Multidrug-resistant transport proteins in yeast: Complete inventory and phylogenetic characterization of yeast open reading frames within the major facilitator superfamily

Yeast

Volumn 13, Issue 1, 1997, Pages 43-54

  Goffeau, André ^a   Park, Jay ^b   Paulsen, Ian T ^b   Jonniaux, Jean Luc ^a   Dinh, Thien ^b   Mordant, Philippe ^a   Saier Jr , Milton H ^b  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Drug resistance; MFS; Transport; Yeast

Indexed keywords

ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; GENE CLUSTER; MULTIDRUG RESISTANCE; NONHUMAN; OPEN READING FRAME; PHYLOGENY; PRIORITY JOURNAL; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE;

AMINO ACID SEQUENCE; CARRIER PROTEINS; DRUG RESISTANCE, MULTIPLE; FUNGAL PROTEINS; GENOME, FUNGAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; OPEN READING FRAMES; PROTEIN CONFORMATION; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; YEASTS;

EID: 0031020837     PISSN: 0749503X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0061(199701)13:1<43::AID-YEA56>3.0.CO;2-J     Document Type: Article

References (44)

1. Altschul, S. F., Gish, W., Miller, W., Myers, E. W. and Lipman, D. J. (1990). Basic local alignment search tool. J. Mol. Biol. 215, 403-410.
2. Altschul, S. F., Boguski, M. S., Gish, W. and Wootton, J. C. (1994). Issues in searching molecular sequence data bases. Nature Genetics 6, 119-129.
3. Amakasu, H., Suzuki, Y., Nishizawa, M. and Fukasawa, T. (1993). Isolation and characterization of SGE1: a yeast gene that partially suppresses the gal11 mutation in multiple copies. Genetics 134, 675-683.
4. André, B. (1995). An overview of membrane transport proteins in Saccharomyces cerevisiae. Yeast 11, 1575-1611.
5. Baldwin, S. A. (1993). Mammalian passive glucose transporters: members of an ubiquitous family of active and passive transport proteins. Biochim. Biophys. Acta 115, 17-49.
6. Balzi, E. and Goffeau, A. (1995). Yeast multidrug resistance: the PDR network. J. Bioenerg. Biomem. 27, 71-76.
7. Ben-Yaacov, R., Knoller, S., Caldwell, G. A., Becker, J. M. and Koltin, Y. (1994). Candida albicans gene encoding resistance to benomyl and methotrexate is a multidrug resistance gene. Antimicrob. Agents Chemother. 38, 648-652.
8. Cherry, J. M. (1995). Genetic nomenclature guide. Yeast, Saccharomyces cerevisiae (Elsevier). Trends in Genetics 11-12.
9. Claros, M. and von Heijne, G. (1994). Toppred II-An improved software for membrane protein structure predictions. Comput. Applic. Biosci. 10, 685-686.
10. Dayhoff, M. O., Barker, W. C. and Hunt, L. T. (1983). Establishing homologies in protein sequences. Methods Enzymol. 91, 524-545.
11. Decottignies, A., Kolaczkowski, M., Balzi, E. and Goffeau, A. (1994). Solubilization and characterization of the overexpressed PDR5 multidrug resistance nucleotide triphosphatase of yeast. J. Biol. Chem. 269, 12797-12803.
12. Decottignies, A., Lambert, L., Catty, P., et al. (1995). Identification and characterization of SNQ2, a new multidrug ATP binding cassette transporter of the yeast plasma membrane. J. Biol. Chem. 270, 18150-18157.
13. Dujon, B., et al. (1994). Complete DNA sequence of yeast chromosome XI. Nature 369, 371-378.
14. Ehrenhofer-Murray, A. E., Würgler, F. E. and Sengstag, (1994). The Saccharomyces cerevisiae SGE1 gene product: a novel drug-resistance protein within the major facilitator superfamily. Mol. Gen. Genet. 244, 287-294.
15. Feldmann, H., et al. (1994). Complete DNA sequence of yeast chromosome II. EMBO J. 13, 5795-5809.
16. Fling, M. E., Kopf, J., Tamarkin, A., Gorman, J. A., Smith, H. A. and Koltin, Y. (1991). Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate. Mol. Gen. Genet. 227, 318-329.
17. Goffeau, A. and Slayman, C. (1981). The protontranslocating ATPase of the fungal plasma membrane. Biochim. Biophys. Acta 639, 197-223.
18. Goffeau, A., Slonimski, P. P., Nakai, K. and Risler, J. L. (1993). How many yeast genes code for membrane spanning proteins? Yeast 9, 692-702.
19. Gompel-Klein, P. and Brendel, M. (1990). Allelism of SNQ1 and ATR1 genes of the yeast Saccharomyces cerevisiae required for controlling sensitivity to 4-nitroquinoline-N-oxide and aminotriazole. Curr. Genet. 18, 93-96.
20. Gottesman, M. and Pastan, I. (1993). Biochemistry of multidrug resistance mediated by the multidrug transporter. Ann. Rev. Biochem. 62, 385-427.
21. Griffith, J. J., Baker, M. E., Rouch, D. A., et al. (1992). Membrane transport proteins: implications of sequence comparisons. Cell Biol. 4, 684-695.
22. Henderson, P. J. and Maiden, M. C. (1990). Homologous sugar transport proteins in Escherichia coli and their relatives in both prokaryotes and eukaryotes. Phil. Trans. R. Soc. Lond. B 326, 391-410.
23. Jia, Z.-P., McCullough, N., Wong, L. and Young, P. G. (1993). The amiloride resistance gene car1 of Schizosaccharomyces pombe. Mol. Gen. Genet. 241, 298-304.
24. Johnston, M., et al. (1994). Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII. Science 265, 2077-2082.
25. Kanazawa, S., Driscoll, M. and Struhl, K. (1988). Saccharomyces cerevisiae gene encoding a transmembrane protein required for aminotriazole resistance. Mol Cell. Biol. 8, 664-673.
26. Karlin, S. and Altschul, F. (1993). Applications and statistics for multiple high-scoring segments in molecular sequences. Proc. Natl. Acad. Sci. USA 90, 5873-5877.
27. Klein, P., Kanehisa, M. and Delici, C. (1985). The detection and classification of membrane-spanning proteins. Biochim. Biophys. Acta 815, 468-476.
28. Koonin, E. V., Bork, P. and Sander, C. (1994). Yeast chromosome III: new gene functions. EMBO J. 13, 493-503.
29. Kuan, G., Dassa, E., Saurin, W., Hofnung, M. and Saier, M. Jr. (1995). Phylogenetic analysis of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases. Res. Microbiol. 146, 271-278.
30. Kyte, J. and Doolittle, R. (1982). A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157, 105-132.
31. Lewis, K. (1994). Multidrug resistance pumps in bacteria: variations on a theme. Trends Biochem. Sci. 19, 119-123.
32. Marger, M. D. and Saier, M. Jr. (1993). A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport. Trends Biochem. Sci. 18, 13-20.
33. Mossé, M. O., Linder, P., Lazowska, J. and Slonimski, P. P. (1993). A comprehensive compilation of 1001 nucleotide sequences coding for proteins from the yeast Saccharomyces cerevisiae (ListA2). Curr. Genet. 23, 66-91.
34. Murakami, et al. (1995). Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae. Nature Genetics 10, 261-268.
35. Nelissen, B., Mordant, P., Jonniaux, J. L., De Wachter, R. and Goffeau, A. (1995). Phylogenetic classification of the major superfamily of membrane transport facilitators as deduced from yeast genome sequencing. FEBS Letters 377, 232-236.
36. Oliver, S. G., et al. (1992). The complete DNA sequence of yeast chromosome III. Nature 357, 38-46.
37. Paulsen, I. and Skurray, R. (1993). Topology, structure and evolution of 2 families of proteins involved in antibiotic and antiseptic resistance in eukaryotes and prokaryotes-an analysis. Gene 124, 1-11.
38. Paulsen, I., Skurray, R., Tam, R., et al. (1995). The SMR family: a novel family of multidrug pumps involved with the efflux of lipophilic drugs. Molec. Microbiol., in press.
39. Pearson, W. R. and Lipman, D. J. (1988). Improved tools for biological sequence comparison. Proc. Natl. Acad. Sci. USA 87, 2264-2268.
40. Saier, M. H. Jr. (1994). Computer-aided analyses of transport protein sequences: gleaning evidence concerning function, structure, biogenesis and evolution. Microbiol. Revs. 58, 71-93.
41. Saier, M. H. Jr., Tam, R., Reizer, A. and Reizer, J. (1994). Two novel families of bacterial membrane proteins concerned with nodulation, cell division and transport. Molec. Microbiol. 11, 841-847.
42. Sasnauskas, K., Jomatiene, R., Lebedys, E., Januska, J. and Janulaitis, A. (1992). Cloning and sequence analysis of a Candida maltosa gene which confers resistance to cycloheximide. Gene 116, 105-108.
43. Slonimski, P. P. and Brouillet, S. (1993). A data-base of chromosome III of Saccharomyces cerevisiae. Yeast 9, 941-1030.
44. Yelin, R. and Schuldiner, S. (1995). The pharmaceutical profile of the vesicular monoamine transporter resembles that of multidrug transporters. FEBS Letters 377, 201-207.