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Volumn 5, Issue 2, 1999, Pages 87-95

Interleukin-3 in hematology and oncology: Current state of knowledge and future directions

Author keywords

Bone marrow failure; Bone marrow transplant; Cancer chemotherapy; Immunotherapy; Interleukin 3

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLOSPORIN A; CYTARABINE; DANIPLESTIN; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEMOPOIETIC GROWTH FACTOR; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 3; INTERLEUKIN 3 RECEPTOR; INTERLEUKIN 3 RECEPTOR AGONIST; INTERLEUKIN 5; LERIDISTIM; LYMPHOCYTE ANTIBODY; MILODISTIM; PROMEGAPOIETIN; RECOMBINANT INTERLEUKIN 3; SC 70935; UNCLASSIFIED DRUG;

EID: 0032809058     PISSN: 13684736     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (59)

References (96)
  • 1
    • 0024502040 scopus 로고
    • The molecular control of cell division, differentiation, commitment and maturation
    • Metcalf D, The molecular control of cell division, differentiation, commitment and maturation. Nature (1989) 339: 27-30.
    • (1989) Nature , vol.339 , pp. 27-30
    • Metcalf, D.1
  • 2
    • 0027136259 scopus 로고
    • Hematopoietic regulators: Redundancy or subtlety?
    • Metcalf D, Hematopoietic regulators: redundancy or subtlety? Blood (1993) 82: 3515-23.
    • (1993) Blood , vol.82 , pp. 3515-3523
    • Metcalf, D.1
  • 4
    • 0029837429 scopus 로고    scopus 로고
    • Cytokine regulation of early lymphohematopoietic development
    • Hirayama F, Ogawa M, Cytokine regulation of early lymphohematopoietic development. Stem Cells (1996) 4: 369-75.
    • (1996) Stem Cells , vol.4 , pp. 369-375
    • Hirayama, F.1    Ogawa, M.2
  • 5
    • 0029986331 scopus 로고    scopus 로고
    • The biology of cytokine sequence cascade
    • Fraser JK, Lill MC, Figlin RA, The biology of cytokine sequence cascade. Semin Oncol (1996) 23(Suppl 4): 2-8.
    • (1996) Semin Oncol , vol.23 , Issue.SUPPL. 4 , pp. 2-8
    • Fraser, J.K.1    Lill, M.C.2    Figlin, R.A.3
  • 6
    • 0026555097 scopus 로고
    • Interleukin-3 and hematopoiesis
    • Ihle JN, Interleukin-3 and hematopoiesis. Chem Immunol (1992) 51: 65-106.
    • (1992) Chem Immunol , vol.51 , pp. 65-106
    • Ihle, J.N.1
  • 7
    • 0028158358 scopus 로고
    • Mapping of the human gene encoding the mutual signal-transducing subunit (beta chain) of granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin 3 (IL-3) and interleukin 5 (IL-5) receptor complexes to chromosome 22q13.1
    • Takai S, Yamada K, Hirayama N et al, Mapping of the human gene encoding the mutual signal-transducing subunit (beta chain) of granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin 3 (IL-3) and interleukin 5 (IL-5) receptor complexes to chromosome 22q13.1. Hum Genet (1994) 93: 198-200.
    • (1994) Hum Genet , vol.93 , pp. 198-200
    • Takai, S.1    Yamada, K.2    Hirayama, N.3
  • 8
    • 0025963701 scopus 로고
    • Receptors for colony stimulating factors
    • Nicola NA, Receptors for colony stimulating factors. Br J Haematol (1991) 77: 133-8.
    • (1991) Br J Haematol , vol.77 , pp. 133-138
    • Nicola, N.A.1
  • 9
    • 0029806613 scopus 로고    scopus 로고
    • Functional and signal transduction mediated by the interleukin-3 receptor system
    • Hara T, Miyajima A, Functional and signal transduction mediated by the interleukin-3 receptor system. Stem Cells (1996) 14: 605-18.
    • (1996) Stem Cells , vol.14 , pp. 605-618
    • Hara, T.1    Miyajima, A.2
  • 10
    • 0023196323 scopus 로고
    • Why do hematopoietic growth factor receptors interact with each other?
    • Nicola NA, Why do hematopoietic growth factor receptors interact with each other? Immunol Today (1987) 8: 134-9.
    • (1987) Immunol Today , vol.8 , pp. 134-139
    • Nicola, N.A.1
  • 11
    • 0025938465 scopus 로고
    • Subunit promiscuity among hemopoietic growth factor receptors
    • Nicola NA, Metcalf D, Subunit promiscuity among hemopoietic growth factor receptors. Cell (1991) 67: 1-4.
    • (1991) Cell , vol.67 , pp. 1-4
    • Nicola, N.A.1    Metcalf, D.2
  • 12
    • 0022468416 scopus 로고
    • Effects of purified bacterially synthesised murine multi CSF (IL3) on hematopoiesis in normal adult mice
    • Metcalf D, Begley CG, Johnson GR et al, Effects of purified bacterially synthesised murine multi CSF (IL3) on hematopoiesis in normal adult mice. Blood (1986) 68: 46-57.
    • (1986) Blood , vol.68 , pp. 46-57
    • Metcalf, D.1    Begley, C.G.2    Johnson, G.R.3
  • 13
    • 0027436098 scopus 로고
    • Interleukin 3 in vivo: Kinetic response of target cells
    • Anglietta M, Sanavio F, Stacchini A, Fubini A, Interleukin 3 in vivo: kinetic response of target cells. Blood (1993) 82: 2054-61.
    • (1993) Blood , vol.82 , pp. 2054-2061
    • Anglietta, M.1    Sanavio, F.2    Stacchini, A.3    Fubini, A.4
  • 14
    • 0023681970 scopus 로고    scopus 로고
    • Human interleukin 3 and GM-CSF act synergistically in stimulating hematopoiesis in primates
    • Donahue RE, Sectra J, Metzger M et al, Human interleukin 3 and GM-CSF act synergistically in stimulating hematopoiesis in primates. Science (1998) 241: 1820-3.
    • (1998) Science , vol.241 , pp. 1820-1823
    • Donahue, R.E.1    Sectra, J.2    Metzger, M.3
  • 15
    • 11944274203 scopus 로고
    • In vivo synergism of recombinant human interleukin-3 and recombinant human interleukin-6 on thrombopoiesis in primates
    • Geissler K, Valent P, Bettelheim P et al, In vivo synergism of recombinant human interleukin-3 and recombinant human interleukin-6 on thrombopoiesis in primates. Blood (1992) 79: 1155-60.
    • (1992) Blood , vol.79 , pp. 1155-1160
    • Geissler, K.1    Valent, P.2    Bettelheim, P.3
  • 16
    • 0345203782 scopus 로고
    • Neutralising antibodies during treatment of homologous non-glycosylated IL-3 in rhesus monkeys
    • Van Gils, Westerman Y, Visser TP et al, Neutralising antibodies during treatment of homologous non-glycosylated IL-3 in rhesus monkeys. Leukemia (1994) 8: 846-51.
    • (1994) Leukemia , vol.8 , pp. 846-851
    • Gils, V.1    Westerman, Y.2    Visser, T.P.3
  • 17
    • 0344446649 scopus 로고
    • Clinical effects of recombinant human interleukin 3
    • Ganser A, Lindemann A, Seipelt G, Clinical effects of recombinant human interleukin 3. Am J Clin Oncol (1991) 14(Suppl 1): S51-63.
    • (1991) Am J Clin Oncol , vol.14 , Issue.SUPPL. 1
    • Ganser, A.1    Lindemann, A.2    Seipelt, G.3
  • 18
    • 0024375430 scopus 로고
    • Clinical promise of new hematopoietic growth factors: M-CSF, IL3 and IL6
    • Garnick MB, O'Reilly RJ, Clinical promise of new hematopoietic growth factors: M-CSF, IL3 and IL6. Hematol Oncol Clin North Am (1989) 3: 495-509.
    • (1989) Hematol Oncol Clin North Am , vol.3 , pp. 495-509
    • Garnick, M.B.1    O'Reilly, R.J.2
  • 19
    • 0024334907 scopus 로고
    • Interleukin-3: Molecular biology and biologic activities
    • Yang YC, Clark SC, Interleukin-3: molecular biology and biologic activities. Hematol Oncol Clin North Am (1989) 3: 441-52.
    • (1989) Hematol Oncol Clin North Am , vol.3 , pp. 441-452
    • Yang, Y.C.1    Clark, S.C.2
  • 20
    • 0027324305 scopus 로고
    • Interleukin-3 structure and function
    • Lindmann A, Mertelsmann R, Interleukin-3 structure and function. Cancer Invest (1993) 11: 609-23.
    • (1993) Cancer Invest , vol.11 , pp. 609-623
    • Lindmann, A.1    Mertelsmann, R.2
  • 21
    • 0026020708 scopus 로고
    • IL-3: Biological and clinical effects
    • Oster W, Schulz G, IL-3: biological and clinical effects. Int J Cell Cloning (1991) 9: 5-23.
    • (1991) Int J Cell Cloning , vol.9 , pp. 5-23
    • Oster, W.1    Schulz, G.2
  • 22
    • 0029789648 scopus 로고    scopus 로고
    • Is interleukin 3 active in anticancer drug-induced thrombocytopenia?
    • Newland AC, Is interleukin 3 active in anticancer drug-induced thrombocytopenia? Cancer Chemother Pharmacol (1996) 8(Suppl): S83-8.
    • (1996) Cancer Chemother Pharmacol , vol.8 , Issue.SUPPL.
    • Newland, A.C.1
  • 23
    • 0027137483 scopus 로고
    • Pharmacokinetics of human interleukin-3 administered subcutaneously and by continuous intravenous infusion in patients after chemotherapy for ovarian cancer
    • Biesma B, Pokorny R, Kovarik JM et al, Pharmacokinetics of human interleukin-3 administered subcutaneously and by continuous intravenous infusion in patients after chemotherapy for ovarian cancer. Cancer Res (1993) 53: 5915-19.
    • (1993) Cancer Res , vol.53 , pp. 5915-5919
    • Biesma, B.1    Pokorny, R.2    Kovarik, J.M.3
  • 24
    • 0028093654 scopus 로고
    • Recombinant human interleukin-3: Pharmacokinetics after intravenous and subcutaneous bolus injection and effects on granulocyte kinetics
    • Hovgaard DJ, Folke M, Mortensen BT, NIssen NI, Recombinant human interleukin-3: pharmacokinetics after intravenous and subcutaneous bolus injection and effects on granulocyte kinetics. Br J Haematol (1994) 87: 700-7.
    • (1994) Br J Haematol , vol.87 , pp. 700-707
    • Hovgaard, D.J.1    Folke, M.2    Mortensen, B.T.3    NIssen, N.I.4
  • 25
    • 0027451010 scopus 로고
    • IL-3 and IL-3/GM-CSF combination therapy - Clinical implications
    • Ganser A, Ottman OG, Hoelzer D, IL-3 and IL-3/GM-CSF combination therapy - clinical implications. Stem Cells (1993) 11: 465-73.
    • (1993) Stem Cells , vol.11 , pp. 465-473
    • Ganser, A.1    Ottman, O.G.2    Hoelzer, D.3
  • 26
    • 0025188699 scopus 로고
    • Effects of recombinant IL-3 in aplastic anemia
    • Ganser A, Lindemann A, Seipelt G et al, Effects of recombinant IL-3 in aplastic anemia. Blood (1990) 76: 1287-92.
    • (1990) Blood , vol.76 , pp. 1287-1292
    • Ganser, A.1    Lindemann, A.2    Seipelt, G.3
  • 27
    • 0028784560 scopus 로고
    • Recombinant IL-3 in refractory severe aplastic anaemia: A phase I/II trial
    • Bargetzi MJ, Gluckman E, Tichelli A et al, Recombinant IL-3 in refractory severe aplastic anaemia: a phase I/II trial. Br J Haematol (1995) 91: 306-12.
    • (1995) Br J Haematol , vol.91 , pp. 306-312
    • Bargetzi, M.J.1    Gluckman, E.2    Tichelli, A.3
  • 28
    • 0028094426 scopus 로고
    • A phase I/II study of IL-3 in patients with aplastic anemia and myelodysplasia
    • Nimer SD, Paquette RL, Ireland P et al, A phase I/II study of IL-3 in patients with aplastic anemia and myelodysplasia. Exp Hematol (1994) 22: 875-80.
    • (1994) Exp Hematol , vol.22 , pp. 875-880
    • Nimer, S.D.1    Paquette, R.L.2    Ireland, P.3
  • 29
    • 0028349713 scopus 로고
    • In vitro response of normal and aplastic anaemia bone marrow to mast cell growth factor and in combination with GM-CSF and IL 3
    • Gibson FM, Scopes J, Daly S et al, In vitro response of normal and aplastic anaemia bone marrow to mast cell growth factor and in combination with GM-CSF and IL 3. Exp Hematol (1994) 22: 302-12.
    • (1994) Exp Hematol , vol.22 , pp. 302-312
    • Gibson, F.M.1    Scopes, J.2    Daly, S.3
  • 30
    • 0026734508 scopus 로고
    • Effects of IL-3 on responsiveness to GM-CSF in severe aplastic anaemia
    • Geissler K, Forstinger C, Kalhs P et al, Effects of IL-3 on responsiveness to GM-CSF in severe aplastic anaemia. Ann Intern Med (1992) 117: 223-5.
    • (1992) Ann Intern Med , vol.117 , pp. 223-225
    • Geissler, K.1    Forstinger, C.2    Kalhs, P.3
  • 31
    • 0030502943 scopus 로고    scopus 로고
    • Long term IL-3 and intensive immunosuppression in the treatment of aplastic anemia
    • Raghavachar A, Ganse A, Freund M et al, Long term IL-3 and intensive immunosuppression in the treatment of aplastic anemia. Cytokines Mol Ther (1996) 2: 215-23.
    • (1996) Cytokines Mol Ther , vol.2 , pp. 215-223
    • Raghavachar, A.1    Ganse, A.2    Freund, M.3
  • 33
    • 0028951418 scopus 로고
    • Diamond Blackfan anaemia: Three patterns of in vitro response to hemopoietic growth factors
    • McGuckin CP, Uhr MR, Gordon-Smith EC, Diamond Blackfan anaemia: three patterns of in vitro response to hemopoietic growth factors. Br J Haematol (1995) 89: 457-64.
    • (1995) Br J Haematol , vol.89 , pp. 457-464
    • McGuckin, C.P.1    Uhr, M.R.2    Gordon-Smith, E.C.3
  • 34
    • 0027185538 scopus 로고
    • Treatment of Diamond-Blackfan anemia with recombinant human interleukin-3
    • Gillio AP, Faulkner LB, Alter BP et al, Treatment of Diamond-Blackfan anemia with recombinant human interleukin-3. Blood (1993) 82: 744-51.
    • (1993) Blood , vol.82 , pp. 744-751
    • Gillio, A.P.1    Faulkner, L.B.2    Alter, B.P.3
  • 35
    • 0029986725 scopus 로고    scopus 로고
    • In vitro progenitor analysis in a Diamond-Blackfan anaemia patient who responded once but not twice to IL-3 therapy, using short term and long term culture and c-kit analysis
    • McGuckin CP, Uhr MR, Ball SE, Gordon-Smith EC, In vitro progenitor analysis in a Diamond-Blackfan anaemia patient who responded once but not twice to IL-3 therapy, using short term and long term culture and c-kit analysis. Br J Haematol (1996) 93: 319-25.
    • (1996) Br J Haematol , vol.93 , pp. 319-325
    • McGuckin, C.P.1    Uhr, M.R.2    Ball, S.E.3    Gordon-Smith, E.C.4
  • 36
    • 0028825858 scopus 로고
    • Is there a role of IL-3 in Diamond-Blackfan anaemia?
    • Ball SE, Tchernia G, Wranne L et al, Is there a role of IL-3 in Diamond-Blackfan anaemia? Br J Haematol (1995) 91: 313-18.
    • (1995) Br J Haematol , vol.91 , pp. 313-318
    • Ball, S.E.1    Tchernia, G.2    Wranne, L.3
  • 37
    • 0026075449 scopus 로고
    • Treatment of Diamond Blackfan anaemia with haematopoietic growth factors, GM-CSF and IL-3: Sustained remission following IL-3
    • Dunbar CE, Smith D, Kimball J et al, Treatment of Diamond Blackfan anaemia with haematopoietic growth factors, GM-CSF and IL-3: sustained remission following IL-3. Br J Haematol (1991) 79: 316-21.
    • (1991) Br J Haematol , vol.79 , pp. 316-321
    • Dunbar, C.E.1    Smith, D.2    Kimball, J.3
  • 38
    • 0028354627 scopus 로고
    • Failure of recombinant IL-3 therapy to induce erythropoiesis in patients with refractory Diamond-Blackfan anemia
    • Olivieri NF, Feig SA, Valentino L et al, Failure of recombinant IL-3 therapy to induce erythropoiesis in patients with refractory Diamond-Blackfan anemia. Blood (1994) 83: 2444-50.
    • (1994) Blood , vol.83 , pp. 2444-2450
    • Olivieri, N.F.1    Feig, S.A.2    Valentino, L.3
  • 39
    • 0027527674 scopus 로고
    • Erythropoiesis in Diamond-Blackfan anemia and the role of IL-3 and Steel factor
    • Freedman MH, Erythropoiesis in Diamond-Blackfan anemia and the role of IL-3 and Steel factor. Stem Cells (1993) 11: 98-104.
    • (1993) Stem Cells , vol.11 , pp. 98-104
    • Freedman, M.H.1
  • 40
    • 0027470022 scopus 로고
    • Effects of IL-3 and GM-CSF on thrombopoiesis in congenital amegakaryocytic thrombocytopenia
    • Guinan EC, Lee YS, Lopez KD et al, Effects of IL-3 and GM-CSF on thrombopoiesis in congenital amegakaryocytic thrombocytopenia. Blood (1993) 81: 1691-8.
    • (1993) Blood , vol.81 , pp. 1691-1698
    • Guinan, E.C.1    Lee, Y.S.2    Lopez, K.D.3
  • 41
    • 0028332474 scopus 로고
    • Promotion of megakaryocytic progenitor expansion and differentiation by the c-MPL ligand thrombopoietin
    • Kaushansky K, Lok S, Holly RD et al, Promotion of megakaryocytic progenitor expansion and differentiation by the c-MPL ligand thrombopoietin. Nature (1994) 369: 568-71.
    • (1994) Nature , vol.369 , pp. 568-571
    • Kaushansky, K.1    Lok, S.2    Holly, R.D.3
  • 42
    • 0029807901 scopus 로고    scopus 로고
    • Recombinant human ligand for MPL, megakaryocyte growth and development factor (MDGF), stimulates thrombopoiesis in vivo in normal and myelo-suppressed baboons
    • Andrews RJ, Winkler A, Myerson D et al, Recombinant human ligand for MPL, megakaryocyte growth and development factor (MDGF), stimulates thrombopoiesis in vivo in normal and myelo-suppressed baboons. Stem Cells (1996) 14: 651-60.
    • (1996) Stem Cells , vol.14 , pp. 651-660
    • Andrews, R.J.1    Winkler, A.2    Myerson, D.3
  • 43
    • 0029056860 scopus 로고
    • In vivo effects of IL-3 in HIV type I infected patients with cytopenia
    • Scadden DT, Levine JD, Bresnathan J et al, In vivo effects of IL-3 in HIV type I infected patients with cytopenia. AIDS Res Hum Retroviruses (1995) 11: 731-40.
    • (1995) AIDS Res Hum Retroviruses , vol.11 , pp. 731-740
    • Scadden, D.T.1    Levine, J.D.2    Bresnathan, J.3
  • 44
    • 0025082534 scopus 로고
    • Effects of recombinant human interleukin-3 in patients with myelodysplastic syndromes
    • Ganser A, Seipelt G, Lindemann A et al, Effects of recombinant human interleukin-3 in patients with myelodysplastic syndromes. Blood (1990) 6: 455-62.
    • (1990) Blood , vol.6 , pp. 455-462
    • Ganser, A.1    Seipelt, G.2    Lindemann, A.3
  • 45
    • 0027267421 scopus 로고
    • Effects of long term treatment with recombinant human interleukin-3 in patients with myelodysplastic syndromes
    • Ganser A, Ottmann OG, Speipelt G et al, Effects of long term treatment with recombinant human interleukin-3 in patients with myelodysplastic syndromes. Leukemia (1993) 7: 696-701.
    • (1993) Leukemia , vol.7 , pp. 696-701
    • Ganser, A.1    Ottmann, O.G.2    Speipelt, G.3
  • 46
    • 0025852635 scopus 로고
    • In vivo effects of GM-CSF and IL-3 on clonal and non-clonal cell populations in patients with clonal hematopoietic disorder
    • Ganser A, Janssen JWG, Ottmann OG et al, In vivo effects of GM-CSF and IL-3 on clonal and non-clonal cell populations in patients with clonal hematopoietic disorder. Leukemia (1991) 5: 487-92.
    • (1991) Leukemia , vol.5 , pp. 487-492
    • Ganser, A.1    Janssen, J.W.G.2    Ottmann, O.G.3
  • 47
    • 8944236087 scopus 로고    scopus 로고
    • IL-3 plus low doses of cytosine arabinoside (LD-AraC) for the treatment of advanced myelodysplasia. A pilot study of EORTC leukemia group
    • Gerhartz HH, Zwierzina HH, Walther J et al, IL-3 plus low doses of cytosine arabinoside (LD-AraC) for the treatment of advanced myelodysplasia. A pilot study of EORTC Leukemia Group. Cancer Invest (1996) 14: 299-306.
    • (1996) Cancer Invest , vol.14 , pp. 299-306
    • Gerhartz, H.H.1    Zwierzina, H.H.2    Walther, J.3
  • 48
    • 0031898964 scopus 로고    scopus 로고
    • Hematopoietic growth factors for the treatment of myelodysplastic syndromes
    • Hansen PB, Penkowa M, Johnsen HE, Hematopoietic growth factors for the treatment of myelodysplastic syndromes. Leuk Lymphoma (1998) 28: 491-500.
    • (1998) Leuk Lymphoma , vol.28 , pp. 491-500
    • Hansen, P.B.1    Penkowa, M.2    Johnsen, H.E.3
  • 49
    • 25344439576 scopus 로고    scopus 로고
    • Randomized 3-armed phase III study of IL-3 or GM-CSF as an adjuvant to low doses of cytosine arabinoside (LD-AraC) for the treatment of high risk myelodsplastic syndromes
    • Gerhartz HH, Walther J, Neuwirtova R et al, Randomized 3-armed phase III study of IL-3 or GM-CSF as an adjuvant to low doses of cytosine arabinoside (LD-AraC) for the treatment of high risk myelodsplastic syndromes. Blood (1996) 88: 580a.
    • (1996) Blood , vol.88
    • Gerhartz, H.H.1    Walther, J.2    Neuwirtova, R.3
  • 50
    • 0014170018 scopus 로고
    • Criteria associated with destruction of leukemia and solid tumors in experimental animals
    • Skipper HE, Criteria associated with destruction of leukemia and solid tumors in experimental animals. Cancer Res (1967) 27: 2636-45.
    • (1967) Cancer Res , vol.27 , pp. 2636-2645
    • Skipper, H.E.1
  • 51
    • 0000057388 scopus 로고
    • Principles of chemotherapy
    • (ed VT DeVita, S Hellman, SA Rosenberg) JB Lippincott, Philadelphia
    • DeVita VT, Principles of chemotherapy. In: Cancer: Principles and Practice of Oncology (ed VT DeVita, S Hellman, SA Rosenberg) 276-300. JB Lippincott, Philadelphia, 1989.
    • (1989) Cancer: Principles and Practice of Oncology , pp. 276-300
    • DeVita, V.T.1
  • 52
    • 0018931869 scopus 로고
    • Dose, a critical factor in cancer chemotherapy
    • Frei E, Canellos G, Dose, a critical factor in cancer chemotherapy. Am J Med (1980) 69: 585-94.
    • (1980) Am J Med , vol.69 , pp. 585-594
    • Frei, E.1    Canellos, G.2
  • 53
    • 0027384242 scopus 로고
    • Dose dependent IL-3 stimulation of thrombopoiesis and neutropoiesis in patients with small cell lung carcinoma before and following chemotherapy: A placebo controlled randomized phase Ib study
    • D'Hondt V, Weynants P, Humblet Y et al, Dose dependent IL-3 stimulation of thrombopoiesis and neutropoiesis in patients with small cell lung carcinoma before and following chemotherapy: a placebo controlled randomized phase Ib study. J Clin Oncol (1993) 11: 2063-71.
    • (1993) J Clin Oncol , vol.11 , pp. 2063-2071
    • D'Hondt, V.1    Weynants, P.2    Humblet, Y.3
  • 54
    • 0030059693 scopus 로고    scopus 로고
    • A pilot study of high dose IL-3 treatment of relapsed follicular small cleaved cell lymphoma: Hematologic, immunologic and clinical results
    • Younes A, Sarris A, Consoli U et al, A pilot study of high dose IL-3 treatment of relapsed follicular small cleaved cell lymphoma: hematologic, immunologic and clinical results. Blood (1996) 87: 1698-703.
    • (1996) Blood , vol.87 , pp. 1698-1703
    • Younes, A.1    Sarris, A.2    Consoli, U.3
  • 55
    • 0027517507 scopus 로고
    • Effects of interleukin 3 on myelosuppression induced by chemotherapy for ovarian cancer and small cell undifferentiated tumours
    • Dercksen MW, Hoekman K, Bokkel T et al, Effects of interleukin 3 on myelosuppression induced by chemotherapy for ovarian cancer and small cell undifferentiated tumours. Br J Cancer (1993) 68: 996-1003.
    • (1993) Br J Cancer , vol.68 , pp. 996-1003
    • Dercksen, M.W.1    Hoekman, K.2    Bokkel, T.3
  • 56
    • 0026761309 scopus 로고
    • Effects of interleukin 3 after chemotherapy for advanced ovarian cancer
    • Biesma B, Willemse PHB, Mulder NH, Effects of interleukin 3 after chemotherapy for advanced ovarian cancer. Blood (1992) 80: 1141-8.
    • (1992) Blood , vol.80 , pp. 1141-1148
    • Biesma, B.1    Willemse, P.H.B.2    Mulder, N.H.3
  • 58
    • 0027436525 scopus 로고
    • The tolerability of continuous intravenous infusion of interleukin 3 after DHAP chemotherapy in patients with relapsed malignant lymphoma: A phase I study
    • Raemakers J, van Imhoff G, Verdonck L et al, The tolerability of continuous intravenous infusion of interleukin 3 after DHAP chemotherapy in patients with relapsed malignant lymphoma: a phase I study. Am J Hematol (1993) 67: 175-81.
    • (1993) Am J Hematol , vol.67 , pp. 175-181
    • Raemakers, J.1    Van Imhoff, G.2    Verdonck, L.3
  • 59
    • 0027380728 scopus 로고
    • Interleukin 3: A potential useful agent for treating chemotherapy related thrombocytopenia
    • Hoffman R, Interleukin 3: a potential useful agent for treating chemotherapy related thrombocytopenia. J Clin Oncol (1993) 4: 2057-9.
    • (1993) J Clin Oncol , vol.4 , pp. 2057-2059
    • Hoffman, R.1
  • 60
    • 0029591244 scopus 로고
    • The problem of thrombocytopenia and its management
    • Newland AC, The problem of thrombocytopenia and its management. Advanced Drugs (1995) 6: 65-73.
    • (1995) Advanced Drugs , vol.6 , pp. 65-73
    • Newland, A.C.1
  • 61
    • 0026485283 scopus 로고
    • Differential effects of sequential, simultaneous and single agent interleukin 3 and granulocyte macrophage colony stimulating factors in megakaryocyte maturation and platelet response in primates
    • Stahl CP, Winton EF, Monroe MO, Differential effects of sequential, simultaneous and single agent interleukin 3 and granulocyte macrophage colony stimulating factors in megakaryocyte maturation and platelet response in primates. Blood (1992) 80: 2479-85.
    • (1992) Blood , vol.80 , pp. 2479-2485
    • Stahl, C.P.1    Winton, E.F.2    Monroe, M.O.3
  • 62
    • 0031172780 scopus 로고    scopus 로고
    • Clinical use of hematopoietic growth factors in patients with myelodysplastic syndromes
    • Giessler RG, Schulte P, Ganser A, Clinical use of hematopoietic growth factors in patients with myelodysplastic syndromes. Int J Hematol (1997) 65: 339-54.
    • (1997) Int J Hematol , vol.65 , pp. 339-354
    • Giessler, R.G.1    Schulte, P.2    Ganser, A.3
  • 63
    • 24444476591 scopus 로고    scopus 로고
    • Phase III double blind study of PIXY321 vs G-CSF after CEP for breast or ovarian carcinoma
    • Ellis GK, Hutchins L, Limenez-Martin M et al, Phase III double blind study of PIXY321 vs G-CSF after CEP for breast or ovarian carcinoma. Blood (1996) 88: 449a.
    • (1996) Blood , vol.88
    • Ellis, G.K.1    Hutchins, L.2    Limenez-Martin, M.3
  • 64
    • 0030061368 scopus 로고    scopus 로고
    • Phase I/II trials of PIXY 321 to enhance engraftment following autologous bone marrow transplantation
    • Vose JM, Anderson JE, Bierman PJ et al, Phase I/II trials of PIXY 321 to enhance engraftment following autologous bone marrow transplantation. J Clin Oncol (1996) 14: 520-6.
    • (1996) J Clin Oncol , vol.14 , pp. 520-526
    • Vose, J.M.1    Anderson, J.E.2    Bierman, P.J.3
  • 65
    • 0030034609 scopus 로고    scopus 로고
    • Recombinant IL-3 in combination with remission induction chemotherapy in patients with relapsed acute myelogenous leukemia (AML): A phase I/II study
    • Wielenga JJ, Vellenga E, Groenewegen A et al, Recombinant IL-3 in combination with remission induction chemotherapy in patients with relapsed acute myelogenous leukemia (AML): a phase I/II study. Leukemia (1996) 10: 43-7.
    • (1996) Leukemia , vol.10 , pp. 43-47
    • Wielenga, J.J.1    Vellenga, E.2    Groenewegen, A.3
  • 66
    • 0031909587 scopus 로고    scopus 로고
    • Prospective evaluation accompanying a trial of GM-CSF/IL-3 in patients undergoing autologous bone marrow transplantation for Hodgkin's and non-Hodgkin's lymphoma. IL-3 BMT Team
    • Schulman KA, Dorsainvil D, Yabroff KR et al, Prospective evaluation accompanying a trial of GM-CSF/IL-3 in patients undergoing autologous bone marrow transplantation for Hodgkin's and non-Hodgkin's lymphoma. IL-3 BMT Team. Bone Marrow Transplant (1998) 21: 607-14.
    • (1998) Bone Marrow Transplant , vol.21 , pp. 607-614
    • Schulman, K.A.1    Dorsainvil, D.2    Yabroff, K.R.3
  • 67
    • 0344405536 scopus 로고    scopus 로고
    • Update of recommendations for the use of hematopoietic colony stimulating factors: Evidence based clinical practice guidelines
    • American Society of Clinical Oncology, Update of recommendations for the use of hematopoietic colony stimulating factors: evidence based clinical practice guidelines. J Clin Oncol (1996) 14: 1957-60.
    • (1996) J Clin Oncol , vol.14 , pp. 1957-1960
  • 68
    • 0030990241 scopus 로고    scopus 로고
    • Hematopoietic growth factors - Not whether, but when and where
    • Hoelzer D, Hematopoietic growth factors - Not whether, but when and where. N Engl J Med (1997) 336: 1822-3.
    • (1997) N Engl J Med , vol.336 , pp. 1822-1823
    • Hoelzer, D.1
  • 69
    • 0027300670 scopus 로고
    • IL-3 and peripheral blood stem cell harvesting
    • Guillaume T, D'Hondt V, Symann M, IL-3 and peripheral blood stem cell harvesting. Stem Cells (1993) 11: 173-81.
    • (1993) Stem Cells , vol.11 , pp. 173-181
    • Guillaume, T.1    D'Hondt, V.2    Symann, M.3
  • 70
    • 0012798427 scopus 로고
    • The use of rhIL-3 for mobilization of peripheral blood stem cells in previously treated patients with lymphoid malignancies
    • Vose JM, Kessinger A, Bierman PJ et al, The use of rhIL-3 for mobilization of peripheral blood stem cells in previously treated patients with lymphoid malignancies. Int J Cell Cloning (1992) 10: 62-4.
    • (1992) Int J Cell Cloning , vol.10 , pp. 62-64
    • Vose, J.M.1    Kessinger, A.2    Bierman, P.J.3
  • 71
    • 0027851331 scopus 로고
    • Potentiation of GM-CSF or G-CSF induced mobilization of circulating progenitor cells by pretreatment with IL-3 and harvest by apheresis
    • Hockner P, Giessler K, Kurz M et al, Potentiation of GM-CSF or G-CSF induced mobilization of circulating progenitor cells by pretreatment with IL-3 and harvest by apheresis. Int J Artif Organs (1993) 16(S-5): 25-9.
    • (1993) Int J Artif Organs , vol.16 , Issue.S-5 , pp. 25-29
    • Hockner, P.1    Giessler, K.2    Kurz, M.3
  • 72
    • 0031930236 scopus 로고    scopus 로고
    • Quality of IL-3 and G-CSF mobilized stem cells in patients with early chronic phase CML
    • Heinzinger M, Waller C, Rosensteil A et al, Quality of IL-3 and G-CSF mobilized stem cells in patients with early chronic phase CML. Leukemia (1998) 12: 333-9.
    • (1998) Leukemia , vol.12 , pp. 333-339
    • Heinzinger, M.1    Waller, C.2    Rosensteil, A.3
  • 73
    • 0026518567 scopus 로고
    • Mobilisation of peripheral blood progenitor cells by sequential administration of interleukin 3 and granulocyte monocyte colony stimulating factor following polychemotherapy with etoposide, ifosfamide and cisplatin
    • Brugger W, Bross K, Frischi J et al, Mobilisation of peripheral blood progenitor cells by sequential administration of interleukin 3 and granulocyte monocyte colony stimulating factor following polychemotherapy with etoposide, ifosfamide and cisplatin. Blood (1992) 79: 1193-200.
    • (1992) Blood , vol.79 , pp. 1193-1200
    • Brugger, W.1    Bross, K.2    Frischi, J.3
  • 74
    • 0027861097 scopus 로고
    • Interleukin-3 followed by GM-CSF for delayed engraftment after autologous bone marrow transplantation
    • Crump M, Couture F, Kovacs M et al, Interleukin-3 followed by GM-CSF for delayed engraftment after autologous bone marrow transplantation. Exp Hematol (1993) 21: 405-10.
    • (1993) Exp Hematol , vol.21 , pp. 405-410
    • Crump, M.1    Couture, F.2    Kovacs, M.3
  • 75
    • 0027368563 scopus 로고
    • Phase I trial with recombinant human interleukin 3 in patients with lymphoma undergoing autologous bone marrow transplantation
    • Nemaunaitis J, Appelbaum FR, Singer JW, Phase I trial with recombinant human interleukin 3 in patients with lymphoma undergoing autologous bone marrow transplantation. Blood (1993) 82: 3273-8.
    • (1993) Blood , vol.82 , pp. 3273-3278
    • Nemaunaitis, J.1    Appelbaum, F.R.2    Singer, J.W.3
  • 76
    • 0029868701 scopus 로고    scopus 로고
    • Recombinant IL-3 and GM-CSF after autologous bone marrow transplantation for malignant lymphoma
    • Fay JW, Bernstein SH, Recombinant IL-3 and GM-CSF after autologous bone marrow transplantation for malignant lymphoma. Semin Oncol (1996) Suppl 4: 22-7.
    • (1996) Semin Oncol , Issue.SUPPL. 4 , pp. 22-27
    • Fay, J.W.1    Bernstein, S.H.2
  • 77
    • 0026504705 scopus 로고
    • Effects of peripheral blood progenitor cells mobilised by filgrastim (G-CSF) on platelet recovery after high dose chemotherapy
    • Sheridan WP, Begley CG, Jutkner CA et al, Effects of peripheral blood progenitor cells mobilised by filgrastim (G-CSF) on platelet recovery after high dose chemotherapy. Lancet (1992) 339: 640-4.
    • (1992) Lancet , vol.339 , pp. 640-644
    • Sheridan, W.P.1    Begley, C.G.2    Jutkner, C.A.3
  • 78
    • 0026649387 scopus 로고
    • Enhanced marrow recovery by short preincubation of marrow allograft with human recombinant IL-3 and GM-CSF
    • Naparstak E, Harden Y, Ben-Shahar M et al, Enhanced marrow recovery by short preincubation of marrow allograft with human recombinant IL-3 and GM-CSF. Blood (1992) 80: 1673-8.
    • (1992) Blood , vol.80 , pp. 1673-1678
    • Naparstak, E.1    Harden, Y.2    Ben-Shahar, M.3
  • 79
    • 0029007090 scopus 로고
    • Potent IL-3 receptor agonist with selectively enhanced hematopoietic activity relative to recombinant human interleukin 3
    • Thomas JW, Baum CM, Hood WF et al, Potent IL-3 receptor agonist with selectively enhanced hematopoietic activity relative to recombinant human interleukin 3. Proc Natl Acad Sci USA (1995) 92: 3779-83.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3779-3783
    • Thomas, J.W.1    Baum, C.M.2    Hood, W.F.3
  • 80
    • 0030044584 scopus 로고    scopus 로고
    • Acceleration of hematopoietic reconstitution with a synthetic cytokine (SC-55494) after radiation induced bone marrow aplasia
    • Farese AM, Herodin F, McKearn JP et al, Acceleration of hematopoietic reconstitution with a synthetic cytokine (SC-55494) after radiation induced bone marrow aplasia. Blood (1996) 87: 581-91.
    • (1996) Blood , vol.87 , pp. 581-591
    • Farese, A.M.1    Herodin, F.2    McKearn, J.P.3
  • 81
    • 0011914181 scopus 로고    scopus 로고
    • Phase I/II study to determine the safety and tolerability of SC70935 in patients with relapsed lymphoma receiving ESHAP
    • Abboud CN, DiPersio JF, Gordon L et al, Phase I/II study to determine the safety and tolerability of SC70935 in patients with relapsed lymphoma receiving ESHAP. Blood (1997) 90(Suppl 1): 173a.
    • (1997) Blood , vol.90 , Issue.SUPPL. 1
    • Abboud, C.N.1    DiPersio, J.F.2    Gordon, L.3
  • 82
    • 0003347792 scopus 로고    scopus 로고
    • Promegapoietin, a chimeric growth factor for megakaryocyte and platelet restoration
    • Giri JG, Smith WG, Kahn LE et al, Promegapoietin, a chimeric growth factor for megakaryocyte and platelet restoration. Blood (1997) 90(Suppl 1): 580a.
    • (1997) Blood , vol.90 , Issue.SUPPL. 1
    • Giri, J.G.1    Smith, W.G.2    Kahn, L.E.3
  • 83
    • 13344295077 scopus 로고    scopus 로고
    • Selection and expansion of peripheral blood CD34+ cell transplantation for breast cancer
    • Williams SF, Lee WJ, Bender JG et al, Selection and expansion of peripheral blood CD34+ cell transplantation for breast cancer. Blood (1996) 87: 1687-91.
    • (1996) Blood , vol.87 , pp. 1687-1691
    • Williams, S.F.1    Lee, W.J.2    Bender, J.G.3
  • 84
    • 0028176643 scopus 로고
    • c-kit ligand combined with GM-CSF and or IL-3 can expand CD34+ hematopoietic progenitor subsets for several weeks in vitro
    • Steen R, Morkrid L, Tjonnfjord GE, Egeland T, c-kit ligand combined with GM-CSF and or IL-3 can expand CD34+ hematopoietic progenitor subsets for several weeks in vitro. Stem Cells (1994) 12: 214-24.
    • (1994) Stem Cells , vol.12 , pp. 214-224
    • Steen, R.1    Morkrid, L.2    Tjonnfjord, G.E.3    Egeland, T.4
  • 85
    • 0028596002 scopus 로고
    • Accelerated and long-term hematopoietic engraftment in mice transplanted with ex-vivo expanded bone marrow
    • Serrano F, Varas F, Bernard A, Bueren JA, Accelerated and long-term hematopoietic engraftment in mice transplanted with ex-vivo expanded bone marrow. Bone Marrow Transplant (1994) 14: 855-62.
    • (1994) Bone Marrow Transplant , vol.14 , pp. 855-862
    • Serrano, F.1    Varas, F.2    Bernard, A.3    Bueren, J.A.4
  • 86
    • 0030051967 scopus 로고    scopus 로고
    • Ex-vivo expansion of murine marrow cells with IL-3, IL-6, IL-11 and SCF leads to impaired engraftment in irradiated host
    • Peters SO, Kittler EL, Ramshaw HS, Quesenberry PJ, Ex-vivo expansion of murine marrow cells with IL-3, IL-6, IL-11 and SCF leads to impaired engraftment in irradiated host. Blood (1996) 87: 30-7.
    • (1996) Blood , vol.87 , pp. 30-37
    • Peters, S.O.1    Kittler, E.L.2    Ramshaw, H.S.3    Quesenberry, P.J.4
  • 87
    • 4244070723 scopus 로고    scopus 로고
    • Ex-vivo blood stem cell expansion in liquid culture with cytokine cocktails. Role of thrombopoietin
    • Adelmann M, Schulze D, Osten CV et al, Ex-vivo blood stem cell expansion in liquid culture with cytokine cocktails. Role of thrombopoietin. Blood (1996) 88: 604a.
    • (1996) Blood , vol.88
    • Adelmann, M.1    Schulze, D.2    Osten, C.V.3
  • 88
    • 25544477259 scopus 로고    scopus 로고
    • Gene transduction of human CD34+ CD38-, HLA-DR+ hematopoietic stem cell/progenitor cells
    • Huang S, Peterson S, Li X et al, Gene transduction of human CD34+ CD38-, HLA-DR+ hematopoietic stem cell/progenitor cells. Blood (1996) 88: 429a.
    • (1996) Blood , vol.88
    • Huang, S.1    Peterson, S.2    Li, X.3
  • 89
    • 0030827301 scopus 로고    scopus 로고
    • Inclusion of IL-3 during retroviral-mediated transduction on stromal support does not increases the extent of gene transfer into long term engrafting human hematopoietic progenitors
    • Doa MA, Nolta JA, Inclusion of IL-3 during retroviral-mediated transduction on stromal support does not increases the extent of gene transfer into long term engrafting human hematopoietic progenitors. Cytokines Cell Mol Ther (1997) 3: 81-90.
    • (1997) Cytokines Cell Mol Ther , vol.3 , pp. 81-90
    • Doa, M.A.1    Nolta, J.A.2
  • 90
  • 91
    • 0030781916 scopus 로고    scopus 로고
    • Dendritic cells: Unique leukocyte populations which control the primary immune response
    • NJ Hart, Dendritic cells: unique leukocyte populations which control the primary immune response. Blood (1997) 90: 3245-87.
    • (1997) Blood , vol.90 , pp. 3245-3287
    • Hart, N.J.1
  • 92
    • 0025735629 scopus 로고
    • The dendritic cell system and its role in immunogenicity
    • Steinman RM, The dendritic cell system and its role in immunogenicity. Annu Rev Immunol (1991) 9: 271-96.
    • (1991) Annu Rev Immunol , vol.9 , pp. 271-296
    • Steinman, R.M.1
  • 93
    • 0029929271 scopus 로고    scopus 로고
    • Interleukin 3 cooperates with tumor necrosis factor alpha for the development of human dendritic/Langerhans cells for cord blood CD34+ hematopoietic progenitor cells
    • Caux C, Vanbervliet B, Massacrier C et al, Interleukin 3 cooperates with tumor necrosis factor alpha for the development of human dendritic/Langerhans cells for cord blood CD34+ hematopoietic progenitor cells. Blood (1996) 87: 2376-85.
    • (1996) Blood , vol.87 , pp. 2376-2385
    • Caux, C.1    Vanbervliet, B.2    Massacrier, C.3
  • 94
    • 0031039483 scopus 로고    scopus 로고
    • Antigen presenting cells pulsed with unfractional tumor-derived peptides are potent tumor vaccines
    • Nair SK, Boczkowski D, Snyder D, Gilboa E, Antigen presenting cells pulsed with unfractional tumor-derived peptides are potent tumor vaccines. Eur J Immunol (1997) 27: 589-97.
    • (1997) Eur J Immunol , vol.27 , pp. 589-597
    • Nair, S.K.1    Boczkowski, D.2    Snyder, D.3    Gilboa, E.4
  • 95
    • 0030759537 scopus 로고    scopus 로고
    • Enhanced immune costimulatory activity of primary acute myeloid leukaemia blasts after retroviral mediated gene transfer of B7.1
    • Hirst WJ, Buggins A, Darling D et al, Enhanced immune costimulatory activity of primary acute myeloid leukaemia blasts after retroviral mediated gene transfer of B7.1. Gene Ther (1997) 4: 691-9.
    • (1997) Gene Ther , vol.4 , pp. 691-699
    • Hirst, W.J.1    Buggins, A.2    Darling, D.3
  • 96
    • 0027942023 scopus 로고
    • Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity
    • Guinan EC, Gribben JG, Boussiotis VA et al, Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity. Blood (1994) 84: 3261-82.
    • (1994) Blood , vol.84 , pp. 3261-3282
    • Guinan, E.C.1    Gribben, J.G.2    Boussiotis, V.A.3


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