Neurohumoral control of the exocrine pancreas

Current Opinion in Gastroenterology

Volumn 15, Issue 5, 1999, Pages 380-384

  Shetzline, Michael A ^a   Liddle, Rodger A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLASE; BICARBONATE; BOMBESIN; CALCITONIN GENE RELATED PEPTIDE; CARRIER PROTEIN; CHOLECYSTOKININ; CHOLECYSTOKININ B RECEPTOR; CHOLINERGIC RECEPTOR; DIAZEPAM BINDING INHIBITOR; DOPAMINE; ENKEPHALIN; GASTRIN; GASTRIN RELEASING PEPTIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; HISTAMINE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; INSULIN; NEUROHORMONE; NEUROPEPTIDE Y; NEUROTENSIN; PANCREAS POLYPEPTIDE; PANCREASTATIN; PEPTIDE YY; PROTIRELIN; SECRETIN; SODIUM ION; VASOACTIVE INTESTINAL POLYPEPTIDE;

ACINAR CELL; ARTICLE; HORMONE RELEASE; HUMAN; NEGATIVE FEEDBACK; NEUROPHYSIOLOGY; NONHUMAN; PANCREAS DUCT; PANCREAS SECRETION; PARASYMPATHETIC INNERVATION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; SODIUM TRANSPORT;

EID: 0032799504     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001574-199909000-00002     Document Type: Article

References (24)

1. 1 Abuladze N, Lee I, Newman D, Hwang J, Boorer K, Pushkin A, et al.: Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter. J Biol Chem 1998, 273:17689-17695. This paper reports the molecular cloning of the human pancreatic sodium-bicarbonate cotransporter. Established molecular techniques were used to demonstrate expression in the human pancreas and, to a lesser extent, in the kidney, brain, liver, and stomach. In the pancreas, in situ hybridization localized expression to acinar and ductal cells; no labeling was found in the pancreatic islets.
2. 2 Liddle RA: Regulation of cholecystokinin secretion by intraluminal releasing factors. Am J Physiol 1995, 269:G319-G27
3. 3 Wank SA: G protein-coupled receptors in gastrointestinal physiology. I. CCK receptors: an exemplary family. Am J Physiol 1998, 274:G607-G613. This excellent review of the features of the CCK and gastrin family of GPCRs provides insight into the biochemical properties of the CCK and gastrin receptors, including their ligands, localization, function, coupling, and structural basis for hormone-receptor binding.
4. 4 Go WY, Holicky EL, Hadac EM, Rao RV, Miller LJ: Identification of a domain in the carboxy terminus of CCK receptor that affects its intracellular trafficking. Am J Physiol 1998, 275:G56-G62. This study used molecular techniques to investigate the structural determinants responsible for CCK-receptor trafficking. It identifies a region that gets the CCK receptor for internalization.
5. 5 Saillan-Barreau C, Clerc P, Adato M, Escrieut C, Vaysse N, Fourmy D, et al.: Transgenic CCK-B/gastrin receptor mediates murine exocrine pancreatic secretion. Gastroenterology 1998, 115:988-996. Humans, but not rodents, express the CCK-B receptor in the pancreas. This has hampered the use of rats as models of human pancreatic function in functional studies of the CCK-B receptor. These investigators produced a transgenic mouse that expresses the CCK-B receptor in the exocrine pancreas and provides new information on the mechanisms of pancreatic secretion.
6. 6 Liddle RA, Goldfine ID, Williams JA: Bioassay of plasma cholecystokinin in rats: effects of food, trypsin inhibitor, and alcohol. Gastroenterology 1984, 87:542-549.
7. 7 Blevins GT Jr, McCullough SS, Wilbert TN, Isom RM, Chowdhury P, Miller ST: Estradiol alters cholecystokinin stimulus-response coupling in rat pancreatic acini. Am J Physiol 1998, 275:G993-G998.
8. 8 Yamamoto M, Shirohara H, Otsuki M: CCK-, secretin-, and cholinergic-independent pancreatic fluid hypersecretion in protease inhibitor-treated rats. Am J Physiol 1998, 274:G406-G412.
9. 9 Shetzline MA, Liddle RA: Neurohumoral control of the exocrine pancreas. Curr Opin Gastroenterol 1998, 12:423-428.
10. 10 Herzig KH, Wilgus C, Schon I, Tatemoto K, Folsch UR: Regulation of the action of the novel cholecystokinin-releasing peptide diazepam binding inhibitor by inhibitory hormones and taurocholate. Regul Pept 1998, 74:193-198. In rat intestinal mucosal cells, synthetic porcine DBI caused dose-dependent stimulation of CCK release, which was inhibited by somatostatin but not by taurocholate and peptide YY. These findings suggest that DBI and somatostatin act directly on intestinal mucosal cells, but regulation of CCK by taurocholate or peptide YY probably occurs via indirect effects.
11. 11 Ulrich CD, Holtmann M, Miller LJ: Secretin and vasoactive intestinal peptide receptors: members of a unique family of G protein-coupled receptors. Gastroenterology 1998, 114:382-397.
12. 12 Ulrich CD, Wood P, Hadac EM, Kopras E, Whitcomb DC, Miller LJ: Cellular distribution of secretin receptor expression in rat pancreas. Am J Physiol 1998, 275:G1437-G1444.
13. 13 Shetzline MA, Premont RT, Walker JK, Vigna SR, Caron MG: A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor. J Biol Chem 1998, 273:6756-6762.
14. 14 Wettergren A, Wojdemann M, Holst JJ: Glucagon-like peptide-1 inhibits gastropancreatic function by inhibiting central parasympathetic outflow. Am J Physiol 1998, 275:G984-G992.
15. 15 Lee ST, Lee KY, Li P, Coy D, Chang TM, Chey WY: Pituitary adenylate cyclase-activating peptide stimulates rat pancreatic secretion via secretin and cholecystokinin releases. Gastroenterology 1998, 114:1054-1060.
16. 16 Lhoste EF, Levenez F, Chabanet C, Fiszlewicz M, Corring T: Effect of bombesin at low doses on the secretion of the exocrine pancreas and on plasma gastrin concentration in the conscious pig. Regul Pept 1998, 74:41-45.
17. 17 Nishino H, Tsunoda Y, Owyang C: Mammalian bombesin receptors are coupled to multiple signal transduction pathways in pancreatic acini. Am J Physiol 1998, 274:G525-G534. The rat bombesin receptor was shown to activate multiple intracellular pathways, including phospholipase C, protein tyrosine kinase, and phospholipase A2. Each of these second messengers elicited an increase in intracellular calcium and subsequent amylase secretion.
18. 18 Feick P, Gilhaus S, Schulz I: Pervanadate stimulates amylase release and protein tyrosine phosphorylation of paxillin and p125(FAK) in differentiated AR4-2J pancreatic acinar cells. J Biol Chem 1998, 273:16366-16373.
19. 19 Li Y, Jiang YC, Owyang C: Central CGRP inhibits pancreatic enzyme secretion by modulation of vagal parasympathetic outflow. Am J Physiol 1998, 275:G957-G963. Vagal regulation from the brain is a common mechanism of action for many brain-gut peptides.
20. 20 Schmid SW, Modlin IM, Tang LH, Stoch A, Rhee S, Nathanson MH, et al.: Telenzepine-sensitive muscarinic receptors on rat pancreatic acinar cells. Am J Physiol 1998, 274:G734-G741.
21. 21 Park HS, Lee YL, Kwon HY, Chey WY, Park HJ: Significant cholinergic role in secretin-stimulated exocrine secretion in isolated rat pancreas. Am J Physiol 1998, 274:G413-G418. In the isolated perfused rat pancreas, electrical-field stimulation was used to show that intrapancreatic cholinergic neurons potentiate intra-arterially infused secretin-stimulated pancreatic exocrine secretion. This suggests that cholinergic innervation and secretin may have synergistic effects on pancreatic secretion.
22. 22 Masuda M, Kanai S, Miyasaka K: Inhibitory effect of central dopamine on basal pancreatic secretion in conscious rats. Am J Physiol 1998, 274:G29-G34.
23. 23 Nguyen TD, Okolo CN, Moody MW: Histamine stimulates ion transport by dog pancreatic duct epithelial cells through H1 receptors. Am J Physiol 1998, 275:G76-G84.
24. 24 Nguyen TD, Moody MW, Savard CE, Lee SP: Secretory effects of ATP on nontransformed dog pancreatic duct epithelial cells. Am J Physiol 1998, 275:G104-G113. In long-term pancreatic duct epithelial cell cultures, adenosine 5′-triphosphate activates potassium and chloride ion conductance and increases mucin secretion. This effect is mediated by purinergic receptors (P2) via intracellular calcium.