Differences in the effectiveness of delivery of B- and CTL-epitopes incorporated into the hepatitis B core antigen (HBcAg) c/e1-region

Archives of Virology

Volumn 144, Issue 7, 1999, Pages 1323-1343

  Street, M ^a   Herd, K ^a   Londono, P ^b   Doan, T ^a   Dougan, G ^b   Kast, W M ^c   Tindle, R W ^a  

^a ROYAL CHILDREN'S HOSPITAL   (Australia)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c LOYOLA UNIVERSITY HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE; CYTOTOXIC T LYMPHOCYTE; EPITOPE; HEPATITIS B; IMMUNODOMINANCE; VACCINE PRODUCTION;

AMINO ACID SEQUENCE; ANIMALS; EPITOPES, B-LYMPHOCYTE; EPITOPES, T-LYMPHOCYTE; H-2 ANTIGENS; HEPATITIS B CORE ANTIGENS; HEPATITIS B VACCINES; HLA-A ANTIGENS; IMMUNIZATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PLASMIDS; RECOMBINANT PROTEINS; SALMONELLA; T-LYMPHOCYTES, CYTOTOXIC; VACCINES, SYNTHETIC;

HUMAN ECHOVIRUS 1; HUMAN PAPILLOMAVIRUS; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0032789111     PISSN: 03048608     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007050050590     Document Type: Article

References (48)

1. 1. Argos P, Fuller SD (1988) A model for the hepatitis B virus core protein: prediction of antigenic sites and relationship to RNA virus capsid proteins. EMBO J 7: 819-824
2. 2. Beesley KM, Francis MJ, Clarke BE, Beesley JE, Dopping Hepenstal PJ, Clare JJ, Brown F, Romanos MA (1990) Expression in yeast of amino-terminal peptide fusions to hepatitis B core antigen and their immunological properties. Biotechnology 8: 644-649
3. 3. Bertoletti A, Chisari FV, Penna A, Guilhot S, Galati L, Missale G, Fowler P, Schlicht HJ, Vitiello A, Chesnut RC et al. (1993) Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nucleocapsid protein. J Virol 67: 2376-2380
4. 4. Bottcher B, Wynne SA, Crowther RA (1997) Determination of the fold of the core protein of hepatitis B virus by electron cryomicroscopy [see comments]. Nature 386: 88-91
5. 5. Bringas R (1997) Folding and assembly of hepatitis B virus core protein: a new model proposal. J Struct Biol 118: 189-196
6. 6. Brown AL, Francis MJ, Hastings GZ, Parry NR, Barnett PV, Rowlands DJ, Clarke BE (1991) Foreign epitopes in immunodominant regions of hepatitis B core particles are highly immunogenic and conformationally restricted. Vaccine 9: 595-601
7. 7. Chatfield SN, Charles IG, Makoff AJ, Oxer MD, Dougan G, Pickard D, Slater D, Fairweather NF (1992) Use of the nirB promoter to direct the stable expression of heterologous antigens in Salmonella oral vaccine strains: development of a single-dose oral tetanus vaccine. Biotechnology 10: 888-892
8. 8. Clarke BE, Brown AL, Grace KG, Hastings GZ, Brown F, Rowlands DJ, Francis MJ (1990) Presentation and immunogenicity of viral epitopes on the surface of hybrid hepatitis B virus core particles produced in bacteria. J Gen Virol 71: 1109-1117
9. 9. Conway JF, Cheng N, Zlotnick A, Stahl SJ, Wingfield PT, Belnap DM, Kanngiesser U, Noah M, Steven AC (1998) Hepatitis B virus capsid: localization of the putative immunodominant loop (residues 78 to 83) on the capsid surface, and implications for the distinction between c and e-antigens. J Mol Biol 279: 1111-1121
10. 10. Del Val M, Schlicht HJ, Volkmer H, Messerle M, Reddehase MJ, Koszinowski UH (1991) Protection against lethal cytomegalovirus infection by a recombinant vaccine containing a single nonameric T-cell epitope. J Virol 65: 3641-3646
11. 11. Doan T, Chambers M, Street M, Fernando GJ, Herd K, Lambert P, Tindle R (1998) Mice expressing the E7 oncogene of HPV16 in epithelium show central tolerance, and evidence of peripheral anergising tolerance, to E7-encoded cytotoxic T-lymphocyte epitopes. Virology 244: 352-364
12. 12. Everest P, Frankel G, Li J, Lund P, Chatfield S, Dougan G (1995) Expression of LacZ from the htrA, nirB and groE promoters in a Salmonella vaccine strain: influence of growth in mammalian cells. FEMS Microbiol Lett 126: 97-101
13. 13. Feltkamp MC, Smits HL, Vierboom MP, Minnaar RP, de Jongh BM, Drijfhout JW, ter Schegget J, Melief CJ, Kast WM (1993) Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells. Eur J Immunol 23: 2242-2249
14. 14. Finlay BB, Falkow S (1989) Salmonella as an intracellular parasite. Mol Microbiol 3: 1833-1841
15. 15. Fomsgaard A, Freudenberg MA, Galanos C (1990) Modification of the silver staining technique to detect lipopolysaccharide in polyacrylamide gels. J Clin Microbiol 28: 2627-2631
16. 16. Fossum C, Bergstrom M, Lovgren K, Watson DL, Morein B (1990) Effect of iscoms and their adjuvant moiety (matrix) on the initial proliferation and IL-2 responses: comparison of spleen cells from mice inoculated with iscoms and/or matrix. Cell Immunol 129:414-425
17. 17. Gentschev I, Dietrich G, Mollenkopf HJ, Sokolovic Z, Hess J, Kaufmann SH, Goebel W (1997) The Escherichia coli hemolysin secretion apparatus-a versatile antigen delivery system in attenuated Salmonella. Behring Inst Mitt 103-113
18. 18. Hahn HP, Hess C, Gabelsberger J, Domdey H, von Specht BU (1998) A Salmonella typhimurium strain genetically engineered to secrete effectively a bioactive human interleukin (hIL)-6 via the Escherichia coli hemolysin secretion apparatus. FEMS Immunol Med Microbiol 20: 111-119
19. 19. Harding CV, Pfeifer JD (1994) Antigen expressed by Salmonella typhimurium is processed for class I major histocompatibility complex presentation by macrophages but not infected epithelial cells. Immunology 83: 670-674
20. 20. Herd K, Fernando GJ, Dunn LA, Frazer IH, Lambert P, Tindle RW (1997) E7 oncoprotein of human papillomavirus type 16 expressed constitutively in the epidermis has no effect on E7-specific B-or Th-repertoires or on the immune response induced or sustained after immunization with E7 protein. Virology 231: 155-165
21. 21. Hone DM, Wu S, Powell RJ, Pascual DW, Van Cott J, McGhee J, Fouts TR, Tuskan RG, Lewis GK (1996) Optimization of live oral Salmonella-HIV-1 vaccine vectors for the induction of HIV-specific mucosal and systemic immune responses. J Biotechnol 44: 203-207
22. 22. Kuhober A, Pudollek HP, Reifenberg K, Chisari FV, Schlicht HJ, Reimann J, Schirmbeck R (1996) DNA immunization induces antibody and cytotoxic T cell responses to hepatitis B core antigen in H-2b mice. J Immunol 156: 3687-3695
23. 23. Kyte J, Doolittle RF (1982) A simple method for displaying the hydropathic character of a protein. J Mol Biol 157: 105-132
24. 24. Lanford RE, Luckow V, Kennedy RC, Dreesman GR, Notvall L, Summers MD (1989) Expression and characterization of hepatitis B virus surface antigen polypeptides in insect cells with a baculovirus expression system. J Virol 63: 1549-1557
25. 25. Libby SJ, Goebel W, Ludwig A, Buchmeier N, Bowe F, Fang FC, Guiney DG, Songer JG, Heffron F (1994) A cytolysin encoded by Salmonella is required for survival within macrophages. Proc Natl Acad Sci USA 91: 489-493
26. 26. Londono LP, Chatfield S, Tindle RW, Herd K, Gao XM, Frazer I, Dougan G (1996) Immunisation of mice using Salmonella typhimurium expressing human papillomavirus type 16 E7 epitopes inserted into hepatitis B virus core antigen. Vaccine 14: 545-552
27. 27. Pfeifer JD, Wick MJ, Roberts RL, Findlay K, Normark SJ, Harding CV (1993) Phagocytic processing of bacterial antigens for class I MHC presentation to T cells. Nature 361: 359-362
28. 28. Pumpens P, Borisova GP, Crowther RA, Grens E (1995) Hepatitis B virus core particles as epitope carriers. Intervirology 38: 63-74
29. 29. Ressing ME, Sette A, Brandt RM, Ruppert J, Wentworth PA, Hartman M, Oseroff C, Grey HM, Melief CJ, Kast WM (1995) Human CTL epitopes encoded by human papillomavirus type 16 E6 and E7 identified through in vivo and in vitro immunogenicity studies of HLA-A*0201-binding peptides. J Immunol 154: 5934-5943
30. 30. Roberts M, Li J, Bacon A, Chatfield S (1998) Oral vaccination against tetanus: comparison of the immunogenicities of Salmonella strains expressing fragment C from the nirB and htrA promoters. Infect Immun 66: 3080-3087
31. 31. Schodel F, Kelly SM, Peterson D, Milich D, Hughes J, Tinge S, Wirtz R, Curtiss R (1994) Development of recombinant Salmonellae expressing hybrid hepatitis B virus core particles as candidate oral vaccines. Dev Biol Stand 82: 151-158
32. 32. Schodel F, Peterson D, Milich D (1996) Hepatitis B virus core and e antigen: immune recognition and use as a vaccine carrier moiety. Intervirology 39: 104-110
33. 33. Smotkin D, Wettstein FO (1987) The major human papillomavirus protein in cervical cancers is a cytoplasmic phosphoprotein. J Virol 61: 1686-1689
34. 34. Strugnell R, Dougan G, Chatfield S, Charles I, Fairweather N, Tite J, Li JL, Beesley J, Roberts M (1992) Characterization of a Salmonella typhimurium aro vaccine strain expressing the P.69 antigen of Bordetella pertussis. Infect Immun 60: 3994-4002
35. 35. Sztein MB, Wasserman SS, Tacket CO, Edelman R, Hone D, Lindberg AA, Levine MM (1994) Cytokine production patterns and lymphoproliferative responses in volunteers orally immunized with attenuated vaccine strains of Salmonella typhi. J Infect Dis 170: 1508-1517
36. 36. Tacket CO, Kelly SM, Schodel F, Losonsky G, Nataro JP, Edelman R, Levine MM, Curtiss R (1997) Safety and immunogenicity in humans of an attenuated Salmonella typhi vaccine vector strain expressing plasmid-encoded hepatitis B antigens stabilized by the Asd-balanced lethal vector system. Infect Immun 65: 3381-3385
37. 37. Thatte J, Rath S, Bal V (1993) Immunization with live versus killed Salmonella typhimurium leads to the generation of an IFN-gamma-dominant versus an IL-4-dominant immune response. Int Immunol 5: 1431-1436
38. 38. Tindle RW, Smith JA, Geysen HM, Selvey LA, Frazer IH (1990) Identification of B epitopes in human papillomavirus type 16 E7 open reading frame protein. J Gen Virol 71: 1347-1354
39. 39. Tindle RW, Fernando GJ, Sterling JC, Frazer IH (1991) A "public" T-helper epitope of the E7 transforming protein of human papillomavirus 16 provides cognate help for several E7 B-cell epitopes from cervical cancer-associated human papillomavirus genotypes. Proc Natl Acad Sci USA 88: 5887-5891
40. 40. Tindle RW, Herd K, Londono P, Fernando GJ, Chatfield SN, Malcolm K, Dougan G (1994) Chimeric hepatitis B core antigen particles containing B-and Th-epitopes of human papillomavirus type 16 E7 protein induce specific antibody and T-helper responses in immunised mice. Virology 200: 547-557
41. 41. Tindle RW, Croft S, Herd K, Malcolm K, Geczy AF, Stewart T, Fernando GJ (1995) A vaccine conjugate of 'ISCAR' immunocarrier and peptide epitopes of the E7 cervical cancer-associated protein of human papillomavirus type 16 elicits specific Th1-and Th2-type responses in immunized mice in the absence of oil-based adjuvants. Clin Exp Immunol 101: 265-271
42. 42. Tindle RW (1996) Human papillomavirus vaccines for cervical cancer. Curr Opin Immunol 8: 643-650
43. 43. Tsai CM, Frasch CE (1982) A sensitive silver stain for detecting lipopolysaccharide in polyacrylamide gels. Anal Biochem 119: 115-9
44. 44. Turner SJ, Carbone FR, Strugnell RA (1993) Salmonella typhimurium delta aroA delta aroD mutants expressing a foreign recombinant protein induce specific major histocompatibility complex class I-restricted cytotoxic T Lymphocytes in mice. Infect Immun 61: 5374-5380
45. 45. Tzschaschel BD, Guzman CA, Timmis KN, de Lorenzo V (1996) An Escherichia coli hemolysin transport system-based vector for the export of polypeptides: export of Shigalike toxin IIeB subunit by Salmonella typhimurium aroA. Nat Biotechnol 14: 765-769
46. 46. Ulrich R, Nassal M, Meisel H, Kruger DH (1998) Core particles of hepatitis B virus as carrier for foreign epitopes. Adv Virus Res 50: 141-182
47. 47. Vitiello A, Marchesini D, Furze J, Sherman LA, Chesnut RW (1991) Analysis of the HLA-restricted influenza-specific cytotoxic T lymphocyte response in transgenic mice carrying a chimeric human-mouse class I major histocompatibility complex. J Exp Med 173: 1007-1015
48. 48. Xu D, McSorley SJ, Tetley L, Chatfield S, Dougan G, Chan WL, Satoskar A, David JR, Liew FY (1998) Protective effect on Leishmania major infection of migration inhibitory factor, TNF-alpha, and IFN-gamma administered orally via attenuated Salmonella typhimurium. J Immunol 160: 1285-1289