Depression of glutathione content, elevation of CYP2E1-dependent activation, and the principal determinant of the fasting-mediated enhancement of 1,3-dichloro-2-propanol hepatotoxicity in the rat

Food and Chemical Toxicology

Volumn 37, Issue 4, 1999, Pages 351-355

  Fry, J R ^a   Sinclair, D ^a   Piper, C Holly ^a   Townsend, S L ^a   Thomas, N W ^a  

^a QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

1,3 Dichloropropanol; CYP2E1; Fasting; Glutathione; Hepatotoxicity; Rat

Indexed keywords

CYTOCHROME P450; GLUTATHIONE; PROPANOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; ENZYME ACTIVATION; ENZYME ACTIVITY; LIVER TOXICITY; LIVER WEIGHT; MALE; NONHUMAN; RAT;

ALPHA-CHLOROHYDRIN; ANIMALS; CYTOCHROME P-450 CYP2E1; ENZYME ACTIVATION; FASTING; GLUTATHIONE; LIVER DISEASES; MALE; ORGAN SIZE; PROTEINS; RATS; RATS, WISTAR; TOXICITY TESTS;

EID: 0032783125     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(99)00012-5     Document Type: Article

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