Effects of flavonoids on glutathione-S-transferase in human blood platelets, rat liver, rat kidney and HT-29 colon adenocarcinoma cell-lines: Potential in drug metabolism and chemoprevention

Medical Science Research

Volumn 27, Issue 7, 1999, Pages 449-451

  Ghazali, R ^a   Waring, R H ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

; and GST isoforms daidzein; ; Flavonoids; Genistein; Glutathione S transferase; Quercetin

Indexed keywords

DAIDZEIN; FLAVONOID; GENISTEIN; GLUTATHIONE TRANSFERASE; QUERCETIN;

ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CHEMOPROPHYLAXIS; COLON ADENOCARCINOMA; CONTROLLED STUDY; DRUG METABOLISM; ENZYME REGULATION; GASTROINTESTINAL TRACT; HUMAN; HUMAN CELL; KIDNEY; LIVER; NONHUMAN; RAT; THROMBOCYTE;

EID: 0032788146     PISSN: 02698951     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Bravo L. Polyphenols: chemistry, dietary sources, metabolism and nutritional significance. Nutrit Rev 1998; 56(11):317-333.
2. Davies MH, Elias E, Acharya S, Cotton W, Faulder GC, Freyer AA, et al. GST1 Null polymorphism of the GST Ml locus-phenotype and genotype studies in patients with primary biliary-cirrhosis. Gut 1993; 34(4):549-553.
3. Sousa D, Marietta MB. Inhibition of cytochrome P450 in rat liver microsomes by the naturally-occurring flavonoid, quercetin. Arch Biochem Biophys 1985; 240:345-357.
4. Eaton EA, Walle UK, Lewis AJ, Hudson T, Wilson AA, Walle. Flavonoids, potent inhibitors of the human P-form phenosulfotransferase. Drug Metabolism and Disposition 1996; 24(2):232-237.
5. Bradford MM. A rapid method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Analyt Biochem 1976; 72:248-254.
6. Habig WH, Jakoby WB. Glutathione S-transferases. Assays for different forms of glutathione S-transferases. Meth Enzymol 1981; 249:398-405.
7. Laemmli UK. Cleavage of structural proteins during the assembly of the head of Bacteriophage T4. Nature 1970; 227:680-685.
8. Towbin H, Staechelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets in procedure and some applications. Proc Natl Acad Sci USA 1979; 76(9):4350-4354.
9. Harada S, Abei M. Human Glutathione-S-transferases. In: Kalow W (editor): Pharmacogenetics of Drug Metabolism. New York: Pergamon Press; 1992. pp. 249-259.
10. Hollman PC, Katan MB. Bioavailability and health effects of dietary flavonols in man. Arch Toxicol Suppl 1998; 20:237-248.
11. Franke AA, Custer LJ, Cerna CM, Narala K. Rapid HPLC analysis of dietary phytoestrogens from legumes and from human urine. P Soc Exp BiolMed 1995:208:18-26.
12. Steinmetz K, Potter JD. Vegetables, fruit and cancer prevention: a review. J Am Diet Assoc 1996; 96(10): 1027-1039.
13. Kuo SM. Dietary flavonoids and cancer prevention: evidence and potential mechanisms. Crit Rev Oncogen 1997; 8(l):47-69.