Moderate-level resistance to glycopeptide LY333328 mediated by genes of the vanA and vanB clusters in enterococci

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 8, 1999, Pages 1875-1880

  Arthur, Michel ^a,c   Depardieu, Florence ^a   Reynolds, Peter ^b   Courvalin, Patrice ^a  

^a INSTITUT PASTEUR   (France)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPEPTIDE; ORITAVANCIN; TEICOPLANIN;

ANTIBIOTIC RESISTANCE; ARTICLE; ENTEROCOCCUS; ENTEROCOCCUS FAECALIS; GENE CLUSTER; GENE EXPRESSION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PLASMID; PRIORITY JOURNAL;

EID: 0032818228     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.8.1875     Document Type: Article

References (36)

1. Allen, N. E., J. N. Hobbs, Jr., and T. I. Nicas. 1996. Inhibition of peptidoglycan biosynthesis in vancomycin-susceptible and -resistant bacteria by a semi-synthetic glycopeptide antibiotic. Antimicrob. Agents Chemother. 40:2356-2362.
2. Allen, N. E., D. L. LeTourneau, and J. N. Hobbs, Jr. 1997. Molecular interactions of a semisynthetic glycopeptide antibiotic with D-alanyl-D-alanine and D-alanyl-D-lactate residues. Antimicrob. Agents Chermother. 41:66-71.
3. Arthur, M., and P. Courvalin. 1993. Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob. Agents Chemother. 37:1563-1571.
4. Arthur, M., F. Depardieu, L. Cabanié, P. Reynolds, and P. Courvalin. 1998. Requirement of the VanY and VanX D,D-peptidases for glycopeptide resistance in enterococci. Mol. Microbiol. 30:819-830.
5. Arthur, M., F. Depardieu, G. Gerbaud, M. Galimand, R. Leclercq, and P. Courvalin. 1997. The VanS sensor negatively controls VanR-mediated transcriptional activation of glycopeptide resistance genes of Tn1546 and related elements in the absence of induction. J. Bacteriol. 179:97-106.
6. Arthur, M., F. Depardieu, C. Molinas, P. Reynolds, and P. Courvalin. 1995. The vanZ gene of Tn1546 from Enterococcus faecium BM4147 confers resistance to teicoplanin. Gene 154:87-92.
7. Arthur, M., F. Depardieu, P. Reynolds, and P. Courvalin. 1996. Quantitative analysis of the metabolism of soluble cytoplasmic peptidoglycan precursors of glycopeptide-resistant enterococci. Mol. Microbiol. 21:33-44.
8. Arthur, M., F. Depardieu, H. A. Snaith, P. E. Reynolds, and P. Courvalin. 1994. Contribution of VanY D,D-carboxypeptidase to glycopeptide resistance in Enterococcus faecalis by hydrolysis of peptidoglycan precursors. Antimicrob. Agents Chemother. 38:1899-1903.
9. Arthur, M., C. Molinas, T. D. H. Bugg, G. D. Wright, C. T. Walsh, and P. Courvalin. 1992. Evidence for in vivo incorporation of D-lactate into peptidoglycan precursors of vancomycin-resistant enterococci. Antimicrob. Agents Chemother. 34:867-869.
10. Arthur, M., C. Molinas, and P. Courvalin. 1992. The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J. Bacteriol. 174:2582-2591.
11. Arthur, M., P. Reynolds, and P. Courvalin. 1996. Glycopeptide resistance in enterococci. Trends Microbiol. 4:401-407.
12. Aslangul, E., M. Baptista, B. Fantin, F. Depardieu, M. Arthur, P. Courvalin, and C. Carbon. 1997. Selection of glycopeptide-resistant mutants of VanB-type Enterococcus faecalis BM4281 in vitro and in experimental endocarditis. J. Infect. Dis. 175:598-605.
13. Baptista, M., F. Depardieu, P. Reynolds, P. Courvalin, and M. Arthur. 1997. Mutations leading to increased levels of resistance to glycopeptide antibiotics in VanB-type enterococci. Mol. Microbiol. 25:93-105.
14. Barna, J. C. J., and D. H. Williams. 1984. The structure and mode of action of glycopeptide antibiotics of the vancomycin group. Annu. Rev. Microbiol. 38:339-357.
15. Beauregard, D., A. Maguire, D. Williams, and P. Reynolds. 1997. Semiquantitation of cooperatively in binding of vancomycin-group antibiotics to vancomycin-susceptible and -resistant organisms. Antimicrob. Agents Chemother. 41:2418-2423.
16. Biavasco, F., C. Vignaroli, R. Lupidi, E. Manso, B. Facinelli, and P. E. Varaldo, 1997. In vitro antibacterial activity of LY333328, a new semisynthetic glycopeptide. Antimicrob. Agents Chemother. 41:2165-2172.
17. Billot-Klein, D., D. Blanot, L. Gutmann, and J. van Heijenoort. 1994. Association constants for the binding of vancomycin and teicoplanin to N-acetyl-D-alanyl-D-alanine and N-acetyl-D-alanyl-D-serine. Biochem. J. 304: 1021-1022.
18. Bugg, T. D. H., G. D. Wright, S. Dutka-Malen, M. Arthur, P. Courvalin, and C. T. Walsh. 1991. Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA. Biochemistry 30:10408-10415.
19. Chopra, I. 1997. N-alkyl-substituted glycopeptide antibiotics. Exp. Opin. Investig. Drugs 6:299-303.
20. Courvalin, P., and C. Carlier. 1986. Transposable multiple antibiotic resistance in Streptococcus pneumoniae. Mol. Gen. Genet. 205:291-297.
21. B two-component regulatory system in Enterococcus faecalis V583. J. Bacteriol. 178:1302-1309.
22. Fraimow, H. S., D. L. Jungkind, D. W. Lander, D. R. Delso, and J. L. Dean. 1994. Urinary tract infection with an Enterococcus faecalis isolate that requires vancomycin for growth. Ann. Intern. Med. 121:22-26.
23. Ge, M., Z. Chen, H. R. Onishi, J. Kohler, L. L. Silver, R. Kerns, S. Fukusawa, C. Thompson, and D. Kahne. 1999. Vancomycin derivatives that inhibit peptidoglycan biosynthesis without binding D-Ala-D-Ala. Science 284:507-511.
24. Hayden, M. K., G. M. Trenholme, J. E. Schultz, and D. F. Sahm. 1993. In vivo development of teicoplanin resistance in a VanB Enterococcus faecium isolate. J. Infect. Dis. 167:1224-1227.
25. Jacob, A. E., and S. J. Hobbs. 1974. Conjugal transfer of plasmid-borne multiple antibiotic resistance in Streptococcus faecalis var, zymogenes. J. Bacteriol. 117:360-372.
26. Leclercq, R., E. Derlot, J. Duval, and P. Courvalin. 1988. Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faecium. N. Engl. J. Med. 319:157-161.
27. Messer, J., and P. E. Reynolds. 1992. Modified peptidoglycan precursors produced by glycopeptide-resistant enterococci. FEMS Microbiol. Lett. 94: 195-200.
28. Nicas, T., M. Zeckel, and D. Braun. 1997. Beyond vancomycin: new therapies to meet the challenge of glycopeptide resistance. Trends Microbiol. 5:240-249.
29. Nieto, M., and H. R. Perkins. 1971. Modifications of the acyl-D-alanyl-D-alanine terminus affecting complex-formation with vancomycin. Biochem. J. 123:789-803.
30. Quintiliani, R., Jr., and P. Courvalin. 1996. Characterization of Tn1547, a composite transposon flanked by the IS16 and IS256-like elements, that confers vancomycin resistance in Enterococcus faecalis BM4281. Gene 172: 1-8.
31. Rosato, A., J. Pierre, D. Billot-Klein, A. Bun-Hoi, and L. Gutmann. 1995. Inducible and constitutive expression of resistance to glycopeptides and vancomycin dependence in glycopeptide-resistant Enterococcus avium. Antimicrob. Agents Chemother. 39:830-833.
32. Saleh-Mghir, A., A. Lefort, Y. Petegnief, S. Dautrey, J.-M. Vallois, D. Le Guludec, C. Carbon, and B. Fantin. 1999. Activity and diffusion of LY333328 in experimental endocarditis due to vancomycin-resistant Enterococcus faecalis. Antimicrob. Agents Chemother. 43:115-120.
33. Steers, E., E. L. Foltz, B. S. Graves, and J. Riden. 1959. An inocula replicating apparatus for routine testing of bacterial susceptibility to antibiotics. Antibiot. Chemother. (Basel) 9:307-311.
34. Van Bambeke, F., M. Chauvel, P. Reynolds, H. Fraimow, and P. Courvalin. 1999. Vancomycin-dependent Enterococcus faecalis clinical isolates and revenant mutants. Antimicrob. Agents Chemother. 43:41-47.
35. Wright G. D., and C. T. Walsh. 1992. D-Alanyl-D-alanine ligases and the molecular mechanism of vancomycin resistance. Acc. Chem. Res. 25:468-473.
36. Zelenitsky, S. A., B. Booker, N. Laing, J. A. Karlowsky, D. J. Hoban, and G. G. Zhanel. 1999. Synergy of an investigational glycopeptide, LY333328, with once-daily gentamicin against vancomycin-resistant Enterococcus faecium in a multiple-dose, in vitro pharmacodynamic model. Antimicrob. Agents Chemother. 43:592-597.