Chemotyping of yeast mutants using robotics

Yeast

Volumn 15, Issue 10 B, 1999, Pages 973-986

  Rieger, Klaus Jörg ^a,b,d   El Alama, Mohamed ^b,e   Stein, Georg ^c   Bradshaw, Charles ^b,e   Slonimski, Piotr P ^a   Maundrell, Kinsey ^b,e  

^a CENTRE DE GÉNÉTIQUE MOLÉCULAIRE   (France)

^b GLAXOSMITHKLINE   (United States)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d CNRS   (France)

^e SERONO PHARMACEUTICAL RES INSTITUTE   (Switzerland)

Author keywords

Drug sensitivity resistance; Functional analysis; Genome; Robotics; Saccharomyces cerevisiae

Indexed keywords

ARTICLE; CHEMICAL ANALYSIS; CHEMOTYPE; CHROMOSOME 3; COMPUTER PROGRAM; FUNGAL GENETICS; FUNGUS MUTANT; GENE DELETION; GENOTYPE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; ROBOTICS; YEAST;

SACCHAROMYCES CEREVISIAE;

EID: 0032782142     PISSN: 0749503X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1097-0061(199907)15:10b<973::aid-yea402>3.0.co;2-l     Document Type: Article

References (43)

1. Alexis Biochemicals Catalog (1997/98). Apoptosis. Cell Trafficking and Signal Transduction. Alexis Corporation, Alte Hauensteinstrasse 4, CH-4448 Läufelingen, Switzerland.
2. Aronow, B., Toll, D., Patrick, J., Hollingsworth, P., McCartan, K. and Ullman, B. (1986). Expression of a novel high-affinity purine nucleobase transport function in mutant mammalian T lymphoblasts. Mol. Cell. Biol. 6, 2957-2962.
3. Austriaco, N. R. Jr (1996). Review: to bud until death: the genetics of ageing in the yeast Saccharomyces. Yeast 12, 623-630.
4. Baudin, A., Ozier-Kalogeropoulos, O., Denouel, A., Lacroute, F. and Cullin, C. (1993). A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae. Nucleic Acids Res. 21, 3329-3330.
5. Becker, M. A. and Kim, M. (1987). Regulation of purine synthesis de novo in human fibroblasts by purine nucleotides and phosphoribosylpyrophosphate. J. Biol. Chem. 262, 14 531-14 537.
6. Bertani, L. E. and Campbell, J. L. (1994). The isolation and characterization of the gene (dfr1) encoding dihydrofolate reductase (DHFR) in Schizosaccharomyces pombe. Gene 147, 131-135.
7. Boguslawski, G. (1992). PBS2, a yeast gene encoding a putative protein kinase, interacts with the RAS2 pathway and affects osmotic sensitivity of Saccharomyces cerevisiae. J. Gen. Microbiol. 138, 2425-2432.
8. Bonangelino, C. J., Catlett, N. L. and Weisman, L. S. (1997). Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology. Mol. Cell. Biol. 17, 6847-6858.
9. 2+ mobilization pathways at the vacuolar membrane of Candida albicans. J. Biol. Chem. 270, 7272-7280.
10. Castano, I. B., Heath-Pagliuso, S., Sadoff, B. U., Fitzhugh, D. J. and Christman, M. F. (1996). A novel family of TRF (DNA topoisomerase I-related function) genes required for proper nuclear segregation. Nucleic Acids Res. 24, 2404-2410.
11. Chetelat, A., Albertini, S., Dresp, J. H., Strobel, R. and Gocke, E. (1993). Photomutagenesis test development: I. 8-Methoxysporalen, chlorpromazine and sunscreen compounds in bacterial and yeast assays. Mutat. Res. 292, 241-250.
12. Chong, J. P. J., Mahbubani, H. M., Khoo, C.-Y. and Blow, J. J. (1995). Purification of an MCM-containing complex as a component of the DNA replication licensing system. Nature 375, 418-421.
13. Coates, P. J., Jamieson, D. J., Smart, K., Prescott, A. R. and Hall, P. A. (1997). The prohibitin family of mitochondrial proteins regulate replicative lifespan. Curr. Biol. 7, 607-610.
14. De Risi, J. L., Iyer, V. R. and Brown, P. O. (1997). Exploring the metabolic and genetic control of gene expression on a genomic scale. Science 278, 680-686.
15. Du, L. L., Collins, R. N. and Novick, P. J. (1998). Identification of a Sec4p GTPase-activating protein (GAP) as a novel member of a Rab GAP family. J. Biol. Chem. 273, 3253-3256.
16. Felix, M. A., Pines, J., Hunt, T. and Karsenti, E. (1989). Temporal regulation of cdc2 mitotic kinase activity and cyclin degradation in cell-free extracts of Xenopus eggs. J. Cell Sci. Suppl. 12, 99-116.
17. Goffeau, A., Park, J., Paulsen, I. T., Jonniaux, J. L., Dinh, T., Mordant, P. and Saier, M. H. Jr (1997). Multidrug-resistant transport proteins in yeast: complete inventory and phylogenetic characterization of yeast open reading frames with the major facilitator superfamily. Yeast 13, 43-54.
18. Holthuis, J. C. M., Nichols, B. J., Dhruvakumar, S. and Pelham, H. R. B. (1998). Two syntaxin homologues in the TGN/endosomal system of yeast. EMBO J. 17, 113-126.
19. Huhse, B., Rehling, P., Albertini, M., Meller, K. and Kunau, W. H. (1998). Pex17p of Saccharomyces cerevisiae is a novel peroxin and component of the peroxisomal protein translocation machinery. J. Cell Biol. 140, 49-60.
20. Jensen, E. C., Ogg, C. and Nickerson, K. W. (1992). Lipoxygenase inhibitors shift the yeast/mycelium dimorphism in Ceratocystis ulmi. Appl. Environ. Microbiol. 58, 2505-2508.
21. Johnson, J. L., Rajagopalan, K. V. and Cohen, H. J. (1974). Molecular basis of the biological function of molybdenum. J. Biol. Chem. 249, 859-866.
22. Kuge, S., Jones, N. and Nomoto, A. (1997). Regulation of yAP-1 nuclear localization in response to oxidative stress. EMBO J. 16, 1710-1720.
23. Kule, C., Ondrejickova, O. and Verner, K. (1994). Doxorubicin, daunorubicin, and mitoxantrone cytotoxicity in yeast. Mol. Pharmacol. 46, 1234-1240.
24. Kustimur, S., Memis, L., Kilinc, M. and Ercan, Z. S. (1997). Effect of nordihydroguaretic acid and fluconazole on the LTC4/PGE2 ratio in the kidney of mice damaged by Candida albicans, Prostaglandins Leukot. Essent. Fatty Acids 56, 281-283.
25. Lesuisse, E., Casteras-Simon, M. and Labbe, P. (1996). Evidence for the Saccharomyces cerevisiae ferrireductase system being a multicomponent electron transport chain. J. Biol. Chem. 271, 13 578-13 583.
26. Loukin, S. and Kung, C. (1995). Manganese effectively supports yeast cell-cycle progression in place of calcium. J. Cell. Biol. 131, 1025-1037.
27. Matviw, H., Yu, G. and Young, D. (1993). Identification and genetic analysis of Schizosaccharomyces pombe cDNAs that suppress deletion of 1RA1 in Saccharomyces cerevisiae. Gene 129, 147-152.
28. Morino, Y., Kojima, H. and Tanase, S. (1979). Affinity labeling of alanine aminotransferase by 3-chloro-L-alanine. J. Biol. Chem. 254, 279-285.
29. Nelissen, B., De Wachter, R. and Goffeau, A. (1997). Classification of all putative permeases of the major facilitator superfamily encoded by the complete genome of Saccharomyces cerevisiae. FEMS Microbiol Rev. 21, 113-134.
30. Patel, S., Sprung, A. U., Keller, B. A., Heaton, V. J. and Fisher, L. M. (1997). Identification of yeast DNA topoisomerase II mutants resistant to the antitumor drug doxorubicin: implications for the mechanisms of doxorubicin action and cytotoxicity. Mol. Pharmacol. 52, 658-666.
31. Pearce, D. A. and Sherman, F. (1997). BTN1, a yeast gene corresponding to the human gene responsible for Batten's disease, is not essential for viability, mitochondrial function, or degradation of mitochondrial ATP synthase. Yeast 13, 691-697.
32. Pearson, B. M., Hernando, Y. and Schweizer, M. (1998). Construction of PCR-ligated long flanking homology cassettes for use in the functional analysis of six unknown open reading frames from the left and right arms of Saccharomyces cerevisiae chromosome XV. Yeast 14, 391-399.
33. Poli, F., Pancaldi, S., Dall'Olio, G. and Fasulo, M. P. (1995). Morphogenetic effects induced by spermine and ruthenium red in yeasts. Cytobios. 81, 201-211.
34. Rieger, K.-J., Kaniak, A., Coppée, J.-Y., Aljinovic, G., Baudin-Baillieu, A., Orlowska, G., Gromadka, R., Groudinsky, O., di Rago, J.-P. and Slonimski, P. P. (1997). Large-scale phenotypic analysis - the pilot project on yeast chromosome III. Yeast 13, 1547-1562.
35. Rieger, K.-J., Orlowska, G., Kaniak, A., Coppée, J.-Y., Aljinovic, G. and Slonimski, P. P. (1998). Large-scale phenotypic analysis in microtiter plates of mutants with deleted open reading frames from yeast chromosome III: key-step between genomic sequencing and protein function. Methods in Microbiology. Automation, Academic Press (in press).
36. Ruiz, T. and Todriguez, L. (1986). Effect of anticalmodulin drugs on the action of yeast alpha factor pheromone. Arch. Microbiol. 145, 104-106.
37. Tachikawa, H., Funahashi, W., Takeuchi, Y., Nakanishi, H., Nishihara, R., Katoh, S., Gao, X. D., Mizunaga, T. and Fujimoto, D. (1997). Overproduction of Mpd2p suppresses the lethality of protein disulfide isomerase depletion in a CXXC sequence dependent manner. Biochem. Biophys. Res. Commun. 239, 710-714.
38. Tang, H. Y. and Cai, M. (1996). The EH-domain-containing protein Pan1 is required for normal organization of the actin cytoskeleton in Saccharomyces cerevisiae. Mol. Cell. Biol. 16, 4897-4914.
39. Verna, J., Lodder, A., Lee, K., Vagts, A. and Ballester, R. (1997). A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae. Proc. Natl Acad. Sci. USA 94, 13 804-13 809.
40. Wendland, B. and Emr, S. D. (1998). Pan1p, yeast eps15, functions as a multivalent adaptor that coordinates protein-protein interactions essential for endocytosis. J. Cell. Biol. 141, 71-84.
41. Yu, P. H. (1994). Pharmacological and clinical implications of MAO-B inhibitors. Gen. Pharmacol. 25, 1527-1539.
42. Zhao, H. and Eide, D. J. (1997). Zap1, a metalloregulatory protein involved in zinc-responsive transcriptional regulation in Saccharomyces cerevisiae. Mol Cell. Biol. 17, 5044-5052.
43. Zumstein, E., Pearson, B. M., Kalogeropoulos, A. and Schweizer, M. (1995). A 29.425 kb segment on the left arm of yeast chromosome XV contains more than twice as many unknown as known open reading frames. Yeast 11, 975-986.