Effects of LU-111995 in three models of disrupted prepulse inhibition in rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 290, Issue 2, 1999, Pages 716-724

  Geyer, Mark A ^a   Swerdlow, Neal R ^a   Lehmann Masten, Virginia ^a   Teschendorf, Hans Jürgen ^b   Traut, Martin ^b   Gross, Gerhard ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Knoll AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 [2 [6 (4 FLUOROPHENYL) 3 AZABICYCLO[3.2.0]HEPTANE 3 YL] ETHYL] 1H,3H QUINAZOLINE 2,4 DIONE FUMARATE; APOMORPHINE; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR STIMULATING AGENT; LU 11195; NEUROLEPTIC AGENT; PHENCYCLIDINE; PSYCHEDELIC AGENT; SEROTONIN 2A RECEPTOR; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DOSE RESPONSE; DRUG EFFECT; MALE; NONHUMAN; PREPULSE INHIBITION; PRIORITY JOURNAL; RAT; SCHIZOPHRENIA; SEROTONINERGIC SYSTEM; SOCIAL ISOLATION; STARTLE REFLEX; SUBCUTANEOUS DRUG ADMINISTRATION;

ACOUSTIC STIMULATION; ANIMALS; ANTIPSYCHOTIC AGENTS; APOMORPHINE; BEHAVIOR, ANIMAL; DOPAMINE AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FUMARATES; HALLUCINOGENS; MALE; PHENCYCLIDINE; QUINAZOLINES; RATS; RATS, SPRAGUE-DAWLEY; SOCIAL ISOLATION; STARTLE REACTION;

EID: 0032808085     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Bakshi VP and Geyer MA (1995) Antagonism of phencyclidine-induced deficits in prepulse inhibition by the putative atypical antipsychotic olanzapine. Psychopharmacology 122:198-201.
2. Bakshi VP, Schwarzkopf SB, Braff DL and Geyer MA (1996) Long-term behavioral and neurochemical changes after isolation rearing in rats (Abstract). Biol Psychiatry 39:555.
3. Bakshi VP, Swerdlow NR, Braff DL and Geyer MA (1998) Reversal of isolation rearing-induced deficits in prepulse inhibition by Seroquel and olanzapine. Biol Psychiatry 43:436-445.
4. Bakshi VP, Swerdlow NR and Geyer MA (1994) Clozapine antagonizes phencyclidine-induced deficits in sensorimotor gating of the startle response. J Pharmacol Exp Ther 271:787-794.
5. Bolino F, Di Michele V, Di Cicco L, Manna V, Daneluzzo E and Cassachia M (1994) Sensorimotor gating and habituation evoked by electrocutaneous stimulation in schizophrenia. Biol Psychiatry 36:670-679.
6. Braff DL and Geyer MA (1990) Sensorimotor gating and schizophrenia: Human and animal model studies. Arch Gen Psychiatry 47:181-188.
7. Braff DL, Grillon C and Geyer MA (1992) Gating and habituation of the startle reflex in schizophrenic patients. Arch Gen Psychiatry 49:206-215.
8. Braff DL, Stone C, Callaway E, Geyer MA, Glick ID and Bali L (1978) Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology 15:339-343.
9. 4 receptor antagonist, does not exhibit a neuroleptic-like profile in rodent behavioral tests. J Pharmacol Exp Ther 283: 1256-1263.
10. Bristow LJ, Landon L, Saywell KL and Tricklebank MD (1995) The glycine/NMDA receptor antagonist, L-701,324, reverses isolation-induced deficits in prepulse inhibition in the rat. Psychopharmacalogy 118:230-232.
11. Cadenhead KS, Geyer MA and Braff DL (1993) Impaired startle prepulse inhibition and habituation in patients with schizotypal personality disorder. Am J Psychiatry 150:1862-1867.
12. 4 antagonists on prepulse inhibition of acoustic startle and amphetamine-stimulated locomotion in rats. Soc Neurosci Abstr 23:2417.
13. Dixon W (1992) BMDP Statistical Software Manual - to accompany the 7.0 software release. University of California Press, Berkeley.
14. 2A receptor antagonist and putative antipsychotic, reverses prepulse inhibition deficits in isolation-reared rats. Soc Neurosci Abstr 24:1740.
15. Geyer MA and Swerdlow NR (1998) Measurement of the startle response, prepulse inhibition, and habituation, in Current Protocols in Neuroscience (Crawley JN and Skolnick P eds) chapter 8, pp 8.7.1-8.7.15, John Wiley & Sons, New York.
16. Geyer MA, Swerdlow NR, Mansbach RS and Braff DL (1990) Startle response models of sensorimotor gating and habituation deficits in schizophrenia. Brain Res Bull 25:485-498.
17. Geyer MA, Wilkinson LS, Humby T and Robbins TW (1993) Isolation rearing of rats produces a deficit in prepulse inhibition of acoustic startle similar to that in schizophrenia. Biol Psychiatry 34:361-372.
18. Grillon C, Ameli R, Charney DS, Krystal J and Braff DL (1992) Startle gating deficits occur across prepulse intensities in schizophrenic patients. Biol Psychiatry 32: 939-943.
19. Hall FS, Wilkinson LS, Humby T, Inglis W, Kendall DA, Marsden CA and Robbins TW (1998) Isolation rearing in rats: Pre-and postsynaptic changes in striatal dopaminergic systems. Pharmacol Biochem Behav 59:859-872.
20. Ison JR and Hoffman HS (1983) Reflex modification in the domain of startle. II. The anomalous history of a robust and ubiquitous phenomenon. Psychol Bull 94:3-17.
21. Keith VA, Mansbach RS and Geyer MA (1991) Failure of haloperidol to block the effects of phencyclidine and dizocilpine on prepulse inhibition of startle. Biol Psychiatry 30:557-566.
22. Lahti AC, Koffel B, LaPorte D and Tamminga CA (1995) Subanesthetic doses of ketamine stimulate psychosis in schizophrenia. Neuropsychopharmacology 13:9-19.
23. Malhotra AK, Finals DA, Weingartner H, Sirocco K, Missar CD, Pickar D and Breier A (1996) NMDA receptor function and human cognition: The effects of ketamine in healthy volunteers. Neuropsychopharmacology 14:301-307.
24. Mansbach RS, Brooks EW, Sanner MA and Zorn SH (1998) Selective dopamine D4 receptor antagonists reverse apomorphine-induced blockade of prepulse inhibition. Psychopharmacology 135:194-200.
25. Mansbach RS and Geyer MA (1989) Effects of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat. Neuropsychopharmacology 2:299-308.
26. Mansbach RS, Geyer MA and Braff DL (1988) Dopaminergic stimulation disrupts sensorimotor gating in the rat. Psychopharmacology 94:507-514.
27. McGhie A and Chapman J (1961) Disorders of attention and perception in early schizophrenia. Br J Med Psychol 34:103-116.
28. Moore NA, Calligaro DO, Wong DT, Bymaster F and Tye NC (1993) The pharmacology of olanzapine and other new antipsychotic agents. Curr Opin Investig Drugs 2:281-293.
29. 2 dopamine receptor agonist disrupts sensorimotor gating in rats: Implications for dopaminergic abnormalities in schizophrenia. Neuropsychopharmacology 3:211-218.
30. 2A eceptor antagonists: LU-111995 and other potential new antipsychotics in development. Drugs Future 23:191-204.
31. Swerdlow NR, Bakshi VP and Geyer MA (1996) Seroquel restores sensorimotor gating in phencyclidine (PCP)-treated rats. J Pharmacol Exp Ther 279:1290-1299.
32. Swerdlow NR and Geyer MA (1993) Clozapine and haloperidol in an animal model of sensorimotor gating deficits in schizophrenia. Pharmacol Biochem Behav 44:741-744.
33. Swerdlow NR, Keith VA, Braff DL and Geyer MA (1991) Effects of spiperone, raclopride, SCH23390 and clozapine on apomorphine-inhibition of sensorimotor gating of the startle response in the rat. J Pharmacol Exp Ther 256:530-536.
34. Swerdlow NR, Zisook D and Taaid N (1994) Seroquel (ICI 204,636) restores prepulse inhibition of acoustic startle in apomorphine-treated rats: Similarities to clozapine. Psychopharmacology 114:675-678.
35. 2A receptor antagonist and putative antipsychotic, blocks dizocilpine-induced prepulse inhibition deficits in Sprague-Dawley and Wistar rats. Neuropsychopharmacology 20: 311-321.
36. Varty GB and Higgins GA (1995) Examination of drug-induced and isolation-induced disruptions of prepulse inhibition as models to screen antipsychotic drugs. Psychopharmacology 122:15-26.
37. Weike A, Globisch J, Hamm A and Bauer U (1996) Prepulse inhibition and habituation of skin conductance responses in schizophrenics: Neuroleptic drug effects. Psychophysiology 33(Suppl 1):S88.
38. Weinberger DR (1987) Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 44:660-669.
39. Wilkinson LS, Killcross SS, Humby T, Hall FS, Geyer MA and Robbins TW (1994) Social isolation in the rat produces developmentally specific deficits in prepulse inhibition of the acoustic startle response without disrupting latent inhibition. Neuropsychopharmacology 10:61-72.
40. 4 dopamine antagonist with an in vitro and in vivo profile suggestive of an atypical antipsychotic. Soc Neurosci Abstr 22:1771.