Leptin concentrations in maternal serum and amniotic fluid during the second trimenon: Differential relation to fetal gender and maternal morphometry

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 86, Issue 2, 1999, Pages 151-157

  Schubring, C ^a   Prohaska, F ^a   Prohaska, A ^a   Englaro, P ^b   Blum, W ^c   Siebler, T ^d   Kratzsch, J ^d   Kiess, W ^d  

^a Agaplesion Evangelisches Krankenhaus Mittelhessen   (Germany)

^b UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^c SAARLAND UNIVERSITY   (Germany)

^d UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Amniotic fluid; BMI; Leptin; Midgestation; Skinfolds

Indexed keywords

LEPTIN;

ADIPOSE TISSUE; ADULT; AMNIOCENTESIS; AMNION FLUID ANALYSIS; ARTICLE; CONTROLLED STUDY; ECHOGRAPHY; FEMALE; FETUS; GENDER; HUMAN; LIPID STORAGE; MAJOR CLINICAL STUDY; OBESITY; PREGNANCY; PRIORITY JOURNAL; RADIOIMMUNOASSAY; SKINFOLD THICKNESS;

EID: 0032800163     PISSN: 03012115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-2115(99)00059-7     Document Type: Article

References (30)

1. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature. 372:1994;425-432.
2. Sinha M.K. Human leptin: the hormone of adipose tissue. Eur J Endocrinol. 136:1997;461-464.
3. Campfield L.A., Smith F.J., Guisez Y., Devos R., Burn P. Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 269:1995;546-549.
4. Halaas J.L., Gajiwala K.S., Maffei M., Cohen S.L., Chait B.T., Rabinowitz D., Lallone R.L., Burley S.K., Friedman J.M. Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 269:1995;543-546.
5. Saladin R., De Vos P., Guerre-Millo M., Leturque A., Girard J., Staels B., Auwern J. Transient increase in obese gene expression after food intake or insulin administration. Nature. 377:1995;527-529.
6. Campfield L.A., Smith F.J., Burn P. The OB protein (leptin) pathway - a link between adipose tissue mass and central neural networks. Horm Metab Res. 28:1996;619-632.
7. Blum W.F., Kiess W., Rascher W. (eds.) Leptin - The voice of the adipose tissue, J&J Edition, JA Barth Verlag, Heidelberg, 1997.
8. Kiess W., Blum W.F., Aubert M.L. Leptin, puberty and reproductive function: lessons from animal studies and observations in humans. Eur J Endocrinol. 138:1997;1-4.
9. Chehab F., Lim M., Lu R. Correction of the sterility defect in homocygous obese female mice by treatment with the human recombinant leptin. Nature Genetics. 12:1996;318-320.
10. Kiess W., Schubring C., Prohaska F., Englaro P., Rascher W., Attanasio A., Blum W.F. Leptin in amniotic fluid at term and at midgestation. Blum W.F., Kiess W., Rascher W. Leptin - The voice of the adipose tissue. J&J Edition :1997;JA Barth Verlag, Heidelberg.
11. Blum W.F., Englaro P., Heiman M., Attanasio Am Kiess W., Rascher W. Clinical studies of serum leptin. Blum W.F., Kiess W., Rascher W. Leptin - The voice of the adipose tissue. J&J Edition :1997;J.A. Barth Verlag, Heidelberg.
12. Blum W.F., Englaro P., Heiman M., Attanasio A.M., Kiess W., Rascher W. Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage and testosterone. J Clin Endocrinol Metab. 82:1997;2904-2910.
13. Schubring C., Kiess W., Englaro P., Rascher W., Dötsch J., Hanitsch S., Attanasio A., Blum W.F. Levels of leptin in maternal serum, amniotic fluid, and arterial and venous cord blood: relation to neonatal and placental weight. J Clin Endocrinol Metab. 82:1997;1480-1483.
14. Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., Ohannesian J.P., Marco C.C., Mckee U., Bauer T.L., Caro J.F. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New Engl J Medicine. 334:1996;292-295.
15. Malmström R., Taskinen M.R., Karonen S.L., Yki-Järvinen H. Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM. Diabetologia. 39:1996;993-996.
16. Hassink S.G., Sheslow D.V., de Lancey E., Opentanova I., Considine R.V., Caro J.F. Serum leptin in children with obesity: Relationship to gender and development. Pediatrics. 98:1996;201-203.
17. Rosenbaum M., Nicolson M., Hirsch J. Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab. 81:1996;3424-3427.
18. Sagawa N., Mori T., Masuzaki H., Ogawa Y., Nakao K. Leptin production by hydatiform mole. Lancet. 350:1997;1518-1518.
19. Butte N.F., Hopkinson J.M., Nicolson M.A. Leptin in human reproduction: serum leptin levels in pregnant and lactating women. J Clin Endocrinol Metab. 82:1997;585-589.
20. Hassink S.G., Spear M.L., de Lancey E., et al. Placental leptin: An important new growth factor in intrauterine and neonatal development. Ped Res. 41:1997;A232.
21. Manzzoros C.S., Varvarigou A., Kaklamani V.G., Beratis N.G., Flier J.S. Effect of birth weight and maternal smoking on cord blood leptin concentrations of full-term and preterm newborns. J Clin Endocrinol Metab. 82:1997;2856-2861.
22. Highman T.J., Friedman J.E., Huston L.P., Wong W.W., Catalano P.M. Longitudinal changes in maternal serum leptin concentrations, body composition and resting metabolic rate in pregnancy. Amer J Obstet Gynecol. 178:1998;1010-1015.
23. Schubring C., Englaro P., Siebler T., Blum W.F., Demirakca T., Kratzsch J., Kiess W. Longitudinal analysis of maternal serum leptin levels during pregnancy, at birth and up to six weeks after birth: relation to body mass index, skinfolds, sex steroids and umbilical cord blood leptin levels. Horm. Res. 50:1998;276-283.
24. Masuzaki H., Ogawa Y., Sagawa N., et al. Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med. 3:1997;1029-1033.
25. Cousins L., Rigg L., Hollingsworth D., Brink G., Aurand J., Yen S.S.C. The 24-hour excursion and diurnal rhythm of glucose, insulin, and C-peptide in normal pregnancy. Am J Obstet Gynecol. 136:1980;483-488.
26. Catalano P.M., Tyzbir E.D., Roman N.M., Amini S.B., Sims E.A.H. Longitudinal changes in insulin release and insulin resistance in nonobese pregnant women. Am J Obstet Gynecol. 165:1991;1667-1672.
27. Buchanan T.A., Metzger B.E., Freinkel N., Bergman R.N. Insulin sensitivity and B-cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild gestational diabetes. Am J Obstet Gynecol. 162:1990;1008-1014.
28. Havel P.J., Kasim-Karakas S., Dubuc G.R., Müller W., Phinney S.D. Gender differences in plasma leptin concentrations. Nat Med. 2:1996;949-950.
29. Hardie L., Trayhurn P., Abramovich D., Fowler P. Circulating leptin in women: a longitidinal study in the menstrual cycle and during pregnancy. Clin. Endocrinol. 47:1997;101-106.
30. Hay D.L. Placental histology and the production of human choriongonadotropin and its subunits in pregnancy. Brit Obstet Gynecol. 95:1988;1268-1270.