Expression of CD69 on T-cells from HIV-1-infected children and adolescents increases with increasing viral load

European Journal of Pediatrics

Volumn 158, Issue 8, 1999, Pages 638-644

  Bohler T ^a   Walcher, J ^a   Holzl Wenig G ^a   Schnitzler, P ^b   Geiss, M ^b   Buchholz, B ^b   Linde, R ^c   Rutschle H ^d   Debatin, K M ^a,e  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c GOETHE UNIVERSITY   (Germany)

^d Children's Hospital St Anna Stift   (Germany)

^e UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

Activation; CD69; Children; HIV 1; T cells

Indexed keywords

CD4 ANTIGEN; CD69 ANTIGEN; CD8 ANTIGEN;

ADOLESCENT; ANTIGEN EXPRESSION; ARTICLE; CELL DEATH; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; T LYMPHOCYTE ACTIVATION; VIRUS LOAD;

ADOLESCENT; ANTIGENS, CD; CHILD; CHILD, PRESCHOOL; EVALUATION STUDIES; FEMALE; FLOW CYTOMETRY; HIV INFECTIONS; HIV-1; HUMANS; MALE; T-LYMPHOCYTES; VIRAL LOAD;

EID: 0032780233     PISSN: 03406199     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004310051167     Document Type: Article

References (30)

1. + T cell homeostasis and function in advanced HIV disease. Science 277:112-116
2. Baier-Bitterlich G, Fuchs D, Wachter H (1997) Chronic immune stimulation, oxidative stress, and apoptosis in HIV infection. Biochem Pharmacol 53:755-763
3. Bäumler CB, Böhler T, Herr I, Benner A, Krammer PH, Debatin K-M (1996) Activation of the CD95 (APO-1/Fas) system in T cells from human immunodeficiency type-1-infected children. Blood 88:1741-1746
4. Böhler T, Bäumler C, Herr I, Groll A, Kurz M, Debatin K-M (1997) Activation of the CD95 system increases with disease progression in human immunodeficiency virus type 1-infected children and adolescents. Pediatr Infect Dis J 16:754-759
5. Böhler T, Herr I, Debatin K-M, Geiss M, Haas J (1997) Downregulation of increased CD95 (APO-1/Fas) ligand in T cells from human immunodeficiency virus-type 1-infected children after antiretroviral therapy. Blood 90:886-887
6. Böhler T, Nedel S, Debatin K-M (1997) CD95-induced apoptosis contributes to loss of primed/memory but not resting/naive T cells in children infected with human immunodeficiency virus type 1. Pediatr Res 41:878-885
7. Caruso A, Licenziati S, Canaris AD, Corulli M, De Francesco MA, Cantalamessa A, Fallacara F, Fiorentini S, Balsari A, Turano A (1997) T cells from individuals in advanced stages of HIV-1 infection do not proliferate but express activation antigens in response to HIV-1-specific antigens. J Acquir Immune Defic Syndr 15:61-69
8. Caruso A, Licenziati S, Corulli M, Canaris AD, De Francesco MA, Fiorentini S, Peroni L, Fallacara F, Dima F, Balsari A, Turano A (1997) Flow cytometric analysis of activation markers on stimulated T cells and their correlation with cell proliferation. Cytometry 27:71-76
9. + T-cell determinations in persons with human immunodeficiency virus infection. MMWR 41 (RR-8):1-17
10. Centers for Disease Control (1994) Revised classification system for human immunodeficiency virus infection in children less than 13 years of age. MMWR 43 (RR-12):1-10
11. Chen JC, Davis BH, Leon MA, Leong LC (1997) Gamma radiation induces CD69 expression on lymphocytes. Cytometry 30:304-312
12. European Collaborative Study (1994) CD4 T cell count as a predictor of pneumocystis carinii pneumonia in children born to mothers infected with HIV. B M J 308:437-440
13. Funk M, Mentzer D, Klarmann D, Cinatl J, Kreuz W, Kornhuber B (1997) Viral load and syncytium inducing HIV-1 variants indicate progression of perinatal HIV-infection. Eur J Pediatr 90:339
14. Gougeon ML, Lecoeur H, Dulioust A, Enouf MG, Crovoisier M, Goujard C, Debord T, Montagnier L (1996) Programmed cell death in peripheral lymphocytes from HIV-infected persons. J Immunol 156:3509-3520
15. Hickey TE, Blair PJ, Perfetto S, Smoot DS, Wagner KF, St. Louis DC, Mayers DL, Siegel JN, June CH (1996) Intact antigen receptor-mediated calcium signals in patients with early stage HIV-1 infection. J Immunol 156:4012-4017
16. Klas C, Debatin K-M, Jonker RR, Krammer PH (1993) Activation interferes with the APO-1 pathway in mature human T-cells. Int Immunol 5:625-630
17. Krowka JF, Cuevas B, Maron DC, Steimer KS, Ascher MS, Sheppard HW (1996) Expression of CD69 after in vitro stimulation: a rapid method for quantitating impaired lymphocyte responses in HIV-infected individuals. J Acquir Immune Defic Syndr 11:95-104
18. Levy J (1993) Pathogenesis of human immunodeficiency virus infection. Microbiol Rev 57:183-289
19. Maino VC, Suni MA, Ruitenberg JJ (1995) Rapid flow cytometric method for measuring lymphocyte subset activation. Cytometry 20:127-133
20. Pachl C, Todd JA, Kern DG, Sheridan PJ, Fong SJ, Stempien M, Hoo B, Besemer D, Yeghiazarian T, Irvine B, Kolberg J, Kokka R, Neuwald P, Urdea MS (1995) Rapid and precise quantification of HIV-1 RNA in plasma using a branched DNA signal amplification system. J Acquir Immune Defic Syndr 8:446-454
21. Pediatric European Network for Treatment of AIDS (PENTA) (1998) HIV-1 viral load and CD4 cell count in untreated children with vertically acquired asymptomatic or mild disease. AIDS 12:F1-F8
22. Perfetto SP, Hickey TE, Blair PJ, Maino VC, Wagner KF, Zhou S, Mayers DL, St Louis D, June CH, Siegel JN (1996) Measurement of CD69 induction in the assessment of immune function in asymptomatic HIV-infected individuals. Cytometry 30:1-9
23. Roilides E, Clerici M, DePalma L, Rubin M, Pizzo PA, Shearer GM (1991) Helper T-cell responses in children infected with human immunodeficiency virus type 1. J Pediatr 118:724-730
24. Rümmelein N, Wintergerst U, Belohradsky BH (1998) Prophylaxis of Pneumocystis carinii Pneumonia in HIV-infected children one to five years old: a multicenter surveillance study in paediatric hospitals in Germany. Infection 26:135
25. Saag MS, Holodniy M, Kuritzkes DR, O'Brien WA, Coombs R, Poscher ME, Jacobsen DM, Shaw GM, Richman DD, Volberding PA (1996) HIV viral load markers in clinical practice. Nature Med 2:625-629
26. Shearer WT, Quinn TC, LaRussa P, Lew JF, Mofenson L, Almy S, Rich K, Handelsman E, Diaz C, Pagano M, Smeriglio V, Kalish LA (1997) Viral load and disease progression in infants infected with human immunodeficiency virus type 1. N Engl J Med 336:1337-1342
27. + T cells. Blood 90:1588-1593
28. Testi R, D'Ambrosio D, De Maria R, Santoni A (1994) The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells. Immunol Today 5:479-483
29. Wahn V, Landwehr-Dobberstein C, Enenkel-Stoodt S, Debatin K-M, Ganschow R, Belohradsky BH, Wintergerst U, Grosch-Wörner I (1998) Is the lymphocyte transformation test with mitogens a useful predictor for AIDS-defining events in children born to HIV-infected mothers? Results of the German multicenter study. Pädiatrie Grenzgeb (in press)
30. Westendorp MO, Frank R, Ochsenbauer C, Stricker K, Dhein J, Walczak H, Debatin KM, Krammer PH (1995) The mechanism of HIV Tat and gp120-sensitized T cell apoptosis. Nature 375:497-500