Regulation of glucose turnover and hormonal responses during electrical cycling in tetraplegic humans

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 271, Issue 1 40-1, 1996, Pages

  Kjaer M ^a   Pollack, S F ^b   Mohr, T ^b   Weiss, H ^b   Gleim, G W ^b   Bach, F W ^b   Nicolaisen, T ^b   Galbo, H ^b   Ragnarsson, K T ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NONE

Author keywords

adrenocorticotropin; catecholamines; cortisol; epinephrine; functional electrical stimulation; glucagon; growth hormone; hepatic glucose production; insulin; metabolic regulation; norepinephrine; renin; spinal cord injury; endorphin

Indexed keywords

3 HYDROXYBUTYRIC ACID; ADRENALIN; BETA ENDORPHIN; CORTICOTROPIN; FATTY ACID; GLUCOSE; GROWTH HORMONE; LACTIC ACID; NORADRENALIN; POTASSIUM; RENIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYCLING; ELECTROSTIMULATION; EXERCISE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HEART RATE; HORMONE BLOOD LEVEL; HORMONE RESPONSE; HUMAN; LIPOLYSIS; MALE; MUSCLE FATIGUE; PRIORITY JOURNAL; QUADRIPLEGIA; SPINAL CORD INJURY; VOLUNTARY MOVEMENT;

EID: 33745368878     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1996.271.1.r191     Document Type: Article

References (48)

1. Adams, L., J. Garlick, A. Guz, K. Murphy, and S. J. G. Semple. Is the voluntary control of exercise in man necessary for the ventilatory response? J. Physiol. Lond. 355: 71-83, 1984.
2. Ahlborg, G., P. Felig, L. Hagenfeldt, R. Hendler, and J. Wahren. Substrate turnover during prolonged exercise in man J. Clin. Invest. 53: 1080-1090, 1974.
3. Bach, F. W., J. Fahrenkrug, K. Jensen, G. Dahlstrøm, and R. Ekman. Plasma β-endorphin during clinical and experimental ischaemic pain. Scand. J. Clin. Lab. Invest. 47: 751-758, 1987.
4. Ben-Jonathan, N., and J. G. Porter. A sensitive radioenzymatic assay for dopamine, norepinephrine and epinephrine in plasma and tissue. Endocrinology 98: 1497-1507, 1976.
5. Claus-Walker, J., and L. S. Halstead. Metabolic and endocrine changes in spinal cord injury. Partial decentralization of the autonomic nervous system. Arch. Phys. Med. Rehabil. 63: 576-580, 1982.
6. Coote, J. H., S. M. Hilton, and J. F. Perez-Gonzalez. The reflex nature of the pressor response to muscular exercise. J. Physiol. Lond. 215: 789-804, 1971.
7. Debarge, O., N. J. Christensen, J. L. Corbett, B. H. Eidelman, H. L. Frankel, and C. J. Mathias. Plasma catecholamines in tetraplegics. Paraplegia 12: 44-49, 1974.
8. De Meirleir, K., N. Naaktgeboren, A. V. Steiteghem, F. Gorus, J. Olbrecht, and P. Block. Beta-endorphin and ACTH levels in peripheral blood during and after aerobic and anaerobic exercise. Eur. J. Appl. Physiol. 55: 5-8, 1986.
9. Farrell, P. A., M. Kjær, F. W. Bach, and H. Galbo. Beta-endorphin and adrenocorticotropin response to supramaximal treadmill exercise in trained and untrained males. Acta Physiol. Scand. 130: 619-625, 1987.
10. Galbo, H. Hormonal and Metabolic Adaptation to Exercise. New York: Thieme-Stratton, 1983.
11. Galbo, H., N. J. Christensen, and J. J. Holst. Catecholamines and pancreatic hormones during autonomic blockade in exercising man. Acta Physiol. Scand. 101: 428-437, 1977.
12. Galbo, H., J. J. Holst, and N. J. Christensen. The effect of different diets and of insulin on the hormonal response to prolonged exercise. Acta Physiol. Scand. 107: 19-32, 1979.
13. Hales, C. N., and R. D. G. Milner. The role of sodium and potassium in insulin secretion from rabbit pancreas in vitro. J. Physiol. Lond. 194: 725-743, 1968.
14. Hoelzer, D. R., G. P. Dalsky, N. S. Schwartz, W. E. Clutter, S. D. Shah, J. O. Holloszy, and P. E. Cryer. Epinephrine is not critical to prevention of hypoglycemia during exercise in humans. Am. J. Physiol. 251 (Endocrinol. Metab. 14): E104-E110, 1986.
15. Issekutz, B. Role of beta-adrenergic receptors in mobilization of energy sources in exercising dogs. J. Appl. Physiol. 44: 869-876, 1978.
16. Kjær, M., K. Engfred, A. Fernandes, N. H. Secher, and H. Galbo. Regulation of hepatic glucose production during exercise in man: role of sympathoadrenergic activity. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E275-E283, 1993.
17. Kjær, M., P. A. Farrell, N. J. Christensen, and H. Galbo. Increased epinephrine response and inaccurate glucoregulation in exercising athletes. J. Appl. Physiol. 61: 1693-1700, 1986.
18. Kjær, M., S. Keiding, K. Engfred, K. Rasmussen, B. Sonne, P. Kirkegård, and H. Galbo. Glucose homeostasis during exercise in humans with a liver or kidney trasplant. Am. J. Physiol. 268 (Endocrinol. Metab. 31): E636-E644, 1995.
19. Kjær, M., G. Perko, N. H. Secher, R. Boushel, N. Beyer, S. Pollack, A. Horn, A. Fernandes, T. Mohr, S. F. Lewis, and H. Galbo. Cardiovascular and ventilatory responses to electrically induced cycling with complete epidural anaesthesia in humans. Acta Physiol. Scand. 151: 199-207, 1994.
20. Kjær, M., N. H. Secher, F. W. Bach, and H. Galbo. Role of motor center activity for hormonal changes and substrate mobilization in exercising man. Am. J. Physiol. 253 (Regulatory Integrative Comp. Physiol. 22): R687-R695, 1987.
21. Kjær, M., N. H. Secher, F. W. Bach, H. Galbo, D. R. Reeves, Jr., and J. H. Mitchell. Hormonal, metabolic, and cardiovascular responses to static exercise in humans: influence of epidural anesthesia. Am. J. Physiol. 261 (Endocrinol. Metab. 24): E214-E220, 1991.
22. Kjær, M., N. H. Secher, F. W. Bach, S. Sheikh, and H. Galbo. Hormonal and metabolic responses to exercise in humans: effect of sensory nervous blockade. Am. J. Physiol. 257 (Endocrinol. Metab. 20): E95-E101, 1989.
23. Krebs, M., K. T. Ragnarsson, and J. Tuckman. Orthostatic vasomotor response in spinal man. Paraplegia 21: 72-80, 1983.
24. Loubatieres-Mariani, M. M., A. L. Loubatieres, and J. P. Blayac. Comparative study of the insulin-secreting effects of L(+) and of D(-) sodium lactate. C. R. Soc. Biol. 170: 833-836, 1976.
25. Mathias, C. J., N. J. Christensen, J. L. Corbett, H. L. Frankel, and J. Spalding. Plasma catecholamines during paroxysmal neurogenic hypertension in quadriplegic man. Circ. Res. 39: 204-208, 1976.
26. Mathias, C. J., N. J. Christensen, H. L. Frankel, and W. S. Peart. Renin release during head-up tilt occurs independently of sympathetic nervous activity in tetraplegic man. Clin. Sci. 59: 251-256, 1980.
27. Mathias, C. J., H. L. Frankel, R. C. Turner, and N. J. Christensen. Physiological responses to insulin hypoglycemic in spinal man. Paraplegia 17: 319-326, 1979.
28. McCloskey, D. I., and J. H. Mitchell. Reflex cardiovascular and respiratory responses originating in exercising muscle. J. Physiol. Lond. 224: 173-186, 1972.
29. Medbø, J. I., and O. M. Sejersted. Plasma potassium changes with high intensity exercise. J. Physiol. Lond. 421: 105-122, 1990.
30. Mitchell, J. H., W. C. Reardon, and D. I. McCloskey. Reflex effects on circulation and respiration from contracting skeletal muscle. Am. J. Physiol. 233 (Heart Circ. Physiol. 2): H374-H378, 1977.
31. Pollack, S. F., K. Axen, N. Spielholz, N. Levin, F. Haas, and K. T. Ragnarsson. Aerobic training effects of electrically induced lower extremity exercises in spinal cord injured people. Arch. Phys. Med. Rehabil. 70: 214-219, 1989.
32. Ragnarsson, K. T., S. Pollack, W. O'Daniel, R. Edgar, J. Petrofsky, and M. S. Nash. Clinical evaluation of computerized functional electrical stimulation after spinal cord injury: A multicenter pilot study. Arch. Phys. Med. Rehabil. 69: 672-677, 1988.
33. Rosell, S., and K. Ballard. Adrenergic neuro-humoral control of lipolysis in adipose tissue. In: Muscle Metabolism During Exercise, edited by B. Pernow and B. Saltin. New York: Plenum, 1971, p. 111-117.
34. Rowell, L. B., J. R. Blackmon, and R. A. Bruce. Indocyanine green clearance and estimated hepatic blood flow during mild to maximal exercise in upright man. J. Clin. Invest. 43: 1677-1690, 1964.
35. Siegel, S., and H. J. Castellan. Non-Parametric Statistics for the Behavioral Sciences (2nd ed.). New York: McGraw-Hill, 1988.
36. Sonne, B., and H. Galbo. Carbohydrate metabolism in fructose-fed and food-restricted running rats. J. Appl. Physiol. 61: 1457-1466, 1986.
37. Stjernberg, L., H. Blumberg, and B. G. Wallin. Sympathetic activity in man after spinal cord injury. Outflow to muscle below the lesion. Brain 109: 695-715, 1986.
38. Tabata, I., Y. Atomi, and M. Miyashita. Blood glucose concentration dependent ACTH and cortisol responses to prolonged exercise. Clin. Physiol. 4: 299-307, 1984.
39. Tajima, F., S. Sagawa, J. Iwamoto, K. Miki, B. J. Freund, J. R. Claybaugh, and K. Shiraki. Cardiovascular, renal, and endocrine responses in male quadriplegics during head-out water immersion. Am. J. Physiol. 258 (Regulatory Integrative Comp. Physiol. 27): R1424-R1430, 1990.
40. Twist, D. J., J. A. Culpepper-Morgan, K. T. Ragnarsson, C. R. Petrillo, and M. J. Kreek. Neuroendocrine changes during functional electrical stimulation. Am. J. Phys. Med. Rehabil. 71: 156-163, 1992.
41. Vissing, J., G. A. Iwamoto, I. E. Fuchs, H. Galbo, and J. H. Mitchell. Reflex control of glucoregulatory exercise responses by group III and IV muscle afferents. Am. J. Physiol. 266 (Regulatory Integrative Comp. Physiol. 35): R824-R830, 1994.
42. Vissing, J., G. A. Iwamoto, K. J. Rybicki, H. Galbo, and J. H. Mitchell. Mobilization of glucoregulatory hormones and glucose by hypothalamic locomotor centers. Am. J. Physiol. 257 (Endocrinol. Metab. 20): E722-E728, 1989.
43. Vissing, J., B. Sonne, and H. Galbo. Role of metabolic feedback regulation in glucose production of running rats. Am. J. Physiol. 255 (Regulatory Integrative Comp. Physiol. 24): R400-R406, 1988.
44. Wallin, B. G., and L. Stjernberg. Sympathetic activity in man after spinal cord injury. Outflow to skin below the lesion. Brain 107: 183-198, 1984.
45. Wasserman, D. H., D. B. Lacy, R. E. Goldstein, P. E. Williams, and A. D. Cherrington. Exercise-induced fall in insulin and increase in fat metabolism during prolonged muscular work. Diabetes 38: 484-490, 1989.
46. Wasserman, D. H., D. B. Lacy, D. R. Green, P. E. Williams, and A. D. Cherrington. Dynamics of hepatic lactate and glucose balances during prolonged exercise and recovery in the dog. J. Appl. Physiol. 63: 2411-2417, 1987.
47. Wasserman, D. H., P. E. Williams, D. B. Lacy, R. E. Goldstein, and A. D. Cherrington. Exercise-induced fall in insulin and hepatic carbohydrate metabolism during muscular work. Am. J. Physiol. 256 (Endocrinol. Metab. 19): E500-E509, 1989.
48. Zambraiski, E. J., M. S. Tucker, C. S. Lakas, S. M. Grassl, and C. G. Scanes. Mechanism of renin release in exercising dog. Am. J. Physiol. 246 (Endocrinol. Metab. 9): E71-E78, 1984.