Very-low-density lipoprotein apolipoprotein B100 kinetics in adult hypopituitarism

Metabolism: Clinical and Experimental

Volumn 48, Issue 8, 1999, Pages 1057-1062

  Chrisoulidou, Alexandra ^a   Kousta, Eleni ^a   Venkatesan, Soundararajan ^a   Gray, Robert ^a   Bannister, Peter A ^a   Gallagher, John J ^a   Johnston, Desmond G ^a  

^a ST MARY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B100; FATTY ACID; VERY LOW DENSITY LIPOPROTEIN;

ADULT; ARTICLE; CLINICAL ARTICLE; DISEASE ASSOCIATION; FEMALE; HUMAN; HYPERLIPIDEMIA; HYPOPITUITARISM; LIPOPROTEIN BLOOD LEVEL; LIPOPROTEIN METABOLISM; MALE; PRIORITY JOURNAL;

EID: 0032817179     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(99)90206-8     Document Type: Article

References (34)

1. Merimee TJ, Hollander W, Fineberg SE: Studies of hyperlipidaemia in the HGH-deficient state. Metabolism 21:1053-1061, 1972
2. Summers VK, Hipkin LJ, Davis JC: Serum lipids in diseases of the pituitary. Metabolism 16:1106-1113, 1967
3. Beshyah SA, Henderson A, Niththyanathan R, et al: Metabolic abnormalities in growth hormone deficient adults: II. Carbohydrate tolerance and lipid metabolism. Endocrinol Metab 1:173-180, 1994
4. De Boer H, Blok GJ, Voerman HJ, et al: Serum lipids in growth hormone-deficient men. Metabolism 43:199-203, 1994
5. Rosén T, Edén S, Larson G, et al: Cardiovascular risk factors in adult patients with growth hormone deficiency. Acta Endocrinol (Copenh) 129:195-200, 1993
6. Al-Shoumer KAS, Cox KH, Hughes CL, et al: Fasting and postprandial lipid abnormalities in hypopituitary women receiving conventional replacement therapy. J Clin Endocrinol Metab 82:2653-2659, 1997
7. Rosén T, Bengtsson B-Å: Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 336:285-288, 1990
8. Bulow B, Hagmar L, Mikoczy Z, et al: Increased cerebrovascular mortality in patients with hypopituitarism. Clin Endocrinol (Oxf) 46:75-78, 1997
9. Havel RJ, Eder HA, Bragdon JH The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 34:1345-1353, 1955
10. Venkatesan S, Cullen P, Pacy P, et al: Stable isotopes show a direct relation between VLDL apo B100 overproduction and serum triglyceride levels and indicate a metabolically and biochemically coherent basis for familial combined hyperhpidaemia. Arterioscler Thromb 13:1110-1118, 1993
11. 13C] KIC in plasma by capillary gas chromatography/mass spectrometry in protein turnover studies. Biomed Mass Spectrom 12:432-436, 1985
12. Cobelli C, Toffolo G, Bier DM, et al: Models to interpret kinetic data in stable isotope studies. Am J Physiol 253:E551-E564, 1987
13. Parhofer KG, Hugh P, Barett R, et al: Determination of kinetic parameters of apolipoprotein B metabolism using aminoacids labeled with stable isotopes. J Lipid Res 32:1311-1323, 1991
14. Gregersen MI, Rawson RA: Blood volume. Physiol Rev 39:307-342, 1959
15. Siedel J, Hagele EO, Ziegenhorn J, et al: Reagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency. Clin Chem 29:1075-1080, 1983
16. Elphick MC: Modified colorimetric ultramicro method for estimating NEFA in serum. J Clin Pathol 21:567-570, 1968
17. Cummings MH, Christ E. Umpleby AM, et al: Abnormalities of very low density hpoprotein apolipoprotein B-100 metabolism contribute to the dyslipidaemia of adult growth hormone deficiency. J Clin Endocrinol Metab 82:2010-2013, 1997
18. Beshyah SA, Henderson A, Baynes C, et al Post-heparin plasma lipase activity in hypopituitary adults. Horm Res 44:69-74, 1995
19. Mostaza JM, Vega GL, Snell P, et al: Abnormal metabolism of free fatty acids in hypertriglyceridaermic men: Apparent insulin resistance of adipose tissue. J Intern Med 243:265-274, 1998
20. Ginsberg HN: Diabetic dyshpidemia: Basic mechanisms underlying the common hypertriglyceridemia and low HDL levels. Diabetes 45:S27-S30, 1996 (suppl 3)
21. Johansson JO, Fowelin J, Landin K, et al: Growth hormone-deficient adults are insulin-resistant. Metabolism 44:1126-1129, 1995
22. Al-Shoumer KAS, Ali K, Anyaoku V. et al: Overnight metabolic fuel deficiency in patients treated conventionally for hypopituitarism. Clin Endocrinol (Oxf) 45:171-178, 1996
23. Dinneen S, Alzaid A, Miles J, et al: Metabolic effects of the nocturnal rise in cortisol on carbohydrate metabolism in normal humans. J Clin Invest 92:2283-2290, 1993
24. Divertie GD, Jensen MD, Miles JM: Stimulation of lipolysis in humans by physiological hypercortisolemia. Diabetes 40:1228-1232, 1991
25. Aarsland A, Chinkes D, Wolfe RR: Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal man. J Clin Invest 98:2008-2017, 1996
26. Johnston DG, Alberti KG, Nattrass M, et al: Hormonal and metabolic rhythms in Cushing's syndrome. Metabolism 29:1046-1052, 1980
27. Franklyn JA, Daykin J, Betteridge J, et al: Thyroxine replacement therapy and circulating lipid concentrations. Clin Endocrinol (Oxf) 38:453-459, 1993
28. Cuneo RC, Salomon F, McGauley GA, et al: The growth hormone deficiency syndrome in adults. Clin Endocrinol (Oxf) 37:387-397, 1992
29. Johansson G, Oscarsson J, Rosén T, et al: Effects of 1 year of growth hormone therapy on serum lipoprotein levels in growth hormone deficient adults. Arterioscler Thromb Vasc Biol 15:2142-2150, 1995
30. Vahl N, Jorgensen JO, Hansen TB, et al: The favourable effects of growth hormone (GH) substitution on hypercholesterolaemia in GH-deficient adults are not associated with concomitant reductions in adiposity. A 12 month placebo-controlled study. Int J Obes Relat Metab Disord 22:529-536, 1998
31. Beshyah SA, Henderson A, Niththyanathan R, et al: The effects of short and long term growth hormone replacement therapy in hypopituitary adults on lipid metabolism and carbohydrate tolerance. J Clin Endocrinol Metab 80:356-362, 1995
32. Cuneo RC, Judd S, Wallace JD, et al: The Australian Multicenter Trial of Growth Hormone (GH) Treatment in GH-deflcient adults. J Clin Endocrinol Metab 83:107-116, 1998
33. Campos H, Wilson PW, Jimenez D, et al: Differences in apolipoproteins and low-density lipoprotein subfractions in postmenopausal women on and off estrogen therapy: Results from the Framingham Offspring Study. Metabolism 39:1033-1038, 1990
34. Tibblin G, Adlerberth A, Lindstedt G, et al: The pituitarygonadal axis and health in elderly men: A study of men born in 1913. Diabetes 45:1605-1609, 1996