STAT6-deficient mice exhibit normal induction of murine AIDS and expression of immunoglobulin E following infection with LP-BM5 murine leukemia viruses

Journal of Virology

Volumn 73, Issue 8, 1999, Pages 7093-7095

  Morse III, Herbert C ^a,d   Mccarty, Thomas ^a   Giese, Nathalia A ^a   Taddesse Heath, Lekidelu ^a   Grusby, Michael J ^b,c  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; IMMUNOGLOBULIN E; INSULIN RECEPTOR; INTERLEUKIN 4; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ARTICLE; B LYMPHOCYTE ACTIVATION; CELL DIFFERENTIATION; CELL PROLIFERATION; ENZYME ACTIVITY; GENE REPLICATION; GENETIC TRANSCRIPTION; GENOTYPE; LYMPHOCYTE PROLIFERATION; MOUSE; MURINE LEUKEMIA VIRUS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VIRUS INFECTION;

EID: 0032798399     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.8.7093-7095.1999     Document Type: Article

References (20)

1. Chattopadhyay, S. K., D. N. Sengupta, T. N. Fredrickson, H. C. Morse III, and J. W. Hartley. 1991. Characteristics and contributions of defective, ecotropic, and mink cell focus-inducing viruses involved in a retrovirus-induced immunodeficiency syndrome of mice. J. Virol. 65:4232-4241.
2. + subset regulation in viral infection. J. Immunol. 148:182-188.
3. + T cells. J. Virol. 68:5819-5824.
4. Hartley, J. W., T. N. Fredrickson, R. A. Vetter, M. Makino, and H. C. Morse III. 1989. Retrovirus-induced murine acquired immunodeficiency syndrome: natural history of infection and differing susceptibility of inbred mouse strains. J. Virol. 63:1223-1231.
5. Hilton, D. J., J.-G. Zhang, D. Metcalf, W. S. Alexander, N. A. Nicola, and T. A. Wilson. 1996. Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Proc. Natl. Acad. Sci. USA 93:497-501.
6. + T cells lacking Thy-1 is expanded in a murine retrovirus-induced immunodeficiency syndrome, MAIDS. Eur. J. Immunol. 20:2783-2787.
7. Hou, J., U. Schindler, W. J. Henzel, T. C. Ho, M. Brasseur, and S. L. McKnlght. 1994. An interleukin-4-induced transcription factor: 1L-4 Stat. Science 245:1701-1705.
8. Johnson, J. A., L.-M. Wang, E. P. Hanson, X.-J. Sun, M. F. White, S. A. Oakes, J. H. Pierce, and J. J. O'Shea. 1995. Interleukins 1, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. J. Biol. Chem. 270:28527-28530.
9. Jolicoeur, P. 1991. Murine acquired immunodeficiency syndrome (MAIDS): an animal model to study the AIDS pathogenesis. FASEB J. 5:2398-2405.
10. Kaplan, M. H., U. Schindler, S. T. Smiley, and M. J. Grusby. 1996. Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells. Immunity 4:313-319.
11. Klinman, D. M., and H. C. Morse III. 1989. Characteristics of B cell proliferation and activation in murine AIDS. J. Immunol. 142:1144-1149.
12. Morawetz, R. A., T. M. Doherty, N. A, Giese, J. W. Hartley, W. Müller, R. Kühn, K. Rajewsky, R. Coffman, and H. C. Morse III. 1994. Resistance to murine acquired immunodeficiency syndrome (MAIDS). Science 265:264-267.
13. Morawetz, R. A., L. Gabriele, L. V. Rizzo, N. Noben-Trauth, R. Kühn, K. Rajewsky, W. Müller, T. M. Doherty, F. Finkelman, R. L. Coffman, and H. C. Morse III. 1996. Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse. J. Exp. Med. 184:1651-1661.
14. Morawetz, R. A., N. A. Giese, L. Gabriele, P. Rothman, I. Horak, K. Ozato, and H. C. Morse III. 1998. Relationship of cytokines and cytokine signaling to immunodeficiency disorders in the mouse. Braz. J. Med. Biol. Res. 31: 61-67.
15. Morse, H. C., III, S. K. Chattopadhyay, M. Makino, T. N. Fredrickson, A. W. Hügin, and J. W. Hartley. 1992. Retrovirus-induced immunodeficiency in the mouse: MAIDS as a model for AIDS. AIDS 6:607-621.
16. Mosley, B., M. P. Beckmann, C. J. March, R. L. Idzerda, S. D. Gimpel, T. vandenBos, D. Friend, A. Alpert. D. Anderson, J. Jackson, J. M. Wignall, C. Smith, B. Gallis, J. E. Sims, D. Urdal, M. B. Widmer, D. Cosman, and L. S. Park. 1989. The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms. Cell 59:335-348.
17. Reichel, M., B. H. Nelson, P. D. Greenberg, and P. B. Rothman. 1997. The IL-4 receptor α-chain cytoplasmic domain is sufficient for activation of JAK-1 and STAT6 and the induction of IL-4-specific gene expression. J. Immunol. 158:5860-5867.
18. Shimoda, K., J. vanDeursen, M. Y. Sangster, S. R. Sarawar, R. T. Carson, R. A. Tripp, C. Chu, F. W. Quelle, T. Nosaka, D. A. A. Vignali, P. C. Doherty, G. Grosveld, W. E. Paul, and J. N. Ihle. 1996. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380:630-633.
19. Uehara, S., Y. Hitoshi, F. Numata, M. Makino, M. Howard, T. Mizuochi, and K. Takatsu. 1994. An IFN-γ-dependent pathway plays a critical role in the pathogenesis of murine immunodeficiency syndrome induced by LP-BM5 murine leukemia virus. Int. Immunol. 6:1937-1947.
20. Zamorano, J., H. Y. Wang, L.-M. Wang, J. H. Pierce, and A. D. Keegan. 1996. IL-4 protects cells from apoptosis via the insulin receptor substrate pathway and a second independent signaling pathway. J. Immunol. 157:4926-4934.