Localization and possible functions of phospholipase D isozymes

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1439, Issue 2, 1999, Pages 245-263

  Liscovitch, Mordechai ^a   Czarny, Malgorzata ^a   Fiucci, Giusy ^a   Lavie, Yaakov ^a   Tang, Xiaoqing ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Phosphatidic acid; Phosphatidylinositol 4,5 bisphosphate; Phospholipase D; Subcellular localization

Indexed keywords

GUANOSINE TRIPHOSPHATASE; ISOENZYME; PHOSPHATIDIC ACID; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE D;

CELL ORGANELLE; CELLULAR DISTRIBUTION; ENZYME LOCALIZATION; ENZYME REGULATION; HUMAN; MEMBRANE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; CLONING, MOLECULAR; DETERGENTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GTP PHOSPHOHYDROLASES; HUMANS; ISOENZYMES; MEMBRANES; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHOLIPASE D; SUBCELLULAR FRACTIONS;

MAMMALIA;

EID: 0032815737     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1388-1981(99)00098-0     Document Type: Review

References (160)

1. Liscovitch M., Cantley L.C. Lipid second messengers. Cell. 77:1994;329-334.
2. Divecha N., Irvine R.F. Phospholipid signaling. Cell. 80:1995;269-278.
3. Nishizuka Y. Protein kinase C and lipid signaling for sustained cellular responses. FASEB J. 9:1995;484-496.
4. Ghosh S., Strum J.C., Bell R.M. Lipid biochemistry: functions of glycerolipids and sphingolipids in cellular signaling. FASEB J. 11:1997;45-50.
5. M. Heller, Phospholipase D, in: R. Paoletty, D. Kritchevsky (Eds.), Advances in Lipid Research, vol. 16, Academic Press, New York, 1978, pp. 267-326.
6. Exton J.H. Signaling through phosphatidylcholine breakdown. J. Biol. Chem. 265:1990;1-4.
7. Billah M.M., Anthes J.C. The regulation and cellular functions of phosphatidylcholine hydrolysis. Biochem. J. 269:1990;281-291.
8. English D., Cui Y., Siddiqui R.A. Messenger functions of phosphatidic acid. Chem. Phys. Lipids. 80:1996;117-132.
9. Hodgkin M.N., Pettitt T.R., Martin A., Michell R.H., Pemberton A.J., Wakelam M.J. Diacylglycerols and phosphatidates: which molecular species are intracellular messengers? Trends Biochem. Sci. 23:1998;200-204.
10. Natarajan V.E. Phospholipase D and signal transduction in mammalian cells. Chem. Phys. Lipids. 80:1996;1-142.
11. Exton J.H. New developments in phospholipase D. J. Biol. Chem. 272:1997;15579-15582.
12. Morris A.J., Hammond S.M., Colley C., Sung T.-C., Jenco J.M., Sciorra V.A., Rudge S.A., Frohman M.A. Regulation and functions of phospholipases D. Biochem. Soc. Transact. 25:1997;1151-1157.
13. Gomez-Cambronero J., Keire P. Phospholipase D: A novel major player in signal transduction. Cell. Signal. 10:1998;387-397.
14. Taki T., Kanfer J.N. Partial purification and properties of a rat brain phospholipase D. J. Biol. Chem. 254:1979;9761-9765.
15. Brown H.A., Gutowski S., Kahn R.A., Sternweis P.C. Partial purification and characterization of ARF-sensitive phospholipase D from porcine brain. J. Biol. Chem. 270:1995;14935-14943.
16. Vinggaard A.M., Hansen H.S. Characterization and partial purification of phospholipase D from human placenta. Biochim. Biophys. Acta. 1258:1995;169-176.
17. Abousalham A., Riviere M., Teissere M., Verger R. Improved purification and biochemical characterization of phospholipase D from cabbage. Biochim. Biophys. Acta. 1158:1993;1-7.
18. Wang X., Dyer J.H., Zheng L. Purification and immunological analysis of phospholipase D from castor bean endosperm. Arch. Biochem. Biophys. 306:1993;486-494.
19. Wang X., Xu L., Zheng L. Cloning and expression of phosphatidylcholine-hydrolyzing phospholipase D from Ricinus communis L. J. Biol. Chem. 269:1994;20312-20317.
20. Ueki J., Morioka S., Komari T., Kumashiro T. Purification and characterization of phospholipase D (PLD) from rice (Oryza sativa L.) and cloning of cDNA for PLD from rice and maize (Zea mays L.). Plant Cell Physiol. 36:1995;903-914.
21. Rose K., Rudge S.A., Frohman M.A., Morris A.J., Engebrecht J. Phospholipase D signaling is essential for meiosis. Proc. Natl. Acad. Sci. USA. 92:1995;12151-12155.
22. Waksman M., Eli Y., Liscovitch M., Gerst J.E. Identification and characterization of a gene encoding phospholipase D activity in yeast. J. Biol. Chem. 271:1996;2361-2364.
23. Ella K., Dolan J.W., Qi C., Meier K.E. Characterization of Saccharomyces cerevisiae deficient in expression of phospholipase D. Biochem. J. 314:1996;15-19.
24. Hammond S.M., Altshuller Y.M., Sung T.-C., Rudge S.A., Rose K., Engebrecht J., Morris A.J., Frohman M.A. Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family. J. Biol. Chem. 270:1995;29640-29643.
25. Wang X. Molecular analysis of phospholipase D. Trends Plant Sci. 2:1997;261-266.
26. Qin W., Pappan K., Wang X. Molecular heterogeneity of phospholipase D (PLD). Cloning of PLDγ and regulation of plant PLDγ, -β, and -α by polyphosphoinositides. J. Biol. Chem. 272:1997;28267-28273.
27. Park S.K., Provost J.J., Bae C.D., Ho W.T., Exton J.H. Cloning and characterization of phospholipase D from rat brain. J. Biol. Chem. 272:1997;29263-29271.
28. Colley W.C., Sung T.-C., Roll R., Jenco J., Hammond S.M., Altshuller Y., Bar-Sagi D., Morris A.J., Frohman M.A. Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provoke cytoskeletal reorganization. Curr. Biol. 7:1997;191-201.
29. Kodaki T., Yamashita S. Cloning, expression and characterization of a novel phospholipase D complementary DNA from rat brain. J. Biol. Chem. 272:1997;11408-11413.
30. Morris A.J., Engebrecht J., Frohman M.A. Structure and regulation of phospholipase D. Trends Pharmacol. Sci. 17:1996;182-185.
31. Ribbes G., Henry J., Cariven C., Pontarotti P., Chap H., Record M. Expressed sequence tags identify human isologs of the ARF-dependent phospholipase D. Biochem. Biophys. Res. Commun. 224:1996;206-211.
32. Ponting C.P., Kerr I.D. A novel family of phospholipase D homologues that includes phospholipid synthases and putative endonucleases: Identification of duplicated repeats and potential active site residues. Protein Sci. 5:1996;914-922.
33. 2+-dependent phospholipase D with preference for phosphatidylserine and phosphatidylethanolamine in Saccharomyces cerevisiae. FEBS Lett. 393:1996;236-240.
34. 2+-dependent, phosphatidylethanolamine-hydrolyzing phospholipase D in yeast bearing a disruption in PLD1. J. Biol. Chem. 272:1997;36-39.
35. Exton J.H. Phospholipase D. Biochim. Biophys. Acta. 1436:1998;105-115.
36. Anthes J.C., Wang P., Siegel M.I., Egan R.W., Billah M.M. Granulocyte phospholipase D is activated by a guanine nucleotide dependent protein factor. Biochem. Biophys. Res. Commun. 175:1991;236-243.
37. Olson S.C., Bowman E.P., Lambeth J.D. Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5′-O-(3-thiotriphosphate). Activation is calcium dependent and requires protein factors in both the plasma membrane and cytosol. J. Biol. Chem. 266:1991;17236-17242.
38. Geny B., Fensome A., Cockcroft S. Rat brain cytosol contains a factor which reconstitutes guanine-nucleotide-binding-protein-regulated phospholipase D activation in HL-60 cells previously permeabilized with streptolysin O. Eur. J. Biochem. 215:1993;389-396.
39. Brown H.A., Gutowski S., Moomaw C.R., Slaughter C., Sternweis P.C. ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity. Cell. 75:1993;1137-1144.
40. Cockcroft S., Thomas G.M.H., Fensome A., Geny B., Cunningham E., Gout I., Hiles I., Totty N.F., Truong O., Hsuan J.J. Phospholipase D: a downstream effector of ARF in granulocytes. Science. 263:1994;523-526.
41. Kahn R.A., Yucel J.K., Malhotra V. ARF signaling: A potential role of phospholipase D in membrane traffic. Cell. 75:1993;1045-1048.
42. Moss J., Vaughan M. Structure and function of ARF proteins: Activators of cholera toxin and critical components of intracellular vesicular transport processes. J. Biol. Chem. 270:1995;12327-12330.
43. Vidal M.J., Stahl P.D. The small G proteins Rab4 and ARF are associated with released exosomes during reticulocyte maturation. Eur. J. Cell Biol. 60:1993;261-267.
44. A.L. Boman, K.M.C. Sullivan, K.L. Wilson, Regulation of nuclear envelope assembly and disassembly by ARF and other GTP-binding proteins, in: V.W. Hu (Ed.), The Cell Cycle: Regulators, Targets, and Clinical Applications, Plenum, New York, 1994, pp. 197-202.
45. Lehnard J.M., Colombo M.I., Stahl P.D. Heterotrimeric GTP-binding proteins (G proteins) and ADP-ribosylation factor (ARF) regulate priming of endosomal membranes for fusion. Arch. Biochem. Biophys. 312:1994;474-479.
46. Hammond S.M., Jenco J.M., Nakashima S., Cadwallader K., Gu Q., Cook S., Nozawa Y., Prestwich G.D., Frohman M.A., Morris A.J. Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP- binding proteins and protein kinase C-alpha. J. Biol. Chem. 272:1997;3860-3868.
47. Katayama K., Kodaki T., Nagamachi Y., Yamashita S. Cloning, differential regulation and tissue distribution of alternatively spliced isoforms of ADP-ribosylation-factor-dependent phospholipase D from rat liver. Biochem. J. 329:1998;647-652.
48. Ktistakis N.T., Brown H.A., Sternweis P.C., Roth M.G. Phospholipase D is present in Golgi-enriched membranes and its activation by ADP-ribosylation factor is sensitive to brefeldin A. Proc. Natl. Acad. Sci. USA. 92:1995;4952-4956.
49. Rumenapp U., Geiszt M., Wahn F., Schmidt M., Jakobs K.H. Evidence for ADP-ribosylation factor-mediated activation of phospholipase D by m3 muscarinic acetylcholine receptor. Eur. J. Biochem. 234:1995;240-244.
50. Mitchell R., McCulloch D., Lutz E., Johnson M., MacKenzie C., Fennel M., Fink G., Zhou W., Sealfon S.C. Rhodopsin-family receptors associate with small G proteins to activate phospholipase D. Nature. 392:1998;411-414.
51. Moss J., Vaughan M. Molecules in the ARF orbit. J. Biol. Chem. 273:1998;21431-21434.
52. Bowman E.P., Uhlinger D.J., Lambeth J.D. Neutrophil phospholipase D is activated by a membrane-associated Rho family small molecular weight GTP-binding protein. J. Biol. Chem. 268:1993;21509-21512.
53. Malcolm K.C., Ross A.H., Qiu R.-G., Symons M., Exton J.H. Activation of rat liver phospholipase D by the small GTP-binding protein RhoA. J. Biol. Chem. 269:1994;25951-25954.
54. Siddiqui A.R., Smith J.L., Ross A.H., Qiu R.-G., Symons M., Exton J.H. Regulation of phospholipase D in HL60 cells. Evidence for a cytosolic phospholipase D. J. Biol. Chem. 270:1995;8466-8473.
55. Martin A., Brown F.D., Hodgkin M.N., Bradwell A.J., Cook S.J., Hart M., Wakelam M.J.O. Activation of phospholipase D and phosphatidylinositol 4-phosphate 5-kinase in HL60 membranes is mediated by endogenous Arf but not Rho. J. Biol. Chem. 271:1996;17397-17403.
56. Balboa M.A., Insel P.A. Nuclear phospholipase D in Madin-Darby canine kidney cells. Guanosine 5′-O-(thiotriphosphate)-stimulated activation is mediated by RhoA and is downstream of protein kinase C. J. Biol. Chem. 270:1995;29843-29847.
57. Kwak J.Y., Lopez I., Uhlinger D.J., Ryu S.H., Lambeth J.D. RhoA and a cytosolic 50-kDa factor reconstitute GTP gamma S-dependent phospholipase D activity in human neutrophil subcellular fractions. J. Biol. Chem. 270:1995;27093-27098.
58. Ohguchi K., Banno Y., Nakashima S., Nozawa Y. Activation of membrane-bound phospholipase D by protein kinase C in HL 60 cells: Synergistic action of a small GTP-binding protein RhoA. Biochem. Biophys. Res. Commun. 211:1995;306-311.
59. Ohguchi K., Banno Y., Nakashima S., Nozawa Y. Regulation of membrane-bound phospholipase D by protein kinase C in HL60 cells. Synergistic action of small GTP-binding protein RhoA. J. Biol. Chem. 271:1996;4366-4372.
60. Singer W.D., Brown H.A., Bokoch G.M., Sternweis P.C. Resolved phospholipase D activity is modulated by cytosolic factors other than ARF. J. Biol. Chem. 270:1995;14944-14950.
61. Kuribara H., Tago K., Yokozeki T., Sasaki T., Takai Y., Morii N., Narumiya S., Katada T., Kanaho Y. Synergistic activation of rat brain phospholipase D by ADP-ribosylation factor and rhoA p21, and its inhibition by Clostridium botulinum C3 exoenzyme. J. Biol. Chem. 270:1995;25667-25671.
62. Machesky L.M., Hall A. Rho: a connection between membrane receptor signalling and the cytoskeleton. Trends Cell Biol. 6:1996;304-310.
63. Schmidt M., Rumenapp U., Bienek C., Keller J., von Eichel-Streiber C., Jakobs K.H. Inhibition of receptor signaling to phospholipase D by Clostridium difficile toxin B. Role of Rho proteins. J. Biol. Chem. 271:1996;2422-2426.
64. Malcolm K.C., Elliott C.M., Exton J.H. Evidence for Rho-mediated agonist stimulation of phospholipase D in Rat1 fibroblasts. Effects of Clostridium butulinum C3 exoenzyme. J. Biol. Chem. 271:1996;13135-13139.
65. Singer W.D., Brown H.A., Jiang X., Sternweis P.C. Regulation of phospholipase D by protein kinase C is synergistic with ADP-ribosylation factor and independent of protein kinase activity. J. Biol. Chem. 271:1996;4504-4510.
66. Shimooku K., Akisue T., Jinnai H., Hitomi T., Ogino C., Yoshida K., Nakamura S.-I., Nishizuka Y. Reconstitution of GTP-γ-S-dependent phospholipase D activity with ARF, Rho, and a soluble 36-kDa protein. FEBS Lett. 387:1996;141-144.
67. Schmidt M., Huwe S.M., Fasselt B., Homann D., Rumenapp U., Sandmann J., Jakobs K.H. Mechanisms of phospholipase D stimulation by m3 muscarinic acetylcholine receptors. Evidence for involvement of tyrosine phosphorylation. Eur. J. Biochem. 225:1994;667-675.
68. Sung T.C., Zhang Y., Morris A.J., Frohman M.A. Structural analysis of human phospholipase D1. J. Biol. Chem. 274:1999;3659-3666.
69. Yamazaki M., Zhang Y., Watanabe H., Yokozeki T., Ohno S., Kaibuchi K., Shibata H., Mukai H., Ono Y., Frohman M.A., Kanaho Y. Interaction of the small G protein RhoA with the C terminus of human phospholipase D1. J. Biol. Chem. 274:1999;6035-6038.
70. Kanfer J.N. The base exchange enzymes and phospholipase D of mammalian tissue. Can. J. Biochem. 58:1980;1370-1380.
71. M. Danin, V. Chalifa, H. Möhn, U.S. Schmidt, M. Liscovitch, Rat brain membrane-bound phospholipase D, in: J.N. Fain (Ed.), Lipid Metabolism in Signaling Systems, vol. 18, Academic Press, San Diego, 1993, pp. 14-24.
72. Panagia V., Ou C., Taira Y., Dai J., Dhalla N.S. Phospholipase D activity in subcellular membranes of rat ventricular myocardium. Biochim. Biophys. Acta. 1064:1991;242-250.
73. Horwitz J., Davis L.L. The substrate specificity of brain microsomal phospholipase D. Biochem. J. 295:1993;793-798.
74. Möhn H., Chalifa V., Liscovitch M. Substrate specificity of neutral phospholipase D from rat brain studied by selective labeling of endogenous synaptic membrane phospholipids in vitro. J. Biol. Chem. 267:1992;11131-11136.
75. Kobayashi M., Kanfer J.N. Phosphatidylethanol formation via transphosphatidylation by rat brain synaptosomal phospholipase D. J. Neurochem. 48:1987;1597-1603.
76. Kanfer J.N., McCartney D. Phospholipase D activity of isolated rat brain plasma membranes. FEBS Lett. 337:1994;251-254.
77. Siddiqui R.A., Exton J.H. Oleate stimulation of diacylglycerol formation from phosphatidylcholine through effects on phospholipase D and phosphatidate phosphohydrolase. Eur. J. Biochem. 210:1992;601-607.
78. Kanfer J.N., McCartney D., Singh I.N., Freysz L. Phospholipase D activity of rat brain neuronal nuclei. J. Neurochem. 67:1996;760-766.
79. Banno Y., Tamiya-Koizumi K., Oshima H., Morikawa A., Yoshida S., Nozawa Y. Nuclear ADP-ribosylation factor (ARF)- and oleate-dependent phospholipase D (PLD) in rat liver cells. Increases of ARF-dependent PLD activity in regenerating liver cells. J. Biol. Chem. 272:1997;5208-5213.
80. Okamura S., Yamashita S. Purification and characterization of phosphatidylcholine phospholipase D from pig lung. J. Biol. Chem. 269:1994;31207-31213.
81. Williams S.A., Tappia P.S., Yu C.H., Binaglia L., Panagia V., Dhalla N.S. Subcellular alterations in cardiac phospholipase D activity in chronic diabetes. Prostaglandins Leukot. Essent. Fatty Acids. 57:1997;95-99.
82. Massenburg D., Han J.-S., Liyanage M., Patton W.A., Rhee S.G., Moss J., Vaughan M. Activation of rat brain phospholipase D by ADP-ribosylation factors 1, 5, and 6: Separation of ADP-ribosylation factor-dependent and oleate-dependent enzymes. Proc. Natl. Acad. Sci. USA. 91:1994;11718-11722.
83. Balsinde J., Diez E., Fernandez B., Mollinedo F. Biochemical characterization of phospholipase D activity from human neutrophils. Eur. J. Biochem. 186:1989;717-724.
84. Wang P., Anthes J.C., Siegel I.M., Egan R.W., Billah M.M. Existence of cytosolic phospholipase D. Identification and comparison with membrane-bound enzyme. J. Biol. Chem. 266:1991;14877-14880.
85. Huang C., Wykle R.L., Daniel L., Cabot M.C. Identification of phosphatidylcholine-selective and phosphatidylinositol-selective phospholipase D in Madin-Darby canine kidney cells. J. Biol. Chem. 267:1992;16859-16865.
86. Vinggaard A.M., Provost J.J., Exton J.H., Hansen H.S. Arf and RhoA regulate both the cytosolic and the membrane-bound phospholipase D from human placenta. Cell. Signal. 9:1997;189-196.
87. Nemat-Gorgani M., Wilson J.E. Ambiquitous behavior - a biological phenomenon of general significance? Curr. Top. Cell Regul. 16:1980;45-54.
88. Ribbes G., Cane A., Planat V., Breton M., Chap H., Bereziat G., Record M., Colard O. Transacylase-mediated alkylacyl-GPC synthesis and its hydrolysis by phospholipase D occur in separate cell compartments in the human neutrophil. J. Cell. Biochem. 62:1996;56-68.
89. Edwards Y.S., Murray A.W. Accumulation of phosphatidylalcohol in cultured cells: use of subcellular fractionation to investigate phospholipase D activity during signal transduction. Biochem. J. 308:1995;473-480.
90. Decker C., Miro Obradors M.J., Sillence D.J., Allan D. Phorbol ester-sensitive phospholipase D is mainly localized in the endoplasmic reticulum of BHK cells. Biochem. J. 320:1996;885-890.
91. Whatmore J., Morgan C.P., Cunningham E., Collison K.S., Willison K.R., Cockcroft S. ADP-ribosylation factor 1-regulated phospholipase D activity is localized at the plasma membrane and intracellular organelles in HL60 cells. Biochem. J. 320:1996;785-794.
92. Provost J.J., Fudge J., Israelit S., Siddiqi A.R., Exton J.H. Tissue-specific distribution and subcellular distribution of phospholipase D in rat: evidence for distinct RhoA- and ADP- ribosylation factor (ARF)-regulated isoenzymes. Biochem. J. 319:1996;285-291.
93. M. Liscovitch, V. Chalifa, Signal-activated phospholipase D, in: M. Liscovitch (Ed.), Signal-activated Phospholipases, R.G. Landes, Austin, 1994, pp. 31-63.
94. Cross M.J., Roberts S., Ridley A.J., Hodgkin M.N., Stewart A., Claesson-Welsh L., Wakelam M.J.O. Stimulation of stress fibre formation mediated by activation of phospholipase D. Curr. Biol. 6:1996;588-597.
95. Shome K., Vasudevan C., Romero G. ARF proteins mediate insulin-dependent activation of phospholipase D. Curr. Biol. 7:1997;387-396.
96. Slaaby R., Jensen T., Hansen H.S., Frohman M.A., Seedorf K. PLD2 complexes with the EGF receptor and undergoes tyrosine phosphorylation at a single site upon agonist stimulation. J. Biol. Chem. 273:1998;33722-33727.
97. Ghosh S., Bell R.M. Regulation of Raf-1 kinase by interaction with the lipid second messenger, phosphatidic acid. Biochem. Soc. Trans. 25:1997;561-565.
98. Rizzo M.A., Shome K., Vasudevan C., Stolz D.B., Sung T.C., Frohman M.A., Watkins S.C., Romero G. Phospholipase D and its product, phosphatidic acid, mediate agonist- dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway. J. Biol. Chem. 274:1999;1131-1139.
99. Balboa M.A., Balsinde J., Dennis E.A., Insel P.A. A phospholipase D-mediated pathway for generating diacylglycerol in nuclei from Madin-Darby canine kidney cells. J. Biol. Chem. 270:1995;11738-11740.
100. Baldassare J.J., Jarpe M.B., Alferes L., Raben D.M. Nuclear translocation of RhoA mediates the mitogen-induced activation of phospholipase D involved in nuclear envelope signal transduction. J. Biol. Chem. 272:1997;4911-4914.
101. Clark J.M., Hodgkin M.N., Wakelam M.J. HL60 nuclei lacking the nuclear double membrane contain a PLD activity which is insensitive to the ADP-ribosylation factor. Biochem. Soc. Trans. 25:1997;S590.
102. Raben D.M., Jarpe M.B., Leach K.L. Nuclear lipid metabolism in NEST: Nuclear Envelope Signal Transduction. J. Membr. Biol. 142:1994;1-7.
103. Divecha N., Banfic H., Treagus J.E., Vann L., Irvine R.F., D'Santos C. Nuclear diacylglycerol, the cell cycle, the enzymes and a red herring (or how we came to love phosphatidylcholine). Biochem. Soc. Trans. 25:1997;571-575.
104. Ktistakis N.T., Brown H.A., Waters M.G., Sternweis P.C., Roth M.G. Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles. J. Cell Biol. 134:1996;295-306.
105. Bi K., Roth M.G., Ktistakis N.T. Phosphatidic acid formation by phospholipase D is required for transport from the endoplasmic reticulum to the Golgi complex. Curr. Biol. 7:1997;301-307.
106. Brown F.D., Thompson N., Saqib K.M., Clark J.M., Powner D., Thompson N.T., Solari R., Wakelam M.J. Phospholipase D1 localises to secretory granules and lysosomes and is plasma-membrane translocated on cellular stimulation. Curr. Biol. 8:1998;835-838.
107. Spang A., Matsuoka K., Hamamoto S., Schekman R., Orci L. Coatomer, Arf1p, and nucleotide are required to bud coat protein complex I-coated vesicles from large synthetic liposomes. Proc. Natl. Acad. Sci. USA. 95:1998;11199-11204.
108. Bremser M., Nickel W., Schweikert M., Ravazzola M., Amherdt M., A H.C., Sollner T.H., Rothman J.E., Wieland F.T. Coupling of coat assembly and vesicle budding to packaging of putative cargo receptors. Cell. 96:1999;495-506.
109. Chen Y.G., Siddhanta A., Austin C.D., Hammond S.M., Sung T.C., Frohman M.A., Morris A.J., Shields D. Phospholipase D stimulates release of nascent secretory vesicles from the trans-Golgi network. J. Cell Biol. 138:1997;495-504.
110. Tuscher O., Lorra C., Bouma B., Wirtz K.W., Huttner W.B. Cooperativity of phosphatidylinositol transfer protein and phospholipase D in secretory vesicle formation from the TGN - phosphoinositides as a common denominator? FEBS Lett. 419:1997;271-275.
111. Siddhanta A., Shields D. Secretory vesicle budding from the trans-Golgi network is mediated by phosphatidic acid levels. J. Biol. Chem. 273:1998;17995-17998.
112. West M.A., Bright N.A., Robinson M.S. The role of ADP-ribosylation factor and phospholipase D in adaptor recruitment. J. Cell Biol. 138:1997;1239-1254.
113. Morgan C.P., Sengelov H., Whatmore J., Borregaard N., Cockcroft S. ADP-ribosylation-factor-regulated phospholipase D activity localizes to secretory vesicles and mobilizes to the plasma membrane following N-formylmethionyl-leucyl-phenylalanine stimulation of human neutrophils. Biochem. J. 325:1997;581-585.
114. Caumont A.S., Galas M.C., Vitale N., Aunis D., Bader M.F. Regulated exocytosis in chromaffin cells. Translocation of ARF6 stimulates a plasma membrane-associated phospholipase D. J. Biol. Chem. 273:1998;1373-1379.
115. Martin T.F.J. Identification of proteins required for Ca(2+)-activated secretion. Ann. NY Acad. Sci. 710:1994;328-332.
116. Martin T.F., Loyet K.M., Barry V.A., Kowalchyk J.A. The role of PtdIns(4,5)P2 in exocytotic membrane fusion. Biochem. Soc. Trans. 25:1997;1137-1141.
117. Liscovitch M., Chalifa V., Pertile P., Chen C.-S., Cantley L.C. Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D. J. Biol. Chem. 269:1994;21403-21406.
118. Madesh M., Balasubramanian K.A. Metal ion stimulation of phospholipase D-like activity of isolated rat intestinal mitochondria. Lipids. 32:1997;471-479.
119. Madesh M., Ibrahim S.A., Balasubramanian K.A. Phospholipase D activity in the intestinal mitochondria: activation by oxygen free radicals. Free Radic. Biol. Med. 23:1997;271-277.
120. Ha K.-S., Yeo E.-J., Exton J.H. Lysophosphatidic acid activation of phosphatidylcholine-hydrolysing phospholipase D and actin polymerization by a pertussis toxin-sensitive mechanism. Biochem. J. 303:1994;55-59.
121. Iyer S.S., Kusner D.J. Association of phospholipase D activity with the detergent-insoluble cytoskeleton of U937 promonocytic leukocytes. J. Biol. Chem. 274:1999;2350-2359.
122. Rudge S.A., Morris A.J., Engebrecht J. Relocalization of phospholipase D activity mediates membrane formation during meiosis. J. Cell Biol. 140:1998;81-90.
123. Lukowski S., Lecomte M.C., Mira J.P., Marin P., Gautero H., Marie-Russo F., Geny B. Inhibition of phospholipase D activity by fodrin. An active role for the cytoskeleton. J. Biol. Chem. 271:1996;24164-24171.
124. Pertile P., Liscovitch M., Chalifa V., Cantley L.C. Phosphatidylinositol 4,5-bisphosphate synthesis is required for activation of phospholipase D in U937 cells. J. Biol. Chem. 270:1995;5130-5135.
125. Yokozeki T., Kuribara H., Katada T., Touhara K., Kanaho Y. Partially purified RhoA-stimulated phospholipase D activity specifically binds to phosphatidylinositol 4,5-bisphosphate. J. Neurochem. 66:1996;1234-1239.
126. Chalifa-Caspi V., Eli Y., Liscovitch M. Kinetic analysis in mixed micelles of partially purified rat brain phospholipase D activity and its activation by phosphatidylinositol 4,5-bisphosphate. Neurochem. Res. 23:1998;589-599.
127. Liscovitch M., Chalifa V., Danin M., Eli Y. Inhibition of neural phospholipase D activity by aminoglycoside antibiotics. Biochem. J. 279:1991;319-321.
128. 2, C, and D by decreasing polyphosphoinositide cell content. Biochem. Biophys. Res. Commun. 248:1998;278-284.
129. Schmidt M., Rumenapp U., Nehls C., Ott S., Keller J., Von E., Streiber C., Jakobs K.H. Restoration of Clostridium difficile toxin-B-inhibited phospholipase D by phosphatidylinositol 4,5-bisphosphate. Eur. J. Biochem. 240:1996;707-712.
130. Pappan K., Qin W., Dyer J.H., Zheng L., Wang X. Molecular cloning and functional analysis of polyphosphoinositide-dependent phospholipase D, PLDβ, from Arabidopsis. J. Biol. Chem. 272:1997;7055-7061.
131. Nakamura S., Kiyohara Y., Jinnai H., Hitomi T., Ogino C., Yoshida K., Nishizuka Y. Mammalian phospholipase D: phosphatidylethanolamine as an essential component. Proc. Natl. Acad. Sci. USA. 93:1996;4300-4304.
132. Simons K., Ikonen E. Functional rafts in cell membranes. Nature. 387:1997;569-572.
133. Brown D.A., London E. Structure of detergent-resistant membrane domains: does phase separation occur in biological membranes? Biochem. Biophys. Res. Commun. 240:1997;1-7.
134. Brown D., Rose J.K. Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. Cell. 68:1992;533-544.
135. Harder T., Simons K. Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains. Curr. Opin. Cell Biol. 9:1997;534-542.
136. Severs N.J. Caveolae: static inpocketings of the plasma membrane, dynamic vesicles or plain artifact? J. Cell Sci. 90:1988;341-348.
137. Parton R.G. Caveolae and caveolins. Curr. Opin. Cell Biol. 8:1996;542-548.
138. Lisanti M.P., Tang Z., Scherer P.E., Sargiacomo M. Caveolae purification and glycosylphosphatidylinositol-linked protein sorting in polarized epithelia. Methods Enzymol. 250:1995;655-668.
139. Oh P., McIntosh D.P., Schnitzer J.E. Dynamin at the neck of caveolae mediates their budding to form transport vesicles by GTP-driven fission from the plasma membrane of endothelium. J. Cell Biol. 141:1998;101-114.
140. Fielding C.J., Fielding P.E. Intracellular cholesterol transport. J. Lipid Res. 38:1997;1503-1521.
141. Lisanti M.P., Tang Z., Scherer P.E., Kubler E., Koleske A.J., Sargiacomo M. Caveolae, transmembrane signalling and cellular transformation. Mol. Membr. Biol. 12:1995;121-124.
142. Okamoto T., Schlegel A., Scherer P.E., Lisanti M.P. Caveolins, a family of scaffolding proteins for organizing 'preassembled signaling complexes' at the plasma membrane. J. Biol. Chem. 273:1998;5419-5422.
143. Hope H.R., Pike L.J. Phosphoinositides and phosphoinositide-utilizing enzymes in detergent-insoluble lipid domains. Mol. Biol. Cell. 7:1996;843-851.
144. Pike L.J., Casey L. Localization and turnover of phosphatidylinositol 4,5-bisphosphate in caveolin-enriched membrane domains. J. Biol. Chem. 271:1996;26453-26456.
145. Liu J., Oh P., Horner T., Rogers R.A., Schnitzer J.E. Organized endothelial cell surface signal transduction in caveolae distinct from glycosylphosphatidylinositol-anchored protein microdomains. J. Biol. Chem. 272:1997;7211-7222.
146. Waugh M.G., Lawson D., Tan S.K., Hsuan J.J. Phosphatidylinositol 4-phosphate synthesis in immunoisolated caveolae-like vesicles and low buoyant density non-caveolar membranes. J. Biol. Chem. 273:1998;17115-17121.
147. Liu Y., Casey L., Pike L.J. Compartmentalization of phosphatidylinositol 4,5-bisphosphate in low- density membrane domains in the absence of caveolin. Biochem. Biophys. Res. Commun. 245:1998;684-690.
148. Lavie Y., Czarny M., Liscovitch M. Localization of phospholipase D in caveolae and its up-regulation in multidrug resistant cancer cells. FASEB J. 11:1997;A1346.
149. 82-101. J. Biol. Chem. 274:1999;2717-2724.
150. Lavie Y., Fiucci G., Liscovitch M. Up-regulation of caveolae and caveolar constituents in multidrug-resistant cancer cells. J. Biol. Chem. 273:1998;32380-32383.
151. Ghosh S., Strum J.C., Sciorra V.A., Daniel L., Bell R.M. Raf-1 kinase possesses distinct binding domains for phosphatidylserine and phosphatidic acid. Phosphatidic acid regulates the translocation of Raf-1 in 12-O-tetradecanoylphorbol-13-acetate-stimulated Madin-Darby canine kidney cells. J. Biol. Chem. 271:1996;8472-8480.
152. Waite K.A., Wallin R., Qualliotine-Mann D., McPhail L.C. Phosphatidic acid-mediated phosphorylation of the NADPH oxidase component p47-phox. Evidence that phosphatidic acid may activate a novel protein kinase. J. Biol. Chem. 272:1997;15569-15578.
153. Zhao Z., Shen S.-H., Fischer E.H. Stimulation by phospholipids of a protein-tyrosine-phosphatase containing two src homology 2 domains. Proc. Natl. Acad. Sci. USA. 90:1993;4251-4255.
154. Juneja L.R., Kazuoka T., Yamane T., Shimizu S. Kinetic evaluation of conversion of phosphatidylcholine to phosphatidylethanolamine by phospholipase D from different sources. Biochim. Biophys. Acta. 960:1988;334-341.
155. Sung T.C., Roper R.L., Zhang Y., Rudge S.A., Temel R., Hammond S.M., Morris A.J., Moss B., Engebrecht J., Frohman M.A. Mutagenesis of phospholipase D defines a superfamily including a trans- Golgi viral protein required for poxvirus pathogenicity. EMBO J. 16:1997;4519-4530.
156. Gottlin E.B., Rudolph A.E., Zhao Y., Matthews H.R., Dixon J.E. Catalytic mechanism of the phospholipase D superfamily proceeds via a covalent phosphohistidine intermediate. Proc. Natl. Acad. Sci. USA. 95:1998;9202-9207.
157. Ponting C.P., Parker P.J. Extending the C2 domain family: C2s in PKCs δ, ε, η, θ, phospholipases. GAPs and perforin. Protein Sci. 5:1996;162-166.
158. 2+-dependent translocation domain with homology to PKC and GAP. Cell. 65:1991;1043-1051.
159. Mochly-Rosen D. Localization of protein kinases by anchoring proteins: A theme in signal transduction. Science. 268:1995;247-251.
160. Chung J.K., Sekiya F., Kang H.S., Lee C., Han J.S., Kim S.R., Bae Y.S., Morris A.J., Rhee S.G. Synaptojanin inhibition of phospholipase D activity by hydrolysis of phosphatidylinositol 4,5-bisphosphate. J. Biol. Chem. 272:1997;15980-15985.