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Volumn 8, Issue 5, 1996, Pages 643-650

Human papillomavirus vaccines for cervical cancer

Author keywords

[No Author keywords available]

Indexed keywords

CANCER VACCINE; VIRUS PROTEIN;

EID: 0030272323     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(96)80080-X     Document Type: Article
Times cited : (80)

References (63)
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    • of outstanding interest. This paper extends the work reported in [46] into the in vivo situation. Immunization of mice with recombinant vaccinia E7/LAMP-1 conveyed enhanced protection against a E7-containing epithelial tumour challenge and in small-tumour-bearing mice it induced remission. Little effect was seen by immunization with recombinant vaccinia E7. This underscores the importance of appropriate with recombinant vaccinia E7. This underscores the importance of appropriate presentation of vaccine antigen and how it may be maximized by rerouting antigen into the MHC class II associated processing machinery. The findings also expose the limitations of recombinant vaccinia exp ressing unmodified tumour antigens.
    • Lin KY, Guarnieri FG, Staveley-O'Carroll KF, Levitsky H, Pardoll DM, Wu TC. Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen. of outstanding interest Cancer Res. 56:1996;21-26 This paper extends the work reported in [46] into the in vivo situation. Immunization of mice with recombinant vaccinia E7/LAMP-1 conveyed enhanced protection against a E7-containing epithelial tumour challenge and in small-tumour-bearing mice it induced remission. Little effect was seen by immunization with recombinant vaccinia E7. This underscores the importance of appropriate with recombinant vaccinia E7. This underscores the importance of appropriate presentation of vaccine antigen and how it may be maximized by rerouting antigen into the MHC class II associated processing machinery. The findings also expose the limitations of recombinant vaccinia exp ressing unmodified tumour antigens.
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    • of special interest. This paper demonstrates the principle of the induction of an enhanced immune response by antigen-pulsed dendritic cells as applied to a CTL epitope of HPV16.
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    • Interleukin-6 and Interleukin-6 soluble receptor regulate proliferation of normal human papillomavirus-immortalized, and carcinoma-derived cervical cells in vitro
    • of special interest. IL-6 stimulates the proliferation of HPV immortalized cervical cells via an epidermal growth factor (EGF) receptor-dependent pathway involving autocrine stimulation by transforming growth factor (TGF)-α and amphiregulin. Blockage of this pathway is a possible strategy for HPV-induced cervical dysplasia.
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    • Both immunization with protein and recombinant vaccinia virus can stimulate CTL specific for the E7 protein of human papilloma virus 16 in H-2d mice
    • of special interest. Immunization of mice with either a vaccinia-E7 recombinant, or E7 protein in MF59 adjuvant, stimulated CTLs with similar fine specificity for E7. This observation is meaningful when considering delivery strategies for E7-mediated therapeutic vaccines in humans.
    • Zhu X, Tommasino M, Vousden K, Sadovnikava F, Rappuoli R, Crawford L, Kast M, Melief CJ, Beverley PC, Stauss HJ. Both immunization with protein and recombinant vaccinia virus can stimulate CTL specific for the E7 protein of human papilloma virus 16 in H-2d mice. of special interest J Immunol. 47:1995;557-563 Immunization of mice with either a vaccinia-E7 recombinant, or E7 protein in MF59 adjuvant, stimulated CTLs with similar fine specificity for E7. This observation is meaningful when considering delivery strategies for E7-mediated therapeutic vaccines in humans.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.