn 34, Issue 4, 1999, Pages 217-224

  Boado, Ruben J ^a   Wu, Dafang ^a   Windisch, Manfred ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Research Initiative Ebewe   (Austria)

Author keywords

Blood brain barrier; Brain peptides; Cerebrolysin; Gene regulation; Glucose transporter; GLUT1; Immunocytochemistry; mRNA

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CARBON 14; CEREBROLYSIN; DIAZEPAM; GLUCOSE; GLUCOSE TRANSPORTER; MESSENGER RNA; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY PERFUSION; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE CONTROL; GLUCOSE TRANSPORT; IMMUNOCYTOCHEMISTRY; INTERNAL CAROTID ARTERY; INTRAPERITONEAL DRUG ADMINISTRATION; NONHUMAN; NORTHERN BLOTTING; PERMEABILITY; PRIORITY JOURNAL; RAT; WESTERN BLOTTING;

AMINO ACIDS; ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; GLUCOSE; GLUCOSE TRANSPORTER TYPE 1; MALE; MONOSACCHARIDE TRANSPORT PROTEINS; NEUROPEPTIDES; RATS; RATS, WISTAR; RNA, MESSENGER; UP-REGULATION;

EID: 0032822496     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-0102(99)00056-5     Document Type: Article

References (41)

1. Akai F., Himura S., Sato T., Iwamoto N., Fujimoto M., Ioku M., Hashimoto S. Neurotrophic factor-like effect of FPF1070 on septal cholinergic neurons after transections of fimbria-fornix in the rat. Histol. Histopathol. 7:1992;213-221.
2. Boado R.J. Brain-derived peptides regulate the steady state levels and increase stability of the blood-brain barrier GLUT1 glucose transporter mRNA. Neurosc. Let. 197:1995;179-182.
3. Boado R.J. Molecular biology of brain capillaries. Pardridge W.M. An Introduction to the Blood-Brain Barrier: Methodology and Biology. 1998;151-162 Cambridge University Press, Cambridge.
4. Boado R.J. Brain-derived peptides increase blood-brain barrier GLUT1 glucose transporter gene expression via mRNA stabilization. Neurosci. Lett. 255:1998b;147-150.
5. Boado R.J. Modulation of blood-brain barrier GLUT1 glucose transporter gene expression by brain-derived peptides. J. Neural Transm. (Suppl). 53:1998;323-331.
6. Boado R.J., Pardridge W.M. The brain-type glucose transporter mRNA is specifically expressed at the blood-brain barrier. Biochem. Biophys. Res. Commun. 166:1990;174-179.
7. Boado R.J., Pardridge W.M. Molecular cloning of the bovine blood-brain barrier glucose transporter cDNA and demonstration of phylogenetic conservation of the 5 untranslated region. Mol. Cell. Neurosci. 1:1990;224-232.
8. Boado R.J., Pardridge W.M. A one-step procedure for isolation of poly(A)+ mRNA from isolated brain capillaries and endothelial cells in culture. J. Neurochem. 57:1991;2136-2139.
9. Boado R.J., Pardridge W.M. Glucose deprivation causes post-transcriptional enhancement of brain capillary endothelial glucose transporter gene expression via GLUT1 mRNA stabilization. J. Neurochem. 60:1993;2290-2296.
10. Boado R.J., Pardridge W.M. Ten nucleotide cis element in the 3′-untranslated region of the GLUT1 glucose transporter mRNA increases gene expression via mRNA stabilization. Mol. Brain Res. 59:1998;109-113.
11. Boado R.J., Black K.L., Pardridge W.M. Gene expression of GLUT3 and GLUT1 glucose transporters in human brain tumors. Mol. Brain Res. 27:1994;51-57.
12. Boado R.J., Golden P., Levin N., Pardridge W.M. Upregulation of the blood-brain barrier short form leptin receptor gene products in rats fed a high fat diet. J. Neurochem. 71:1998;1761-1764.
13. Boado R.J., Wang L., Pardridge W.M. Enhanced expression of the blood-brain barrier GLUT1 glucose transporter gene by brain-derived factors. Molec. Brain Res. 22:1994;259-267.
14. Boyle P.J., Kempers S.F., O'Connor A.M., Nagy R.J. Brain glucose uptake and unawareness of hypoglycemia in patients with insulin-dependent diabetes mellitus. New Engl. J. Med. 333:1995;1726-1731.
15. Crane P.D., Pardridge W.M., Braun L.D., Nyerges A.M., Oldendorf W.H. The interaction of transport and metabolism on brain glucose utilization: a reevaluation of the lumped constant. J. Neurochem. 36:1981;1601-1604.
16. Dwyer K.J., Boado R.J., Pardridge W.M. Cis-element/cytoplasmic protein interaction within the 3′-untranslated region of the GLUT1 glucose transporter mRNA. J. Neurochem. 66:1996;449-458.
17. Flier J.S., Mueckler M., McCall A.L., Lodish H.F. Distribution of glucose transporter messenger RNA transcripts in tissues of rat and man. J. Clin. Invest. 79:1987;657-661.
18. Francis-Turner L., Valouskova V. Nerve growth factor and nootropic drug cerebrolysin but not fibroblast growth factor can reduce spatial memory impairment elicited by fimbria-fornix transection: short-term study. Neuros. Let. 202:1996;1-4.
19. Funke M., Fiehler J., Mewes I., Eiselt M., Rother I., Windisch M. Dose-dependent effects of cerebrolysin on EEG and short-term memory of healthy volunteers during control and hyperventilation induced cerebral ischemia. J. Neural Transm. (Suppl). 53:1998;385-398.
20. Gerhart D.Z., LeVasseur R.J., Broderius M.A., Drewes L.R. Glucose transporter localization in brain using light and electron immunocytochemistry. J. Neurosci. Res. 22:1989;464-472.
21. Gschanes A., Windisch M. The influence of cerebrolysin and E021 on spatial navigation of 24-month-old rats. J. Neural Transm. (Suppl). 53:1998;313-321.
22. Hawkins R.A., Mans A.M., Davis D.W., Hibbard L.S., Lu D.M. Glucose availability to individual cerebral structures is correlated to glucose metabolism. J. Neurochem. 40:1983;1013-1018.
23. Jain R.G., Andrews L.G., McGowan K.M., Pekala P.H., Keene J.D. Ectopic expression of Hel-N1, an RNA-binding protein increases glucose transporter (GLUT1) expression in 3T3-L1 adipocytes. Mol. Cell. Biol. 17:1997;954-962.
24. Koroleva V.I., Korolev O.S., Loseva E., Bures J. The effect of MK-801 and of brain-derived polypeptides on the development of ischemic lesion induced by photothrombotic occlusion of the distal middle cerebral artery in rats. Brain Res. 786:1998;104-114.
25. Kumagai A.K., Kang Y.S., Boado R.J., Pardridge W.M. Upregulation of blood-brain barrier GLUT1 glucose transporter protein and mRNA in experimental chronic hypoglycemia. Diabetes. 44:1995;1399-1404.
26. Levy A.P., Levy N.S., Goldberg M.A. Hypoxia-inducible protein binding to vascular endothelial growth factor mRNA and its modulation by the von Hippel-Lindau protein. J. Biol. Chem. 271:1996;25492-25497.
27. Masliah E., Armasolo F., Veinbergs I., Mallory M., Samuel W. Cerebrolysin ameliorates performance deficits and neuronal damage in apolipoprotein E-deficient mice. Pharmacol. Biochem. Behav. 62:1999;2239-2245.
28. McGowan K.M., Police S., Winslow J.B., Pekala P.H. Tumor necrosis factor-α regulation of glucose transporter (GLUT1) mRNA turnover: Contribution of the 3′-untranslated region of the GLUT1 message. J. Biol. Chem. 272:1997;1331-1337.
29. Mitrakou A., Fanelli C., Veneman T., Perriello G., Calderone S., Platanisiotis D., Rambotti A., Raptis S., Brunetti P., Cryer P. et al. Reversibility of unawareness of hypoglycemia in patients with insulinomas. New Engl. J. Med. 329:1993;834-839.
30. Pardridge, W.M., Boado, R.J., 1993. Molecular cloning and regulation of gene expression of blood-brain barrier glucose transporter, in The Blood-Brain Barrier: Cellular and Molecular Biology, Raven Press, NY, pp. 395-440.
31. Pardridge W.M., Boado R.J., Farrell C.R. Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridization. J. Biol. Chem. 265:1990;18035-18040.
32. Ruther E., Ritter R., Apecechea M., Freytag S., Windisch M. Efficacy of the peptidergic nootropic drug cerebrolysin in patients with senile dementia of the Alzheimer type (SDAT). Pharmacopsychiatry. 27:1994;32-40.
33. Sandouk T., Reda D., Hofmann C. The antidiabetic agent pioglitazone increases expression of glucose transporters in 3T3-F442A cells by increasing messenger ribonucleic acid transcript stability. Endocrinology. 133:1993;352-359.
34. Stephens J.M., Carter B.Z., Pekala P.H., Malter J.S. Tumor necrosis factor α-induced glucose transporter (GLUT-1) mRNA stabilization in 3T3-L1 preadipocytes. J. Biol. Chem. 267:1992;8336-8341.
35. Sugita Y., Kondo T., Kanazawa A., Itou T., Mizuno Y. Protective effect of FPF (Cerebrolysin) on delayed neuronal death in the gerbil-detection of hydroxyl radicals with salicylic acid. Brain and Nerve. 45:1993;4325-4331.
36. Schwab M., Schaller R., Bauer R., Zwiener U. Morphofunctional effects of moderate forebrain ischemia combined with short-term hypoxia in rats: protective effects of cerebrolysin. Exp. Toxicol. Pathol. 49:1997;29-37.
37. Takata K., Kasahara T., Kasahara M., Ezaki O., Hirano H. Erythrocyte/HepG2-type glucose transporter is concentrated in cells of blood-tissue barriers. Biochem. Biophys. Res. Commun. 173:1990;67-73.
38. Takasato Y., Rapoport S.I., Smith Q.R. An in situ brain perfusion technique to study cerebrovascular transport in the rat. Am. J. Physiol. 247:1984;H484-H493.
39. Tsukamoto H., Boado R.J., Pardridge W.M. Differential expression in glioblastoma multiforme and cerebral hemangioblastoma of cytoplasmic proteins that bind two different domains within the 3′-untranslated region of the human GLUT1 glucose transporter mRNA. J. Clin. Invest. 97:1996;2823-2832.
40. Tsukamoto H., Boado R.J., Pardridge W.M. Site-directed deletion of a 10-nucleotide domain of the 3′-untranslated region of the GLUT1 glucose transporter mRNA eliminates cytosolic protein binding in human brain tumors and induction of reporter gene expression. J. Neurochem. 68:1997;2587-2592.
41. Tsukamoto H., Hamada Y., Wu D., Boado R.J., Pardridge W.M. GLUT1 glucose transporter: differential gene transcription and mRNA binding to cytosolic and polysome proteins in brain and peripheral tissues. Molec. Brain Res. 58:1998;170-177.