메뉴 건너뛰기




Volumn 15, Issue 10 A, 1999, Pages 843-854

Overproduction of the Opi1 repressor inhibits transcriptional activation of structural genes required for phospholipid biosynthesis in the yeast Saccharomyces cerevisiae

Author keywords

Opi1 repressor; Phospholipid biosynthesis; Saccharomyces cerevisiae; Transcriptional regulation

Indexed keywords

CHOLINE; DNA BINDING PROTEIN; INOSITOL; LEUCINE ZIPPER PROTEIN; PHOSPHOLIPID;

EID: 0032812984     PISSN: 0749503X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0061(199907)15:10A<843::AID-YEA424>3.0.CO;2-M     Document Type: Article
Times cited : (47)

References (42)
  • 1
    • 0028363566 scopus 로고
    • INO2 and INO4 gene products, positive regulators of phospholipid biosynthesis in Saccharomyces cerevisiae, form a complex that binds to the INO1 promoter
    • Ambroziak, J. and Henry, S. A. (1994). INO2 and INO4 gene products, positive regulators of phospholipid biosynthesis in Saccharomyces cerevisiae, form a complex that binds to the INO1 promoter. J. Biol. Chem. 269, 15 344-15 349.
    • (1994) J. Biol. Chem. , vol.269 , pp. 15344-15349
    • Ambroziak, J.1    Henry, S.A.2
  • 2
    • 0028876869 scopus 로고
    • Autoregulated expression of the yeast INO2 and INO4 helix-loop-helix activator genes effects cooperative regulation on their target genes
    • Ashburner, B. P. and Lopes, J. M. (1995a). Autoregulated expression of the yeast INO2 and INO4 helix-loop-helix activator genes effects cooperative regulation on their target genes. Mol. Cell Biol. 15, 1709-1715.
    • (1995) Mol. Cell Biol. , vol.15 , pp. 1709-1715
    • Ashburner, B.P.1    Lopes, J.M.2
  • 3
    • 0028826137 scopus 로고
    • Regulation of yeast phospholipid biosynthetic gene expression in response to inositol involves two superimposed mechanisms
    • Ashburner, B. P. and Lopes, J. M. (1995b). Regulation of yeast phospholipid biosynthetic gene expression in response to inositol involves two superimposed mechanisms. Proc. Natl Acad. Sci. U S A 92, 9722-9726.
    • (1995) Proc. Natl Acad. Sci. U S A , vol.92 , pp. 9722-9726
    • Ashburner, B.P.1    Lopes, J.M.2
  • 4
    • 0028851909 scopus 로고
    • Functional characterization of an inositol-sensitive upstream activation sequence in yeast
    • Bachhawat, N., Ouyang, Q. and Henry, S. A. (1995). Functional characterization of an inositol-sensitive upstream activation sequence in yeast. J. Biol. Chem. 270, 25 087-25 095.
    • (1995) J. Biol. Chem. , vol.270 , pp. 25087-25095
    • Bachhawat, N.1    Ouyang, Q.2    Henry, S.A.3
  • 5
    • 0000884978 scopus 로고
    • Using the two-hybrid system to detect protein-protein interactions
    • Hartley, D. A. (Ed.), IRL Press, Oxford
    • Bartel, P. L., Chien, C.-T., Sternglanz, R. and Fields, S. (1993). Using the two-hybrid system to detect protein-protein interactions. In Hartley, D. A. (Ed.), Cellular Interactions in Development. IRL Press, Oxford, pp. 153-179.
    • (1993) Cellular Interactions in Development , pp. 153-179
    • Bartel, P.L.1    Chien, C.-T.2    Sternglanz, R.3    Fields, S.4
  • 7
    • 0025572707 scopus 로고
    • Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selection
    • Blackwell, T. K. and Weintraub, H. (1990). Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selection. Science 250, 1104-1110.
    • (1990) Science , vol.250 , pp. 1104-1110
    • Blackwell, T.K.1    Weintraub, H.2
  • 8
    • 0025799905 scopus 로고
    • Vectors for the expression and analysis of DNA-binding proteins in yeast
    • Bonner, J. J. (1991). Vectors for the expression and analysis of DNA-binding proteins in yeast. Gene 104, 113-118.
    • (1991) Gene , vol.104 , pp. 113-118
    • Bonner, J.J.1
  • 9
    • 0030883032 scopus 로고    scopus 로고
    • Regulated nuclear translocation of the Mig1 glucose repressor
    • De Vit, M. J., Waddle, J. A. and Johnston, M. (1997). Regulated nuclear translocation of the Mig1 glucose repressor. Mol. Biol. Cell 8, 1603-1618.
    • (1997) Mol. Biol. Cell , vol.8 , pp. 1603-1618
    • De Vit, M.J.1    Waddle, J.A.2    Johnston, M.3
  • 10
    • 0030003051 scopus 로고    scopus 로고
    • Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4
    • Edmondson, D. G., Smith, M. M. and Roth, S. Y. (1996). Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4. Genes Dev. 10, 1247-1259.
    • (1996) Genes Dev. , vol.10 , pp. 1247-1259
    • Edmondson, D.G.1    Smith, M.M.2    Roth, S.Y.3
  • 11
    • 0024266139 scopus 로고
    • New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites
    • Gietz, R. D. and Sugino, A. (1988). New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene 74, 527-534.
    • (1988) Gene , vol.74 , pp. 527-534
    • Gietz, R.D.1    Sugino, A.2
  • 12
    • 0019988791 scopus 로고
    • Characterization of a yeast regulatory mutant constitutive for synthesis of inositol-1-phosphate synthase
    • Greenberg, M. L., Goldwasser, P. and Henry, S. A. (1982). Characterization of a yeast regulatory mutant constitutive for synthesis of inositol-1-phosphate synthase. Mol. Gen. Genet. 186, 157-163.
    • (1982) Mol. Gen. Genet. , vol.186 , pp. 157-163
    • Greenberg, M.L.1    Goldwasser, P.2    Henry, S.A.3
  • 13
    • 0029963923 scopus 로고    scopus 로고
    • Genetic regulation of phospholipid biosynthesis in Saccharomyces cerevisiae
    • Greenberg, M. L. and Lopes, J. M. (1996). Genetic regulation of phospholipid biosynthesis in Saccharomyces cerevisiae. Microbiol. Rev. 60, 1-20.
    • (1996) Microbiol. Rev. , vol.60 , pp. 1-20
    • Greenberg, M.L.1    Lopes, J.M.2
  • 14
    • 0027289677 scopus 로고
    • Acetyl-CoA carboxylase from yeast is an essential enzyme and is regulated by factors that control phospholipid metabolism
    • Hasslacher, M., Ivessa, A. S., Paltauf, F. and Kohlwein, S. D. (1993). Acetyl-CoA carboxylase from yeast is an essential enzyme and is regulated by factors that control phospholipid metabolism. J. Biol. Chem. 268, 10 946-10 952.
    • (1993) J. Biol. Chem. , vol.268 , pp. 10946-10952
    • Hasslacher, M.1    Ivessa, A.S.2    Paltauf, F.3    Kohlwein, S.D.4
  • 15
    • 0030769977 scopus 로고    scopus 로고
    • The acetyl-CoA synthetase gene ACS2 of the yeast Saccharomyces cerevisiae is co-regulated with structural genes of fatty acid biosynthesis by the transcriptional activators Ino2p and Ino4p
    • Hiesinger, M., Wagner, C. and Schüller, H.-J. (1997). The acetyl-CoA synthetase gene ACS2 of the yeast Saccharomyces cerevisiae is co-regulated with structural genes of fatty acid biosynthesis by the transcriptional activators Ino2p and Ino4p. FEBS Lett. 415, 16-20.
    • (1997) FEBS Lett. , vol.415 , pp. 16-20
    • Hiesinger, M.1    Wagner, C.2    Schüller, H.-J.3
  • 16
    • 0022781503 scopus 로고
    • Yeast/E. coli shuttle vectors with multiple unique restriction sites
    • Hill, J. E., Myers, A. M., Koerner, T. J. and Tzagoloff, A. (1986). Yeast/E. coli shuttle vectors with multiple unique restriction sites. Yeast 2, 163-167.
    • (1986) Yeast , vol.2 , pp. 163-167
    • Hill, J.E.1    Myers, A.M.2    Koerner, T.J.3    Tzagoloff, A.4
  • 17
    • 0022799260 scopus 로고
    • Expression of the Saccharomyces cerevisiae inositol-1-phosphate synthase (INO1) gene is regulated by factors that affect phospholipid synthesis
    • Hirsch, J. P. and Henry, S. A. (1986). Expression of the Saccharomyces cerevisiae inositol-1-phosphate synthase (INO1) gene is regulated by factors that affect phospholipid synthesis. Mol. Cell Biol. 6, 3320-3328.
    • (1986) Mol. Cell Biol. , vol.6 , pp. 3320-3328
    • Hirsch, J.P.1    Henry, S.A.2
  • 18
    • 0028096095 scopus 로고
    • Cloning and characterization of the SCSI gene required for the expression of genes in yeast phospholipid synthesis
    • Hosaka, K., Nikawa, J.-i., Kosaki, T. and Yamashita, S. (1994). Cloning and characterization of the SCSI gene required for the expression of genes in yeast phospholipid synthesis. J. Biochem. 115, 131-136.
    • (1994) J. Biochem. , vol.115 , pp. 131-136
    • Hosaka, K.1    Nikawa, J.-I.2    Kosaki, T.3    Yamashita, S.4
  • 19
    • 0025249935 scopus 로고
    • The Saccharomyces cerevisiae INO4 gene encodes a small, highly basic protein required for derepression of phospholipid biosynthetic enzymes
    • Hoshizaki, D. K., Hill, J. E. and Henry, S. A. (1990). The Saccharomyces cerevisiae INO4 gene encodes a small, highly basic protein required for derepression of phospholipid biosynthetic enzymes. J. Biol. Chem. 265, 4736-4745.
    • (1990) J. Biol. Chem. , vol.265 , pp. 4736-4745
    • Hoshizaki, D.K.1    Hill, J.E.2    Henry, S.A.3
  • 20
    • 0023643044 scopus 로고
    • Interaction of positive and negative regulatory proteins in the galactose regulon of yeast
    • Johnston, S. A., Salmeron, J. M. and Dincher, S. S. (1987). Interaction of positive and negative regulatory proteins in the galactose regulon of yeast. Cell 50, 143-146.
    • (1987) Cell , vol.50 , pp. 143-146
    • Johnston, S.A.1    Salmeron, J.M.2    Dincher, S.S.3
  • 21
    • 0343924289 scopus 로고    scopus 로고
    • Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters
    • Kadosh, D. and Struhl, K. (1997). Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters. Cell 89, 365-371.
    • (1997) Cell , vol.89 , pp. 365-371
    • Kadosh, D.1    Struhl, K.2
  • 22
    • 0021848614 scopus 로고
    • Coordinate regulation of phospholipid biosynthesis in Saccharomyces cerevisiae: Pleiotropically constitutive opi1 mutant
    • Klig, L. S., Homann, M. J., Carman, G. M. and Henry, S. A. (1985). Coordinate regulation of phospholipid biosynthesis in Saccharomyces cerevisiae: pleiotropically constitutive opi1 mutant. J. Bacteriol. 162, 1135-1141.
    • (1985) J. Bacteriol. , vol.162 , pp. 1135-1141
    • Klig, L.S.1    Homann, M.J.2    Carman, G.M.3    Henry, S.A.4
  • 23
    • 0026333918 scopus 로고
    • Functional analysis of the regulatory region of the yeast phosphatidylserine synthase gene, PSS
    • Kodaki, T., Nikawa, J.-I., Hosaka, K. and Yamashita, S. (1991). Functional analysis of the regulatory region of the yeast phosphatidylserine synthase gene, PSS. J. Bacteriol. 173, 7992-7995.
    • (1991) J. Bacteriol. , vol.173 , pp. 7992-7995
    • Kodaki, T.1    Nikawa, J.-I.2    Hosaka, K.3    Yamashita, S.4
  • 24
    • 0028607143 scopus 로고
    • Regulated degradation of the transcription factor Gcn4
    • Kornitzer, D., Raboy, B., Kulka, R. G. and Fink, G. R. (1994). Regulated degradation of the transcription factor Gcn4. EMBO J. 13, 6021-6030.
    • (1994) EMBO J. , vol.13 , pp. 6021-6030
    • Kornitzer, D.1    Raboy, B.2    Kulka, R.G.3    Fink, G.R.4
  • 25
    • 0025643362 scopus 로고
    • A general method for rapid site-directed mutagenesis using the polymerase chain reaction
    • Landt, O., Grunert, H.-P. and Hahn, U. (1990). A general method for rapid site-directed mutagenesis using the polymerase chain reaction. Gene 96, 125-128.
    • (1990) Gene , vol.96 , pp. 125-128
    • Landt, O.1    Grunert, H.-P.2    Hahn, U.3
  • 26
    • 0026606084 scopus 로고
    • Fos and Jun repress transcriptional activation by myogenin and MyoD: The amino terminus of Jun can mediate repression
    • Li, L., Chambard, J.-C., Karin, M. and Olson, E. N. (1992). Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression. Genes Dev. 6, 676-689.
    • (1992) Genes Dev. , vol.6 , pp. 676-689
    • Li, L.1    Chambard, J.-C.2    Karin, M.3    Olson, E.N.4
  • 27
    • 0025880361 scopus 로고
    • Interaction of trans and cis regulatory elements in the INO1 promoter of Saccharomyces cerevisiae
    • Lopes, J. M. and Henry, S. A. (1991). Interaction of trans and cis regulatory elements in the INO1 promoter of Saccharomyces cerevisiae. Nucleic Acids Res. 19, 3987-3994.
    • (1991) Nucleic Acids Res. , vol.19 , pp. 3987-3994
    • Lopes, J.M.1    Henry, S.A.2
  • 28
    • 0025755893 scopus 로고
    • Analysis of sequences in the INO1 promoter that are involved in its regulation by phospholipid precursors
    • Lopes, J. M., Hirsch, J. P., Chorgo, P. A., Schulze, K. L. and Henry, S. A. (1991). Analysis of sequences in the INO1 promoter that are involved in its regulation by phospholipid precursors. Nucleic Acids Res. 19, 1687-1693.
    • (1991) Nucleic Acids Res. , vol.19 , pp. 1687-1693
    • Lopes, J.M.1    Hirsch, J.P.2    Chorgo, P.A.3    Schulze, K.L.4    Henry, S.A.5
  • 29
    • 0025764782 scopus 로고
    • The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SW15
    • Moll, T., Tebb, G., Surana, U., Robitsch, H. and Nasmyth, K. (1991). The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SW15. Cell 66, 743-758.
    • (1991) Cell , vol.66 , pp. 743-758
    • Moll, T.1    Tebb, G.2    Surana, U.3    Robitsch, H.4    Nasmyth, K.5
  • 30
    • 0028586017 scopus 로고
    • Regulatable promoters of Saccharomyces cerevisiae: Comparison of transcriptional activity and their use for heterologous expression
    • Mumberg, D., Müller, R. and Funk, M. (1994). Regulatable promoters of Saccharomyces cerevisiae: comparison of transcriptional activity and their use for heterologous expression. Nucleic Acids Res. 22, 5767-5768.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 5767-5768
    • Mumberg, D.1    Müller, R.2    Funk, M.3
  • 31
    • 0023034916 scopus 로고
    • Yeast shuttle and integrative vectors with multiple cloning sites suitable for construction of lacZ fusions
    • Myers, A. M., Tzagoloff, A., Kinney, D. M. and Lusty, C. J. (1986). Yeast shuttle and integrative vectors with multiple cloning sites suitable for construction of lacZ fusions. Gene 45, 299-310.
    • (1986) Gene , vol.45 , pp. 299-310
    • Myers, A.M.1    Tzagoloff, A.2    Kinney, D.M.3    Lusty, C.J.4
  • 32
    • 0025004155 scopus 로고
    • Yeast MIG1 repressor is related to the mammalian early growth response and wilms' tumour finger proteins
    • Nehlin, J. O. and Ronne, H. (1990). Yeast MIG1 repressor is related to the mammalian early growth response and Wilms' tumour finger proteins. EMBO J. 9, 2891-2898.
    • (1990) EMBO J. , vol.9 , pp. 2891-2898
    • Nehlin, J.O.1    Ronne, H.2
  • 33
    • 0027126924 scopus 로고
    • The INO2 gene of Saccharomyces cerevisiae encodes a helix-loop-helix protein that is required for activation of phospholipid synthesis
    • Nikoloff, D. M., McGraw, P. and Henry, S. A. (1992). The INO2 gene of Saccharomyces cerevisiae encodes a helix-loop-helix protein that is required for activation of phospholipid synthesis. Nucleic Acids Res. 20, 3253.
    • (1992) Nucleic Acids Res. , vol.20 , pp. 3253
    • Nikoloff, D.M.1    McGraw, P.2    Henry, S.A.3
  • 34
    • 0030059223 scopus 로고    scopus 로고
    • Regulation of PHO4 nuclear localization by the PHO80-PHO85 cyclin-CDK complex
    • O'Neill, E. M., Kaffman, A., Jolly, E. R. and O'Shea, E. K. (1996). Regulation of PHO4 nuclear localization by the PHO80-PHO85 cyclin-CDK complex. Science 271, 209-212.
    • (1996) Science , vol.271 , pp. 209-212
    • O'Neill, E.M.1    Kaffman, A.2    Jolly, E.R.3    O'Shea, E.K.4
  • 35
    • 0026529044 scopus 로고
    • Coordinate genetic control of yeast fatty acid synthase genes FAS1 and FAS2 by an upstream activation site common to genes involved in membrane lipid biosynthesis
    • Schüller, H.-J., Hahn, A., Tröster, F., Schütz, A. and Schweizer, E. (1992a). Coordinate genetic control of yeast fatty acid synthase genes FAS1 and FAS2 by an upstream activation site common to genes involved in membrane lipid biosynthesis. EMBO J. 11, 107-114.
    • (1992) EMBO J. , vol.11 , pp. 107-114
    • Schüller, H.-J.1    Hahn, A.2    Tröster, F.3    Schütz, A.4    Schweizer, E.5
  • 36
    • 0026463938 scopus 로고
    • Regulatory gene INo4 of yeast phospholipid biosynthesis is positively autoregulated and functions as a trans-activator of fatty acid synthase genes FAS1 and FAS2 from saccharomyces cerevisiae
    • Schüller, H.-J., Schorr, R., Hoffmann, B. and Schweizer, E. (1992b). Regulatory gene INO4 of yeast phospholipid biosynthesis is positively autoregulated and functions as a trans-activator of fatty acid synthase genes FAS1 and FAS2 from Saccharomyces cerevisiae. Nucleic Acids Res. 20, 5955-5961.
    • (1992) . Nucleic Acids Res. , vol.20 , pp. 5955-5961
    • Schüller, H.-J.1    Schorr, R.2    Hoffmann, B.3    Schweizer, E.4
  • 37
    • 0029149344 scopus 로고
    • DNA binding site of the yeast heteromeric Ino2p/Ino4p basic helix-loop-helix transcription factor; structural requirements as defined by saturation mutagenesis
    • Schüller, H.-J., Richter, K., Hoffmann, B., Ebbert, R. and Schweizer, E. (1995). DNA binding site of the yeast heteromeric Ino2p/Ino4p basic helix-loop-helix transcription factor; structural requirements as defined by saturation mutagenesis. FEBS Lett. 370, 149-152.
    • (1995) FEBS Lett. , vol.370 , pp. 149-152
    • Schüller, H.-J.1    Richter, K.2    Hoffmann, B.3    Ebbert, R.4    Schweizer, E.5
  • 38
    • 0023424198 scopus 로고
    • Molecular analysis of SSN6, a gene functionally related to the SNF1 protein kinase of Saccharomyces cerevisiae
    • Schultz, J. and Carlson, M. (1987). Molecular analysis of SSN6, a gene functionally related to the SNF1 protein kinase of Saccharomyces cerevisiae. Mol. Cell Biol. 7, 3637-3645.
    • (1987) Mol. Cell Biol. , vol.7 , pp. 3637-3645
    • Schultz, J.1    Carlson, M.2
  • 39
    • 0028963304 scopus 로고
    • Yeast transcriptional activator INO2 interacts as an Ino2p/Ino4p basic helix-loop-helix heteromeric complex with the inositol/choline-responsive element necessary for expression of phospholipid biosynthetic genes in Saccharomyces cerevisiae
    • Schwank, S., Ebbert, R., Rautenstrauss, K., Schweizer, E. and Schüller, H.-J. (1995). Yeast transcriptional activator INO2 interacts as an Ino2p/Ino4p basic helix-loop-helix heteromeric complex with the inositol/choline-responsive element necessary for expression of phospholipid biosynthetic genes in Saccharomyces cerevisiae. Nucleic Acids Res. 23, 230-237.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 230-237
    • Schwank, S.1    Ebbert, R.2    Rautenstrauss, K.3    Schweizer, E.4    Schüller, H.-J.5
  • 40
    • 0030789454 scopus 로고    scopus 로고
    • Influence of gene dosage and autoregulation of the regulatory genes INO2 and INO4 on inositol/choline-repressible gene transcription in the yeast Saccharomyces cerevisiae
    • Schwank, S., Hoffmann, B. and Schüller, H.-J. (1997). Influence of gene dosage and autoregulation of the regulatory genes INO2 and INO4 on inositol/choline-repressible gene transcription in the yeast Saccharomyces cerevisiae. Curr. Genet. 31, 462-468.
    • (1997) Curr. Genet. , vol.31 , pp. 462-468
    • Schwank, S.1    Hoffmann, B.2    Schüller, H.-J.3
  • 41
    • 0026088571 scopus 로고
    • The OPI1 gene of Saccharomyces cerevisiae, a negative regulator of phospholipid biosynthesis, encodes a protein containing polyglutamine tracts and a leucine zipper
    • White, M. J., Hirsch, J. P. and Henry, S. A. (1991). The OPI1 gene of Saccharomyces cerevisiae, a negative regulator of phospholipid biosynthesis, encodes a protein containing polyglutamine tracts and a leucine zipper. J. Biol. Chem. 266, 863-872.
    • (1991) J. Biol. Chem. , vol.266 , pp. 863-872
    • White, M.J.1    Hirsch, J.P.2    Henry, S.A.3
  • 42
    • 0025220996 scopus 로고
    • Characterization of TUP1, a mediator of glucose repression in Saccharomyces cerevisiae
    • Williams, F. E. and Trumbly, R. J. (1990). Characterization of TUP1, a mediator of glucose repression in Saccharomyces cerevisiae. Mol. Cell Biol. 10, 6500-6511.
    • (1990) Mol. Cell Biol. , vol.10 , pp. 6500-6511
    • Williams, F.E.1    Trumbly, R.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.