Characterization of a multi-tissue tumour suppressor and senescence gene

British Journal of Cancer

Volumn 80, Issue SUPPL. 1, 1999, Pages 42-45

  Black, D M ^a  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER GENETICS; CELL AGING; CELL DIVISION; CHROMOSOME 7Q; CONFERENCE PAPER; CONTROLLED STUDY; GENE MAPPING; HUMAN; HUMAN CELL; ONCOGENE; PRIORITY JOURNAL; SENESCENCE; SOLID TUMOR; TISSUE DISTRIBUTION; TUMOR SUPPRESSOR GENE;

ANIMALS; CELL AGING; CHROMOSOMES, HUMAN, PAIR 7; GENES, TUMOR SUPPRESSOR; GENETIC COMPLEMENTATION TEST; HUMANS; NEOPLASMS; NEOPLASMS, EXPERIMENTAL;

EID: 0032794797     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (46)

1. Achille A, Brasi MO, Zamboni G, Bogina G, Magalini AR, Pederzoli P, Perucho M and Scarpa A (1996) Chromosome 7q allelic losses in pancreatic carcinoma. Cancer Res 56: 3808-3813
2. Bieche I, Champeme MH, Matifas F, Hacene K, Callahan R and Lidereau R (1992) Loss of heterozygosity on chromosome 7q and aggressive primary breast cancer. Lancet 339: 139-143
3. Bond JA, Wyllie FS and Wynford-Thomas D (1994) Escape from senescence in human diploid fibroblasts induced directly by mutant p53. Oncogene 9: 1885-1889
4. Brown JP, Wei W and Sedivy JM (1997) Bypass of senescence after disruption of p21CIP/WAFI gene in normal diploid human fibroblats. Science 277: 831-834
5. Bunn CL and Tarrant GM (1980) Limited lifespan in somatic cell hybrids and cybrids. Exp Cell Res 127: 385-396
6. Campisi J (1996) Replicative senescence; an old lives' tale? Cell 23: 497-500
7. Counter CM, Avilion AA, LeFeuvre CE, Stewart NG, Greider CW, Harley CB and Bacchetti S (1992) Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J II: 1921-1929
8. Edington KG, Loughran OP, Berry IJ and Parkinson EK (1995) Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss. Mol Carcinogen 13: 254-265
9. Feng J, Funk WD, Wang SS, Weinrich SL, Avilion AA, Chiu CP, Adams RR, Chang E, Allsopp RC and Yu J, Le S, West MD, Harley CB, Andrews WH, Greider CW and Villeponteau B (1995) The RNA component of human telomerase. Science 269: 1236-1241
10. Hayflick L (1965) The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 37: 614-636
11. Hensler PJ, Annah LA, Barrett JC and Pereira-Smith OM (1994) A gene involved in control of human cellular senescence on human chromosome Iq. Mol Cell Biol 14: 2291-2297
12. Holt SE, Shay JW and Wright WF. (1996) Refining the telomere-telomerase hypothesis of aging and cancer. Nature Biotech 14: 834-837
13. Kerr J, Leary JA, Hurst T, Shih YC, Antalis TM, Friedlander M, Crawford E, Khoo SK, Ward B and Chenevix-Trench G (1996) Allelic loss on chromosome 7q in ovarian adenocarcinomas: two critical regions and a rearrangement of the PLANHI locus. Oncogene 13: 1815-1818
14. Kim NW (1997) Clinical implications of telomerase in cancer. Eur J Cancer 33: 781-786
15. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL and Shay JW (1944) Specific association of human telomerase activity with immortal cells and cancer. Science 266: 2011-2015
16. Koi M, Johnson LA, Kalikin LM, Little PF, Nakamura Y and Feinberg AP (1993) Tumor cell growth arrest caused by subchromosomal transferable DNA fragments from chromosome 11. Science 260: 361-364
17. Koike M, Takeuchi S, Yokota J, Park S, Hatla Y, Miller CW, Tsuruoka N and Koeffler HP (1997) Frequent loss of heterozygosity in the region of the D7S523 locus in advanced ovarian cancer. Gene Chromosomes Cancer 19: 1-5
18. Kuniyasu H, Yasui W, Yokozaki H, Akagi M, Akama Y, Kitahara K, Fujii K and Tahara F. (1994) Frequent loss of heterozygosity of the long arm of chromosome 7 is closely associated with progression of human gastric carcinomas. Int J Cancer 59: 597-600
19. Loughran O, Clark LJ, Bond J, Baker A, Berry IJ, Edington KG, Ly ES, Simmons R, Haw R, Black DM, Newbold RF and Parkinson EK (1997) Evidence for the inactivation of multiple replicative lifespan genes in immortal human squamous cell carcinomas keratinocytes. Oncogene 14: 1955-1964
20. Meyerson M, Counter CM, Eaton EN, Ellisen LW, Steiner P, Caddle SD, Ziaugra L, Biejershergen RL, Davidopff MJ, Lin Q, Bacchetti S, Haber DA and Weinberg RA (1997) hEST2. the putative human telomerase catalytic subunit gene, is upregulated in tumor cells and during immortalization, Cell 90: 785-795
21. Muggleton-Harris AL and DeSimone DW (1980) Replicative potentials of various fusion products between WI-38 and SV40 transformed WI-38 cells and their components. Somatic Cell Genet 6: 689-698
22. Nakabayaslu K, Ogala T, Fujii H, Tahara H, Ide T, Wadhwa R, Kaul SC, Mitsui Y and Ayusawa D (1997) Decrease in amplified telomeric sequences and induction of senescence markers by introduction of human chromosome 7 or its segments in SUSM-I. Exp Cell Res 235: 345-353
23. Ning Y, Weber JL, Killary AM, Ledbetter DH, Smith JR and Pereira-Smith OM (1991) Genetic analysis of indefinite division in human cells: evidence for a cell senescence-related gene(s) on human chromosome 4. Proc Natl Acad Sci USA 88: 5635-5639
24. Ogata T, Ayusawa D, Namha M, Takahashi E, Oshimura M and Oishi M (1993) Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-I, Mol Cell Biol 13: 6036-6043
25. Ogala T, Oshimura M, Namba M, Fujii M, Oishi M and Ayusawa D (1995) Genetic complementation of the immortal phenotype in group D cell lines by introduction of chromosome 7. Jpm J Cancer Res 86: 35-40
26. Ohmura H, Tahara H, Suzuki M, Ide T, Shimizu M, Yoshida MA, Tahara E, Shay JW, Barrett JC and Oshimura M (1995) Restoration of the cellular senescence program and repression of telomerase by human chromosome 3. Jpn J Cancer Res 86: 899-904
27. Pereira-Smith OM and Smith JR (1981) Expression of SV40 T antigen in finite life span hybrids of normal and SV40-transformed fibroblasts. Somatic Cell Genet 7: 411-421
28. Pereira-Smith OM and Smith JR (1983) Evidence for the recessive nature of cellular immortality. Science 221: 964-966
29. Pereira Smith OM and Smith JR (1988) Genetic analysis of indefinite division in human cells: identification of four complementation groups. Proc Natl Acad Sci USA 85: 6042-6046
30. Rheinwald JG and Green H (1975) Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell 6: 331-343
31. Rogan EM, Bryan TM, Hukku B, Maclean K, Chang AC, Moy EL, Englezou A, Warneford SG, Dalla-Pozza L and Reddel RR (1995) Alterations in p53 and p161INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts. Mol Cell Biol 15: 4745-4753
32. Shay JW and Wright WF (1996) Telomerase activity in human cancer. Curr Opin Oncol 8: 66-71
33. Shay JW, Wright WE Brasiskyte D and Van der Haegen BA (1993) E6 of human papillomavirus type 16 can overcome the MI stage of immortalization in human mammary epithelial cells but not in human fibroblasts. Oncogene 8: 1407-1413
34. Sandhu AK, Hubbard K, Kaur GP, Jha KK, Ozer HL and Athwal RS (1994) Senescence of immortal human fibroblasts by the introduction of normal human chromosome 6. Proc Natl Acad Sci USA 91: 5498-5502
35. Takahashi S, Shan AL, Ritland SR, Declacey KA, Bostwick DG, Lieber MM, Thibodeau SN and Jenkins RB (1995) Frequent loss of heterozygosity at 7q31.1 in primary prostate cancer is associated with tumor aggressiveness and progression. Cancer Res 55: 4114-4119
36. Uejima H, Mitsuya K, Kugoh H, Horikawa I and Oshiniura M (1995) Normal human chromosome 2 induces cellular senescence in the human cervical carcinoma cell line Silla, Genes Chromosome Cancer 14: 120-127
37. Wadhwa R, Pereira-Smith OM, Reddel RR, Sugimoto Y, Mitsui Y and Kaul SC (1995) Correlation between complementation group for immortality and the cellular distribution of mortalin. Exp Cell Res 216: 101-106
38. Yamada H. Wake N, Fujimoto S, Barrett JC and Oshimura M (1990) Multiple chromosomes carrying tumur suppressor activity for a uterine endometrial carcinoma cell line identified by microcell-mediated chromosome transfer. Oncogene 5: 1141-1147
39. Zenklusen JC and Conti CJ (1996) Cytogenetic, molecular and functional evidence for novel tumor suppressor genes on the long arm of human chromosome 7. Mol Carcinogen 15: 167-175
40. Zenklusen JC, Oshimuro M, Barrett JC and Conti CJ (1994a) Inhibition of tumorigenicity of a murine squamous cell carcinoma (SCC) cell line by a putative tumor suppressor gene on human chromosome 7. Oncogene 9: 2817-2825
41. Zenklusen JC, Bieche I, Lidereau R and Conti CJ (1994b) (C-A)n microsatellite repeat D7S522 is the most commonly deleted region in human primary breast cancer. Proc Natl Acad Sci USA 91: 12155-12158
42. Zenklusen JC, Thompson JC, Troncoso P, Kagan J and Conti CJ (1994c) Loss of heterozygosity in human primary prostate carcinomas: a possible tumor suppressor gene at 7q31.1. Cancer Res. 54: 6370-6373
43. Zenklusen JC, Thompson JC, Klein-Szanto AJ and Conti CJ (1995a) Frequent loss of hiterozygosity in human primary squamous cell and colon carcinomas at 7q31.1: evidence for a broad range tumor suppressor gene. Cancer Res 55: 1347-1350
44. Zenklusen JC, Weitzel JN, Ball HG and Conti CJ (1995b) Allelic loss at 7q31.1 in human primary ovarian carcinomas suggests the existence of a tumor suppressor gene. Oncogene 11: 359-363
45. Zenklusen JC, Rodriguez LV, LaCava M, Wang Z, Goldstein LS, Conti CJ (1996) Novel susceptibility locus for mouse hepatomas: evidence for a conserved tumor suppressor gene, Genome Res 6: 1070-1076
46. Zenklusen JC, Hodges LC and Conti CJ (1997) Loss of heterozygosity on murine chromosome 6 in two-stage carcinogenesis: evidence for a conserved tumor suppressor gene. Oncogene 14: 109-114