Failure of exogenously administered interferon-γ or blockage of endogenous interleukin-4 with specific inhibitors to augment the incidence of autoimmune diabetes in male NOD mice

Autoimmunity

Volumn 30, Issue 2, 1999, Pages 71-80

  Xiang, Ming ^d   Zaccone, Paola ^d   Di Marco, Roberto ^a   Harris, Robert ^a   Magro, Gaetano ^d   Di Mauro, Maurizio ^d   Meroni, Pier Luigi ^b   Garotta, Gianni ^c   Nicoletti, Ferdinando ^d  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b IRCCS   (Italy)

^c Serono International SA   (Switzerland)

^d NONE

Author keywords

Diabetes; Immunotherapy; Interferon ; Interleukin 4; NOD mouse

Indexed keywords

CYCLOPHOSPHAMIDE; GAMMA INTERFERON; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETOGENESIS; INCIDENCE; INSULITIS; MALE; MOUSE; NONHUMAN;

EID: 0032816397     PISSN: 08916934     EISSN: None     Source Type: Journal    
DOI: 10.3109/08916939908994763     Document Type: Article

References (45)

1. A.A. Rossini, E.S. Handler, J.P. Mordes and D.L. Greiner. Human autoimmune diabetes mellitus: Lessons from BB rats and NOD mice - Caveat Emptor. Clin. Immunol. Immunopathol., 1995, 74: 2-9.
2. A. Rabinovitch, W.L. Suarez, O. Sorensen, R.C. Bleackley and R.F. Power. IFN-γ gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice. J. Immunol., 1995, 154: 4874-4882.
3. C.J. Fox and J.S. Danska. IL-4 expression at the onset of islet inflammation predicts nondestructive insulitis in non-obese diabetic mice. J. Immunol., 1997, 158: 2414-2424.
4. A. Rabinovitch, W.L. Suarez-Pinzon and O. Sorensen. Interleukin 12 mRNA expression in islets correlates with beta-cell destruction in NOD mice. J. Autoimmun., 1996, 9: 645-651.
5. H. Rothe, A. Faust, U. Schade, R. Kleeman, G. Bosse, T. Hibino, S. Martin and H. Kolb. Cyclophosphamide treatment of female non-obese diabetic mice causes enhanced expression of inducible nitric oxide synthase and interferon-gamma, but not of interleukin-4. Diabetologia, 1994, 37: 1154-1158.
6. K.J. Pennline, E. Roque-Gaffney and M. Monahan. Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse. Clin. Immunol. Immunopathol., 1994, 71: 169-175.
7. F. Nicoletti, P. Zaccone, R. Di Marco, M. Di Mauro, G. Magro, S. Grasso, L. Mughini, P.L. Meroni and G. Garotta. The effects of a nonimmunogenic form of murine soluble interferon-gamma receptor on the development of autoimmune diabetes in NOD mouse. Endocrinology, 1996, 137: 5567-5575.
8. M.A. Rapoport, D. Jaramillo, D. Zipris, A.H. Lazarus, D. Serreze, E.H. Leiter, P. Cyopick, J.S. Danska and T.L. Delovitch. Interleukin-4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in non-obese diabetic mice. J. Exp. Med., 1993, 178: 87-99.
9. R. Mueller, T. Krahl and N. Sarvetnick. Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice. J. Exp. Med., 1996, 184: 1093-1099.
10. A. Rabinovitch. Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation? Diabetes, 1994, 43: 613-621.
11. T. Mandrup-Poulsen, J. Nerup, J.I. Reimers, F. Pociot, H.U. Andersen, A. Karlsen, U. Bjerre and R. Bergholdt. Cytokines and the endocrine system. II. Roles in substrate metabolism, modulation of thyroidal and pancreatic endocrine cell functions and autoimmune endocrine diseases. Eur. J. Endocrinol., 1996, 134: 21-30.
12. P.H. Van der Meide, M. Dubbeld, K. Vijverberg, T. Kos and H. Schellekens. The purification and characterization of rat gamma interferon by the use of two monoclonal antibodies. J. General. Virol., 1986, 67: 1059-1071.
13. P.W. Gray and D.V. Goeddel. Cloning and expression of murine interferon cDNA. Proc. Natl. Acad. Sci. USA, 1983, 80: 5842-5846.
14. M.C. Boissier, G. Chiocchia, N. Bessis, J. Hajnal, G. Garotta, F. Nicoletti and C. Fournier. Biphasic effect of interferon-γ in murine collagen-induced arthritis. Eur. J. Immunol., 1995, 25: 1184-1190.
15. Y. Kawakami, N. Kuzuka, T. Watanabe, Y. Uchiyama and K. Yamashita. Induction of experimental thyroiditis in mice by recombinant interferon γ administration. Acta Endocrinol. (Copenh.), 1990, 122: 41-48.
16. C.H. Jacob, P.H. van der Meide and H.O. McDevitt. In vivo treatment of (NZB × NZW)Fl lupus-like nephritis with monoclonal antibody to γ interferon. J. Exp. Med., 1987, 166: 798-802.
17. M. Prat, C. Gribaudo, P. Comoglio, G. Cavallo and S. Landolfo. Monoclonal antibodies against murine γ interferon. Proc. Natl. Acad. Sci. USA, 1984, 81: 4515-4519.
18. H. Tang, K. Mignon-Godefroy, P.L. Meroni, G. Garotta, J. Charreire and F. Nicoletti. The effects of a monoclonal antibody to interferon-γ on Experimental Autoimmune Thyroiditis (EAT): prevention of disease and decrease of EAT-specific T cells. Eur. J. Immunol., 1993, 23: 275-279.
19. M.J.M. Jacobs, A.E.M. Van den Hoeck, P.L.E.M. van Lent, A.J.J. van de Loo, L.B.A. van de Putte and W.B. Van der Berg. Role of IL-2 and IL-4 in exacerbations of murine antigen-induced arthritis. Immunology, 1994, 83: 390-396.
20. L.A.B. Joosten, E. Lubberts, P. Durez, M.A. Helsen, M.A. Jacobs, M. Goldman and W. Van den Berg. Role of interleukin-4 and interleukin-10 in murine collagen-induced arthritis. Arthritis and Rheum., 1997, 40: 249-260.
21. M. Hesse, S. Bayrak and A. Mitchison. Protective major histocompatibility complex genes and the role of interleukin-4 in collagen-induced arthritis. Eur. J. Immunol., 1996, 26: 3234-3237.
22. B. Mosley, M.P. Beckmann, C.J. March, R.L. Idzerda, S.D. Gimpel, T. Van den Bos, D. Friend, A. Alpert, D. Anderson, J. Jackson et al. The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms. Cell, 1989, 59: 335-348.
23. W.C. Fanslow, K.N. Clifford, L.S. Park, A.S. Rubin, R.F. Voice, M.P. Beckmann and M.B. Widmer. Regulation of alloreactivity in vivo by IL-4 and the soluble IL-4 receptor. J. Immunol., 1991, 147: 535-540.
24. A. Gessner, K. Schroppel, K.H. Enssle, L. Lauffer and M. Rollinghoff. Recombinant soluble interleukin-4 (IL-4) receptor acts as an antagonist of IL-4 in murine cutaneous Leishmaniasis. Infect. Immun., 1994, 62: 4112-4117.
25. L.M. Bagenstose, P. Salgame and M. Monestier. IL-12 down-regulates autoantibody production in mercury-induced autoimmunity. J. Immunol., 1998, 160: 1612-1617.
26. N.M. Parish, P.R. Hutchings, L. O'Reilly, L. Quartey-Papafio, D. Healey, P. Ozegbe and A. Cooke. Tolerance induction as a therapeutic strategy for the control of autoimmune endocrine disease in mouse models. Immunol. Rev., 1995, 144: 269-300.
27. B. Kelin and H. Brailly. Cytokine-binding proteins: stimulating antagonists. Immunol. Today, 1995, 16: 216-220.
28. S.L. Swain. CD4 T cell development and cytokine polarization: an overview. J. Leukoc. Biol., 1995, 57: 795-798.
29. J. Satoh, H. Seino, T. Abo, S.-I. Tanaka, S. Shintani, S. Ohta, K. Tamura, T. Sawai, T. Nobunaga, T. Oteki, K. Kumagai and T. Toyota. Recombinant human tumor necrosis factor-α suppresses autoimmune diabetes in nonobese diabetic mice. J. Clin. Invest., 1989, 84: 1345-1348.
30. C.O. Jacob, S. Aiso, R.D. Schreiber and H.O. McDevitt. Monoclonal anti-tumor necrosis factor antibody renders non-obese diabetic mice hypersensitive to irradiation and enhances insulitis development. Int. Immunol., 1992, 4: 611-614.
31. I.L. Campbell, L. Oxbrow and L.C. Harrison. Reduction of insulitis following administration of IFN-γ and TNF-α in the NOD mouse. J. Autoimmun., 1991, 4: 249-262.
32. C.A. Piccirillo, Y. Chang and G.J. Prud'homme. TGF-β1 somatic gene therapy prevents autoimmune diabetes in nonobese diabetic mice. J. Immunol., 1998, 161: 3950-3956.
33. H. Rothe, R.M. O'Hara, S. Martin and H. Kolb. Suppression of cyclophosphamide induced diabetes development and and pancreatic Th1 reactivity in NOD mice treated with the interleukin (IL)-12 antagonist IL-12(p40)2. Diabetologia, 1996, 39: 119-122.
34. S. Trembleau, G. Penna, S. Gregori, M.C. Gately and L. Adorini. Deviation of pancreas-infiltrating cells to Th2 by interleukin-12 antagonist administration inhibits autoimmune diabetes. Eur. J. Immunol., 1997, 27: 2330-2339.
35. d mice is mediated by interferon-γ (IFN-γ). Clin. Exp. Immunol., 1997, 109: 149-156.
36. M. Ochel, H.-W. Vohr, C. Pfeiffer and E. Gleichman. IL-4 required for the IgE and IgG1 increase and IgG1 autoantibody formation in mice treated with mercuric chloride. J. Immunol. 1991, 146: 3006-3011.
37. F. Nicoletti, R. Di Marco, W. Barcellini, G. Magro, H.U. Schorlemmer, R. Kurrle, M. Lunetta, S. Grasso, P. Zaccone and P.L. Meroni. Protection from experimental autoimmune diabetes in the nonobese diabetic mouse with soluble interleukin-1 receptor. Eur. J. Immunol., 1994, 24: 1843-1847.
38. F. Nicoletti, P. Zaccone, R. Di Marco, G. Magro, S. Grasso, F. Stivala, G. Calori, L. Mughini, P.L. Meroni and G. Garotta. Paradoxical antidiabetogenic effect of γ-interferon in DP-BB rats. Diabetes, 1998, 47: 32-38.
39. G. Valente, L. Ozmen, F. Novelli, M. Geuna, G. Palestro, G. Forni and G. Garotta. Distribution of interferon-γ receptor in human tissues. Eur. J. Immunol., 1992, 22: 2403-2412.
40. S. Landolfo and G. Garotta. IFN-γ. An immunomodulatory and proinflammatory lymphokine. J. Immunol. Res., 1991, 9: 81-94.
41. B. Wang, A. Gonzalez, P. Hoglund, J.D. Katz, C. Benoist and D. Mathis. Interleukin-4 deficiency does not exacerbate disease in NOD mice. Diabetes, 1998, 47: 1207-1211.
42. K. Bendtzen. Cytokines and natural regulatur of cytokines. Immunol. Lett., 1994, 43: 111-123.
43. G.J. McKenzie, A. Bancroft, R.K. Grencis and A.N. McKenzie. A distinct role for interleukin-13 in Th2 cell mediated immune responses. Curr. Biol., 1998, 8: 339-342.
44. X.D. Yang, R. Tisch, S.M. Singer, Z.A. Cao, R.S. Liblau, R.D. Schreiber and H.O. McDevitt. Effect of tumor necrosis factor-α on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process. J. Exp. Med., 1994, 180: 995-1004.
45. H. Amital, Y. Levi, M. Blank, V. Barak, P. Langevitz, A. Afek, F. Nicoletti, J Kopolovic, B. Gilburd, P.L. Meroni and Y. Shoenfeld. Immunomodulation of murine experimental SLE-like disease by interferon-γ. Lupus, 1998, 7: 445-454.