Hepatic dendritic cells: Immunobiology and role in liver transplantation

Journal of Leukocyte Biology

Volumn 66, Issue 2, 1999, Pages 322-330

  Thomson, A W ^a   Drakes, M L ^b   Zahorchak, A F ^b   O'Connell, P J ^b   Steptoe, R J ^b   Qian, S ^b   Lu, L ^b  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b NONE

Author keywords

Immunity; Tolerance

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR;

ANTIGEN PRESENTATION; ARTICLE; CELL MIGRATION; CELLULAR DISTRIBUTION; DENDRITIC CELL; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOHISTOCHEMISTRY; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; LIVER TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0032796057     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.66.2.322     Document Type: Article

References (68)

1. Murase, N., Starzl, T. E., Ye, Q., Tsamandas, A., Thomson, A. W., Rao, A. S., Demetris, A. J. (1996) Multilineage hematopoietic reconstitution of supralethally irradiated rats by syngeneic whole organ transplantation. With particular reference to the liver. Transplant. 61, 1-4.
2. Kamada, N. (1993) Animal models of liver transplantation and their clinical relevance. In Immunology of Liver Transplantation (J. Neuberger and D. Adams, eds.), Boston: Little Brown, 161-186.
3. Wood, K., Farges, O. (1993) Tolerance. In Immunology of Liver Transplantation (J. Neuberger and D. Adams, eds.), Boston: Little Brown, 139-151.
4. Qian, S., Thai, N. L., Lu, L., Fung, J. J., Thomson, A. W. (1997) Liver transplant tolerance: mechanistic insights from animal models, with particular reference to the mouse. Transplant. Rev. 11, 151-164.
5. Lechler, R. I., Batchelor, J. R. (1982) Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells. J. Exp. Med. 155, 31-41.
6. Larsen, C. P., Morris, P. J., Austyn, J. M. (1990) Migration of dendritic leukocytes from cardiac allografts into host spleens: a novel pathway for initiation of rejection. J. Exp. Med. 171, 307-314.
7. Austyn, J. M. (1993) The initiation of immune responses and allograft rejection. In Immunology of Heart and Lung Rejection (M. L. Rose and M. H. Yacoub, eds.), Boston: Little Brown, 22-41.
8. Thomson, A. W., Lu, L., Murase, N., Demetris, A. J., Rao, A. S., Starzl, T. E. (1995) Microchimerism, dendritic cell progenitors and transplantation tolerance. Stem Cells 13, 622-639.
9. Viney, J. L., Mowat, A. M., O'Malley, J. M., Williamson, E., Fanger, N. A. (1998) Expanding dendritic cells in vivo enhances the induction of oral tolerance. J. Immunol. 160, 5815-5825.
10. Thomson, A. W., Lu, L., Steptoe, R. J., Starzl, T. E. (1996) Dendritic cells and the balance between transplant tolerance and immunity. In Immune Tolerance (R. Schwartz and J. Banchereau, eds), Paris: Elsevier, 173-185.
11. Starzl, T. E., Thomson, A. W., Murase, N., Demetris, A. J. (1996) Liver transplants contribute to their own success. Nature Med. 2, 163-165.
12. Thomson, A. W., Lu, L. (1999) Are dendritic cells the key to liver transplant tolerance? Immunol. Today 20, 27-32.
13. Bishop, G. A., Sun, J., DeCruz, D. J., Rokahr, K. L., Sedgwick, J. D., Sheil, A. G., Gallagher, N. D., McCaughan, G. W. (1996) Tolerance to rat liver allografts: III. Donor cell migration and tolerance-associated cytokine production in peripheral lymphoid tissues. J. Immunol. 156, 4925-4931.
14. Wood, K. J., Sachs, D. H. (1996) Chimerism and transplantation tolerance: cause and effect. Immunol. Today 17, 584-587.
15. Inaba, K., Witmer-Pack, M., Inaba, M., Hathcock, K. S., Sakuta, H., Azuma, M., Yagita, H., Okumura, K., Linsley, P. S., Ikehara, S., Muramatsu, S., Hodes, R. J., Steinman, R. M. (1994) The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro. J. Exp. Med. 180, 1849-1860.
16. Shaw, S. G., Maung, A. A., Steptoe, R. J., Thomson, A. W., Vujanović, N. L. (1998) Expansion of functional NK cells in multiple tissue compartments of mice treated with Flt3-Ligand: implications for anti-cancer and anti-viral therapy. J. Immunol. 161, 2817-2124.
17. Matsuno, K., Ezaki, T., Kudo, S., Uehara, Y. (1996) A life stage of particle-laden rat dendritic cells in vivo: their terminal division, active phagocytosis, and translocation from the liver to the draining lymph. J. Exp. Med. 183, 1865-1878.
18. Kudo, S., Matsuno, K., Ezaki, T., Ogawa, M. (1997) A novel migration pathway for rat dendritic cells from the blood: hepatic sinusoids-lymph translocation. J. Exp. Med. 185, 777-784.
19. Valdivia, L. A., Demetris, A. J., Langer, A. M., Celli, S., Fung, J. J., Starzl, T. E. (1993) Dendritic cell replacement in long-surviving liver and cardiac xenografts. Transplant. 56, 482-484.
20. Matsuno, K., Kudo, S., Ezaki, T., Miyakawa, K. (1995) Isolation of dendritic cells in the rat liver lymph. Transplant. 60, 765-768.
21. Sun, J., McCaughan, G. W., Gallagher, N. D., Sheil, A. G. R., Bishop, G. A. (1995) Deletion of spontaneous rat liver allograft acceptance by donor irradiation. Transplant. 60, 233-236.
22. Maraskovsky, E., Brasel, K., Teepe, M. Roux, E. R., Lyman, S. D., Shortman, K., McKenna, H. J. (1996) Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified. J. Exp. Med. 184, 1953-1962.
23. Steptoe, R. J., Fu, F., Li, W., Drakes, M. L., Lu, L., Demetris, A. J., Qian, S., McKenna, H. J, Thomson, A. W. (1997) Augmentation of dendritic cells in murine organ donors by Flt3 ligand alters the balance between transplant tolerance and immunity. J. Immunol. 159, 5483-5491.
24. Shurin, M. R., Pandharipande, P. P, Zorina, T. D., Haluszczak, C., Subbotin, V. M., Hunter, O., Brumfield, A., Storkus, W. J., Maraskovsky, E., Lotze, M. T. (1997) Flt3 ligand induces the generation of functionally active dendritic cells in mice. Cell. Immunol. 179, 174-184.
25. Woo, J., Lu, L., Rao, A., Li, L., Subbotin, V., Starzl, T. E., Thomson, A. W. (1994) Isolation, phenotype and allostimulatory activity of mouse liver dendritic cells. Transplant. 58, 484-491.
26. Steinman, R. M. (1991) The dendritic cell and its role in immunogenicity. Annu. Rev. Immunol. 9, 271-296.
27. Lautenschlager, I., Halttunen, J., Hayry, P. (1988) Characteristics of dendritic cells in rat liver. Transplant. 45, 936-939.
28. Inaba, K., Inaba, M., Romani, N., Aya, H., Deguchi, M., Ikehara, S., Muramatsu, S., Steinman, R. M. (1992) Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176, 1693-1702.
29. Inaba, K., Steinman, R. M., Pack, M. W., Aya, H., Inaba, M., Sudo, T., Wolpe, S., Schuler, G. (1992) Identification of proliferating dendritic cell precursors in mouse blood. J. Exp. Med. 175, 1157-1167.
30. Lu, L, Woo, J, Rao, A. S., Li, Y., Watkins, S. C., Qian, S., Starzl, T. E., Demetris, A. J., Thomson, A. W. (1994) Propagation of dendritic cell progenitors from normal mouse liver using GM-CSF and their maturational development in the presence of typel collagen. J. Exp. Med. 179, 1823-1834.
31. Drakes, M. L., Lu, L., Subbotin, V. M., Thomson, A. W. (1997) In vivo administration of flt3 ligand markedly stimulates generation of dendritic cell progenitors from mouse liver. J. Immunol. 159, 4268-4278.
32. Drakes, M. L., Lu, L., McKenna, H. J., Thomson, A. W. (1997) The influence of collagen, fibronectin and laminin on the maturation of dendritic cell progenitors propagated from normal or Flt3-ligand-treated mouse liver. Adv. Exp. Biol. Med. 417, 115-120.
33. McFadden, G., Kelvin, D. (1997) New strategies for chemokine inhibition and modulation: you take the high road and I'll take the low road. Bio. Pharmacol. 54, 1271-1280.
34. Steinman, R. M., Cohn, Z. A. (1973) Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J. Exp. Med. 137, 1142-1162.
35. Vremec, D., Zorbas, M., Scollay, R., Saunders, D. J., Ardavin, C. F., Wu, L., Shortman, K. (1992) The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells. J. Exp. Med. 176, 47-58.
36. Pulendran, B., Lingappa, J., Kennedy, M. K., Smith J., Teepe, M., Rudensky, A., Maliszewski, C. R., Maraskovsky, E. (1997) Developmental pathways of dendritic cells in vivo: distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice. J. Immunol. 159, 2222-2231.
37. Vremec, D., Shortman, K. (1997) Dendritic cell subtypes in mouse lymphoid organs: cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes. J. Immunol. 159, 565-573.
38. Suss, G., Shortman, K. (1996) A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis. J. Exp. Med 183, 1789-1796.
39. Ardavin, C., Wu, L., Li, C. L., Shortman, K. (1993) Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population. Nature 362, 761-763.
40. Kronin, V., Vremec, D., Winkel, K., Classon, B. J., Miller, R. G., Mak, T. W., Shortman, K., Suss, G. (1997) Are CD8 dendritic cells (DC) veto cells? The role of CD8 on DC in DC development and in the regulation of CD4 and CD8 T cell responses. Int. Immunol. 9, 1061-1064.
41. Saunders, D., Lucas, K., Ismaili, J., Wu, L., Maraskovsky, E., Dunn, A., Shortman, K. (1996) Dendritic cell development in culture from thymic precursor cells in the absence of granulocyte/macrophate colony-stimulating factor. J. Exp. Med. 184, 2185-2196.
42. Wu, L., Vremec, D., Ardavin, C., Winkel, K., Suss, G., Georgiou, H., Maraskovsky, E., Cook, W., Shortman, K. (1995) Mouse thymus dendritic cells: kinetics of development and changes in surface markers during maturation. Eur. J. Immunol. 25, 418-425.
43. Kronin, V., Winkel, K., Suss, G., Kelso, A., Heath, W., Kirberg, J., von Boehmer, H., Shortman, K. (1996) A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production. J. Immunol. 157, 3819-3827.
44. Thomson, A. W., Lu, L., Subbotin, V. M., Li, Y., Qian, S., Rao, A. S., Fung, J. J., Starzl, T. E. (1995) In vitro propagation and homing of liver-derived dendritic cell progenitors to lymphoid tissues of allogeneic recipients. Implications for the establishment and maintenance of donor cell chimerism following liver transplantation. Transplant. 59, 544-551.
45. Rastellini, C., Lu, L., Ricordi, C., Starzl, T. E., Rao, A. S., Thomson, A. W. (1995) GM-CSF stimulated hepatic dendritic cell progenitors prolong pancreatic islet allograft survival. Transplant. 60, 1366-1370.
46. -) induce alloantigen-specific hyporesponsiveness in murine T lymphocytes. Transplant. 60, 1539-1545.
47. -) prolong cardiac allograft survival in non-immunosuppressed recipients. Transplant. 62, 659-665.
48. Lu, L., Li, W., Fu, F., Chambers, F. G., Qian, S., Fung, J. J., Thomson, A. W. (1997) Blockade of the CD40-CD40 ligand pathway potentiates the capacity of donor-derived dendritic cell progenitors to induce long-term cardiac allograft survival. Transplant. 64, 1808-1815.
49. Lu, L., Qian, S., Hershberger, P., Rudert, W. A., Lynch, D. H., Thomson, A. W. (1997) Fas ligand (CD95L) and B7 expression on dendritic cells provide counter-regulatory signals for T cell survival and proliferation. J. Immunol. 158, 1576-5684.
50. Steinman, R. M., Inaba, K., Austyn, J. M. (1993) Donor-derived chimerism in recipients of organ transplants. Hepatol. 17, 1153-1156.
51. Qian, S., Lu, L., Fu, F., Li, W., Pan, F., Steptoe, R. J., Chambers, F. G., Starzl, T. E., Fung, J. J., Thomson, A. W. (1998) Donor pretreatment with Flt-3 ligand augments antidonor cytotoxic T lymphocyte, natural killer, and lymphokine-activated killer cell activities within liver allografts and alters the pattern of intragraft apoptotic activity. Transplant. 65, 1590-1598.
52. Qian, S., Lu, L., Fu, F., Li, Y., Li, W., Starzl, T. E., Fung, J. J., Thomson, A. W. (1997) Apoptosis within spontaneously accepted mouse liver allografts: evidence for deletion of cytotoxic T cells and implications for tolerance induction. J. Immunol. 158, 4654-4661.
53. Crispe, I. N., Mehal, W. Z. (1996) Strange brew: T cells in the liver. Immunol. Today 17, 522-525.
54. Starzl, T. E., Demetris, A. J., Murase, N., Ildstad, S., Ricordi, C., Trucco, M. (1992) Cell migration, chimerism, and graft acceptance. Lancet 339, 1579-1582.
55. Bardadin, K. A., Desmet, V. J. (1984) Interdigitating and dendritic reticulum cells in chronic active hepatitis. Histopathol. 8, 657-667.
56. Van Den Oord, J. J., De Vos, R., Facchetti, F., Delabie, J., De Wolf-Peeters, C., Desmet, V. J. (1990) Distribution of non-lymphoid, inflammatory cells in chronic HBV infection. J. Pathol. 160, 223-230.
57. Demetris, A. J., Sever, C., Kakizoe, S., Oguma, S., Starzl, T. E., Jaffe, R. (1989) S100 protein positive dendritic cells in primary biliary cirrhosis and other chronic inflammatory liver disease. Relevance to pathogenesis? Am. J. Pathol. 4, 741-747.
58. Ballardini, G., Fallani, M., Bianchi, F. B., Pisi, E. (1989) Antigen presenting cells in liver biopsies from patients with primary biliary cirrhosis. Autoimmunity 3, 135-144.
59. Kaji, K., Nakanuma, Y., Harada, K., Tsuneyama, K., Kaneko, S., Kobayashi, K. (1997) Dendritic cells in portal tracts in chronic hepatitis C and primary billiary cirrhosis with relevance to bile duct damage - an immunohistochemical study. Hepatol. Res. 8, 1-12.
60. Demetris, A. J., Qian, S., Sun, H., Fung, J. J., Yagihashi, A., Murase, N., Iwaki, Y., Gambrell, B., Starzl, T. E. (1991) Early events in liver allograft rejection. Delineation of sites of simultaneous intragraft and recipient lymphoid tissue sensitization. Am. J. Pathol. 138, 609-618.
61. Oguma, S., Banner, B., Zerbe, T., Starzl, T., Demetris, A. J. (1988) Participation of dendritic cells in vascular lesions of chronic rejection of human allografts. Lancet 2, 933-935.
62. Oguma, S., Zerbe, T., Banner, B., Belle, S., Starzl, T. E., Demetris, A. J. (1989) Chronic liver allograft rejection and obliterative arteriopathy: possible pathogenic mechanisms. Transplant. Proc. 21, 2203-2207.
63. Yang, R., Liu, Q., Grosfeld, J. L. Pescovitz, M. D. (1994) Intestinal venous drainage through the liver is a prerequisite for oral tolerance induction. J. Pediatric. Surg. 29, 1145-1148.
64. Roland, C. R., Mangino, M. J., Duffy, B. F., Flye, M. W. (1993) Lymphocyte suppression by Kupffer cells prevents portal venous tolerance induction: a study of macrophage function after intravenous gadolinium. Transplant. 55, 1151-1158.
65. Gorczynski, R. M., Cohen, Z., Fu, X.-M., Hua, Z., Sun, Y., Chen, Z. (1996) Interleukin-13, in combination with anti-interleukin-12, increases graft prolongation after portal venous immunization with cultured allogeneic bone marrow-derived dendritic cells. Transplant. 62, 1592-1600.
66. Lynch, D. H., Andreasen, A., Maraskovsky, E., Whitmore, J., Miller, R. E., Schuh, J. C. L. (1997) Flt3 ligand induces tumor regression and antitumor immune responses in vivo. Nature Med. 3, 625-631.
67. Sozzani, S., Sallusto, F., Luini, W., Zhou, D., Piemonti, L., Allovena, P., Van Damme, J. V., Valitutti, S., Lanzavecchia, A., Mantovani, A. (1995) Migration of dendritic cells in response to formyl peptides, C5a, and a distinct set of chemokines. J. Immunol. 155, 3293-3295.
68. Sozzani, S., Luini, W., Borsatti, A., Polentarutti, N., Zhou, D., Piemonti, L, D'Amico, G., Power, C. A., Wells, T. N. C., Gobbi, M., Allavena, P., Mantovani, A. (1997) Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines. J. lmmunol. 159, 1993-2000.