Familial pancreatic cancer

Annals of Oncology

Volumn 10, Issue SUPPL. 4, 1999, Pages

  Hruban, Ralph H ^a,d   Petersen, G M ^b   Goggins, M ^a   Tersmette, A C ^c   Offerhaus, G J A ^c   Falatko, F ^a   Yeo, C J ^a   Kern, S E ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Familial; Families; Inheritance; Pancreas; Pancreatic cancer; Tumor suppressor genes

Indexed keywords

PROTEIN P16;

CANCER REGISTRY; CANCER RISK; CANCER SUSCEPTIBILITY; CONFERENCE PAPER; FAMILIAL CANCER; FAMILY STUDY; HUMAN; INHERITANCE; MAJOR CLINICAL STUDY; ONCOGENE; PANCREAS CANCER; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 0032807116     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1093/annonc/10.suppl_4.S69     Document Type: Conference Paper

References (55)

1. Lynch HT, Voorhees GJ, Lanspa S et al. Pancreatic carcinoma and hereditary nonpolyposis colorectal cancer: a family study. Br J Cancer 1985;52:271-3.
2. Lynch HT, Fitzsimmons ML, Smyrk TC et al. Familial pancreatic cancer: Clinicopathologic study of 18 nuclear families. Am J Gastroenterol 1990;85:54-60.
3. Lynch HT, Fusaro RM. Pancreatic cancer and the familial atypical multiple mole melanoma (FAMMM) syndrome. Pancreas 1991;6:127-31.
4. Lynch HT, Fusaro L, Lynch JF. Familial pancreatic cancer: A family study. Pancreas 1992;7:511-5.
5. Lynch HT, Smyrk TC, Watson P et al. Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: An updated review. Gastroenterol 1993;104:1535-49.
6. Lynch HT. Genetics and pancreatic cancer. Arch Surg 1994;129:266-8.
7. Lynch HT, Fusaro L, Smyrk T et al. Medical genetic study of eight pancreatic cancer-prone families. Cancer Invest 1995;13(2):141-9.
8. Bergman W, Watson P, de Jong J et al. Systemic cancer and the FAMMM syndrome. Br J Cancer 1990;61:932-6.
9. Dat N, Sontag S. Pancreatic carcinoma in brothers. Ann Intern Med 1982;97(2):282
10. Ehrenthal D, Haeger L, Griffin T et al. Familial pancreatic adenocarcinoma in three generations. Cancer 1987;59(9):1661-4.
11. Grajower MM. Familial pancreatic cancer. Ann Intern Med 1983;98:111
12. Katkhouda N, Mouiel J. Pancreatic cancer in mother and daughter. Lancet 1986;2:747
13. MacDermott RP, Kramer P. Adenocarcinoma of the pancreas in four siblings. Gastroenterol 1973;65(1):137-9.
14. Reimer R, Fraumeni JF, Jr., Ozols R et al. Pancreatic cancer in father and son. Lancet 1977;1:911-2.
15. Lumadue JA, Griffin CA, Osman M et al. Familial pancreatic cancer and the genetics of pancreatic cancer. Surg Clin North Am 1995;75:845-55.
16. Lynch HT, Smyrk T, Kern SE et al. Familial pancreatic cancer: A review. Semin Oncol 1996;23:251-75.
17. Hruban RH, Petersen GM, Ha PK et al. Genetics of pancreatic cancer. From genes to families. Surg Oncol Clin N Am 1998;7:1-23.
18. Aston CE, Banke MG, McNamara PJ et al. Segregation analysis of pancreatic cancer. [Abstract] Am J Hum Genet 1997;61:A194
19. Crowley KE, Aston CE, MacNamara PJ et al. Familial aggregation of other cancers in families with pancreatic cancer. [Abstract] Am J Hum Genet 1997;61:A196
20. Ghadirian P, Boyle P, Simard A et al. Reported family aggregation of pancreatic cancer within a population-based case-control study in the Francophone community in Montreal, Canada. Int J Pancreatol 1991;10:183-96.
21. Fernandez E, La Vecchia C, D'Avanzo B et al. Family history and the risk of liver, gallbladder, and pancreatic cancer. Cancer Epidemiol Biomarkers Prev 1994;3:209-12.
22. Knudson AG. Hereditary cancer: Two hits revisited. J Cancer Res Clin Oncol 1996;122:135-40.
23. Knudson AG. Hereditary cancer, oncogenes, and antioncogenes. Cancer Res 1985;45:1437-43.
24. Caldas C, Hahn SA, da Costa LT et al. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet 1994;8:27-32.
25. Herman JG, Merlo A, Mao L et al. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancer. Cancer Res 1995;55:4525-30.
26. Schutte M, Hruban RH, Geradts J et al. Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas. Cancer Res 1997;57:3126-30.
27. Kamb A, Gruis NA, Weaver-Feldhaus J et al. A cell cycle regulator potentially involved in genesis of many tumor types. Science 1994;264:436-40.
28. INK44 and CDK4 mutations in familial pancreatic carcinoma. [In Press] Hum Mutat 1998;
29. Goldstein AM, Fraser MC, Struewing JP et al. Increased risk of pancreatic cancer in melanoma-prone kindreds with p16 INK4 mutations. N Engl J Med 1995; 333(15):970-4.
30. Su GH, Hruban RH, Bova GS et al. Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. In Press 1998;
31. Jeghers HMD, McKusick VAMD, Katz KHMD. Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits. N Engl J Med 1949; 241(25):992-1005.
32. Giardiello FM, Welsh SB, Hamilton SR et al. Increased risk of cancer in the peutz-jeghers syndrome. N Engl J Med 1987;316(24):1511-4.
33. Hemminki A, Markie D, Tomlinson I et al. A serine/threonine kinase gene defective in Peutz Jeghers syndrome. Nature 1998;391:184-7.
34. Jenne DE, Reimann H, Nezu J et al. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat Genet 1998;18:38-43.
35. Tulinius H, Olafsdottir GH, Sigvaldason H et al. Neoplastic diseases in families of breat cancer patients. J Med Genet 1994;31:618-21.
36. Thorlacius S, Olafsdottir G, Tryggvadottir L et al. A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes. Nat Genet 1996;13:117-9.
37. Phelan CM, Lancaster J, Tonin P et al. Mutation analysis of the BRCA2 gene in 49 site-specific breast cancer families. Nat Genet 1996;13:120-2.
38. Couch FJ, Farid LM, DeShano ML et al. BRCA2 germline mutations in male breast cancer cases and breast cancer families. Nat Genet 1996;13:123-5.
39. Berman DB, Costalas J, Schultz DC et al. A common mutation in BRCA2 that predisposes to a variety of cancers is found in both Jewish Ashkenazi and non-Jewish individuals. Cancer Res 1996;56(August 1, 1996):3409-14.
40. Ozcelik H, Schmocker B, DiNicola N et al. Germline BRCA2 6174delT mutations in Ashkenazi Jewish pancreatic cancer patients. Nat Genet 1997;16:17-8.
41. Goggins M, Schutte M, Lu J et al. Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res 1996;56:5360-4.
42. de la Garza M, Hill ID, Lebenthal E. et al editors. The Pancreas: Biology, Pathobiology, and Disease. 2nd ed. New York, NY: Raven; 1993; Hereditary pancreatitis. p. 1095
43. de la Garza M, Hill ID, Lebenthal E. et al editors. The Pancreas: Biology, Pathobiology, and Disease. 2nd ed. New York, NY: Raven; 1993; Hereditary pancreatitis. p. 1095
44. Davidson P, Costanza D, Swieconek JA et al. Hereditary pancreatitis: A kindred without gross aminoaciduria. Ann Intern Med 1968;68:88-96.
45. Comfort MW, Steinberg AG. Pedigree of a family with hereditary chronic relapsing pancreatitis. Gastroenterol 1952;21:54-63.
46. Whitcomb DC, Preston RA, Aston CE et al. A gene for hereditary pancreatitis maps to chromosome 7q35. Gastroenterol 1996;110:1975-80.
47. Whitcomb DC, Gorry MC, Preston RA et al. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet 1996;14:141-5.
48. Ekbom A, McLaughlin JK, Karlsson B-M et al. Pancreatitis and pancreatic cancer: A population-based study. J Natl Cancer Inst 1994;86:625-7.
49. Lowenfels AB, Maisonneuve P, Cavallini G et al. Pancreatitis and the risk of pancreatic cancer. N Engl J Med 1993;328:1433-7.
50. Strand M, Prolla TA, Liskay RM et al. Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Letters to Nature 1993;365:274-6.
51. Goggins M, Offerhaus GJA, Hilgers W et al. Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type k-ras and characteristic histopathology: poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+. Am J Pathol 1998;152:1501-7.
52. Parsons R, Li G-M, Longley MJ et al. Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell 1993;75:1227-36.
53. Leach FS, Nicolaides NC, Papadopoulos N et al. Mutations of a mutS homolog in hereditary non-polyposis colorectal cancer. Cell 1993;75:1215-36.
54. Kunkel TA. Slippery DNA and diseases. Nature 1993;365:207-8.
55. Fishel R, Lescoe MK, Rao MRS et al. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 1993; 75:1027-38.