Inflammatory and epithelial responses during the development of ozone- induced mucous cell metaplasia in the nasal epithelium of rats

Toxicological Sciences

Volumn 51, Issue 1, 1999, Pages 135-145

  Cho, Hye Y ^a   Hotchkiss, Jon A ^a   Harkema, Jack R ^a,b  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Inflammation; Mucin gene; Mucous cell metaplasia; Nasal transitional epithelium; Ozone; Rat

Indexed keywords

BROXURIDINE; DNA; MESSENGER RNA; OZONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; EPITHELIUM CELL; INFLAMMATION; MALE; METAPLASIA; MORPHOMETRICS; MUCOUS CELL; NONHUMAN; NOSE CAVITY; NOSE MUCOSA; RAT;

ADMINISTRATION, INHALATION; ANIMALS; BROMODEOXYURIDINE; CELL COUNT; DNA; GOBLET CELLS; MALE; METAPLASIA; MUCINS; NEUTROPHILS; OXIDANTS, PHOTOCHEMICAL; OZONE; RATS; RATS, INBRED F344; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHINITIS; RNA, MESSENGER; TURBINATES; UP-REGULATION;

EID: 0032819953     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/51.1.135     Document Type: Article

References (47)

1. Borchers, M. T., and Leikauf, G. D. (1997). Acrolein-induced mucin gene expression. Am. J. Respir. Crit. Care Med. 152, A778.
2. Breuer, R., Christensen, T. G., Lucey, E. C., Stone, P. J., and Snider, G. L. (1985). Quantitative study of secretory cell metaplasia induced by human neutrophil elastase in the large bronchi of hamsters. J. Lab. Clin. Med. 105, 635-640.
3. Burns-Naas, M. L., Mast, R. W., Klykken, P. C., McCay, J. A., White, K. L., Jr., Mann, P. C., and Naas, D. J. (1998). Toxicoloy and humoral immunity assessment of decamethylcyclopentasiloxane (D5) following a 1-month whole-body inhalation exposure in Fischer 344 rats. Toxicol. Sci. 43, 28-38.
4. Calderon-Garciduenas, L., Osorno Velazquez, A., Bravo Alvarez, H., Delgado Chavez, R., and Barrios Marquez, R. (1992). Histopathologic changes of the nasal mucosa in southwest metropolitan Mexico City inhabitants. Am. J. Pathol. 140, 225-232.
5. Calderon-Garciduenas, L., Rodriguez Alcaraz, A., Garcia, R., Ramirez, L., and Barragan, G. (1995). Nasal inflammatory responses in children exposed to a polluted urban atmosphere. J. Toxicol. Environ. Health 45, 427-437.
6. Castleman, W. L., Dungworth, D. L., Schwartz, L. W., and Tyler, W. S. (1980). Acute respiratory bronchiolitis: An ultrastructural and autoradiographic study of epithelial cell injury and renewal in rhesus monkeys exposed to ozone. Am. J. Pathol. 98, 811-840.
7. Chomczynski, P., and Sacchi, N. (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
8. Graham, D., Henderson, F., and House, D. (1988). Neutrophil influx measured in nasal lavages of humans exposed to ozone. Arch. Environ. Health 43, 228-233.
9. Guzman, K., Gray, T. E., Yoon, J. H., and Nettesheim, P. (1996). Quantitation of mucin RNA by PCR reveals induction of both MUC-2 and MUC-5AC mRNA levels by retinoids. Am. J. Physiol. 271, L1023-1028.
10. Harkema, J. R., and Hotchkiss, J. A. (1993). Ozone- and endotoxin-induced mucous cell metaplasias in rat airway epithelium: Novel animal models to study toxicant-induced epithelial transformation in airways. Toxicol. Lett. 68, 251-263.
11. Harkema, J. R., Hotchkiss, J. A., and Griffith, W. C. (1997). Mucous cell metaplasia in rat nasal epithelium after a 20-month exposure to ozone: A morphometric study of epithelial differentiation. Am. J. Respir. Cell Mol. Biol. 16, 521-530.
12. Harkema, J. R., Hotchkiss, J. A., Harmsen, A. G., and Henderson, R. F. (1988). In vivo effects of transient neutrophil influx on nasal respiratory epithelial mucosubstances. Quantitative histochemistry. Am. J. Pathol. 130, 605-615.
13. Harkema, J. R., Hotchkiss, J. A., and Henderson, R. F. (1989). Effects of 0.12 and 0.80 ppm ozone on rat nasal and nasopharyngeal epithelial mucosubstances: Quantitative histochemistry. Toxicol. Pathol. 17, 525-535.
14. Harkema, J. R., Plopper, C. G., Hyde, D. M., St. George, J. A., and Dungworth, D. L. (1987a). Effects of an ambient level of ozone on primate nasal epithelial mucosubstances. Quantitative histochemistry. Am. J. Pathol. 127, 90-96.
15. Harkema, J. R., Plopper, C. G., Hyde, D. M., St. George, J. A., Wilson, D. W., and Dungworth, D. L. (1987b). Response of the macaque nasal epithelium to ambient levels of ozone: A morphologic and morphometric study of the transitional and respiratory epithelium. Am. J. Pathol. 128, 29-44.
16. Hayashi, M., Sornberger, G. C., and Huber, G. L. (1979). Morphometric analyses of tracheal gland secretion and hypertrophy in male and female rats after exposure to tobacco smoke. Am. Rev. Respir. Dis. 119, 67-73.
17. Hotchkiss, J. A., Harkema, J. R., and Henderson, R. F. (1991). Effect of cumulative ozone exposure on ozone-induced nasal epithelial hyperplasia and secretory metaplasia in rats. Exp.Lung Res. 17, 589-600.
18. Hotchkiss, J. A., Harkema, J. R., and Johnson, N. F. (1997). Kinetics of nasal epithelial cell loss and proliferation in F344 rats following a single exposure to 0.5 ppm ozone. Toxicol. Appl. Pharmacol. 143, 75-82.
19. Hotchkiss, J. A., Harkema, J. R., Sun, J. D., and Henderson, R. F. (1989). Comparison of acute ozone-induced nasal and pulmonary inflammatory responses in rats. Toxicol. Appl. Pharmacol. 98, 289-302.
20. Hotchkiss, J. A., Hilaski, R., Cho, H., Regan, K., Spencer, P., Slack, K., and Harkema, J. R. (1998). Fluticasone propionate attenuates ozone-induced rhinitis and mucous cell metaplasia in rat nasal airway epithelium. Am. J. Respir. Cell Mol. Biol. 18, 91-99.
21. Hyde, D. M., Hubbard, W. C., Wong, V., Wu, R., Pinkerton, K., and Plopper, C. G. (1992). Ozone-induced acute tracheobronchial epithelial injury: Relationship to granulocyte emigration in the lung. Am. J.Respir. Cell Mol. Biol. 6, 481-497.
22. Jany, B., Gallup, M., Tsuda, T., and Basbaum, C. (1991). Mucin gene expression in rat airways following infection and irritation. Biochem. Biophys. Res. Commun. 181, 1-8.
23. Johnson, N. F., Hotchkiss, J. A., Harkema, J. R., and Henderson, R. F. (1990). Proliferative responses of rat nasal epithelia to ozone. Toxicol. Appl. Pharmacol. 103, 143-155.
24. Kai, H., Yoshitake, K., Hisatsune, A., Kido, T., Isohama, Y., Takahama, K., and Miayata, T. (1996). Dexamethasone suppresses mucus production and MUC-2 and MUC-5AC gene expression by NCI-H292 cells. Am. J. Physiol. 271, L484-488.
25. Kern, G., Kern, D., Schmid, F.X., and Fischer, G. (1994). Reassessment of the putative chaperone function of prolyl-cis/trans-isomerases. FEBS Lett. 348, 145-148.
26. Kim, K. C., Wasano, K., Niles, R. M., Schuster, J. E., Stone, P. J., and Brody, J. S. (1987). Human neutrophil elastase releases cell surface mucins from primary cultures of hamster tracheal epithelial cells. Proc. Natl. Acad. Sci.U S A 84, 9304-9308.
27. Lamb, D., and Reid, L. (1969). Goblet cell increase in rat bronchial epithelium after exposure to cigarette and cigar tobacco smoke. Br. Med. J. 1, 33-35.
28. Lee, J. J., McGarry, M. P., Farmer, S. C., Denzler, K. L., Larson, K. A., Carrigan, P. E., Brenneise, I. E., Horton, M. A., Haczku, A., Gelfand, E. W., Leikauf, G. D., and Lee, N. A. (1997). Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma. J. Exp. Med. 185, 2143-2156.
29. Leikauf, G. D., Simpson, L. G., Santrock, J., Zhao, Q., Abbinante-Nissen, J., Zhou, S., and Driscoll, K. E. (1995). Airway epithelial cell responses to ozone injury. Environ. Health Perspect. 103 (suppl. 2), 91-95.
30. Lesuffleur, T., Porchet, N., Aubert, J. P., Swallow, D., Gum, J. R., Kim, Y. S., Real, F. X., and Zweibaum, A. (1993). Differential expression of the human mucin genes MUC1 to MUC5 in relation to growth and differentiation of different mucus-secreting HT-29 cell subpopulations. J. Cell Sci. 106, 771-783.
31. Levine, S. (1995). Bronchial epithelial cell-cytokine interactions in airway inflammation. J. Investig. Med. 43, 241-249.
32. Levine, S. J., Larivee, P., Logun, C., Angus, C. W., Ognibene, F. P., and Shelhamer, J. H. (1995). Tumor necrosis factor-alpha induces mucin hyper-secretion and MUC-2 gene expression by human airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 12, 196-204.
33. Levine, S. J., Larivee, P., Logun, C., and Shelhamer, J. H. (1994). IL-6 induces respiratory mucous glycoprotein secretion and MUC-2 gene expression by human airway epithelial cells. Am. J. Respir. Crit. Care Med. 149, A27
34. Lundgren, J. D., Kaliner, M., Logun, C., and Shelhamer, J. H. (1988). Dexamethasone reduces rat tracheal goblet cell hyperplasia produced by human neutrophil products. Exp. Lung Res. 14, 853-863.
35. Matouschek, A., Rospert, S., Schmid, K., Glick, B. S., and Schatz, G. (1995). Cyclophilin catalyzes protein folding in yeast mitochondria. Proc. Natl. Acad. Sci. U S A 92, 6319-6323.
36. McBride, D. E., Koenig, J. Q., Luchtel, D. L., Williams, P. V., and Henderson, W. R., Jr. (1994). Inflammatory effects of ozone in the upper airways of subjects with asthma. Am. J. Respir. Crit. Care Med. 149, 1192-1197.
37. Pino, M. V., Stovall, M. Y., Levin, J. R., Devlin, R. B., Koren, H. S., and Hyde, D. M. (1992). Acute ozone-induced lung injury in neutrophil-depleted rats. Toxicol. Appl. Pharmacol. 114, 268-276.
38. Rankin, J. A., Picarella, D. E., Geba, G. P., Temann, U. A., Prasad, B., DiCosmo, B., Tarallo, A., Stripp, B., Whitsett, J., and Flavell, R. A. (1996). Phenotypic and physiologic characterization of transgenic mice expressing interleukin-4 in the lung: Lymphocytic and eosinophilic inflammation without airway hyperreactivity. Proc. Natl. Acad. Sci.U S A 93, 7821-7825.
39. Rehm, S., and Kelloff, G. J. (1991). Histologic characterization of mouse bronchiolar cell hyperplasia, metaplasia, and neoplasia induced intratracheally by 3-methylcholanthrene. Exp. Lung Res. 17, 229-244.
40. Schelegle, E. S., Siefkin, A. D., and McDonald, R. J. (1991). Time course of ozone-induced neutrophilia in normal humans. Am. Rev. Respir. Dis. 143, 1353-1358.
41. Shimizu, T., Takahashi, Y., Kawaguchi, S., and Sakakura, Y. (1996). Hypertrophic and metaplastic changes of goblet cells in rat nasal epithelium induced by endotoxin. Am. J.Respir. Crit. Care Med. 153, 1412-1418.
42. Steinfeld, J. H. (1991). Rethinking the Ozone Problem in Urban and Regional Air Polution. National Academy Press, Washington, DC.
43. Stephens, R. J., Sloan, M. F., Evans, M. J., and Freeman, G. (1974). Early response of lung to low levels of ozone. Am. J. Pathol. 74, 31-58.
44. Sun, J. D., Pickrell, J. A., Harkema, J. R., McLaughlin, S. I., Hahn, F. F., and Henderson, R. F. (1988). Effects of buthionine sulfoximine on the development of ozone-induced pulmonary fibrosis. Exp. Mol. Pathol. 49, 254-266.
45. Temann, U., Prasad, B., Gallup, M., Basbaum, C., Ho, S., Flavell, R., and Rankin, J. (1997). A novel role for murine IL-4 in vivo: Induction of MUC5AC gene expression and mucin hypersecretion. Am. J. Respir. Cell Mol. Biol. 16, 471-478.
46. Voynow, J. A., Wang, Y., and Brown, F. (1997). Upregulation of MUC-5 mucin gene expression by neutrophil elastase is post-transcriptionally mediated by tyrosine kinase. Am. J. Respir. Crit. Care Med. 152, A433
47. Wolf, D. C., Morgan, K. T., Gross, E. A., Barrow, C., Moss, O. R., James, R. A., and Popp, J. A. (1995). Two-year inhalation exposure of female and male B6C3F1 mice and F344 rats to chlorine gas induces lesions confined to the nose. Fundam. Appl. Toxicol. 24, 111-131.