The VanS sensor negatively controls VanR-mediated transcriptional activation of glycopeptide resistance genes of Tn1546 and related elements in the absence of induction

Journal of Bacteriology

Volumn 179, Issue 1, 1997, Pages 97-106

  Arthur, Michel ^a   Depardieu, Florence ^a   Gerbaud, Guy ^a   Galimand, Marc ^a   Leclercq, Roland ^b   Courvalin, Patrice ^a  

^a INSTITUT PASTEUR   (France)

^b HENRI MONDOR HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; DIPEPTIDASE; LIGASE; OXIDOREDUCTASE;

ARTICLE; AUTOPHOSPHORYLATION; BACTERIAL GENE; ENTEROCOCCUS FAECALIS; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TRANSACTIVATION; TRANSCRIPTION REGULATION;

BACTERIA (MICROORGANISMS); ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; FELIS CATUS; STREPTOCOCCUS;

EID: 0031026581     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.179.1.97-106.1997     Document Type: Article

References (32)

1. Arthur, M., and P. Courvalin. 1993. Genetics and mechanisms of glycopcptide resistance in enterococci. Antimicroh. Agents Chemother. 37:1563-1571.
2. 1a. Arthur, M., and F. Depardieu. Unpublished results.
3. Arthur, M., F. Depardieu, C. Molinas, P. Reynolds, and P. Courvalin. 1995. The vanZ gene of Tn1546 from Enterococcus faecium BM4147 confers resistance to tcicoplanin. Gene 154:87-92.
4. Arthur, M., F. Depardieu, P. Reynolds, and P. Courvalin. 1996. Quantitative analysis of the metabolism of soluble cytoplasmic peptiduglycan precursors of glycopcplide-resistant enterococci. Mol. Microbiol. 21:33-44.
5. Arthur, M., F. Depardieu, H. A. Snaith, P. E. Reynolds, and P. Courvalin. 1994. Contribution of VanY D,D-carboxypcptidase to glycopeptide resistance in Enterococcus faecalis by hydrolysis of peptidoglycan precursors. Antimicroh. Agents Chemother. 38:1899-1903.
6. Arthur, M., C. Molinas, and P. Courvalin. 1992. The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J. Bacteriol. 174:2582-2591.
7. Arthur, M., C. Molinas, F. Depardieu, and P. Courvalin. 1993. Characterization of Tn1546, a Tn3-related iransposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J. Bacteriol. 175:117-127,
8. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl. 1987. Current protocols in molecular biology. John Wiley & Sons. Inc., New York.
9. Brosius, J. 1984. Plasmid vectors for the selection of promoters. Gene 27:151-160.
10. Bugg, T. D. H., G. D. Wright, S. Dutka-Malen, M. Arthur, P. Courvalin, and C.T. Walsh. 1991. Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA. Biochemistry 30:10408-10415.
11. Cruz-Rodz, A. L., and M. S. Gilmore. 1990. High efficiency introduction of plasmid DNA into glycine treated Enterococcus faccalis by electroporation. Mol. Gen. Genet. 224:152-154.
12. Fisher, S., W. Jiang, B. Wanner, and C. Walsh. 1995. Cross-talk between the histidine protein kinase VanS and the response regulator PhoB. J. Biol. Chem. 270:23143-23149.
13. Handwerger, S., L. Discotto, J. Thanassi, and M. J. Pucci. 1992, Insertional inactivation of a gene which controls expression of vancomycin resistance on plasmid pHKK100. FEMS Microbiol. Lett. 92:11-14.
14. Handwerger, S., and J. Skoble. 1995. Identification of chromosomal mobile element conferring high-level vancomycin resistance in Enterococcus faecium. Antimicrob. Agents Chemother. 39:2446-2453.
15. Handwerger, S., J. Skoble, L. F. Discotto, and M. J. Pucci. 1995. Heterogeneity of the vanA gene cluster in clinical isolates of enterococci from the northeastern United States, Antimicrob. Agents Chemother. 39:362-368.
16. Hoch, J. A., and T. J. Silhavy. 1995. Two-component signal transduction. American Society for Microbiology. Washington, D.C.
17. Holman, T. R., Z. Wu, B. L. Wanner, and C. T. Walsh. 1994. Identification of the DNA-hinding site for the phosphorylated Van R protein required for vancomycin resistance in Enterococcus faecium. Biochemistry 33:4625-4631.
18. Jacob, A. E., and S. J. Hobbs. 1974. Conjugal transfer of plasmid-borne multiple antibiotic resistance in Streptococcus faecalis var. zymoggenes. J. Bacteriol. 117:360-372.
19. US, Kay, R., and J. McPherson. 1987. Hybrid pUC vectors for addition of new restriction enzyme sites to the ends of DNA fragments. Nucleic Acids Res. 15:2778.
20. Le Buuguénec, C., G. de Cespédés, and T. Huraud. 1990. Presence of chromosomal elements resembling the composite structure Tn3701 in streptococci. J. Bacteriol. 172:727-734.
21. Leclercq, R., E. Derlot, M. Weber, J. Duval, and P. Courvalin. 1989. Transferable vancomycin and tcicoplanin resistance in Enterococcus faccium. Antimicrob. Agents Chemother. 33:10-15.
22. Miranda, A. G., K. V. Singh, and B. E. Murray. 1991. DNA fingerprinting of Enterococcus faecium by pulsed-field gel electrophoresis may be a useful epidemiologic tool. J. Clin. Microbiol. 29:2752-2757.
23. Reynolds, P. E. 1989. Structure, biochemistry and mechanism of action of glycopeptide antibiotics. Eur. J. Clin. Microbiol. Infect. Dis. 8:943-950.
24. Reynolds,. P. E., F. Depardieu, S. Dutka-Malen, M. Arthur, and P. Courralin. 1994. Glycupeptide resistance mediated by enterococcal transposon Tn1546 requires production of VanX for hydrolysis of D-alanyl-D-alanine. Mol. Microbiol. 13:1065-1070.
25. Steers, E., E. L. Foltz, B. S. Graves, and J. Riden. 1959. An inocula replicating apparatus for routine testing of bacterial susceptibility to antibiotics, Antibiot. Oil-mother. (Basel) 9:307-311.
26. Stock, J. B., A. J. Ninfa, and A. M. Stock. 1989. Protein phosphorylation and regulation of adaptive responses in bacteria. Microbiol, Rev. 53:450-490.
27. Trieu-Cuot, P., C. Curlier, C. Poyart-Salmeron, and P. Courvalin. 1991. An integrative vector exploiting the transposition properties of Tn1545 for insertional mutagenesis and cloning of genes from Gram-positive bacteria. Gene 106:21-27.
28. Walsh, C., S. Fisher, I.-S. Park, M. Prahalad, and Z. Wu. 1996. Bacterial resistance to vancomycin: five genes and one missing hydrogen bond tell the story. Chem. Biol. 3:21-28.
29. Wanner, B. 1995. Signal transduction and cross regulation in the Escherichia coli phosphate regulon by PhoR, CreC, and acetyl phosphate, p. 203-221. In J. Hoch and T. Silhavy (ed.), Two-component signal transduction. American Society tor Microbiology, Washington. D.C.
30. Wright, G. D., T. R. Holman, and C. T. Walsh. 1993. Purification and characterization of VanR and the cytosolic domain of VanS: a two-component regulatory system required for vancomycin resistance in Enterococcus faecium BM4147. Biochemistry 32:5057-5063.
31. Wu, Z., G. D. Wright, and C. T. Walsh. 1995. Overexpression, purification and characterization of VanX. a D,D-dipeptidase which is essential for vancomycin resistance in Enterococcus faecium BM4147. Biochemistry 34:2455-2463.
32. Yanisch-Perron, C., J. Vieira, and J. Messing. 1985. Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene 33:103-119.