Neurohumoral control of the exocrine pancreas

Current Opinion in Gastroenterology

Volumn 12, Issue 5, 1996, Pages 423-428

  Shetzline, Michael A ^a   Liddle, Rodger A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLECYSTOKININ; NEUROHORMONE; NITRIC OXIDE; PANCREAS POLYPEPTIDE; PEPTIDE;

ADRENERGIC SYSTEM; HORMONAL REGULATION; HORMONE RELEASE; MOLECULAR BIOLOGY; PANCREAS; PANCREAS FUNCTION; PANCREAS SECRETION; PEPTIDERGIC NERVOUS SYSTEM; SHORT SURVEY; SIGNAL TRANSDUCTION; VAGUS NERVE;

EID: 0029851117     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001574-199609000-00003     Document Type: Short Survey

References (29)

1. Layer PH, Chanath, Go VLW, Zinmeister AR, Dimagno EP: Adrenergic modulation on interdigestive pancreatic secretion in humans. Gastroenterology 1992, 103:990-993.
2. Larsson L, Rehfield JF: Peptidergic and adrenergic innervation of pancreatic ganglia. Scand J Gastroenterol 1979, 14:433-437.
3. Li P, Chang M, Chey WY: Neuronal regulation of the release and action of secretin-releasing peptide and secretin. Am J Physiol 1995, 269:G305-G312. Acid-stimulated secretin release is mediated by a secretin-releasing peptide. The authors provided data to support the theory that a vagal afferent pathway is involved in the regulation of the release and action of secretin-releasing peptide and secretin.
4. You CH, Rominger JM, Chey WY: Effects of atropine on the action and release of secretin in humans. Am J Physiol 1982, 242:G608-G611.
5. You CH, Chey WY: Atropine abolishes potentiation effect of secretin and cholecystokinin octapeptide on pancreatic secretion in humans. Pancreas 1988, 3:99-103.
6. Soudah HC, Lu Y, Hasler WL, Owyang C: Cholecystokinin at physiologic levels evokes pancreatic enzyme secretion via a cholinergic pathway. Am J Physiol 1992, 263:G102-G107.
7. Li Y, Owyang C: Vagal afferent pathway mediates physiological action of cholecystokinin on pancreatic enzyme secretion. J Clin Invest 1993, 92:418-424.
8. Kirchgessner AL, Gershon MD: Innervation of the pancreas by neurons in the gut J Neurosci 1990, 10:1626-1642.
9. Kirchgessner AL, Gershon MD: Presynaptic inhibition by serotonin of nerve-mediated secretion of pancreatic amylase. Am J Physiol 1995, 268:G339-G345. The function of serotonergic neurons in isolated pancreatic lobules is evaluated. The secretion of pancreatic amylase in response to serotonin agonists, antagonists, and other neurotransmitters provides evidence for the existence of inhibitory enteropancreatic serotonin input regulating pancreatic exocrine secretion.
10. Maouyco D, Guan D, Rivard N, Adelson JW, Morisset J: Stability of circadian and minor cycles of exocrine pancreatic secretion in atropine-and MK-329-infused rats. Am J Physiol 1995, 268:G251-G259. Basal pancreatic output has a circadian component. Atropine and cholecystokinin A receptor antagonist reduce exocrine secretion but do not abolish the light-dark circadian rhythm.
11. Okumura T, Taylor IL, Pappas TN: Microinjection of TRH analogue into the dorsal vagal complex stimulates pancreatic secretion in rats. Am J Physiol 1995, 269:G328-G334. Pancreatic secretion induced by thyrotropin-releasing hormone is mediated by the the dorsal vagal complex.
12. Glasbrenner B, Dominguez-Munoz E, Riepl RL, Vetsi A, Malfertheiner P: Cholecystokinin and pancreatic polypeptide release in diabetic patients with and without autonomic neuropathy. Dig Dis Sci 1995, 40:406-411. In diabetic patients with and without autonomic neuropathy, the linear correlation of cholecystokinin and PP in response to a test meal was not present in patients with autonomic neuropathy.
13. Putnam WS, Liddle RA, Williams JA: Inhibitory regulation of rat exocrine pancreas by peptide YY and pancreatic polypeptide. Am J Physiol 1989, 256:G698-G703.
14. Okumura T, Pappas TN, Taylor IL: Pancreatic polypeptide microinjection into the dorsal motor nucleus inhibits pancreatic secretion in rats. Gastroenterology 1995, 108:1517-1525. Pancreatic polypeptide in the dorsal motor nucleus, but not the brainstem, inhibited 2-deoxy-D-glucose-stimulated pancreatic exocrine secretion. This response was abolished by vagotomy.
15. Plusczyk T, Bauer M, Marzi I, Harbauer G, Feifel G: Comparative effects of secretin (SED) and cholecystokinin-octapeptide (CCK-8) on pancreatic microcirculation. Dig Dis Sci 1995 40:1199-1206. Both secretin and cholecystokinin modulate pancreatic capillary blood flow.
16. Miyasaka K, Guan D, Liddle RA, Green GM: Feedback regulation by trypsin: evidence for intraluminal CCK-releasing peptide. Am J Physiol 1989, 257:G175-G181.
17. Li Y, Hao Y, Owyang C: Evidence for autoregulation of cholecystokinin secretion during diversion of bile pancreatic juice in rats. Gastroenterology 1995, 109:231-238. Cholecystokinin secretion is stimulated by an intestinal cholecystokinin-releasing peptide. Cholecystokinin stimulates somatostatin release, which in turn inhibits the secretion of a cholecystokinin-releasing peptide.
18. 2.
19. Molero X, Guarner F, Salas A, Mourelle M, Puig V, Malagelada JR: Nitric oxide modulates pancreatic basal secretion and response to cerulein in the rat: effects in acute pancreatitis. Gastroenterology 1995, 108:1855-1862. Inhibition of NO synthesis reduced amylase secretion in vivo and in vitro. In acute pancreatitis, NO synthase inhibitors increase amylasemia, and NO donors improved chemical and histologic evidence of pancreatitis.
20. Patel AG, Toyama MT, Nguyen TN, Cohen GA, Ignarro LJ, Reber HA, Ashley SW: Role of nitric oxide in the relationship of pancreatic blood flow and exocrine secretion in cats. Gastroenterology 1995, 108:1215-1220. Inhibition of NO synthase reduced both secretin- and cholecystokinin-induced pancreatic secretion and blocked the increase in pancreatic blood flow associated with cholecystokinin stimulation.
21. Liu X, Nakano I, Yamaguchi H, Ito T, Goto M, Koyanagi S, Kinjoh M, Nawata H: Protective effect of nitric oxide on development of acute pancreatitis in rats. Dig Dis Sci 1995, 40:2162-2169. Inhibitors of NO synthase exacerbated, whereas NO donors reduced, the severity of pancreatitis in a cerulein-induced rat model of acute pancreatitis.
22. Thimister PWL, Hopman WPM, Sloots CEJ, Rosenbusch G, Willems HL, Trubels FJM, Jansen JBMJ: Role of intraduodenal proteases in plasma cholecystokinin and pancreaticobiliary responses to protein and amino acids. Gastroenterology 1996, 110:567-575. Protein-stimulated cholecystokinin release, gallbladder emptying, and pancreatic enzyme output were significantly lower with instillation of a synthetic protease inhibitor into the small intestine, suggesting that protein digestion is necessary for stimulation of cholecystokinin secretion.
23. Pappas TN, Debas HT, Taylor LL: Peptide YY: mechanism and effect on pancreatic secretion in dogs. Gastroenterology 1985, 89:1387-1392.
24. Lin HC, Doty JE, Reedy TJ, Meyer JH: Inhibition of gastric emptying by sodium oleate depends on the legth of intestine exposed to nutrient. Am J Physiot 1990, 259:G1031-G1036.
25. Tohno H, Sarr MG, Dimagno EP: Intraileal carbohydrate regulates canine postprandial pancreaticobiliary secretion and upper gut motility. Gastroenterology 1995, 109:1977-1985. Infusion of carbohydrate into the ileum, but not the colon, of dogs stimulated pancreated amylase release, peptide YY levels, and delayed gastric emptying and intestinal transit. Peptide YY may play a role in modifying these effects.
26. Logsdon CD: Pancreatic duct cell cultures: there is more to ducts than salty water. Gastroenterology 1995, 109:1005-1009. An excellent editorial review of the physiology and use of pancreatic duct cultures.
27. Bhattacharyya E, Panchal A, Wilkins TJ, Deondarza J, Hootman SR: Insulin, transforming growth factors, and substrates modulate growth of guinea pig pancreatic duct cells in vitro. Gastroenterology 1995, 109:944-952. Using cultured guinea pig pancreatic duct epithelia, the authors evaluated the effects of regulatory peptides, identifying the importance of insulin, transforming growth factors, and other components in regulating exocrine cell division.
28. Smith JP, Fantaskey AP, Liu G, Zagon IS: Identification of gastrin as a growth peptide in human pancreatic cancer. Am J Physiol 1995, 268:R135-R141. In several pancreatic cancer cell lines, gastrin, acting through cholecystokinin B and gastrin type receptors, promoted cell growth.
29. Rosewicz S, Stier U, Brembeck F, Kaiser A, Papadimitriou A, Berdel WE, et al.: Retinoids: effects on growth, differentiation, and nuclear receptor expression in human pancreatic carcinoma cell lines. Gastroenterology 1995, 109:1646-1660. An evaluation of retinoids on human pancreatic cancer cell lines. Retinoid administration induced differentiation and inhibited growth of pancreatic duct cells but not acinar cells.