Genomic instability and alterations in Apc, Mcc and Dcc in Hong Kong patients with colorectal carcinoma

International Journal of Cancer

Volumn 84, Issue 4, 1999, Pages 404-409

  Ko, Josephine Mun Yee ^a   Cheung, Michael Ho Yin ^b   Kwan, Ming Wa ^b   Wong, Chow Ming ^b   Lau, Kwok Wai ^b   Tang, Cecilia Man Ching ^b   Lung, Maria Li ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b TUEN MUN HOSPITAL   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; COLORECTAL CARCINOMA; DNA DETERMINATION; FEMALE; GENE MUTATION; HETEROZYGOSITY LOSS; HONG KONG; HUMAN; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; PATHOGENESIS; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ASIAN CONTINENTAL ANCESTRY GROUP; CHEMOTHERAPY, ADJUVANT; CHINA; COLORECTAL NEOPLASMS; DISEASE-FREE SURVIVAL; DNA REPLICATION; FEMALE; GENES, APC; GENES, DCC; GENES, MCC; GENES, RAS; HONG KONG; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MIDDLE AGED; MUTATION; NEOPLASM STAGING; POLYMERASE CHAIN REACTION; SEQUENCE DELETION; SURVIVAL RATE;

EID: 0032805226     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19990820)84:4<404::AID-IJC13>3.0.CO;2-L     Document Type: Article

References (23)

1. BOYNTON, R.F., BLOUNT, P.L., YIN, J., HUANG, Y., TONG, Y., BROWN, V.L., MCDANIEL, T., NEWKIRK, C., RESAU, J.H. and MELTZER, S.J., Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers. Proc. nat. Acad. Sci. (Wash.), 89, 3385-3388 (1992).
2. DIX, B.R., ROBBINS, P., SOONG, R., JENNER, D., HOUSE, A.K., IACOPETTA, B.J. and THE GENETIC SURGEONS AT SIR CHARLES GAIRDNER HOSPITAL, The common molecular genetic alterations in Duke's B and C colorectal carcinomas are not short-term prognostic indicators of survival. Int. J. Cancer, 59, 747-751 (1994).
3. DUGGAN, B.D., FELIX, J.C., MUDERSPACH, L.I., TOURGEMAN, D., ZHENG, J. and SHIBATA, D., Microsatellite instability in sporadic endometrial carcinoma. J. nat. Cancer Inst., 86, 1216-1221 (1994).
4. FEARON, E.R. and VOGELSTEIN, B., A genetic model for colorectal tumorigenesis. Cell, 61, 759-767 (1990).
5. HAHN, S.A., SCHUTTE, M., HOQUE, A.T., MOSKALUK, C.A., DA COSTA, L.T., ROZENBLUM, E., WEINSTEIN, C.L., FISCHER, A., YEO, C.J., HRUBAN, R.H. and KERN, S.E., DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science, 271, 350-353 (1996).
6. HOANG, J.M., COTTU, P.H., THUILLE, B., SALMON, R.J., THOMAS, G. and HAMELIN, R., BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines. Cancer Res., 57, 300-303 (1997).
7. HUANG, Y., BOYNTON, R.F., BLOUNT, P.L., SILVERSTEIN, R.J., YIN, J., TONG, Y., MCDANIEL, T.K., NEWKIRK, C., RESAU, J.H., SRIDHARA, R., REID, B.J. and MELTZER, S.J., Loss of heterozygosity involving multiple tumor suppressor genes in human esophageal cancers. Cancer Res., 52, 6525-6530 (1992).
8. IACOPETTA, B., DIGRANDI, S., DIX, B., SOONG, C.R. and HOUSE, A., Loss of heterozygosity of tumor suppressor gene loci in human colorectal carcinoma. Europ. J. Cancer, 30A, 664-670 (1994).
9. IACOPETTA, B.J., WELCH, J., SOONG, R., HOUSE, A.K. and ZHOU, X.P., Mutation of the transforming growth factor-beta type II receptor gene in right-sided colorectal cancer: relationship to clinicopathological features and genetic alterations. J. Pathol., 184, 390-395 (1998).
10. KERN, S.E., FEARON, E.R., TERSMETTE, K.W.F., ENTERLINE, J.P., LEPPERT, M., NAKAMURA, Y., WHITE, R., VOGELSTEIN, B. and HAMILTON, S.R., Allelic loss in colorectal carcinoma. J. Amer. med. Assoc., 261, 3099-3103 (1989).
11. KO, J.M.Y., CHEUNG, M.H.Y., WONG, C.M., LAU, K.W., TANG, C.M.C., KWAN, M.W. and LUNG, M.L., Ki-ras codon 12 point mutational activation in Hong Kong colorectal carcinoma patients. Cancer Lett., 134, 169-176 (1998).
12. LEUNG, C.S., CHEUNG, M.H.Y., WONG, C.M., LAU, K.W., TANG, C.M.C. and LUNG, M.L., p53 mutations detected in colorectal carcinoma patients in Hong Kong. Cancer Epidemiol. Biomarkers Prevent., 6, 925-930 (1997).
13. LIU, B. AND 12 OTHERS, Analysis of mismatch repair genes in hereditary nonpolyposis colorectal cancer patients. Nature (Med.), 2, 169-174 (1996).
14. LOEB, L.A., Mutator phenotype may be required for multi-stage carcinogenesis. Cancer Res., 51, 3075-3079 (1991).
15. LOTHE, R.A. AND 15 OTHERS, Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history. Cancer Res., 53, 5849-5852 (1993).
16. MIYOSHI, Y., NAGASE, H., ANDO, H., HORII, A., ICHII, S., NAKATSURU, S., AOKI, T., MIKI, Y., MORI, T. and NAKAMURA, Y., Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum. mol. Genet., 4, 229-233 (1992).
17. ROEST, P.A.M., ROBERTS, R.G., SUGINO, S., VAN OMMEN, G.J.B, and DEN DUNNEN, J.T., Protein truncation test (PTT) for rapid detection of translation-terminating mutations. Hum. mol. Genet., 2, 1719-1721 (1993)..
18. SPEICHER, M.R., Microsatellite instability in human cancer. Oncol. Res., 7, 267-275 (1995).
19. THIBODEAU, S.N., BREN, G. and SCHAID, D., Microsatellite instability in cancer of the proximal colon. Science, 260, 816-819 (1993).
20. VAN DER LUIJT, R., KHAN, P.M., VASEN, H., VAN LEEUWEN, C., TOPS, C., ROEST, P., DEN DUNNEN, J. and FODDE, R., Rapid detection of translation-terminating mutations at the Adenomatous polyposis coli (Apc) gene by direct protein truncation test. Genomics, 20, 1-4 (1994).
21. VAN LEEUWEN, C., TOPS, C., BREUKEL, C., VAN DER KLIFT, H., FODDE, R. and KHAN, P.M., CA repeat polymorphism at the D5S299 locus linked to adenomatous polyposis coli (APC). Nucleic Acids Res., 19, 5805 (1991).
22. VOGELSTEIN, B., FEARON, E.R., KERN, S.E., HAMILTON, S.R., PREISINGER, A.C., LEPPERT, M., NAKAMURA, Y., WHITE, R., SMITS, A.M.M. and BOS, J.L., Genetic alterations during colorectal-tumor development. N. Engl. J. Med., 319, 525-532 (1988).
23. YAGCI, T., GOKSEL, S., DOGAN, O., OZTURK, M. and YURDUSEV, N., Genomic instability in colorectal cancers in Turkey. Int. J. Cancer, 68, 291-294 (1996).