Effects of melatonin on rat pial arteriolar diameter in vivo

British Journal of Pharmacology

Volumn 127, Issue 7, 1999, Pages 1666-1670

  Régrigny, Olivier ^a   Delagrange, Philippe ^b   Scalbert, Elizabeth ^b   Lartaud Idjouadiene, Isabelle ^a   Atkinson, Jeffrey ^a   Chillon, Jean Marc ^a  

^a UNIVERSITÉ DE LORRAINE   (France)

^b IRIS Institut de Recherches Internationales Servier   (France)

Author keywords

Cerebral arterioles; Cerebral blood bow autoregulation; Melatonin; Potassium channels

Indexed keywords

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; LUZINDOLE; MELATONIN; MUSCARINIC M3 RECEPTOR; MUSCARINIC M3 RECEPTOR ANTAGONIST; N(G) NITROARGININE METHYL ESTER; NITROPRUSSIDE SODIUM; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; TETRYLAMMONIUM;

ANIMAL EXPERIMENT; ARTERIOLE; ARTERY CONSTRICTION; ARTICLE; BRAIN ARTERY; BRAIN BLOOD FLOW; CONCENTRATION RESPONSE; CONTROLLED STUDY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASOCONSTRICTION;

EID: 0032806070     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702714     Document Type: Article

References (21)

1. ARCHER, S.L., HUANG, J.M., HAMPI, V., NELSON, D.P., SHULTZ, P.J. & WEIR, E.K. (1994). Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase. Proc. Natl. Acad. Sci. U.S.A., 91, 7583-7587.
2. BRAYDEN, J.E. & NELSON, M.T. (1992). Regulation of arterial tone by activation of calcium-dependent potassium channels. Science. 256, 532-535.
3. CHILLON, J.M., GHONEIM, S. & BAUMBACH, G.L. (1997). Effects of chronic nitric oxide synthase inhibition on cerebral arterioles in rats. Hypertension, 30, 1097-1104.
4. CHILLON, J.M., HEISTAD, D.D. & BAUMBACH, G.L. (1996). Effects of endothelin receptor inhibition on cerebral arterioles in hypertensive rats. Hypertension, 27, 794-798.
5. Ca) channels. Br. J. Pharmacol., 126, 34P.
6. DAFFERTSHOFER, M. & HENNERICI, M. (1995). Cerebrovascular regulation and vasoneuronal coupling. J. Clin. Ultrasound, 23, 125-138.
7. DUBOCOVICH, M.L. (1995). Melatonin receptors: are there multiple subtypes? Trends Pharmacol. Sci., 16, 50-56.
8. FARACI, F.M. (1989). Effects of endothelin and vasopressin on cerebral blood vessels. Am. J. Physiol., 257, H799-H803.
9. GEARY, G.G., KRAUSE, D.N. & DUCKLES, S.P. (1997). Melatonin directly constricts rat cerebral arteries through modulation of potassium channels. Am. J. Physiol., 273, H1530-H1536.
10. HARPER, S.L. & BOHLEN, H.G. (1984). Microvascular adaptation in the cerebral cortex of adult spontaneously hypertensive rats. Hypertension, 6, 408-419.
11. HEISTAD, D.D., MARCUS, M.L., PIEGORS, D.J. & ARMSTRONG, M.L. (1980). Regulation of cerebral blood flow in atherosclerotic monkeys. Am. J. Physiol., 239, H539-H544.
12. Ca channel activator, NS1619, on rat cerebral artery smooth muscle. Br. J. Pharmacol., 117, 119-129.
13. 2 reactivity and heterogeneity of cerebral blood flow in ischemic, border zone, and normal cortex. Am. J. Physiol., 257, H473-H482.
14. KRAUSE, D.N. & DUBOCOVICH, M.L. (1991). Melatonin receptors. Ann. Rev. Pharmacol. Toxicol., 31, 549-568.
15. PAULSON, O.B. & WALDEMAR, G. (1990). Inhibition of the renin angiotensin system and the autoregulation of cerebral circulation. In Coronary and Cerebrovascular Effects of Antihypertensive Drugs. ed. Atkinson, J., Capdeville, C. & Zannad, F. pp. 129-144. London: Transmedica.
16. RÉGRIGNY, O., DELAGRANGE, P., SCALBERT, E., ATKINSON, J. & LARTAUD-IDJOUADIENE, I. (1998). Melatonin improves cerebral circulation security margin in rats. Am. J. Physiol., 275, H139-H144.
17. REITER, R.J. (1997). Antioxidant actions of melatonin. Advances in Pharmacohgy, 38, 103-117.
18. SHUAIB, A. (1992). Alteration of blood pressure regulation and cerebrovascular disorders in the elderly. Cerebrovasc. Brain Met. Rev., 4, 329-345.
19. SKOOG, I. (1997). The relationship between blood pressure and dementia: a review. Biomed. Pharmacother., 51, 367-375.
20. TING, K.N., DUNN, W.R., DAVIES, D.J., SUGDEN, D., DELAGRANGE, P., GUARDIOLA-LEMAÎTRE, B., SCALBERT, E. & WILSON, V.G. (1997). Studies on the vasoconstrictor action of melatonin and putative melatonin receptor ligands in the tail artery of juvenile Wistar rats. Br. J. Pharmacol., 122, 1299-1306.
21. WEI, E.P., KONTOS, H.A. & PATTERSON, J.L.J. (1980). Dependence of pial arteriolar response to hypercapnia on vessel size. Am. J Physiol., 238, H697-H703.