Differential effects of traumatic brain injury on vesicular acetylcholine transporter and M2 muscarinic receptor mRNA and protein in rat

Journal of Neurotrauma

Volumn 16, Issue 7, 1999, Pages 555-566

  Shao, Lifang ^a   Ciallella, John R ^a   Yan, Hong Qu ^a   Ma, Xiecheng ^a   Wolfson, Brian M ^a   Marion, Donald W ^a   Dekosky, Steven T ^a   Dixon, C Edward ^a,b  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Cholinergic; Cortical impact; M2; Muscarinic; Rat; Vesicular acetylcholine transporter (VAChT)

Indexed keywords

MESSENGER RNA; MUSCARINIC M2 RECEPTOR; PROTEIN; VESICULAR ACETYLCHOLINE TRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CHOLINERGIC SYSTEM; CONTROLLED STUDY; HIPPOCAMPUS; MALE; NEUROTRANSMISSION; NONHUMAN; PATHOGENESIS; PROTEIN ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

EID: 0032787945     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.1999.16.555     Document Type: Article

References (50)

1. 2 receptors. Life Sci. 60, 1015-1021.
2. BERSE, B., and BLUSZTAJN, K. (1995). Coordinated up-regulation of choline acetyltransferase and vesicular acetylcholine transporter gene expression by the retinoic acid receptor α, cAMP, and leukemia inhibitory factor/ciliary neurotrophic factor signaling pathways in a murine septal cell line. J. Biol. Chem. 270, 22101-22104.
3. CARLOS, T.M., CLARK, R.S.B., FRANICOLA-HIGGINS, D., SCHIDING, J.K., and KOCHANEK, P.M. (1997). Expression of endothelial adhesion molecules and recruitment of neutrophils after traumatic brain injury in rats. J. Leukoc. Biol. 61, 279-285.
4. 2 muscarinic receptor protein in rats. Exp. Neurol. 152, 11-19.
5. CLARK, R.S.B., SCHIDING, J.K., KACZOROWSKI, S.L., MARION, D.W., and KOCHANEK, P.M. (1994). Neutrophil accumulation after traumatic brain injury in rats: comparison of weight drop and controlled cortical impact models. J. Neurotrauma 11, 499-506.
6. DASH, P.K., MOORE, A.N., and DIXON, C.E. (1995). Spatial memory deficits, increased phosphorylation of the transcription factor CREB, and induction of the AP-1 complex following experimental brain injury. J. Neurosci. 15, 2030-2039.
7. DEWAR, D., and GRAHAM, D.I. (1996). Depletion of choline acetyltransferase activity but preservation of M1 and M2 muscarinic receptor binding sites in temporal cortex following head injury: a preliminary human postmortem study. J. Neurotrauma 13, 181-187.
8. DIXON, C.E., MA, X., and MARION, D.W. (1997a). Effects of CDP-choline treatment on neurobehavioral deficits after TBI and on hippocampal and neocortical acetylcholine release. J Neurotrauma 14, 161-169.
9. DIXON, C.E., FLINN, P., BAO, J., VENYA, R., and HAYES, R.L. (1997b). Nerve growth factor attenuates cholinergic deficits following traumatic brain injury in rats. Exp. Neurol. 146, 479-490.
10. DIXON, C.E., and HAYES, R.L. (1996). Fluid percussion and cortical impact models of traumatic brain injury, in: Neurotrauma. R.K. Narayan, J.E. Wilberger, Jr., and J.T. Povlishock (eds), McGraw Hill: New York, pp. 1337-1346.
11. DIXON, C.E., BAO, J., LONG, D.A., and HAYES, R.L. (1996). Reduced evoked release of acetylcholine in the rodent hippocampus following traumatic brain injury. Pharmacol. Biochem. Behav. 53, 679-686.
12. DIXON, C.E., and HAYES, R.L. (1995). Rodent models of traumatic brain injury and motor function assessment: controlled cortical impact and fluid percussion models of traumatic brain injury, in: Central Nervous System Trauma: Research Techniques. S.T. Ohnishi and T. Ohnishi (eds), CRC Press: Boca Raton, FL, pp. 255-265.
13. DIXON, C.E., LIU, S.J., JENKINS, L.W., et al. (1995). Time course of increased vulnerability of cholinergic neurotransmission following traumatic brain injury in the rat. Behav. Brain Res. 70, 125-131.
14. DIXON, C.E., HAMM, R.J., TAFT, W.C., and HAYES, R.L. (1994). Increased anticholinergic sensitivity following closed skull impact and controlled cortical impact traumatic brain injury in the rat. J. Neurotrauma 11, 275-287.
15. DIXON, C.E., CLIFTON, G.L., LIGHTHALL, L.W., YAGHMAI, A.A., and HAYES, R.L. (1991). A controlled cortical impact model of traumatic brain injury in the rat. J. Neurosci. Methods 39, 253-262.
16. EIDEN, L.E. (1998). The cholinergic gene locus. J. Neurochem. 70, 2227-2240.
17. ERICKSON, J.D., VAROQUI, H., SCHAFER, M.K., et al. (1994). Functional identification of a vesicular acetylcholine transporter and its expression from a "cholinergic" gene locus. J. Biol. Chem. 269, 21929-21932.
18. FAN, L., YOUNG, P.R., BARONE, F.C., et al. (1996). Experimental brain injury induces differential expression of tumor necrosis factor-alpha mRNA in the CNS. Brain Res. Mol. Brain Res. 36, 287-291.
19. GILMOR, M.L., NASH, N.R., ROGHANI, A., et al. (1996). Expression of the putative vesicular acetylcholine transporter in rat brain and localization in cholinergic synaptic vesicles. J. Neurosci. 16, 2179-2190.
20. GORMAN, L.K., FU, K., HOVDA, D.A., MURRAY, M., and TRAYSTMAN, R.J. (1996). Effects of traumatic brain injury on the cholinergic system in the rat. J. Neurotrauma 13, 457-463.
21. GOSS, J.R., STYREN, S.D., MILLER, P.D., et al. (1995). Hypothermia attenuates the normal increase in interleukin 1β RNA and nerve growth factor following traumatic brain in-jury in the rat. J. Neurotrauma 12, 159-167.
22. GUPTA, A.K., THIRU, S., BRADLEY, J., and MASKELL, L. (1995). Delayed increases in adhesion molecule expression after traumatic brain injury in humans: preliminary results. J. Cereb. Blood Flow Metab. 15, Suppl. 1, S33.
23. HAMM, R.J., DIXON, C.E., GBADEBO, D.M., et al. (1992). Cognitive deficits following traumatic brain injury produced by controlled cortical impact. J. Neurotrauma 9, 11-20.
24. HAYES, R.L., JENKINS, L.W., and LYETH, E.G. (1992). Neurochemical aspects of head injury: role of excitatory neurotransmission. J. Head Trauma 7, 16-28.
25. KACZOROWSKI, S.L., SCHIDING, J.K., TOTH, C.A., and KOCHANEK, P.M. (1995). Effect of soluble complement receptor-1 on neutrophil accumulation after traumatic brain injury in rats. J. Cereb. Blood Flow Metab. 15, 860-864.
26. KAMPFL, A., POSMANTUR, R., NIXON, R., et al. (1996). Mu-calpain activation and calpain-mediated cytoskeletal proteolysis following traumatic brain injury. J. Neurochem. 67, 1575-1583.
27. KATAYAMA, Y., BECKER, D.P., TAMURA, T., AND HOVDA, D.A. (1990). Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury. J. Neurosurg. 73, 889-900.
28. LEONARD, J.R., MARIS, D.O., and GRADY, M.S. (1994). Fluid percussion injury causes loss of forebrain choline acetyltransferase and nerve growth factor receptor immunoreactive cells in the rat. J. Neurotrauma 11, 379-392.
29. LEVEY, A., EDMUNDS, S., KOLIATSOS, V., WILEY, R., and HEILMAN, C. (1995). Expression of ml-m4 muscarinic acetylcholine receptor proteins on rat hippocampus and regulation by cholinergic innervation. J. Neurosci. 15, 4077-4092.
30. MARION, D.W., PENROD, L.E., KELSEY, S.F., et al. (1997). Treatment of traumatic brain injury with moderate hypothermia. N. Engl. J. Med. 336, 540-546.
31. McINTOSH, T.K., SMITH, D.H., and GARDE, E. (1996). Therapeutic approaches for the prevention of secondary brain injury. Eur. J. Anaesthesiol. 13, 291-309.
32. MURDOCH, I., PERRY, E.K., COURT, J.A., GRAHAM, D.I., and DEWAR, D. (1998). Cortical cholinergic dysfunction after human head injury. J. Neurotrauma 15, 295-305.
33. NEWCOMB, J.K., KAMPFL, A., POSMANTUR, R.M., et al. (1997). Immunohistochemical study of calpain-mediated breakdown products to alpha-spectrin following controlled cortical impact injury in the rat. J. Neurotrauma 14, 369-383.
34. O'DELL, D.M., and HAMM, R.J. (1995). Chronic post injury administration of MDL 26,479 (suritozole), a negative modulator at the GABAA receptor, and cognitive impairment in rats following traumatic brain injury. J. Neurosurg. 83, 878-883.
35. PALMER, A.M., MARION, D.W., BOTSCHELLER, M.L., BOWEN, D.M., and DEKOSKY, S.T. (1994). Increased transmitter amino acid concentration in human ventricular CSF after brain trauma. Neuroreport 6, 153-156.
36. 2 receptor antagonist, improves cognitive performance following traumatic brain injury in rats. Brain Res. 686, 37-43.
37. POSMANTUR, R., HAYES, R.L., DIXON, E., and TAFT, W.C. (1994). Neurofilament 68 and neurofilament 200 protein levels decrease after traumatic brain injury. J. Neurotrauma 11, 533-545.
38. POSMANTUR, R., KAMPFL, A., LIU, S.J., et al. (1996). Cytoskeletal derangements of cortical neuronal processes three hours after traumatic brain injury in rats: an immunofluorescence study. J. Neuropathol. Exp. Neurol. 55, 65-80.
39. RAGHUPATHI, R., WELSH, F.A., LOWENSTEIN, D.H., GENNARELLI, T.A., and McINTOSH, T.K. (1995). Regional induction of c-fos and heat shock protein-72 mRNA following fluid-percussion brain injury in the rat. J. Cereb. Blood Flow Metab. 15, 467-473.
40. 2: diverse functional implications of differential synaptic localization. Life Sci. 60, 1031-1038.
41. 3H] vesamicol binding in the temporal cortex of patients with Alzheimer's disease, Parkinson's disease, and rats with basal forebrain lesions. Neuroscience 35, 327-333.
42. SCHMIDT, R.H., and GRADY, M.S. (1995). Loss of forebrain cholinergic neurons following fluid-percussion injury: implications for cognitive impairment in closed head injury. J. Neurosurg. 3, 496-502.
43. SINSON, G., VODDI, M., and McINTOSH, T.K. (1995). Nerve growth factor administration attenuates cognitive but not neurobehavioral motor dysfunction or hippocampal cell loss following fluid-percussion brain injury in rats. J. Neurosurg. 65, 2209-2216.
44. SMITH, D.H., OKIYAMA, K., THOMAS, M.J., CLAUSSEN, B., and McINTOSH, T.K. (1991). Evaluation of memory dysfunction following experimental brain injury using the Morris water maze. J. Neurotrauma 8, 259-269.
45. SMITH, D.H., SOARES, H.D., PIERCE, J.S., et al. (1995). A model of parasagittal controlled cortical impact in the mouse: cognitive and histopathologic effects. J. Neurotrauma 12, 169-178.
46. SCARES, H.D., SINSON, G.P., and McINTOSH, T.K. (1995). Fetal hippocampal transplants CA3 pyramidal cell deth resulting from fluid percussion brain injury in the rat. J. Neurotrauma 12, 1059-1067.
47. SUTTON, R.L., LESCAUDRON, L.L., and STEIN, D.G. (1993). Controlled cortical contusion in the rat: vascular disruption and temporal development of cortical necrosis. J. Neurotrauma 10, 135-149.
48. USDIN, T.B., EIDEN, L.E., BONNER, T.I., and ERICKSON, J.D. (1995). Molecular biology of the vesicular ACh transporter. Trends Neurosci. 18, 218-224.
49. WEI, J., WALTON, E.A., MILICI, A., and BUCCAFUSCO, J.J. (1994). M1-m5 muscarinic receptor distribution in rat CNS by RT-PCR and HPLC. J. Neurochem. 63, 815-821.
50. YAKOLEV, A.G., and FADEN, A.I. (1995). Molecular biology of CNS injury. J. Neurotrauma 12, 767-777.