Naringenin and interindividual variability in interaction of coumarin with grapefruit juice

Experimental and Toxicologic Pathology

Volumn 51, Issue 4-5, 1999, Pages 289-293

  Bourian, M ^a   Runkel, M ^a   Krisp, A ^a   Tegtmeier, M ^b   Freudenstein, J ^b   Legrum, W ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b Schaper & Brummer GmbH & Co KG   (Germany)

Author keywords

Coumarin; CYP2A6; Grapefruit juice; Interindividual; Naringenin; Scopoletin; Umbelliferone; Variability

Indexed keywords

AURANTIIN; COUMARIN; CYTOCHROME; CYTOCHROME P2A6; NARINGENIN; SCOPOLETIN; UMBELLIFERONE; UNCLASSIFIED DRUG;

ADULT; CIGARETTE SMOKING; CONFERENCE PAPER; CROSSOVER PROCEDURE; DRUG BIOAVAILABILITY; DRUG EXCRETION; DRUG METABOLISM; DRUG SCREENING; DRUG URINE LEVEL; ENZYME ACTIVITY; FEMALE; FRUIT JUICE; GRAPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; URINALYSIS;

CITRUS X PARADISI; VITIS SP.;

EID: 0032788771     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0940-2993(99)80008-6     Document Type: Conference Paper

References (15)

1. BAILEY DG, SPENCE JD, MUNOZ C, et al.: Interaction of citrus juices with felodepine and nifedipine. Lancet 1991; 337: 268-269.
2. YEE GC, STANELY DL, PESSA LJ, et al.: Effect of grapefruit juice on blood cyclosporin concentration. Lancet 1995; 345: 955-956.
3. KUPFERSCHMIDT HHT, HA HR, ZIEGLER WH, et al: Interaction between grapefruit juice and midazolam in humans. Clin Pharmacol Ther 1995; 58: 20-28.
4. BENTON RE, HONIG PK, ZAMANI K, et al.: Grapefruit juice alters terfenadine pharmacokinetics, resulting in prolongation of repolarization on the electrocardiogram. Clin Pharmacol Ther 1996; 59: 383-388.
5. BAILEY DG, ARNOLD JMO, SPENCE JD: Grapefruit juice and drugs-how significant is the interaction? Clin Pharmacokinet 1994; 26: 91-98.
6. RUNKEL M, BOURIAN M, TEGTMEIER M, LEGRUM W: The character of inhibition of the metabolism of 1,2-benzopyrone (coumarin) by grapefruit juice in human. Eur J Clin Pharmacol 1997; 53: 265-269.
7. EDWARDS DJ, BELLVUE FH, WOSTER PM: Identification of 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor in grapefruit juice. Drug Metabol Disp 1996; 24: 1287-1290.
8. BAILEY DG, ARNOLD JMO, STRONG HA, et al.: Effect of grapefruit juice and naringin on nisoldipine pharmacokinetics. Clin Pharmacol ther 1993; 54: 589-594.
9. RUNKEL M, TEGTMEIER M, LEGRUM W: Metabolic and analytical interactions of grapefruit juice and coumarin. Eur J Clin Pharmacol 1996; 50: 225-230.
10. RUNKEL M, MOELLER A, TEGTMEIER M, et al.: Detection of scopolin in the grapefruit. Fresenius J Anal Chem 1997; 359: 516-520.
11. FERDENADEZ-SALGUERO P, HUFFMAN SM, CHOLERTON S, et al.: A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. Am J Hum Gen 1995; 57(3): 651-660.
12. WULF LW, NAGEL CW: Analysis of phenolic acids and falvanoids by high-pressure-liquid chromatography. J Chromatogr 1976; 116: 270-279.
13. LANGGUTH P, NEUHOFF S, REGARDH C, SPAHN-LANGGUTH H: Grapefruit juice components modify the intestinal permeability of the P-glycoprotein substrate talinolol. Exp Toxic Pathol 1998; 50: 117.
14. KRISP A, BOURIAN M, RUNKEL M, LEGRUM W: Renal elimination of naringin in human in vivo and its absorption in the isolated rat jejunum in vitro. Naunyn-Schmiedeberg's Arch Pharmacol 1998: 358 (Suppl. 2): R496
15. BENET LZ: Intestinal enzymes, P-glycoprotein and their role in drug absorption and metabolism. Exp Toxic Pathol 1998; 50: 92-93.